Article: Differential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2020 Volume 7, Issue 13, Page(s) 2000323
Abstract: A functional, human, multiorgan, pumpless, immune system-on-a-chip featuring recirculating THP-1 immune cells with cardiomyocytes, skeletal muscle, and liver in separate compartments in a serum-free medium is developed. This in vitro platform can emulate ...
Abstract | A functional, human, multiorgan, pumpless, immune system-on-a-chip featuring recirculating THP-1 immune cells with cardiomyocytes, skeletal muscle, and liver in separate compartments in a serum-free medium is developed. This in vitro platform can emulate both a targeted immune response to tissue-specific damage, and holistic proinflammatory immune response to proinflammatory compound exposure. The targeted response features fluorescently labeled THP-1 monocytes selectively infiltrating into an amiodarone-damaged cardiac module and changes in contractile force measurements without immune-activated damage to the other organ modules. In contrast to the targeted immune response, general proinflammatory treatment of immune human-on-a-chip systems with lipopolysaccharide (LPS) and interferon- |
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Language | English |
Publishing date | 2020-06-02 |
Publishing country | Germany |
Document type | Journal Article |
ZDB-ID | 2808093-2 |
ISSN | 2198-3844 |
ISSN | 2198-3844 |
DOI | 10.1002/advs.202000323 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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