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Article: DNA-nanostructure-templated assembly of planar and curved lipid-bilayer membranes.

Elbahnasawy, Mostafa A / Nasr, Mahmoud L

2023 Volume 10, Page(s) 1047874

Abstract: Lipid-bilayer nanodiscs and liposomes have been developed to stabilize membrane proteins in order to study their structures and functions. Nanodiscs are detergent-free, water-soluble, and size-controlled planar phospholipid-bilayer platforms. On the ... ...

Abstract	Lipid-bilayer nanodiscs and liposomes have been developed to stabilize membrane proteins in order to study their structures and functions. Nanodiscs are detergent-free, water-soluble, and size-controlled planar phospholipid-bilayer platforms. On the other hand, liposomes are curved phospholipid-bilayer spheres with an aqueous core used as drug delivery systems and model membrane platforms for studying cellular activities. A long-standing challenge is the generation of a homogenous and monodispersed lipid-bilayer system with a very wide range of dimensions and curvatures (elongation, bending, and twisting). A DNA-origami template provides a way to control the shapes, sizes, and arrangements of lipid bilayers
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2022.1047874
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Article ; Online: Ecofriendly preparation of silver nanoparticles-based nanocomposite stabilized by polysaccharides with antibacterial, antifungal and antiviral activities.

Hasanin, Mohamed / Elbahnasawy, Mostafa A / Shehabeldine, Amr M / Hashem, Amr H

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

2021 Volume 34, Issue 6, Page(s) 1313–1328

Abstract: In the present work, sustainable and green method was used to prepare silver nanoparticles (Ag-NPs), followed with incorporation into tertiary nanocomposite consisted of starch, oxidized cellulose and ethyl cellulose. The prepared tertiary silver- ... ...

Abstract	In the present work, sustainable and green method was used to prepare silver nanoparticles (Ag-NPs), followed with incorporation into tertiary nanocomposite consisted of starch, oxidized cellulose and ethyl cellulose. The prepared tertiary silver-nanocomposite (Ag-NC) was fully characterized via instrumental analysis (UV-vis, FT-IR, XRD, SEM, EDX and TEM) and evaluated for antibacterial, antifungal, and antiviral activities. Ag-NC significantly suppressed growth of tested bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis) as compared with controls. Antifungal activity revealed that the prepared tertiary Ag-NC has a promising antifungal activity towards unicellular (Candida albicans) and multicellular fungi ( Aspergillus niger, A. terreus, A. flavus and A. fumigatus). In same line, both Ag-NC and free Ag-NPs have shown a dose-dependent reduction in Vero cell line with maximum non-toxic dose at 6.25 and 12.5 μg/mL, respectively. Both Ag-NPs and Ag-NC exhibited antiviral effects against Herpes simplex virus, Adenovirus and Coxsackie B virus in a dose-dependent manner. Combined treatment of Ag-NPs incorporated into tertiary nanocomposite based on starch, oxidized cellulose and ethyl cellulose opens new possibilities to be more efficient nanomaterials for preventing microbial growth. In conclusion, the prepared tertiary Ag-NC has a promising antibacterial, antifungal as well as antiviral activities.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Antiviral Agents/pharmacology ; Bacillus subtilis/metabolism ; Metal Nanoparticles/chemistry ; Microbial Sensitivity Tests ; Nanocomposites/chemistry ; Silver/chemistry ; Silver/pharmacology ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Anti-Bacterial Agents ; Antifungal Agents ; Antiviral Agents ; Silver (3M4G523W1G)
Language	English
Publishing date	2021-09-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1112688-7
ISSN	1572-8773 ; 0966-0844
ISSN (online)	1572-8773
ISSN	0966-0844
DOI	10.1007/s10534-021-00344-7
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Article: Photocatalytic and Antimicrobial Activities of Biosynthesized Silver Nanoparticles Using

Saied, Ebrahim / Hashem, Amr H / Ali, Omar M / Selim, Samy / Almuhayawi, Mohammed S / Elbahnasawy, Mostafa A

Life (Basel, Switzerland)

2022 Volume 12, Issue 9

Abstract: The toxicity of the ecosystem has increased recently as a result of the increased industrial wastewater loaded with organic contaminants, including methylene blue (MB), which exerts serious damage to the environment. Thus, the present work aims to green ... ...

Abstract	The toxicity of the ecosystem has increased recently as a result of the increased industrial wastewater loaded with organic contaminants, including methylene blue (MB), which exerts serious damage to the environment. Thus, the present work aims to green the synthesis of silver nanoparticles (Ag-NPs) and to evaluate their degradability of notorious MB dye, as well as their antimicrobial activities. Ag-NPs were synthesized by
Language	English
Publishing date	2022-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12091331
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Article: Newly isolated coliphages for bio-controlling multidrug-resistant Escherichia coli strains

Elbahnasawy, Mostafa A. / ElSayed, ElSayed E. / Azzam, Mohamed I.

Environmental nanotechnology, monitoring & management. 2021 Dec., v. 16

2021

Abstract: This study presents a novel coliphage-based approach for biocontrol of Multidrug-Resistant (MDR) Escherichia coli (E. coli) and coliforms in wastewater and improve the physicochemical water quality . Newly isolated coliphages and E. coli strains were ... ...

Abstract	This study presents a novel coliphage-based approach for biocontrol of Multidrug-Resistant (MDR) Escherichia coli (E. coli) and coliforms in wastewater and improve the physicochemical water quality . Newly isolated coliphages and E. coli strains were isolated from the Rosetta branch of River Nile and outlet points of five associated drains. Coliphages were characterized by transmission electron microscopy and coat protein-gene analyses. The isolated coliphages PR01, PR02, and PR03 belonged to the Siphoviridae, Myoviridae, and Podoviridae families, respectively. They exhibited, separately or in a cocktail, a wide host range pattern against wild E. coli strains with higher specificity to strains isolated from drains (87%) than those of the Rosetta branch (72%). Phage-sensitive E. coli strains exhibited elevated antibiotics resistance patterns, suggesting that they are MDR strains. Interestingly, the efficacy of phages cocktail (PR01/PR02/PR03) controlled the growth of wild MDR E. coli strains and coliform populations under laboratories conditions. The kinetic trend in removal efficiency (%) for coliforms was gradually increasing in a time-dependent manner and peaked at 12 h post incubation with phages mixture. In all water samples, total and fecal coliforms revealed at least a 30-fold reduction post 12 h of treatment with a mixture of coliphages. Physicochemical analyses of phage-treated wastewater showed reducing levels in biological oxygen demand (BOD), chemical oxygen demand (COD), turbidity, electric conductivity (EC), ammonia (NH₃), total dissolved solids (TDS) and nitrate (NO3), while rising in dissolved oxygen (DO) content compared to untreated wastewater. Overall, this study suggests that phage-based treatment could be an effective and cheap alternative approach for the reduction of water pollutants in drainage drainage and waste water and thus eventually enhance the physicochemical quality of water.
Keywords	Escherichia coli ; Myoviridae ; Podoviridae ; Siphoviridae ; administrative management ; ammonia ; biochemical oxygen demand ; biological control ; chemical oxygen demand ; coliform bacteria ; coliphages ; dissolved oxygen ; drainage ; electrical conductivity ; host range ; multiple drug resistance ; nitrates ; transmission electron microscopy ; turbidity ; wastewater ; water quality ; Nile River
Language	English
Dates of publication	2021-12
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2821777-9
ISSN	2215-1532
ISSN	2215-1532
DOI	10.1016/j.enmm.2021.100542
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Article: First report on isolation of

Kalaba, Mohamed H / Sultan, Mahmoud H / Elbahnasawy, Mostafa A / El-Didamony, Samia E / Bakary, Nermeen M El / Sharaf, Mohamed H

Biotechnology reports (Amsterdam, Netherlands)

2022 Volume 36, Page(s) e00770

Abstract: Fungi are potential biocontrol agents and rich sources of secondary metabolites with demonstrated biological activities. This study aimed to isolate and identify fungi from surface-sterilized honeybees ( ...

Abstract	Fungi are potential biocontrol agents and rich sources of secondary metabolites with demonstrated biological activities. This study aimed to isolate and identify fungi from surface-sterilized honeybees (
Language	English
Publishing date	2022-10-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2801018-8
ISSN	2215-017X
ISSN	2215-017X
DOI	10.1016/j.btre.2022.e00770
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Article ; Online: The impact of hepatitis B virus and hepatitis C virus infections in patients with Hodgkin's and non-Hodgkin's lymphoma.

Kadry, Dalia Y / Elbahnasawy, Mostafa A / Mansour, Mohamed Tm / El Gebaly, Omnia K / Aziz, Hala / Kamel, Mahmoud M / Abdel-Moneim, Ahmed S / Radwan, Samah

International journal of immunopathology and pharmacology

2023 Volume 37, Page(s) 3946320231207342

Abstract: Background: This study aimed to determine the prevalence of HCV and occult HBV among newly diagnosed pre-treatment Egyptian lymphoma patients and evaluate patients' outcomes based on the presence of the viral infections.: Methods: The study included ... ...

Abstract	Background: This study aimed to determine the prevalence of HCV and occult HBV among newly diagnosed pre-treatment Egyptian lymphoma patients and evaluate patients' outcomes based on the presence of the viral infections. Methods: The study included 80 therapy-naïve lymphoma patients including 71 non-Hodgkin lymphoma (NHL) and 9 Hodgkin lymphoma disease (HD) in addition to 100 healthy volunteers. HBV screening using HBsAg and anti-HBc IgM and HCV using AB/Ag ELISA and real-time RT-PCR were screened in tested and control groups. The diagnosis was confirmed by histopathology. Overall survival (OS) and progression-free survival (PFS) were conducted to diseased patients. Results: Healthy patients showed 4/100, (4%) active HCV infection and 1/100, (1%) active HBV infection and no occult HBV infection. Among NHL patients, 28 were positive for HBV (6 active and 22 occult HBV infection). Occult HBV was also detected in 5/9 HD patients. HCV was detected in (30/71, 42.3%) of NHL patients and in a single HD patient. Ten occult HBV NHL patients showed a mixed infection with HCV. The incidence of both HCV and HBV are higher in NHL than HL patients. After antitumor treatment, complete remission for lymphoma was achieved in 45% of patients. Both overall survival (OS) and progression-free survival (PFS) were correlated and significantly associated with patients' LDH levels. Conclusions: Our findings claim the suggestive role of HCV and occult HBV infections in NHL but not HL patients in comparison to healthy control, suggesting pre-screening of related factors including occult HBV in for potential better therapy response.
MeSH term(s)	Humans ; Hepatitis B virus/genetics ; Hepacivirus ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis C/complications ; Lymphoma, Non-Hodgkin/epidemiology ; Lymphoma, Non-Hodgkin/etiology ; Lymphoma, Non-Hodgkin/pathology
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/03946320231207342
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Article: Cloning, expression and nanodiscs assemble of recombinant HIV-1 gp41

Elbahnasawy, Mostafa A / El-Ghamery, Abbas A / Farag, MohamedM.S / Mansour, Mohamed T

Microbial pathogenesis. 2019 Oct. 24,

2019

Abstract: Structural studies of membrane proteins have been hurdled by their difficulty for expression in heterogeneous expression systems due to their intrinsically strong hydrophobicity and their requirements for association with other cellular membranes. This ... ...

Abstract	Structural studies of membrane proteins have been hurdled by their difficulty for expression in heterogeneous expression systems due to their intrinsically strong hydrophobicity and their requirements for association with other cellular membranes. This study aims to design a construct for expression of membrane proteins. Because of its outstanding interest in HIV-1 vaccine design, transmembrane gp41 amino acid residue 662–723 was chosen as a representative membrane protein. Therefore, we constructed expression vectors for expression of gp41(662-723) alone (pET28a-gp41(662-723)) or coupled with a fusion partner: GB1 (pET30a-GB1-gp41(662-723)) and Trx (pET32a-Trx-gp41(662-723)). For enhancing protein expression, the expression plasmids were transformed into E. coli BL-21 (DE3), E. coli T7 Express lysY/Iq and E. coli Lemo21 (DE3). Interestingly, HIV-1 gp41(662-723) was expressed as a C-terminus fusion to the fusion partner Trx (Trx-gp41(662-723)) with an apparent molecular mass of 21.8 kDa. Trx-gp41(662-723) was overexpressed into E. coli T7 Express lysY/Iq by early induction as OD600 ∼0.5 followed by incubation at 20 °C/overnight. Our data demonstrated that almost all recombinant Trx-gp41(662-723) was incorporated into lipid nanodiscs by slowing down the nanodiscs assembly process. Negative-stained electron micrographs revealed homogenous 10 nm Trx-gp41(662-723)-nanodiscs. While the neutralizing epitopes in the purified Trx-gp41(662-723) were accessible and recognizable by anti-MPER bNAbs, that epitopes were less accessibly exposed, particularly in the C-terminal region of MPER, after incorporation of Trx-gp41(662-723) into nanodiscs.
Keywords	amino acids ; cell membranes ; epitopes ; Escherichia coli ; genetic vectors ; Human immunodeficiency virus 1 ; hydrophobicity ; lipids ; membrane proteins ; molecular weight ; plasmids ; protein synthesis ; vaccine development
Language	English
Dates of publication	2019-1024
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2019.103824
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Article ; Online: Co-delivery of a CD4 T cell helper epitope via covalent liposome attachment with a surface-arrayed B cell target antigen fosters higher affinity antibody responses.

Elbahnasawy, Mostafa A / Donius, Luke R / Reinherz, Ellis L / Kim, Mikyung

Vaccine

2018 Volume 36, Issue 41, Page(s) 6191–6201

Abstract: Liposomal vaccines incorporating adjuvant and CD4 T cell helper peptides enhance antibody responses against weakly immunogenic B cell epitopes such as found in the membrane proximal external region (MPER) of the HIV-1 gp41 subunit. While the inclusion of ...

Abstract	Liposomal vaccines incorporating adjuvant and CD4 T cell helper peptides enhance antibody responses against weakly immunogenic B cell epitopes such as found in the membrane proximal external region (MPER) of the HIV-1 gp41 subunit. While the inclusion of exogenous helper peptides in vaccine formulations facilitates stronger and more durable antibody responses, the helper peptide incorporation strategy per se may influence the overall magnitude and quality of B cell target antigen immunogenicity. Both variability in individual peptide encapsulation as well as the potential for liposome surface-associated helper peptides to misdirect the humoral response are potential parameters impacting outcome. In this study, we used MPER/liposome vaccines as a model system to examine how the mode of the potent LACK T helper peptide formulation modulates antibody responses against the MPER antigen. We directly compared liposome surface-arrayed palmitoyl LACK (pLACK) versus soluble LACK (sLACK) encapsulated in the liposomes and free in solution. Independent of LACK formulation methods, dendritic cell activation and LACK presentation were equivalent in vivo. The frequency of MPER-specific GC B cells promoted by sLACK was higher than that stimulated by pLACK formulation, a finding associated with a significantly greater frequency of LACK-specific GC B cells induced by pLACK. While there were no significant differences in the quantity of MPER-specific serological responses, the MPER-specific antibody titer trended higher with sLACK formulated vaccines at the lower dose of LACK. However, pLACK generated relatively greater MPER-specific antibody affinities than those induced by sLACK-formulated vaccines. Overall, the results suggest that liposomal surface-associated LACK enhances immunogenicity of LACK through better engagement of LACK-specific B cells. Of note, this is not detrimental to the induction of MPER-specific immune responses; rather, the elicitation of higher affinity anti-MPER antibodies benefits from augmented help delivered via covalent linkage of the pLACK CD4 T cell epitope in conjunction with MPER/liposome presentation.
MeSH term(s)	Animals ; Antibody Formation/physiology ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; Epitopes, T-Lymphocyte/immunology ; Female ; Liposomes/chemistry ; Mice ; Mice, Inbred BALB C ; T-Lymphocytes, Helper-Inducer/immunology
Chemical Substances	Epitopes, T-Lymphocyte ; Liposomes
Language	English
Publishing date	2018-09-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2018.08.014
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Article ; Online: Cloning, expression and nanodiscs assemble of recombinant HIV-1 gp41.

Elbahnasawy, Mostafa A / Farag, Mohamed M S / Mansour, Mohamed T / El-Ghamery, Abbas A

Microbial pathogenesis

2019 Volume 138, Page(s) 103824

Abstract: Structural studies of membrane proteins have been hurdled by their difficulty for expression in heterogeneous expression systems due to their intrinsically strong hydrophobicity and requirements for association with other cellular membranes. This study ... ...

Abstract	Structural studies of membrane proteins have been hurdled by their difficulty for expression in heterogeneous expression systems due to their intrinsically strong hydrophobicity and requirements for association with other cellular membranes. This study aims to design a construct for expression of membrane proteins. Because of its outstanding interest in HIV-1 vaccine design, transmembrane gp41 amino acid residue 662-723 was chosen as a representative membrane protein. Therefore, we constructed expression vectors for expression of gp41
MeSH term(s)	Amino Acid Sequence ; Base Sequence ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; HIV Envelope Protein gp41/chemistry ; HIV Envelope Protein gp41/genetics ; HIV-1/genetics ; Humans ; Protein Folding ; Protein Interaction Domains and Motifs/genetics ; Protein Refolding ; Protein Unfolding ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification
Chemical Substances	HIV Envelope Protein gp41 ; Recombinant Proteins
Language	English
Publishing date	2019-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2019.103824
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Article: Co-delivery of a CD4 T cell helper epitope via covalent liposome attachment with a surface-arrayed B cell target antigen fosters higher affinity antibody responses

Elbahnasawy, Mostafa A / Donius, Luke R / Reinherz, Ellis L / Kim, Mikyung

Vaccine. 2018 Oct. 01, v. 36, no. 41

2018

Abstract	Liposomal vaccines incorporating adjuvant and CD4 T cell helper peptides enhance antibody responses against weakly immunogenic B cell epitopes such as found in the membrane proximal external region (MPER) of the HIV-1 gp41 subunit. While the inclusion of exogenous helper peptides in vaccine formulations facilitates stronger and more durable antibody responses, the helper peptide incorporation strategy per se may influence the overall magnitude and quality of B cell target antigen immunogenicity. Both variability in individual peptide encapsulation as well as the potential for liposome surface-associated helper peptides to misdirect the humoral response are potential parameters impacting outcome. In this study, we used MPER/liposome vaccines as a model system to examine how the mode of the potent LACK T helper peptide formulation modulates antibody responses against the MPER antigen. We directly compared liposome surface-arrayed palmitoyl LACK (pLACK) versus soluble LACK (sLACK) encapsulated in the liposomes and free in solution. Independent of LACK formulation methods, dendritic cell activation and LACK presentation were equivalent in vivo. The frequency of MPER-specific GC B cells promoted by sLACK was higher than that stimulated by pLACK formulation, a finding associated with a significantly greater frequency of LACK-specific GC B cells induced by pLACK. While there were no significant differences in the quantity of MPER-specific serological responses, the MPER-specific antibody titer trended higher with sLACK formulated vaccines at the lower dose of LACK. However, pLACK generated relatively greater MPER-specific antibody affinities than those induced by sLACK-formulated vaccines. Overall, the results suggest that liposomal surface-associated LACK enhances immunogenicity of LACK through better engagement of LACK-specific B cells. Of note, this is not detrimental to the induction of MPER-specific immune responses; rather, the elicitation of higher affinity anti-MPER antibodies benefits from augmented help delivered via covalent linkage of the pLACK CD4 T cell epitope in conjunction with MPER/liposome presentation.
Keywords	B-lymphocytes ; CD4-positive T-lymphocytes ; Human immunodeficiency virus 1 ; adjuvants ; antibodies ; dendritic cells ; encapsulation ; epitopes ; humoral immunity ; immune response ; immunogenicity ; models ; peptides ; vaccines
Language	English
Dates of publication	2018-1001
Size	p. 6191-6201.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2018.08.014
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