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  1. Article ; Online: Carbapenem Resistance in Gram-Negative Bacteria: A Hospital-Based Study in Egypt.

    Elrahem, Amira Abd / El-Mashad, Noha / Elshaer, Mohammed / Ramadan, Hazem / Damiani, Giovanni / Bahgat, Monir / Mercuri, Santo Raffaele / Elemshaty, Wafaa

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Anti-Bacterial Agents ; beta-Lactamases/genetics ; Carbapenems ; Cross-Sectional Studies ; Egypt ; Escherichia coli ; Gram-Negative Bacteria ; Hospitals, University ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Drug Resistance, Bacterial
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; Carbapenems
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  2. Article ; Online: Diagnosis of cirrhosis in patients with chronic hepatitis C genotype 4: Role of ABCB11 genotype polymorphism and plasma bile acid levels.

    Besheer, Tarek / Arafa, Mona / El-Maksoud, Mohamed Abd / Elalfy, Hatem / Hasson, Amany / Zalata, Khaled / Elkashef, Wagdi / Elshahawy, Heba / Raafat, Doaa / Elemshaty, Wafaa / Elsayed, Eman / Zaghloul, Hosam / Razek, Ahmed Abdel / El-Bendary, Mahmoud

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2018  Volume 29, Issue 3, Page(s) 299–307

    Abstract: Background/aims: Chronic hepatitis C (CHC)-related mortality generally results from cirrhosis and subsequent complications. We aimed to investigate the potential role of plasma bile acid levels and ABCB11 1331T > C (V444A, rs2287622) (ATP-binding ... ...

    Abstract Background/aims: Chronic hepatitis C (CHC)-related mortality generally results from cirrhosis and subsequent complications. We aimed to investigate the potential role of plasma bile acid levels and ABCB11 1331T > C (V444A, rs2287622) (ATP-binding cassette subfamily B, member 11) gene polymorphism in fibrosis prediction in CHC genotype 4 patients.
    Materials and methods: This case control study included 85 healthy control and the following 225 subjects: 170 adult patients infected with hepatitis C virus (HCV) and categorized into three groups according to liver biopsy; no fibrosis group (F0) (n=33), early fibrosis group (F1-F2) (n=61), and advanced fibrosis group (F3-F4) (n=76). Fasting bile acid levels, hepatitis C virus (HCV) genotyping, and ABCB11 1331T > C gene polymorphism were assessed.
    Results: The frequency of the variant homozygote genotype CC in advanced fibrosis was significantly higher than that in early fibrosis (48.7% vs. 36.1%) (odd ratio, OR =2.58; 95% confidence interval, CI=1.07-6.20; p=0.03). C allele was significantly represented in advanced fibrosis (65.8%) compared with that in early fibrosis (51.6%) (OR=1.80, 95% CI=1.10-2.93, p=0.01). A significant elevation of plasma bile acid levels in advanced fibrosis was observed compared with those in early fibrosis (p≤0.001). Receiver operating characteristic curve for plasma bile acid levels at cutoff value of 75.5 μmol/L had a 59% specificity and 97.4% sensitivity as a predictor of advanced hepatic fibrosis (AUROC=0.78%).
    Conclusion: We concluded that Egyptian patients having chronic hepatitis C genotype 4 with CC genotype of ABCB11 SNP 1331T > C and high plasma bile acid levels at cutoff value of 75.5 μmol/L were associated with advanced hepatic fibrosis.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 11/genetics ; Adult ; Alleles ; Bile Acids and Salts/blood ; Biomarkers/blood ; Case-Control Studies ; Egypt ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Hepacivirus/genetics ; Hepatitis C, Chronic/blood ; Hepatitis C, Chronic/genetics ; Hepatitis C, Chronic/virology ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/genetics ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Predictive Value of Tests ; ROC Curve ; Reference Values ; Risk Factors ; Sensitivity and Specificity ; Young Adult
    Chemical Substances ABCB11 protein, human ; ATP Binding Cassette Transporter, Subfamily B, Member 11 ; Bile Acids and Salts ; Biomarkers
    Language English
    Publishing date 2018-05-10
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2018.17570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4524: Show issues Location:
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  3. Article ; Online: Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus.

    Besheer, Tarek / Elalfy, Hatem / Abd El-Maksoud, Mohamed / Abd El-Razek, Ahmed / Taman, Saher / Zalata, Khaled / Elkashef, Wagdy / Zaghloul, Hossam / Elshahawy, Heba / Raafat, Doaa / Elemshaty, Wafaa / Elsayed, Eman / El-Gilany, Abdel-Hady / El-Bendary, Mahmoud

    World journal of gastroenterology

    2019  Volume 25, Issue 11, Page(s) 1366–1377

    Abstract: Background: Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs (miRs) that play important roles in the regulation of biological ...

    Abstract Background: Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs (miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic fibrosis.
    Aim: To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.
    Methods: This prospective study included 208 patients and 82 age- and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological scoring.
    Results: The ADC value decreased significantly with the progression of fibrosis, from controls (F0) to patients with early fibrosis (F1 and F2) to those with late fibrosis (F3 and F4) (median 1.92, 1.53, and 1.25 × 10
    Conclusion: Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.
    MeSH term(s) Adult ; Biomarkers/blood ; Biopsy ; Case-Control Studies ; Circulating MicroRNA/blood ; Diffusion Magnetic Resonance Imaging ; Disease Progression ; Female ; Gene Expression Profiling ; Hepatitis C, Chronic/pathology ; Hepatitis C, Chronic/virology ; Humans ; Image Processing, Computer-Assisted ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Prospective Studies ; ROC Curve
    Chemical Substances Biomarkers ; Circulating MicroRNA
    Language English
    Publishing date 2019-05-15
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v25.i11.1366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  4. Article ; Online: Prediction of Fibrosis Progression Rate in Patients with Chronic Hepatitis C Genotype 4: Role of Cirrhosis Risk Score and Host Factors.

    Besheer, Tarek / El-Bendary, Mahmoud / Elalfy, Hatem / Abd El-Maksoud, Mohamed / Salah, Mohamed / Zalata, Khaled / Elkashef, Wagdi / Elshahawy, Heba / Raafat, Doaa / Elemshaty, Wafaa / Almashad, Noha / Zaghloul, Hosam / El-Gilany, Abdel-Hady / Abdel Razek, Ahmed Abdel Khalek / Abd Elwahab, Mohamed

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2017  Volume 37, Issue 3, Page(s) 97–102

    Abstract: The rate of liver fibrosis progression in chronic hepatitis C (CHC) patients is highly variable and affected by different factors. This study aimed to assess the role of cirrhosis risk score (CRS) based on 7 genetic variants (7 single-nucleotide ... ...

    Abstract The rate of liver fibrosis progression in chronic hepatitis C (CHC) patients is highly variable and affected by different factors. This study aimed to assess the role of cirrhosis risk score (CRS) based on 7 genetic variants (7 single-nucleotide polymorphisms [SNPs]) and host factors (age and sex) in the prediction of the rate of fibrosis progression in CHC. Duration of infection was determined in 115 patients. The fibrosis progression rate (FPR) per year was calculated as the ratio between fibrosis stage and the duration of infection. SNP genotyping were performed and CRS was determined based on it. FPR was significantly elevated in patients who acquired infection at age >40 years versus those who acquired infection at 30-40 years and those who acquired infection at <30 years. Median FPR was significantly higher in males than females (0.17 vs. 0.15) with P = 0.001. CRS value ≥0.8 is predictive of patients with high risk for cirrhosis, and CRS value <0.5 is predictive of patients with low risk for cirrhosis. There was significant positive correlation between CRS and FPR (P ≤ 0.001). CRS based on 7 SNPs at cutoff value ≥0.8, age at infection >40 years, and male sex are predictors of higher FPR.
    MeSH term(s) Adolescent ; Adult ; Aged ; Biomarkers ; Biopsy ; Disease Progression ; Female ; Genotype ; Hepacivirus/genetics ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/virology ; Host-Pathogen Interactions ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/etiology ; Liver Function Tests ; Male ; Middle Aged ; Prognosis ; Risk Assessment ; Time Factors ; Young Adult
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2016.0111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1748: Show issues Location:
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