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Article ; Online: Author Correction: Synthesis and characterization of dendritic compounds containing nitrogen: monomer precursors in the construction of biomimetic membranes.

Guardià, Jordi / Zare, Alireza / Eleeza, John / Giamberini, Marta / Reina, José Antonio / Montané, Xavier

2024 Volume 14, Issue 1, Page(s) 6701

Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57172-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synthesis and characterization of dendritic compounds containing nitrogen: monomer precursors in the construction of biomimetic membranes.

Guardià, Jordi / Zare, Alireza / Eleeza, John / Giamberini, Marta / Reina, José Antonio / Montané, Xavier

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1725

Abstract: In this article, we synthesized a novel dendritic 2-oxazoline, 2-(3,4,5-tris(4-dodecyloxybenzyloxy)phenyl)-4,5-dihydro-1,3-oxazole), and its amide precursor N-(2-hydroxyethyl)-3,4,5-tris(4-dodecyloxybenzyloxy)benzamide. Of the distinct synthetic routes ... ...

Abstract	In this article, we synthesized a novel dendritic 2-oxazoline, 2-(3,4,5-tris(4-dodecyloxybenzyloxy)phenyl)-4,5-dihydro-1,3-oxazole), and its amide precursor N-(2-hydroxyethyl)-3,4,5-tris(4-dodecyloxybenzyloxy)benzamide. Of the distinct synthetic routes explored, it was established that the direct amidation of esters with sodium methoxide followed by the dehydrative cyclisation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone as oxidizing agent and triphenylphosphine was the most efficient route to synthesize the dendritic 2-oxazoline. Besides, N-(2-hydroxyethyl)-3,4,5-tris(4-dodecyloxybenzyloxy)benzamide exhibited a monotropic columnar mesophase, whilst the dendritic 2-oxazoline does not exhibited a liquid crystalline mesophase. At the end, the first attempts to polymerize the 2-oxazoline monomer via cationic ring opening polymerization showed promising results. Therefore, the dendritic 2-oxazoline could be used as a mesogenic monomer in the synthesis of side-chain liquid-crystalline polyoxazolines that might self-assembly into columnar structures.
Language	English
Publishing date	2022-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05747-1
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Article ; Online: Trends in Neisseria meningitidis serogroups amongst patients with suspected cerebrospinal meningitis in the meningitis belt of Ghana: a 5-year retrospective study.

Azure, Stebleson / Abdul-Karim, Abass / Abubakari, Braimah Baba / Eleeza, John B / Agboyie, Daron Davies A / Weyori, Enoch Weikem / Choi, Jun Yong

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 202

Abstract: Background: Serogroup A Neisseria meningitidis was the major cause of meningococcal meningitis epidemics in the African meningitis belt before 2010 when the monovalent meningococcal A conjugate vaccine (MenAfriVac) was introduced in the region. ... ...

Abstract	Background: Serogroup A Neisseria meningitidis was the major cause of meningococcal meningitis epidemics in the African meningitis belt before 2010 when the monovalent meningococcal A conjugate vaccine (MenAfriVac) was introduced in the region. Therefore, this study aimed to establish the trends in N. meningitidis serogroups from 2016 to 2020 in Ghana's meningitis belt. Methods: Polymerase chain reaction (PCR) confirmed laboratory results of suspected cases of cerebrospinal meningitis from January, 2016 to March, 2020 were obtained from the Tamale Public Health Laboratory. The data were subjected to trend analysis using Statistical Package for the Social Sciences version 25. Differences between discrete variables were analyzed using the Cochran-Armitage trend test. Results: Of the 2,426 suspected cases, 395 (16.3%) were confirmed positive for N. meningitidis using PCR. Serogroup X showed a significant upward trend (P < 0.01), and serogroup W showed a downward trend (P < 0.01). However, no significant trend was observed for any other serogroup. Conclusion: This study showed the emergence of serogroup X, a non-vaccine type, as the predominant N. meningitidis serogroup in the wake of a declining serogroup W in Ghana's meningitis belt.
MeSH term(s)	Humans ; Neisseria meningitidis ; Serogroup ; Retrospective Studies ; Ghana/epidemiology ; Meningitis, Meningococcal/epidemiology ; Meningitis, Meningococcal/prevention & control ; Meningococcal Vaccines
Chemical Substances	Meningococcal Vaccines
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08196-x
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Article: Influence of Catalyst Acidity on Fine Particle Deposition during Hydrotreating of Bitumen-Derived Heavy Gas Oil

Eleeza, John / Boahene, Philip / Vedachalam, Sundaramurthy / Dalai, Ajay K. / Adjaye, John

Energy & fuels. 2021 Oct. 01, v. 35, no. 20

2021

Abstract: The effect of catalyst acidity on fines deposition during hydrotreating of bitumen-derived heavy gas oil (HGO) was investigated in a batch reactor using a series of mesoporous NiMo/Ti–Al₂O₃ catalysts. Experimental design based on a three-factor optimal ( ... ...

Abstract	The effect of catalyst acidity on fines deposition during hydrotreating of bitumen-derived heavy gas oil (HGO) was investigated in a batch reactor using a series of mesoporous NiMo/Ti–Al₂O₃ catalysts. Experimental design based on a three-factor optimal (custom) response surface methodology was performed and analyzed, considering temperature, catalyst acidity (Ti/Al), and asphaltene coatings in the ranges of 360–380 °C, 0–0.05, and 0–1084 ppm, respectively. The results of the experiments indicated that fines deposition was independent of the hydrotreating reaction temperature range of 360–380 °C. Additionally, lower deposition of fines was recorded with increasing catalyst acidity. In terms of asphaltene coating, fines with higher asphaltene coating showed higher deposition in the catalyst bed. Analysis of the spent catalyst showed a decrease in the weak acidic sites after hydrotreating. Finally, within the range of process parameters evaluated, a mathematical model with a correlation accuracy of 85% was developed to predict the extent of fines deposition with variable catalyst acidity. Models for hydrodesulfurization and hydrodenitrogenation with R² values of 0.93 and 0.82, respectively, were also developed.
Keywords	acidity ; asphaltenes ; batch systems ; catalysts ; energy ; experimental design ; fuel oils ; mathematical models ; porous media ; response surface methodology ; temperature
Language	English
Dates of publication	2021-1001
Size	p. 16735-16749.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1483539-3
ISSN	1520-5029 ; 0887-0624
ISSN (online)	1520-5029
ISSN	0887-0624
DOI	10.1021/acs.energyfuels.1c01634
Database	NAL-Catalogue (AGRICOLA)

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Article: Deposition of Fine Particles during Hydrotreating of Oil Sands Bitumen-Derived Heavy Gas Oil in a Packed Bed Reactor: Impact of Process Parameters and Surface Charge

Eleeza, John / Vedachalam, Sundaramurthy / Boahene, Philip / Dalai, Ajay K. / Adjaye, John

Industrial & engineering chemistry process design and development. 2021 Oct. 21, v. 60, no. 43

2021

Abstract: Heavy gas oil feed in a packed bed reactor was used to study the influence of temperature (370–400 °C), pressure (1000–1400 psig), and liquid hourly space velocity (LHSV) (0.5–2 h–¹) on the deposition of fines (asphaltene-coated kaolin) during ... ...

Abstract	Heavy gas oil feed in a packed bed reactor was used to study the influence of temperature (370–400 °C), pressure (1000–1400 psig), and liquid hourly space velocity (LHSV) (0.5–2 h–¹) on the deposition of fines (asphaltene-coated kaolin) during hydrotreating. The effects of surface charge on fines deposition on the catalyst bed were also investigated. The study showed that LHSV was the only factor with an individual effect on deposition, where increasing LHSV resulted in a decrease in fines deposition. Contrastingly, pressure and temperature showed interactive effects with a combination of high temperature (>380 °C) and low pressure (<1250 psig) or low temperature (<390 °C) and high pressure (>1150 psig), resulting in minimal deposition. These combinations of temperature and pressure also coincided with the region of high hydrodesulfurization, suggesting the impact of fines deposition on catalyst activity. Opposite surface charges possessed by fines and the catalyst created an attractive force that contributed to fines deposition during hydrotreating.
Keywords	catalysts ; catalytic activity ; fuel oils ; kaolin ; liquids ; process design ; temperature
Language	English
Dates of publication	2021-1021
Size	p. 15464-15471.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.1c03000
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Article ; Online: Estimating the economic burden of pneumococcal meningitis and pneumonia in northern Ghana in the African meningitis belt post-PCV13 introduction.

Kobayashi, Miwako / Abdul-Karim, Abass / Milucky, Jennifer L / Zakariah, Adam / Leidner, Andrew J / Asiedu-Bekoe, Franklin / Opare, David / Eleeza, John B / Ofosu, Winfred / Walker, Chastity / Whitney, Cynthia G / Lessa, Fernanda C

Vaccine

2021 Volume 39, Issue 33, Page(s) 4685–4699

Abstract: Background: Ghana introduced 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant immunization program in 2012, using a three-dose primary series without a booster. Despite ≥ 88% reported three-dose vaccination coverage since 2013, ... ...

Abstract	Background: Ghana introduced 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant immunization program in 2012, using a three-dose primary series without a booster. Despite ≥ 88% reported three-dose vaccination coverage since 2013, PCV13-type pneumococcal meningitis outbreaks have occurred. We estimated the ongoing economic burden of PCV13-type pneumococcal meningitis and pneumonia in northern Ghana, an area within the African meningitis belt with seasonal increases of pneumococcal meningitis post-PCV13 introduction, to inform PCV13 vaccination policy. Methods: We performed a cross-sectional survey among patients with pneumonia or meningitis at three hospitals in northern Ghana to determine patient-level costs (direct medical and nonmedical, indirect patient and caregiver costs) incurred in household, outpatient, and inpatient settings. Pneumonia burden was estimated using 2017-2018 administrative records. Pneumococcal meningitis burden was estimated using 2017-2018 case-based surveillance data. Economic burden was reported in 2019 U.S. dollars ($) from the societal perspective. Results: For an area with a total population of 5,068,521, our model estimated 6,441 PCV13-type pneumonia cases and 286 PCV13-type meningitis cases occurred in a typical year post-PCV13. In the base case scenario, the total economic burden was $5,230,035 per year ($777 per case). By age group, cost per PCV13-type pneumonia case was $423 (<5 years), $911 (5-14 years), and $784 (≥15 years); cost per PCV13-type meningitis case was $2,128 (<5 years), $3,247 (5-14 years), and $2,883 (≥15 years). Most (78.0-93.4%) of the total societal cost was due to indirect costs related to deaths from PCV13-type diseases. Conclusions: The estimated economic burden of PCV13-type disease in northern Ghana remains substantial, especially in older children and adults who were expected to have benefited from indirect effects from infant immunization. Additional interventions such as changes in the infant immunization schedule, reactive vaccination, or catch-up PCV13 vaccination may be needed to control remaining vaccine-type disease.
MeSH term(s)	Adult ; Child ; Child, Preschool ; Cost of Illness ; Cost-Benefit Analysis ; Cross-Sectional Studies ; Ghana/epidemiology ; Humans ; Infant ; Meningitis, Pneumococcal/epidemiology ; Meningitis, Pneumococcal/prevention & control ; Pneumococcal Infections ; Pneumococcal Vaccines ; Pneumonia ; Pneumonia, Pneumococcal ; Vaccination ; Vaccines, Conjugate
Chemical Substances	Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2021-07-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2021.06.043
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article: Estimating the economic burden of pneumococcal meningitis and pneumonia in northern Ghana in the African meningitis belt post-PCV13 introduction

Kobayashi, Miwako / Abdul-Karim, Abass / Milucky, Jennifer L. / Zakariah, Adam / Leidner, Andrew J. / Asiedu-Bekoe, Franklin / Opare, David / Eleeza, John B. / Ofosu, Winfred / Walker, Chastity / Whitney, Cynthia G. / Lessa, Fernanda C.

Vaccine. 2021 July 30, v. 39, no. 33

2021

Abstract: Ghana introduced 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant immunization program in 2012, using a three-dose primary series without a booster. Despite ≥ 88% reported three-dose vaccination coverage since 2013, PCV13-type ... ...

Abstract	Ghana introduced 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant immunization program in 2012, using a three-dose primary series without a booster. Despite ≥ 88% reported three-dose vaccination coverage since 2013, PCV13-type pneumococcal meningitis outbreaks have occurred. We estimated the ongoing economic burden of PCV13-type pneumococcal meningitis and pneumonia in northern Ghana, an area within the African meningitis belt with seasonal increases of pneumococcal meningitis post-PCV13 introduction, to inform PCV13 vaccination policy.We performed a cross-sectional survey among patients with pneumonia or meningitis at three hospitals in northern Ghana to determine patient-level costs (direct medical and nonmedical, indirect patient and caregiver costs) incurred in household, outpatient, and inpatient settings. Pneumonia burden was estimated using 2017–2018 administrative records. Pneumococcal meningitis burden was estimated using 2017–2018 case-based surveillance data. Economic burden was reported in 2019 U.S. dollars ($) from the societal perspective.For an area with a total population of 5,068,521, our model estimated 6,441 PCV13-type pneumonia cases and 286 PCV13-type meningitis cases occurred in a typical year post-PCV13. In the base case scenario, the total economic burden was $5,230,035 per year ($777 per case). By age group, cost per PCV13-type pneumonia case was $423 (<5 years), $911 (5–14 years), and $784 (≥15 years); cost per PCV13-type meningitis case was $2,128 (<5 years), $3,247 (5–14 years), and $2,883 (≥15 years). Most (78.0–93.4%) of the total societal cost was due to indirect costs related to deaths from PCV13-type diseases.The estimated economic burden of PCV13-type disease in northern Ghana remains substantial, especially in older children and adults who were expected to have benefited from indirect effects from infant immunization. Additional interventions such as changes in the infant immunization schedule, reactive vaccination, or catch-up PCV13 vaccination may be needed to control remaining vaccine-type disease.
Keywords	Streptococcus pneumoniae ; caregivers ; cross-sectional studies ; meningitis ; models ; monitoring ; patients ; pneumonia ; vaccination ; vaccines ; Ghana
Language	English
Dates of publication	2021-0730
Size	p. 4685-4699.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2021.06.043
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: Evaluation of the sentinel surveillance system for influenza-like illnesses in the Greater Accra region, Ghana, 2018.

Nuvey, Francis Sena / Edu-Quansah, Elijah Paa / Kuma, George Khumalo / Eleeza, John / Kenu, Ernest / Sackey, Samuel / Ameme, Donne / Abakar, Mahamat Fayiz / Kreppel, Katharina / Ngandolo, Richard Bongo / Afari, Edwin / Bonfoh, Bassirou

PloS one

2019 Volume 14, Issue 3, Page(s) e0213627

Abstract: Background: Influenza-like Illness (ILI) is a medical diagnosis of possible influenza or another respiratory illness with a common set of symptoms. The deaths of four schoolchildren, during a pandemic influenza outbreak in December 2017 in Ghana, raised ...

Abstract	Background: Influenza-like Illness (ILI) is a medical diagnosis of possible influenza or another respiratory illness with a common set of symptoms. The deaths of four schoolchildren, during a pandemic influenza outbreak in December 2017 in Ghana, raised doubts about the ILI surveillance system's performance. We evaluated the ILI surveillance system in the Greater Accra region, Ghana, to assess the system's attributes and its performance on set objectives. Methods: CDC guidelines were used to evaluate the data of the ILI surveillance system between 2013 and 2017. We interviewed the surveillance personnel on the system's description and operation. Additionally, routinely entered ILI data from the National Influenza Center provided by the six sentinel sites in Accra was extracted. We sampled and reviewed 120 ILI case-investigation forms from these sites. Surveillance activities were examined on system's performance indicators, each being scored on a scale of 1 to 3 (poorest to best performance). Results: All population and age groups were under ILI surveillance over the period evaluated. Overall, 2948 suspected case-patients, including 392 (13.3%) children under-five were reported, with 219 being positive for influenza virus (Predictive value positive = 7.4%). The predominant influenza subtype was H3N2, recorded in 90 (41.1%) of positive case-patients. The system only met two out of its four objectives. None of the six sentinel sites consistently met their annual 260 suspected case-detection quota. Samples reached the laboratory on average 48 hours after collection and results were disseminated within 7 days. Of 120 case-investigation forms sampled, 91 (76.3%) were completely filled in. Conclusions: The ILI surveillance system in the Greater Accra region is only partially meeting its objectives. While it is found to be sensitive, representative and timely, the data quality was sub-optimal. We recommend the determination of thresholds for alert and outbreak detection and ensuring that sentinel sites meet their weekly case-detection targets.
MeSH term(s)	Algorithms ; Communicable Disease Control ; Cross-Sectional Studies ; Data Accuracy ; Databases, Factual ; Disease Outbreaks ; Geography ; Ghana/epidemiology ; Guidelines as Topic ; Humans ; Infectious Disease Medicine/methods ; Infectious Disease Medicine/standards ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Outpatients ; Pandemics ; Predictive Value of Tests ; Program Development ; Program Evaluation ; Public Health Administration ; Sentinel Surveillance ; World Health Organization
Keywords	covid19
Language	English
Publishing date	2019-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0213627
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: Synthesis and characterization of dendritic compounds containing nitrogen: monomer precursors in the construction of biomimetic membranes.

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Article ; Online: Synthesis and characterization of dendritic compounds containing nitrogen: monomer precursors in the construction of biomimetic membranes.

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Article ; Online: Trends in Neisseria meningitidis serogroups amongst patients with suspected cerebrospinal meningitis in the meningitis belt of Ghana: a 5-year retrospective study.

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Article: Influence of Catalyst Acidity on Fine Particle Deposition during Hydrotreating of Bitumen-Derived Heavy Gas Oil

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Article: Deposition of Fine Particles during Hydrotreating of Oil Sands Bitumen-Derived Heavy Gas Oil in a Packed Bed Reactor: Impact of Process Parameters and Surface Charge

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Article ; Online: Estimating the economic burden of pneumococcal meningitis and pneumonia in northern Ghana in the African meningitis belt post-PCV13 introduction.

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Article: Estimating the economic burden of pneumococcal meningitis and pneumonia in northern Ghana in the African meningitis belt post-PCV13 introduction

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Article ; Online: Evaluation of the sentinel surveillance system for influenza-like illnesses in the Greater Accra region, Ghana, 2018.

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