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  1. Article ; Online: Re: Kianian et al.: Enhancing the assessment of large language models in medical information generation (Ophthalmol Retina. 2024;8:195-201).

    Eleiwa, Taher K / Elhusseiny, Abdelrahman M

    Ophthalmology. Retina

    2024  Volume 8, Issue 5, Page(s) e15

    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Letter
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2024.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Sustained Release Therapies with the Prostaglandin Analogues Intracameral Implants.

    Elhusseiny, Abdelrahman M / Aref, Ahmad A

    Ophthalmology and therapy

    2024  

    Abstract: The travoprost intracameral implant was recently approved by the US Food and Drug Administration for sustained release medical treatment of open-angle glaucoma in the USA. The approval represents a substantial and progressive step forward in the area of ... ...

    Abstract The travoprost intracameral implant was recently approved by the US Food and Drug Administration for sustained release medical treatment of open-angle glaucoma in the USA. The approval represents a substantial and progressive step forward in the area of sustained-release glaucoma therapy. Topical intraocular pressure-lowering medications for the treatment of glaucoma are faced with a host of challenges for long-term and usually lifelong care. A changing paradigm in glaucoma management involves first-line interventions with laser modalities, micro-invasive surgeries, and sustained-release treatment platforms. Future needs in the area of sustained-release therapy include a non-prostaglandin drug delivery platform and longer-term treatments that do not require surgical reintervention.
    Language English
    Publishing date 2024-05-18
    Publishing country England
    Document type Journal Article
    ISSN 2193-8245
    ISSN 2193-8245
    DOI 10.1007/s40123-024-00965-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Association of Sickle-Cell Disorders With Diabetic Retinopathy: A Large Database Study.

    Chauhan, Muhammad Z / Elhusseiny, Abdelrahman M / Sallam, Ahmed B

    Ophthalmology science

    2024  Volume 4, Issue 4, Page(s) 100490

    Abstract: Purpose: To evaluate the association of sickle-cell disease (SCD) and sickle-cell trait (SCT) disease with diabetic retinopathy (DR) in patients with diabetes mellitus (DM).: Design: Population-based, retrospective cohort study utilizing data from ... ...

    Abstract Purpose: To evaluate the association of sickle-cell disease (SCD) and sickle-cell trait (SCT) disease with diabetic retinopathy (DR) in patients with diabetes mellitus (DM).
    Design: Population-based, retrospective cohort study utilizing data from the TriNetX Research Network, including 119 million patients across 80 health care organizations worldwide.
    Participants: Diabetes mellitus patients (type 1 [T1DM] or 2 [T2DM]), with or without SCD and SCT, were included. Three cohorts were analyzed, including (1) DM patients without SCD, SCT, or sickle-cell/hemoglobin-C; (2) DM with SCD; and (3) DM with SCT.
    Methods: All patients with DM were categorized into 3 cohorts based on the presence of SCD and SCT. Each cohort underwent 1:1 propensity score matching for demographics, blood glucose levels, hemoglobin A1C, and other relevant comorbidities.
    Main outcome measures: Risk of DR in DM patients with and without SCD or SCT.
    Results: There was no significant difference in the risk of any T1DR between those with and without SCD. However, for those with SCT, there was a notable twofold increased risk for T1-proliferative DR (PDR) (relative risk [RR]: 2.03; 95% confidence interval [CI]: 1.33-3.01). In contrast, there was an elevated risk for any T2DR in patients with SCD (RR: 1.50; 95% CI: 1.19-1.88), particularly due to higher PDR risks in T2DM patients (RR: 1.83; 95% CI: 1.29-2.60). The risk of mild to moderate T2DM non-PDR was also found to be higher in patients with SCT.
    Conclusions: The risk of any DR was increased in T2DM patients with SCD or SCT, with increased risks for PDR in patients with SCT and T1DM. This indicates there may be a potential role of sickle-cell disorders in diabetic eye disease progression.
    Financial disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-9145
    ISSN (online) 2666-9145
    DOI 10.1016/j.xops.2024.100490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comment on: Light as a drug: prospective randomized evaluation and comparison of the effect of decreased illumination on visual recovery following cataract surgery.

    Elhusseiny, Abdelrahman M / Chuahan, Muhammad Z / Sallam, Ahmed B

    Journal of cataract and refractive surgery

    2024  Volume 50, Issue 3, Page(s) 314–315

    MeSH term(s) Humans ; Cataract Extraction ; Lighting ; Prospective Studies ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1097/j.jcrs.0000000000001401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Trends in Medicare Submitted Charges to Allowed Payment Ratios for Ophthalmology Services.

    Elhusseiny, Abdelrahman M / Chauhan, Muhammad Z / Sallam, Ahmed B

    Clinical ophthalmology (Auckland, N.Z.)

    2024  Volume 18, Page(s) 859–863

    Abstract: Purpose: Many physicians charge more than the Medicare insurance program pays. Current charge-to-payment ratios in ophthalmology and trends over the years are unknown. In this work, we examined physician charge-to-payment ratios in ophthalmology across ... ...

    Abstract Purpose: Many physicians charge more than the Medicare insurance program pays. Current charge-to-payment ratios in ophthalmology and trends over the years are unknown. In this work, we examined physician charge-to-payment ratios in ophthalmology across procedures and consultations.
    Methods: We utilized data from 100% final-action physician/supplier Part B Medicare fee-for-service (FFS) population from 2015 to 2020. We retrieved data on ophthalmic procedures and consultations, both facility-based and non-facility-based, conducted by ≥ 50 ophthalmologists. We analyzed median charge-to-payment ratios, which were calculated as submitted charges divided by the Medicare-allowed payments, between ophthalmic procedures and consultations to assess for trends over the study period.
    Results: We find that the median charge-to-payment ratio for all current procedural terminology (CPT) codes in 2020 was 2.23 (Interquartile range (IQR): 1.54-3.27) as compared to 2.00 (IQR: 1.39-2.92) in 2015, an overall 2.76% average annual growth rate from 2015-2020. For ophthalmic procedures, the median charge-to-payment ratio in 2020 was 3.03 (IQR: 2.13-4.41) compared to 2.79 (IQR: 1.96-3.97) in 2015, corresponding to a 2.01% AAGR from 2015-2020. For consultations, those rates were 2.06 (IQR: 1.48-2.96), 1.85 (IQR: 1.33-2.59), and 2.71%, respectively.
    Conclusion: We found that the submitted charge-to-Medicare payment ratios among ophthalmic procedures and consultations have steadily increased since 2015. However, there was a relatively low rate of excess charges for ophthalmology services compared to other surgical-based specialties with minimal variation among providers.
    Language English
    Publishing date 2024-03-18
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S436918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Re: Sawyer et al.: Diagnostic role of oral fluorescein angiography in pediatric ambulatory clinics (Ophthalmol Retina. 2024;8:204-206).

    Elhusseiny, Abdelrahman M / Grigorian, Florin / Sallam, Ahmed B

    Ophthalmology. Retina

    2024  Volume 8, Issue 3, Page(s) e6–e7

    MeSH term(s) Child ; Humans ; Fluorescein Angiography ; Retina/diagnostic imaging
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Letter
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Topical insulin in neurotrophic keratopathy after diabetic vitrectomy.

    Eleiwa, Taher K / Khater, Ahmed A / Elhusseiny, Abdelrahman M

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 10986

    Abstract: To assess the efficacy and safety of topical insulin (TI) for treating neurotrophic keratopathy (NK) within one-month post-diabetic vitrectomy (DV) compared to conventional non-invasive measures, we conducted this retrospective case-control study ... ...

    Abstract To assess the efficacy and safety of topical insulin (TI) for treating neurotrophic keratopathy (NK) within one-month post-diabetic vitrectomy (DV) compared to conventional non-invasive measures, we conducted this retrospective case-control study including all eyes that developed acute NK (stages 2 and 3) following DV between October 2020 and June 2023. The control group included NK cases managed with preservative-free lubricant eye drops and prophylactic topical antibiotics. In contrast, the study group included NK cases treated with TI [1 unit per drop] four times daily, in addition to the previously mentioned treatment. The primary outcome measure was time to epithelial healing. Secondary outcome measures included any adverse effect of TI or the need for amniotic membrane transplantation (AMT). During the study period, 19 patients with a mean age of 49.3 ± 8.6 years received TI versus 18 controls with a mean age of 52.5 ± 10.7 years. Corneal epithelial healing was significantly faster in the TI-treated group compared to controls, with a mean difference of 12.16 days (95% CI 6.1-18.3, P = 0.001). Survival analysis indicated that the insulin-treated group had 0% and 20% of NK stages 2 and 3, respectively, that failed to achieve corneal epithelial healing, compared to 20% and 66.7% for the control group (P < 0.001). In the control group, two eyes required AMT due to progressive thinning. Additionally, three patients in the control group, progressing to stage 3 NK, were switched to TI, achieving healing after a mean of 14 days. No adverse effects were reported in the TI-treated group. Our study suggests that TI can effectively and safely promote the healing of NK after DV.
    MeSH term(s) Humans ; Middle Aged ; Male ; Female ; Insulin/administration & dosage ; Retrospective Studies ; Vitrectomy/methods ; Case-Control Studies ; Adult ; Corneal Diseases/drug therapy ; Corneal Diseases/surgery ; Diabetic Retinopathy/drug therapy ; Wound Healing/drug effects ; Administration, Topical ; Aged ; Treatment Outcome
    Language English
    Publishing date 2024-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60699-y
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  8. Article ; Online: Cataract surgery in myopic eyes.

    Elhusseiny, Abdelrahman M / Salim, Sarwat

    Current opinion in ophthalmology

    2022  Volume 34, Issue 1, Page(s) 64–70

    Abstract: Purpose of review: We discuss the preoperative, intraoperative, and postoperative considerations for cataract surgery in eyes with high myopia. We also reviewed the recent literature on refractive outcomes and complications of cataract surgery in myopic ...

    Abstract Purpose of review: We discuss the preoperative, intraoperative, and postoperative considerations for cataract surgery in eyes with high myopia. We also reviewed the recent literature on refractive outcomes and complications of cataract surgery in myopic eyes.
    Recent findings: Several novel intraocular lens (IOL) power calculation formulas have recently been developed to optimize refractive outcomes. Haigis formula is the most accurate among the third-generation IOL formulas. Novel formulas such as Barrett Universal II, Kane, and modified Wang-Koch adjustment for Holladay I formula provide a better refractive prediction compared with old formulas. Intraoperatively, the chopping technique is preferred to minimize pressure on weak zonules and reduce the incidence of posterior capsule rupture. Anterior capsular polishing is recommended to reduce the risk of postoperative capsular contraction syndrome (CCS). Postoperatively, complications such as refractive surprises, intraocular pressure spikes, and CCS remain higher in myopic eyes. Only 63% of myopic patients with axial length more than 26 mm achieve a visual acuity at least 20/40 after cataract surgery, mainly because of coexisting ocular comorbidities.
    Summary: There are multiple preoperative, intraoperative, and postoperative considerations when performing cataract surgery in myopic eyes. Further research is needed to optimize the refractive outcomes in these eyes and determine the best IOL formula. Surgeons should be adept and knowledgeable with different techniques to manage intraoperative complications.
    MeSH term(s) Humans ; Cataract/complications
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000000914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Cataract surgery in adult eyes with short axial length.

    Elhusseiny, Abdelrahman M / Sallam, Ahmed B

    Current opinion in ophthalmology

    2022  Volume 34, Issue 1, Page(s) 84–93

    Abstract: Purpose of review: Cataract surgery in eyes of patients with short axial length (AL) can be technically challenging and is associated with a high risk of intra- and postoperative complications. Several technical and surgical strategies have been ... ...

    Abstract Purpose of review: Cataract surgery in eyes of patients with short axial length (AL) can be technically challenging and is associated with a high risk of intra- and postoperative complications. Several technical and surgical strategies have been proposed to optimize the visual outcome and decrease the rate of surgical complications and it is important to understand their applications in these cases.
    Recent findings: Traditional intraocular lens (IOL) measurement formulas in eyes with short AL have reduced reliability. Novel formulas such as the Kane formula provide a better refractive prediction. Surgery can be difficult in short eyes due to the crowdedness of the anterior chamber (AC) and the associated scleral abnormalities increasing the risk of uveal effusion. Surgical techniques such as prophylactic scleral incisions, limited pars plana anterior vitrectomy, and modified hydrodissection, have been shown to facilitate surgery in extremely short eyes and decrease the rate of operative complications. Although cataract surgery improves vision in these cases, short AL and shallow AC have been associated with worse visual outcomes.
    Summary: Newer 4 th generation IOL formulas have improved the refractive outcomes of cataract surgery in eyes with short AL. There are multiple evolving surgical strategies for optimizing surgery in these eyes. However, studies on the surgical and visual outcomes of cataract surgery in eyes with short AL are limited by their design and sample size. With further research and continued clinical experiences, we hope to develop evidence-based algorithms for the management of these complex cases.
    MeSH term(s) Humans ; Adult ; Reproducibility of Results ; Cataract/complications
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000000913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Corneal opacification in Sanjad-Sakati syndrome.

    Elhusseiny, Abdelrahman M / Saeed, Hajirah N

    American journal of ophthalmology case reports

    2022  Volume 26, Page(s) 101503

    Language English
    Publishing date 2022-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2022.101503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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