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  1. Article ; Online: Primary Cilium Is Involved in Stem Cell Differentiation and Renewal through the Regulation of Multiple Signaling Pathways

    Sila Yanardag / Elena N. Pugacheva

    Cells, Vol 10, Iss 1428, p

    2021  Volume 1428

    Abstract: Signaling networks guide stem cells during their lineage specification and terminal differentiation. Primary cilium, an antenna-like protrusion, directly or indirectly plays a significant role in this guidance. All stem cells characterized so far have ... ...

    Abstract Signaling networks guide stem cells during their lineage specification and terminal differentiation. Primary cilium, an antenna-like protrusion, directly or indirectly plays a significant role in this guidance. All stem cells characterized so far have primary cilia. They serve as entry- or check-points for various signaling events by controlling the signal transduction and stability. Thus, defects in the primary cilia formation or dynamics cause developmental and health problems, including but not limited to obesity, cardiovascular and renal anomalies, hearing and vision loss, and even cancers. In this review, we focus on the recent findings of how primary cilium controls various signaling pathways during stem cell differentiation and identify potential gaps in the field for future research.
    Keywords primary cilia ; stem cells ; cancer stem cells ; signaling ; differentiation ; Notch ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Expression-Based Diagnosis, Treatment Selection, and Drug Development for Breast Cancer

    Qing Ye / Jiajia Wang / Barbara Ducatman / Rebecca A. Raese / Jillian L. Rogers / Ying-Wooi Wan / Chunlin Dong / Lindsay Padden / Elena N. Pugacheva / Yong Qian / Nancy Lan Guo

    International Journal of Molecular Sciences, Vol 24, Iss 10561, p

    2023  Volume 10561

    Abstract: There is currently no gene expression assay that can assess if premalignant lesions will develop into invasive breast cancer. This study sought to identify biomarkers for selecting patients with a high potential for developing invasive carcinoma in the ... ...

    Abstract There is currently no gene expression assay that can assess if premalignant lesions will develop into invasive breast cancer. This study sought to identify biomarkers for selecting patients with a high potential for developing invasive carcinoma in the breast with normal histology, benign lesions, or premalignant lesions. A set of 26-gene mRNA expression profiles were used to identify invasive ductal carcinomas from histologically normal tissue and benign lesions and to select those with a higher potential for future cancer development (ADHC) in the breast associated with atypical ductal hyperplasia (ADH). The expression-defined model achieved an overall accuracy of 94.05% (AUC = 0.96) in classifying invasive ductal carcinomas from histologically normal tissue and benign lesions ( n = 185). This gene signature classified cancer development in ADH tissues with an overall accuracy of 100% ( n = 8). The mRNA expression patterns of these 26 genes were validated using RT-PCR analyses of independent tissue samples ( n = 77) and blood samples ( n = 48). The protein expression of PBX2 and RAD52 assessed with immunohistochemistry were prognostic of breast cancer survival outcomes. This signature provided significant prognostic stratification in The Cancer Genome Atlas breast cancer patients ( n = 1100), as well as basal-like and luminal A subtypes, and was associated with distinct immune infiltration and activities. The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. Eleven genes had significant proliferative potential in CRISPR-Cas9/RNAi screening. Based on this gene expression signature, the VEGFR inhibitor ZM-306416 was discovered as a new drug for treating breast cancer.
    Keywords atypical ductal hyperplasia (ADH) ; atypical ductal hyperplasia with cancer (ADHC) ; diagnosis ; CRISPR-Cas9/RNAi ; immunohistochemistry ; triple-negative breast cancer (TNBC) ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616 ; 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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