Article: Cholestasis.
2003 Volume 52 Suppl 2, Page(s) ii42–8
Abstract: In contrast with urine formation, bile flow is not dependent on hydrostatic forces, but driven by osmotic pressure of solutes secreted across the apical membrane of hepatocytes and bile duct epithelial cells. This secretory process is mediated by a set ... ...
| Abstract | In contrast with urine formation, bile flow is not dependent on hydrostatic forces, but driven by osmotic pressure of solutes secreted across the apical membrane of hepatocytes and bile duct epithelial cells. This secretory process is mediated by a set of primary active transporters that use ATP hydrolysis to pump solutes against the concentration gradient. The most important solutes in bile are bile salts, lipids, electrolytes, and organic anions. The direct consequence of the osmotic mechanism of bile formation is that impaired function of these pumps leads to impaired bile flow-that is, cholestasis. The function of these pumps is highlighted by a number of inherited cholestatic diseases, which are caused by mutations in these genes. Identification of the molecular defect in these diseases was not only important for diagnostic reasons but also emphasised that impaired transporter function has pathological consequences. Indeed, it is now becoming clear that impaired or downregulated transporter function is also involved in the pathogenesis of acquired cholestatic syndromes. |
|---|---|
| MeSH term(s) | Bile/metabolism ; Bile Acids and Salts/metabolism ; Cholestasis/genetics ; Cholestasis/metabolism ; Cholestasis, Intrahepatic/genetics ; Cholestasis, Intrahepatic/metabolism ; Female ; Humans ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Mutation ; Pregnancy ; Pregnancy Complications/metabolism |
| Chemical Substances | Bile Acids and Salts ; Membrane Transport Proteins |
| Language | English |
| Publishing date | 2003-03-18 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 80128-8 |
| ISSN | 1468-3288 ; 0017-5749 |
| ISSN (online) | 1468-3288 |
| ISSN | 0017-5749 |
| DOI | 10.1136/gut.52.suppl_2.ii42 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 160: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.