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  1. AU="Elena Matteucci"
  2. AU="Goettlicher, Peter"
  3. AU=Sakamoto Kei
  4. AU="Shah Nawaz"
  5. AU="Bagley, Dustin C"
  6. AU="Van der Linden, Nicolas"
  7. AU=Cammarota Giovanni
  8. AU=Aziz Arif
  9. AU="Ormandy, Judy"
  10. AU="Akgun, B"
  11. AU="Sang Yup Lee"
  12. AU=Ahuja Preeti
  13. AU=Zulhendri Felix
  14. AU=Suhail Shanzay
  15. AU="Masum, Hassan"
  16. AU="Del Águila, Javier García"
  17. AU="Balian, Dikran Raffi"
  18. AU="Starr, Megan M"
  19. AU=Rajapaksa Shabna
  20. AU="Mohammed Aly Abdou" AU="Mohammed Aly Abdou"
  21. AU=Cooper Isabella D
  22. AU="Luis Rivera-Armenta, Jose"
  23. AU="Zahid Shaikh"
  24. AU="Scovil, Carol"
  25. AU="Grove, Nico"
  26. AU="McGuire, K J"
  27. AU="Martin, Bianca Aparecida"
  28. AU="Hampton, Joshua Trae"
  29. AU=Thesen Thomas
  30. AU=Oliveira Giuliano da Paz
  31. AU="García, Patricia J"
  32. AU="Hosseinpanah, Farhad"
  33. AU="Mayuni, Grace"
  34. AU="Volkova, Yulia L"
  35. AU="Dauwerse, Sierk"

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  1. Artikel ; Online: Ambulatory Blood Pressure Monitoring and Circadian Rhythm of Blood Pressure in Diabetes Mellitus

    Elena Matteucci / Ottavio Giampietro

    European Medical Journal Diabetes, Vol 1, Iss 1, Pp 38-

    2013  Band 43

    Abstract: Systolic and diastolic blood pressures display a circadian rhythmicity that can be assessed by 24-hour ambulatory blood pressure monitoring and analysed using the cosinor procedure. Altered characteristics to the circadian rhythm of blood pressure, which ...

    Abstract Systolic and diastolic blood pressures display a circadian rhythmicity that can be assessed by 24-hour ambulatory blood pressure monitoring and analysed using the cosinor procedure. Altered characteristics to the circadian rhythm of blood pressure, which may result in adverse health outcomes, have been observed in both prediabetes and diabetes. We have investigated the circadian variability of blood pressure in patients with type 1 and type 2 diabetes. Chronobiologically interpreted ambulatory blood pressure monitoring uncovered not only midline estimating statistic of rhythm (MESOR)-hypertension and circadian hyper-amplitude-tension, but also circadian ecphasia (an odd timing of the daily blood pressure swing). Diastolic blood pressure acrophases were found to be phase shifted to earlier along the time axis only in patients with diabetes, but not in those with essential hypertension. Several mechanisms, from changes in nutrient-dependent signalling pathways to diabetic autonomic neuropathy, can contribute to alterations of circadian time structures in diabetic people. The chronology of blood pressure changes in animal models of diabetes and hypertension suggests that a chronobiological approach to the diagnosis of blood pressure disorders could offer advantages, but longitudinal studies in humans are needed to determine its potential relevance in hypertension associated with diabetes.
    Schlagwörter Acrophase ; Ambulatory Blood Pressure Monitoring ; Circadian Rhythm ; Essential Hypertension ; Midline Estimating Statistic of Rhythm ; Type 1 Diabetes Mellitus ; Type 2 Diabetes Mellitus ; Medicine ; R
    Thema/Rubrik (Code) 571 ; 610
    Sprache Englisch
    Erscheinungsdatum 2013-10-01T00:00:00Z
    Verlag European Medical Journal
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The point-of-care testing in diabetology

    Elena Matteucci / Ottavio Giampietro

    Clinical Management Issues, Vol 5, Iss 3, Pp 107-

    2011  Band 112

    Abstract: In diabetic patients glucose, haemoglobin A1c, ketones, lipids, and urinary albumin monitoring allows prevention, early detection, and treatment of diabetes-related acute and chronic complications. The point-of-care testing (PoCT) technology offers ... ...

    Abstract In diabetic patients glucose, haemoglobin A1c, ketones, lipids, and urinary albumin monitoring allows prevention, early detection, and treatment of diabetes-related acute and chronic complications. The point-of-care testing (PoCT) technology offers convenient aspects, as long as pre-analytical, analytical, and post-analytical errors are minimised. The overview summarises the current state-of-the-art of PoCT in diabetes care.
    Schlagwörter Point-of-care systems ; Diabetes mellitus ; Blood glucose ; HbA1c ; Ketones ; Lipids ; Urinary albumin ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2011-09-01T00:00:00Z
    Verlag SEEd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Thiol Signalling Network with an Eye to Diabetes

    Elena Matteucci / Ottavio Giampietro

    Molecules, Vol 15, Iss 12, Pp 8890-

    2010  Band 8903

    Abstract: Redox regulatory system controls normal cellular functions. Controlled changes in redox couples potential serve as components for signal transduction, similarly to the phosphorylation cascade. Cellular redox biology requires both compartimentalisation ... ...

    Abstract Redox regulatory system controls normal cellular functions. Controlled changes in redox couples potential serve as components for signal transduction, similarly to the phosphorylation cascade. Cellular redox biology requires both compartimentalisation and communication of redox systems: the thermodynamic disequilibrium of the major redox switches allows rapid and sensitive responses to perturbations in redox environments. The many oxidation states of sulphur are found in numerous sulphur species with distinct functional groups (thiols, disulphides, polysulphides, sulphenic, sulphinic and sulphonic acids, etc.), which participate in a complicated network of sulphur-based redox events. Human diseases such as diabetes mellitus and its cardiovascular complications have been associated with increased production of reactive oxygen species and perturbations of thiol redox homeostasis. The review surveys literature related to some etiopathogenic aspects and therapeutic perspectives. The dual toxic-protective property of sulphydryl-donor molecules in experimental settings proposes the general problem of designing antioxidants for therapeutic use.
    Schlagwörter oxidation-reduction ; sulphydryl compounds ; N-acetylcysteine ; diabetes mellitus ; arterial hypertension ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2010-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Micro-method for the determination of glutathione in human blood

    Giustarini, Daniela / Elena Matteucci / Paolo Fanti / Ranieri Rossi

    Journal of Chromatography B. 2014 Aug. 01, v. 964

    2014  

    Abstract: A new procedure is described for the visible-range spectrophotometric analysis of glutathione (GSH) in microvolumes of blood (as low as 0.5μL) collected by fingerstick. Samples are diluted 1 to 300 (v/v) in a stabilizing solution, followed by ... ...

    Abstract A new procedure is described for the visible-range spectrophotometric analysis of glutathione (GSH) in microvolumes of blood (as low as 0.5μL) collected by fingerstick. Samples are diluted 1 to 300 (v/v) in a stabilizing solution, followed by determination of haemoglobin concentration and by acid deproteination. GSH is then measured in the clear supernatant by colorimetry using DTNB, i.e., 5,5′-dithio-bis(2-nitrobenzoic acid), in aqueous solution at pH 7.8. The DTNB reagent is prepared and kept at pH 6.2 until just prior its addition, thus avoiding spontaneous decomposition of the reagent. The assay is rapid, easy to adapt to large-scale studies and it avoids artefactual oxidation of GSH, a common methodological shortcoming. The method is precise with 1.7 to 3.4% intra-day relative standard deviation (RSD) and 2.2 to 4.2% inter-day RSD, and accurate with −1.4% to 2.3% intra-day relative error (RE) and −2.8% to 1.6% inter-day RE. GSH is recovered by 97.5 to 100% at all tested concentrations. The new colorimetric micro-method was validated by a reliable previously reported HPLC method. The procedure is suitable for minimally invasive investigation of oxidative stress in peripheral blood.
    Schlagwörter aqueous solutions ; blood ; colorimetry ; glutathione ; hemoglobin ; high performance liquid chromatography ; humans ; nitrobenzoic acids ; oxidation ; oxidative stress ; pH ; spectral analysis ; statistical analysis
    Sprache Englisch
    Erscheinungsverlauf 2014-0801
    Umfang p. 191-194.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ISSN 1570-0232
    DOI 10.1016/j.jchromb.2014.02.018
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Electron Pathways through Erythrocyte Plasma Membrane in Human Physiology and Pathology

    Elena Matteucci / Ottavio Giampietro

    Biomarker Insights, Vol 2, Pp 321-

    Potential Redox Biomarker?

    2007  Band 329

    Abstract: Erythrocytes are involved in the transport of oxygen and carbon dioxide in the body. Since pH is the influential factor in the Bohr-Haldane effect, pHi is actively maintained via secondary active transports Na+/H+ exchange and HC3 -/Cl- anion exchanger. ... ...

    Abstract Erythrocytes are involved in the transport of oxygen and carbon dioxide in the body. Since pH is the influential factor in the Bohr-Haldane effect, pHi is actively maintained via secondary active transports Na+/H+ exchange and HC3 -/Cl- anion exchanger. Because of the redox properties of the iron, hemoglobin generates reactive oxygen species and thus, the human erythrocyte is constantly exposed to oxidative damage. Although the adult erythrocyte lacks protein synthesis and cannot restore damaged proteins, it is equipped with high activity of protective enzymes. Redox changes in the cell initiate various signalling pathways. Plasma membrane oxido-reductases (PMORs) are transmembrane electron transport systems that have been found in the membranes of all cells and have been extensively characterized in the human erythrocyte. Erythrocyte PMORs transfer reducing equivalents from intracellular reductants to extracellular oxidants, thus their most important role seems to be to enable the cell respond to changes in intra- and extra-cellular redox environments.So far the activity of erythrocyte PMORs in disease states has not been systematically investigated. This review summarizes present knowledge on erythrocyte electron transfer activity in humans (health, type 1 diabetes, diabetic nephropathy, and chronic uremia) and hypothesizes an integrated model of the functional organization of erythrocyte plasma membrane where electron pathways work in parallel with transport metabolons to maintain redox homeostasis.
    Schlagwörter Human erythrocyte ; Na/H exchanger ; Plasma membrane oxidoreductase ; Type 1 diabetes ; Diabetic nephropathy ; Uremia ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2007-01-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: Comparison of Nutrition Profile and Diet Record Between Veteran and Nonveteran End-Stage Renal Disease Patients Receiving Hemodialysis in Veterans Affairs and Community Clinics in Metropolitan South-Central Texas

    Cunningham, Sue E. D / Carlos Lorenzo / Darlene Verkaik / Elena Matteucci / Georgiana Gross / Gurav Agarwal / Khalid Khazim / Padam Hirachan / Paolo Fanti / Shweta Bansal

    Nutrition in clinical practice. , v. 30, no. 5

    2015  

    Abstract: Background: U.S. military veterans have high rates of chronic disease and social disadvantage, which are risk factors for protein-energy wasting (PEW). It is not known whether this translates into high prevalence of PEW in veterans with end-stage renal ... ...

    Abstract Background: U.S. military veterans have high rates of chronic disease and social disadvantage, which are risk factors for protein-energy wasting (PEW). It is not known whether this translates into high prevalence of PEW in veterans with end-stage renal disease. Methods: We compared the clinical, socioeconomic, and nutrition status and the diet of 33 veteran and 38 nonveteran clinically stable patients receiving maintenance hemodialysis (MHD) in south-central Texas. Results: The whole cohort included 82% Mexican Americans (MAs), 72% type 2 diabetics, and 73% males. The body mass index was 28.9 ± 6.2, while energy intake was 21.5 ± 8.2 kcal/kg/d and protein intake was 1.0 ± 0.4 g/kg/d. Serum albumin (bromocresol purple) was 3.5 ± 0.4 g/dL, transferrin was 171.9 ± 27.8 mg/d, C-reactive protein was 2.9 (1.4–6.5) mg/L, interleukin-6 (IL-6) was 8.3 (4.2–17.9) pg/mL, neutrophil gelatinase-associated lipocalin was 729 (552–1256) ng/mL, and the malnutrition-inflammation score was 8.8 ± 3.0. In group comparison that adjusted for sex and ethnicity, the veterans had better household income, less MAs (60% vs 100%), more males (94% vs 55%), more use of a renin-angiotensin-aldosterone system blockade (66% vs 33%), and lower IL-6 levels (4.4 [3.1–5.8] vs 15.4 [8.3–20.5] pg/mL; P = .01) than nonveterans. In regression analysis, the lower serum IL-6 level in veterans was independently explained by dialysis clinic, sex, and, possibly, household income (intermediate significance). Conclusion: In a relatively small cohort of clinically stable MHD patients, the veterans showed equivalent nutrition status and dietary intake and less inflammation than the nonveterans, thus not supporting the possibility that veteran MHD patients may have worse nutrition than the nonveteran counterpart.
    Schlagwörter blood serum ; body mass index ; chronic diseases ; C-reactive protein ; dialysis ; energy intake ; food intake ; hemodialysis ; household income ; inflammation ; interleukin-6 ; kidney diseases ; males ; Mexican Americans ; military veterans ; neutrophils ; nutritional status ; patients ; protein intake ; regression analysis ; risk factors ; serum albumin ; transferrin ; Texas
    Sprache Englisch
    Erscheinungsverlauf 2015-10
    Umfang p. 698-708.
    Erscheinungsort SAGE Publications
    Dokumenttyp Artikel
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1177/0884533615575046
    Datenquelle NAL Katalog (AGRICOLA)

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