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Article ; Online: Localization of nanospheres in pheochromocytoma-like cells following exposure to high-frequency electromagnetic fields at 18 GHz

Palalle G. Tharushi Perera / Denver P. Linklater / Erim Kosyer / Rodney Croft / Elena P. Ivanova

Royal Society Open Science, Vol 9, Iss

2022 Volume 6

Abstract: Exposure to high-frequency (HF) electromagnetic fields (EMFs) at 18 GHz was previously found to induce reversible cell permeabilization in eukaryotic cells; however, the fate of internalized foreign objects inside the cell remains unclear. Here, silica ... ...

Abstract	Exposure to high-frequency (HF) electromagnetic fields (EMFs) at 18 GHz was previously found to induce reversible cell permeabilization in eukaryotic cells; however, the fate of internalized foreign objects inside the cell remains unclear. Here, silica core–shell gold nanospheres (Au NS) of 20 ± 5 nm diameter were used to study the localization of Au NS in pheochromocytoma (PC 12) cells after exposure to HF EMFs at 18 GHz. Internalization of Au NS was confirmed using fluorescence microscopy and transmission electron microscopy. Analysis based on corresponding scanning transmission electron microscopy energy-dispersive spectroscopy revealed the presence of the Au NS free within the PC 12 cell membrane, cytoplasm, enclosed within intracellular vesicles and sequestered in vacuoles. The results obtained in this work highlight that exposure to HF EMFs could be used as an efficient technique with potential for effective delivery of drugs, genetic material, and nanomaterials into cells for the purpose of cellular manipulation or therapy.
Keywords	high frequency ; electromagnetic fields (EMFs) ; 18 GHz ; pc 12 neuronal cells ; membrane permeability ; nanosphere localization ; Science ; Q
Subject code	600
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	The Royal Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Plasma and Polymers

Igor Levchenko / Shuyan Xu / Oleg Baranov / Olha Bazaka / Elena P. Ivanova / Kateryna Bazaka

Molecules, Vol 26, Iss 4091, p

Recent Progress and Trends

2021 Volume 4091

Abstract: Plasma-enhanced synthesis and modification of polymers is a field that continues to expand and become increasingly more sophisticated. The highly reactive processing environments afforded by the inherently dynamic nature of plasma media are often ... ...

Abstract	Plasma-enhanced synthesis and modification of polymers is a field that continues to expand and become increasingly more sophisticated. The highly reactive processing environments afforded by the inherently dynamic nature of plasma media are often superior to ambient or thermal environments, offering substantial advantages over other processing methods. The fluxes of energy and matter toward the surface enable rapid and efficient processing, whereas the charged nature of plasma-generated particles provides a means for their control. The range of materials that can be treated by plasmas is incredibly broad, spanning pure polymers, polymer-metal, polymer-wood, polymer-nanocarbon composites, and others. In this review, we briefly outline some of the recent examples of the state-of-the-art in the plasma-based polymer treatment and functionalization techniques.
Keywords	polymers ; plasma ; polymer functionalization ; Organic chemistry ; QD241-441
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Can aquatic exercises contribute to the improvement of the gait stereotype function in patients with Long COVID outcomes?

Lobanov, Andrey A / Irina A Grishechkina / Andronov, Sergei V / Gleb N Barashkov / Andrey I Popov / Anatoliy D Fesyun / Elena P Ivanova / Maccarone, Maria Chiara / Stefano Masiero

European journal of translational myology

2022 Volume 32, Issue 3

Abstract: A variety of rehabilitation programmes can be offered to Long COVID patients, specifically physical training. Indeed 90% of these patients reports impairments of verticalization, stability and spatial orientation, making difficult exercise in the gym. ... ...

Abstract	A variety of rehabilitation programmes can be offered to Long COVID patients, specifically physical training. Indeed 90% of these patients reports impairments of verticalization, stability and spatial orientation, making difficult exercise in the gym. The aim of our study was to assess the effectiveness and safety of aquatic exercise techniques as part of a comprehensive rehabilitation program for patients with Long COVID. The first of a two-stage program involved development of aquatic exercises technique, which was evaluated in 12 patients with impaired upright posture control before and after exercising by "Habilect" video gait analysis system. During the second phase, effectiveness and safety of aqua exercises were tested in water pool as part of a comprehensive rehabilitation programme conducted in 23 patients with Long COVID outcomes. Physical examination, 6-minute step test, Euro-QL-5D questionnaire, Borg scale, laser Doppler flowmetry, cardiointervalography, and spirometry were performed before and after the aquatic exercises program. After the training with aquatic exercises, indices of deviations of the main body axes of the head and the body mass centre ameliorated, as well as direction of body movement vector decreased (p<0.05). This study demonstrated a statistically significant improvement in exercise tolerance in both groups, as measured by the 6-minute step test after rehabilitation. The comparison group averaged 236.7 metres [126; 380] (T=8, p=0.047) after the rehabilitation course and the intervention group averaged 233.71 metres [150; 320] (T=8.0, p=0.047). When tested with the Euro-QL-5D questionnaire, a post-treatment improvement was noted in the comparison group on the anxiety/depression subscale (3 [3;3] (T=0, p=0.043)). In the intervention group, laser Doppler flowmetry revealed a statistically significant increase in microcirculation (6.36 standard units after rehabilitation) [5.54; 8.17] (T=7.0, p=0.004), and a decrease of oxidative metabolism index of 6.89 standard units. [4.76; 6.96] (T=4.0, p=0.03). No serious adverse events were reported. In conclusion, the developed aquatic exercises technique seems to contribute to recovery of impaired upright posture and motor function, normalizing the walking pattern.
Language	English
Publishing date	2022-07-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2545577-1
ISSN	2037-7460 ; 2037-7452
ISSN (online)	2037-7460
ISSN	2037-7452
DOI	10.4081/ejtm.2022.10698
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long-term outcomes of different rehabilitation programs in patients with long COVID syndrome

Irina A. Grishechkina / Andrey A. Lobanov / Sergei V. Andronov / Andrey P. Rachin / Anatoliy D. Fesyun / Elena P. Ivanova / Stefano Masiero / Maria Chiara Maccarone

European Journal of Translational Myology (2023)

a cohort prospective study

2023

Abstract: After the resolution of the acute SARS-COV-2 infection, an important percentage of patients do not fully recover and continue to present several symptoms. Nevertheless, there is a lack of data in the literature on the effects of rehabilitation programs ... ...

Abstract	After the resolution of the acute SARS-COV-2 infection, an important percentage of patients do not fully recover and continue to present several symptoms. Nevertheless, there is a lack of data in the literature on the effects of rehabilitation programs on medium- and long-term long COVID symptoms. Therefore, the aim of this study was to evaluate the long-term outcomes after rehabilitation programs in long COVID syndrome patients. A prospective cohort study was conducted from August 2021 to March 2022, involving 113 patients with long COVID syndrome. The patients in the experimental group (EG, n=25) received a tailored and multidisciplinary rehabilitative program, involving aquatic exercises, respiratory and motor exercises, social integration training and neuropsychologic sessions, LASER therapy and magnetotherapy. Patients in the other three comparison groups received eastern medicine techniques (CG1), balneotherapy and physiotherapy (group CG2), self-training and home-based physical exercise (CG3). Once the several rehabilitation protocols had been performed, a structured telephone contact was made with the patients after 6 months ± 7 days from the end of the rehabilitation treatment, in order to record the frequency of hospital ad-missions due to exacerbation of post-exacerbation syndrome, death or disability, and the need for other types of care or drugs. The patients in the comparison groups were more likely to request therapeutic care for emerging long COVID symptoms (χ2=6.635, p=0.001; χ2=13.463, p=0.001; χ2=10.949, p=0.001, respectively), as well as more likely to be hospitalized (χ2=5.357, p=0.021; χ2=0.125, p=0.724; χ2=0.856, p=0.355, respectively) when compared to the patients of the EG. The relative risk (RR) of hospital admissions in the observed cohort was 0.143 ±1,031 (СI: 0.019; 1.078); 0.580±1,194 (CI: 0.056; 6.022); 0,340±1,087 (CI: 0.040; 2.860). The RR of hospital admissions for patients with long COVID syndrome was reduced by 85.7%; 42.0% and 66.0%, respectively, when the experimental ...
Keywords	Long COVID syndrome ; rehabilitation ; exercise therapy ; relative risk ; balneotherapy ; health resort medicine ; Medicine ; R ; Human anatomy ; QM1-695
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Decontamination-Induced Modification of Bioactivity in Essential Oil-Based Plasma Polymer Coatings

Olha Bazaka / Karthika Prasad / Igor Levchenko / Mohan V. Jacob / Kateryna Bazaka / Peter Kingshott / Russell J. Crawford / Elena P. Ivanova

Molecules, Vol 26, Iss 7133, p

2021 Volume 7133

Abstract: Plasma polymer coatings fabricated from Melaleuca alternifolia essential oil and its derivatives have been previously shown to reduce the extent of microbial adhesion on titanium, polymers, and other implantable materials used in dentistry. Previous ... ...

Abstract	Plasma polymer coatings fabricated from Melaleuca alternifolia essential oil and its derivatives have been previously shown to reduce the extent of microbial adhesion on titanium, polymers, and other implantable materials used in dentistry. Previous studies have shown these coatings to maintain their performance under standard operating conditions; however, when used in e.g., a dental implant, these coatings may inadvertently become subject to in situ cleaning treatments, such as those using an atmospheric pressure plasma jet, a promising tool for the effective in situ removal of biofilms from tissues and implant surfaces. Here, we investigated the effect of such an exposure on the antimicrobial performance of the Melaleuca alternifolia polymer coating. It was found that direct exposure of the polymer coating surface to the jet for periods less than 60 s was sufficient to induce changes in its surface chemistry and topography, affecting its ability to retard subsequent microbial attachment. The exact effect of the jet exposure depended on the chemistry of the polymer coating, the length of plasma treatment, cell type, and incubation conditions. The change in the antimicrobial activity for polymer coatings fabricated at powers of 20–30 W was not statistically significant due to their limited baseline bioactivity. Interestingly, the bioactivity of polymer coatings fabricated at 10 and 15 W against Staphylococcus aureus cells was temporarily improved after the treatment, which could be attributed to the generation of loosely attached bioactive fragments on the treated surface, resulting in an increase in the dose of the bioactive agents being eluted by the surface. Attachment and proliferation of Pseudomonas aeruginosa cells and mixed cultures were less affected by changes in the bioactivity profile of the surface. The sensitivity of the cells to the change imparted by the jet treatment was also found to be dependent on their origin culture, with mature biofilm-derived P. aeruginosa bacterial cells showing a greater ability to colonize the surface when compared to its planktonic broth-grown counterpart. The presence of plasma-generated reactive oxygen and nitrogen species in the culture media was also found to enhance the bioactivity of polymer coatings fabricated at power levels of 10 and 15 W, due to a synergistic effect arising from simultaneous exposure of cells to reactive oxygen and nitrogen species (RONS) and eluted bioactive fragments. These results suggest that it is important to consider the possible implications of inadvertent changes in the properties and performance of plasma polymer coatings as a result of exposure to in situ decontamination, to both prevent suboptimal performance and to exploit possible synergies that may arise for some polymer coating-surface treatment combinations.
Keywords	plasma polymer ; atmospheric pressure plasma ; antibacterial polymer coatings ; Organic chemistry ; QD241-441
Subject code	660
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Simulations of Protein Adsorption on Nanostructured Surfaces

Berardo M. Manzi / Marco Werner / Elena P. Ivanova / Russell J. Crawford / Vladimir A. Baulin

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 13

Abstract: Abstract Recent technological advances have allowed the development of a new generation of nanostructured materials, such as those displaying both mechano-bactericidal activity and substrata that favor the growth of mammalian cells. Nanomaterials that ... ...

Abstract	Abstract Recent technological advances have allowed the development of a new generation of nanostructured materials, such as those displaying both mechano-bactericidal activity and substrata that favor the growth of mammalian cells. Nanomaterials that come into contact with biological media such as blood first interact with proteins, hence understanding the process of adsorption of proteins onto these surfaces is highly important. The Random Sequential Adsorption (RSA) model for protein adsorption on flat surfaces was modified to account for nanostructured surfaces. Phenomena related to the nanofeature geometry have been revealed during the modelling process; e.g., convex geometries can lead to lower steric hindrance between particles, and hence higher degrees of surface coverage per unit area. These properties become more pronounced when a decrease in the size mismatch between the proteins and the surface nanostructures occurs. This model has been used to analyse the adsorption of human serum albumin (HSA) on a nano-structured black silicon (bSi) surface. This allowed the Blocking Function (the rate of adsorption) to be evaluated. The probability of the protein to adsorb as a function of the occupancy was also calculated.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Nano-structured antimicrobial surfaces: From nature to synthetic analogues

Elbourne, Aaron / Elena P. Ivanova / Russell J. Crawford

Journal of colloid and interface science. 2017 Dec. 15, v. 508

2017

Abstract: The scientific and industrial interest in antimicrobial surfaces has significantly increased in recent times. This interest is largely in response to the persistent microbial contamination of industrial and, importantly, medical implant surfaces. ... ...

Abstract	The scientific and industrial interest in antimicrobial surfaces has significantly increased in recent times. This interest is largely in response to the persistent microbial contamination of industrial and, importantly, medical implant surfaces. Bacterial contamination of implant surfaces often leads to infection at the implant-tissue interface, and with the prevalence of increasing levels of antimicrobial resistance, the treatment of these infections is becoming far more challenging. Recently, many naturally occurring, high-aspect-ratio surface topographies have been discovered that exhibit high levels of biocidal efficacy. These include epicuticular lipid nano-architectures that are formed on the surfaces of insect wings, such as cicadae and dragonflies. The antimicrobial activity of such surfaces has been found to be a consequence of the physical interactions between the nanoscale topography of the substrate and the attaching pathogenic cells, meaning that the activity is independent of biochemical surface functionality. Importantly, these desirable surface properties can be translated to synthetic biomimetic surfaces, which, when mimicked, lead to a substantial increase in the antimicrobial properties of such surfaces. This paper reviews the recent advances in understanding the basis of these mechanical antimicrobial mechanisms, and discusses the progress being made towards the fabrication of optimised, biocompatible, synthetic analogues.
Keywords	Anisoptera (Odonata) ; antibiotic resistance ; antimicrobial properties ; bacterial contamination ; biomimetics ; insects ; lipids ; nanomaterials ; wings
Language	English
Dates of publication	2017-1215
Size	p. 603-616.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2017.07.021
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Surface Architecture Influences the Rigidity of Candida albicans Cells

Phuc H. Le / Duy H. K. Nguyen / Arturo Aburto Medina / Denver P. Linklater / Christian Loebbe / Russell J. Crawford / Shane MacLaughlin / Elena P. Ivanova

Nanomaterials, Vol 12, Iss 567, p

2022 Volume 567

Abstract: Atomic force microscopy (AFM) was used to investigate the morphology and rigidity of the opportunistic pathogenic yeast, Candida albicans ATCC 10231, during its attachment to surfaces of three levels of nanoscale surface roughness. Non-polished titanium ( ...

Abstract	Atomic force microscopy (AFM) was used to investigate the morphology and rigidity of the opportunistic pathogenic yeast, Candida albicans ATCC 10231, during its attachment to surfaces of three levels of nanoscale surface roughness. Non-polished titanium (npTi), polished titanium (pTi), and glass with respective average surface roughness ( S a ) values of 389 nm, 14 nm, and 2 nm, kurtosis ( S kur ) values of 4, 16, and 4, and skewness ( S skw ) values of 1, 4, and 1 were used as representative examples of each type of nanoarchitecture. Thus, npTi and glass surfaces exhibited similar S skw and S kur values but highly disparate S a . C. albicans cells that had attached to the pTi surfaces exhibited a twofold increase in rigidity of 364 kPa compared to those yeast cells attached to the surfaces of npTi (164 kPa) and glass (185 kPa). The increased rigidity of the C. albicans cells on pTi was accompanied by a distinct round morphology, condensed F-actin distribution, lack of cortical actin patches, and the negligible production of cell-associated polymeric substances; however, an elevated production of loose extracellular polymeric substances (EPS) was observed. The differences in the physical response of C. albicans cells attached to the three surfaces suggested that the surface nanoarchitecture (characterized by skewness and kurtosis), rather than average surface roughness, could directly influence the rigidity of the C. albicans cells. This work contributes to the next-generation design of antifungal surfaces by exploiting surface architecture to control the extent of biofilm formation undertaken by yeast pathogens and highlights the importance of performing a detailed surface roughness characterization in order to identify and discriminate between the surface characteristics that may influence the extent of cell attachment and the subsequent behavior of the attached cells.
Keywords	surface architecture ; surface roughness ; Candida albicans ; biofilm formation ; cell rigidity ; Young’s modulus ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Single shot multispectral multidimensional imaging using chaotic waves

Vijayakumar Anand / Soon Hock Ng / Jovan Maksimovic / Denver Linklater / Tomas Katkus / Elena P. Ivanova / Saulius Juodkazis

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 13

Abstract: Abstract Multispectral imaging technology is a valuable scientific tool for various applications in astronomy, remote sensing, molecular fingerprinting, and fluorescence imaging. In this study, we demonstrate a single camera shot, lensless, ... ...

Abstract	Abstract Multispectral imaging technology is a valuable scientific tool for various applications in astronomy, remote sensing, molecular fingerprinting, and fluorescence imaging. In this study, we demonstrate a single camera shot, lensless, interferenceless, motionless, non-scanning, space, spectrum, and time resolved five-dimensional incoherent imaging technique using tailored chaotic waves with quasi-random intensity and phase distributions. Chaotic waves can distinctly encode spatial and spectral information of an object in single self-interference intensity distribution. In this study, a tailored chaotic wave with a nearly pure phase function and lowest correlation noise is generated using a quasi-random array of pinholes. A unique sequence of signal processing techniques is applied to extract all possible spatial and spectral channels with the least entropy. The depth-wavelength reciprocity is exploited to see colour from depth and depth from colour and the physics of beam propagation is exploited to see at one depth by calibrating at another.
Keywords	Medicine ; R ; Science ; Q
Subject code	535
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Black-Si as a Photoelectrode

Denver P. Linklater / Fatima Haydous / Cheng Xi / Daniele Pergolesi / Jingwen Hu / Elena P. Ivanova / Saulius Juodkazis / Thomas Lippert / Jurga Juodkazytė

Nanomaterials, Vol 10, Iss 873, p

2020 Volume 873

Abstract: The fabrication and characterization of photoanodes based on black-Si (b-Si) are presented using a photoelectrochemical cell in NaOH solution. B-Si was fabricated by maskless dry plasma etching and was conformally coated by tens-of-nm of TiO 2 using ... ...

Abstract	The fabrication and characterization of photoanodes based on black-Si (b-Si) are presented using a photoelectrochemical cell in NaOH solution. B-Si was fabricated by maskless dry plasma etching and was conformally coated by tens-of-nm of TiO 2 using atomic layer deposition (ALD) with a top layer of CoO <math display="inline"> <semantics> <msub> <mrow></mrow> <mi>x</mi> </msub> </semantics> </math> cocatalyst deposited by pulsed laser deposition (PLD). Low reflectivity <math display="inline"> <semantics> <mrow> <mi>R</mi> <mo><</mo> <mn>5</mn> <mo>%</mo> </mrow> </semantics> </math> of b-Si over the entire visible and near-IR ( <math display="inline"> <semantics> <mrow> <mi>λ</mi> <mo><</mo> <mn>2</mn> <mtext> </mtext> <mi mathvariant="sans-serif">μ</mi> </mrow> </semantics> </math> m) spectral range was favorable for the better absorption of light, while an increased surface area facilitated larger current densities. The photoelectrochemical performance of the heterostructured b-Si photoanode is discussed in terms of the n-n junction between b-Si and TiO 2 .
Keywords	black-Si ; antireflection ; photoanode ; water splitting ; Chemistry ; QD1-999
Subject code	511
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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