Article ; Online: An Unusual Case of Hepatocellular Carcinoma in a Healthy Teenager.
Journal of investigative medicine high impact case reports
2023 Volume 11, Page(s) 23247096231165744
Abstract: Hepatocellular carcinoma (HCC) is a primary liver malignancy known to occur majorly in patients with liver cirrhosis or those with a harbinger of risk factors like viral hepatitis, autoimmune liver disease, alpha-1 antitrypsin deficiency, alcoholic liver ...
| Abstract | Hepatocellular carcinoma (HCC) is a primary liver malignancy known to occur majorly in patients with liver cirrhosis or those with a harbinger of risk factors like viral hepatitis, autoimmune liver disease, alpha-1 antitrypsin deficiency, alcoholic liver disease, and nonalcoholic fatty liver disease. The incidence of HCC has risen in the past 2 decades and currently ranks as the sixth most common cause of cancer-related death worldwide. Most cases are seen in adulthood, and only a very small percentage have been reported in adolescents with risk factors. The 2 pathologic subtypes of pediatric HCC are classic and fibrolamellar. Here, we discussed a very interesting rare case of a healthy male teenager with no apparent liver disease or risk factor who presented with right-upper-quadrant pain, normal alpha-fetoprotein level, and abdominal ultrasound showing a large hepatic mass. A liver biopsy was positive for HCC with fluorescent in situ hybridization showing a PRKACA complex gene pattern, favoring the fibrolamellar type. |
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| MeSH term(s) | Child ; Humans ; Male ; Adolescent ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/pathology ; In Situ Hybridization, Fluorescence ; Liver Cirrhosis/complications |
| Language | English |
| Publishing date | 2023-05-21 |
| Publishing country | United States |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 2710326-2 |
| ISSN | 2324-7096 ; 2324-7096 |
| ISSN (online) | 2324-7096 |
| ISSN | 2324-7096 |
| DOI | 10.1177/23247096231165744 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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