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Article ; Online: Lumbo-aortic lymphadenectomy via laparotomy.

Benqué, Miléna / Eliès, Antoine / Lo Dico, Rea

Journal of visceral surgery

2023 Volume 160, Issue 4, Page(s) 295–302

MeSH term(s)	Humans ; Female ; Laparotomy ; Ovarian Neoplasms/pathology ; Postoperative Complications/surgery ; Lymph Node Excision ; Neoplasm Staging ; Laparoscopy
Language	English
Publishing date	2023-06-27
Publishing country	France
Document type	Journal Article
ISSN	1878-7886
ISSN (online)	1878-7886
DOI	10.1016/j.jviscsurg.2023.03.008
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Article ; Online: Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France.

Eliès, Antoine / Bonneau, Claire / Houzard, Sophie / Rouzier, Roman / Héquet, Delphine

PloS one

2022 Volume 17, Issue 3, Page(s) e0264821

Abstract: Objective: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study.: Methods: We conducted a retrospective real-life cohort study on data collected prospectively by ... ...

Abstract	Objective: To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study. Methods: We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women. Results: The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39-0.90]; p = 0.043). Conclusions: With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
MeSH term(s)	Adolescent ; Adult ; Alphapapillomavirus ; Cohort Studies ; Conization ; Female ; Humans ; Male ; Papillomavirus Infections ; Papillomavirus Vaccines ; Retrospective Studies ; Uterine Cervical Neoplasms ; Vaccination ; Young Adult
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0264821
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Article ; Online: Désir de grossesse et cancer du sein.

Elies, Antoine / Salakos, Eleonora / Rouzier, Roman

Bulletin du cancer

2020 Volume 106, Issue 12S1, Page(s) S53–S59

Abstract: Breast cancer affects about 3,000 new women of childbearing age each year. The desire for pregnancy is therefore a frequent issue in the management of breast cancer. We reviewed the current state of knowledge and recommendations in high-risk women, on ... ...

Title translation	Desire for pregnancy and breast cancer.
Abstract	Breast cancer affects about 3,000 new women of childbearing age each year. The desire for pregnancy is therefore a frequent issue in the management of breast cancer. We reviewed the current state of knowledge and recommendations in high-risk women, on the consideration of this desire for pregnancy in therapeutic management, the way to approach it, the preservation of fertility in the care process and finally on the outcomes of pregnancy after breast cancer. We evaluated the desire for pregnancy, qualitatively and quantitatively, after breast cancer through a literature review.
MeSH term(s)	Adult ; Age Factors ; Antineoplastic Agents/adverse effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/psychology ; Female ; Fertility Preservation/methods ; Genes, BRCA1 ; Genes, BRCA2 ; Health Knowledge, Attitudes, Practice ; Humans ; Middle Aged ; Mutation ; Pregnancy/psychology ; Pregnancy Complications, Neoplastic/genetics ; Pregnancy Complications, Neoplastic/psychology ; Pregnancy Outcome ; Qualitative Research ; Risk
Chemical Substances	Antineoplastic Agents
Language	French
Publishing date	2020-02-13
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/S0007-4551(20)30048-5
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Article ; Online: Impact des régimes alimentaires sur la mortalité et le risque de récidive de cancer du sein : revue de la littérature.

Maumy, Louise / Harrissart, Guillaume / Dewaele, Pauline / Aljaber, Ahmed / Bonneau, Claire / Rouzier, Roman / Eliès, Antoine

Bulletin du cancer

2019 Volume 107, Issue 1, Page(s) 61–71

Abstract: Introduction: There is a growing interest in diets and their effects on cancer prognosis. In 2014, a report from the World Cancer Research Fund on diet and women with a history of breast cancer did not demonstrate a major effect on breast cancer ... ...

Title translation	Impact of nutrition on breast cancer mortality and risk of recurrence, a review of the evidence.
Abstract	Introduction: There is a growing interest in diets and their effects on cancer prognosis. In 2014, a report from the World Cancer Research Fund on diet and women with a history of breast cancer did not demonstrate a major effect on breast cancer prognosis. The aim of this literature review was to provide an update of knowledge in this area. Methods: Randomized trials, prospective cohorts and meta-analyses published between 2012 and 2018 examining the impact of diet on recurrence risk and/or mortality after breast cancer were included, to achieve the objective. We evaluated study quality (according to Haute Autorité de Santé criteria) and the studied diets were categorized: macronutrients, micronutrients and selective foods. Results: We selected eighteen articles that met levels of evidence 1 to 3. For macronutrients, a low-fat diet was associated with better survival. With regard to micronutrients, a diet rich in phytœstrogen reduced the risk of cancer recurrence. Finally, the adoption of a healthy diet was not associated with an improved prognosis for breast cancer but with an improvement in overall survival and risk of death from cardiovascular disease. Discussion: This review suggests that nutrition influences the prognosis of breast cancer. Nevertheless, the level of evidence of the results was insufficient to make recommendations. Ultimately, a healthy and balanced diet could be encouraged in order to reduce global mortality.
MeSH term(s)	Breast Neoplasms/complications ; Breast Neoplasms/diet therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/prevention & control ; Cooking ; Diet, Fat-Restricted ; Diet, Healthy ; Evidence-Based Medicine ; Fasting ; Female ; Food/adverse effects ; Humans ; Inflammation ; Malnutrition/complications ; Malnutrition/diet therapy ; Malnutrition/therapy ; Meta-Analysis as Topic ; Micronutrients/administration & dosage ; Nutrients/administration & dosage ; Nutrition Policy ; Nutritional Status ; Nutritional Support ; Phytoestrogens/therapeutic use ; Prognosis ; Prospective Studies ; Randomized Controlled Trials as Topic ; Recurrence ; Risk
Chemical Substances	Micronutrients ; Phytoestrogens
Language	French
Publishing date	2019-09-26
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2019.08.009
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Article ; Online: Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer.

Blanc-Durand, Félix / Tang, Roseline / Pommier, Margaux / Nashvi, Marzieh / Cotteret, Sophie / Genestie, Catherine / Le Formal, Audrey / Pautier, Patricia / Michels, Judith / Kfoury, Maria / Hervé, Robert / Mengue, Sylvie / Wafo, Estelle / Elies, Antoine / Miailhe, Gregoire / Uzan, Jennifer / Rouleau, Etienne / Leary, Alexandra

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 16, Page(s) 3124–3129

Abstract: Purpose: Homologous recombination deficiency (HRD) is closely related to PARP inhibitor (PARPi) benefit in ovarian cancer. The capacity of BRCA1 promoter methylation to predict prognosis and HRD status remains unclear. We aimed to correlate BRCA1 ... ...

Abstract	Purpose: Homologous recombination deficiency (HRD) is closely related to PARP inhibitor (PARPi) benefit in ovarian cancer. The capacity of BRCA1 promoter methylation to predict prognosis and HRD status remains unclear. We aimed to correlate BRCA1 promoter methylation levels in patients with high-grade ovarian cancer to HRD status and clinical behavior to assess its clinical relevance. Experimental design: This is a retrospective monocentric analysis of patients centrally tested for genomic instability score (GIS) by MyChoice CDx (Myriad Genetics). The detection of BRCA1 promoter methylation and quantification of methylation levels were performed by quantitative droplet digital PCR methodology. High BRCA1 methylation was defined as ≥70% and deemed to be associated with homozygous silencing. Results: Of 100 patients, 11% harbored a deleterious BRCA1/2 mutation. GIS was considered positive (score ≥ 42) for 52 patients and negative for 48 patients. Using a 70% cutoff, 19% (15/79) of BRCA wild-type ovarian cancer had high BRCA1 methylation levels. All of the highly methylated tumors were classified as HRD, achieving a positive predictive value of 100%. We detected 14% (11/79) low-methylated tumors (1%-69%), and all of them were also classified as HRD. Mean GIS was 61.5 for BRCAmut, 66.4 for high-BRCAmeth, 58.9 for low-BRCAmeth, and 33.3 for BRCAwt unmethylated (P < 0.001). Low methylation levels detected in samples previously exposed to chemotherapy appeared to be associated with poor outcome post-platinum. Conclusions: Patients with ovarian cancer with high levels of BRCA1 hypermethylation are very likely to have high GIS and therefore represent good candidates for PARPi treatment. These results may be highly relevant to other tumor types for HRD prediction. See related commentary by Garg and Oza, p. 2957.
MeSH term(s)	Humans ; Female ; BRCA1 Protein/genetics ; Retrospective Studies ; Clinical Relevance ; BRCA2 Protein/genetics ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; DNA Methylation ; Genomic Instability ; Homologous Recombination
Chemical Substances	BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-22-3328
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Zs.A 4223: Show issues

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Article ; Online: Activité physique après diagnostic de cancer du sein et survie : revue de la littérature.

Maumy, Louise / Salakos, Eleonora / Rocher, Grégoire / Al Mamari, Thuraya / Bonneau, Claire / Elies, Antoine / Neuzillet, Cindy / Rouzier, Roman

Bulletin du cancer

2020 Volume 107, Issue 10, Page(s) 1042–1055

Abstract: Introduction: The benefits of physical activity (PA) in breast cancer are currently recognized in primary prevention. The World Cancer Research Fund (WCRF) and then the National Cancer Institute (INCa) have reported conflicting results regarding the ... ...

Title translation	Physical activity after breast cancer diagnosis and survival: A systematic review.
Abstract	Introduction: The benefits of physical activity (PA) in breast cancer are currently recognized in primary prevention. The World Cancer Research Fund (WCRF) and then the National Cancer Institute (INCa) have reported conflicting results regarding the impact of post-diagnosis PA on breast cancer outcomes. The aim of this systematic review is to assess the association between PA after breast cancer diagnosis and overall mortality, specific mortality and risk of breast cancer recurrence in the literature. Methods: Randomized trials, prospective cohorts and meta-analyses studying post-diagnosis PA and overall mortality, breast cancer mortality or risk of recurrence after breast cancer published between January 1, 2014 and October 1, 2019 were included. The articles selected by the INCa report prior to 2014 were included in the literature review. Results: Eighteen articles have been selected. Studies unanimously concluded that overall mortality was reduced by post-diagnosis PA practice. For specific mortality, 5 meta-analyses showed a significant decrease in breast cancer mortality and 2 found a decrease in the risk of recurrence. Conclusion: Post-diagnosis PA reduces overall mortality and appears to impact specific breast cancer mortality and risk of recurrence. However, these results need to be confirmed by larger randomized trials.
MeSH term(s)	Breast Neoplasms/diagnosis ; Breast Neoplasms/mortality ; Exercise ; Female ; Humans ; Survival Rate
Language	French
Publishing date	2020-09-22
Publishing country	France
Document type	Journal Article ; Systematic Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2020.06.013
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Article ; Online: The role of neoadjuvant chemotherapy in ovarian cancer.

Elies, Antoine / Rivière, Sophie / Pouget, Nicolas / Becette, Véronique / Dubot, Coraline / Donnadieu, Anne / Rouzier, Roman / Bonneau, Claire

Expert review of anticancer therapy

2018 Volume 18, Issue 6, Page(s) 555–566

Abstract: Introduction: Ovarian cancer is mostly diagnosed at advanced stage. Better survival is achieved through complete debulking surgery and chemotherapy. Historically, neoadjuvant chemotherapy (NAC) has been introduced for unresectable disease to decrease ... ...

Abstract	Introduction: Ovarian cancer is mostly diagnosed at advanced stage. Better survival is achieved through complete debulking surgery and chemotherapy. Historically, neoadjuvant chemotherapy (NAC) has been introduced for unresectable disease to decrease tumor load and perform a unique complete surgery. Four randomized control trials have compared primary debulking surgery to NAC, but there is still controversy about the use of neoadjuvant chemotherapy and questions about its modalities. Areas covered: We made a review of knowledge on benefits of NAC compared to primary debulking chemotherapy, in terms of survival and morbidity, methods of administration, new drugs in early and late phase trials, the selection of patients. Similar survival was observed after NAC and interval debulking surgery or primary debulking surgery. Morbidity of surgery was decreased after interval debulking compared primary debulking surgery. Conventional drugs are carboplatin and paclitaxel. Safety of bevacizumab was evaluated in phase 2 trials associated with conventional drugs. Immunotherapy trials are enrolling patients in phase 1 study. Expert commentary: NAC followed by debulking surgery is the best treatment for patients with advanced ovarian cancer.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant/methods ; Cytoreduction Surgical Procedures/methods ; Female ; Humans ; Neoadjuvant Therapy/methods ; Neoplasm Staging ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Patient Selection ; Randomized Controlled Trials as Topic ; Survival Rate
Language	English
Publishing date	2018-04-10
Publishing country	England
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1080/14737140.2018.1458614
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Article ; Online: A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer.

Bonneau, Claire / Eliès, Antoine / Kieffer, Yann / Bourachot, Brigitte / Ladoire, Sylvain / Pelon, Floriane / Hequet, Delphine / Guinebretière, Jean-Marc / Blanchet, Christophe / Vincent-Salomon, Anne / Rouzier, Roman / Mechta-Grigoriou, Fatima

Breast cancer research : BCR

2020 Volume 22, Issue 1, Page(s) 76

Abstract: Background: Early luminal breast cancer (BC) represents 70% of newly diagnosed BC cases. Among them, small (under 2 cm) BC without lymph node metastasis (classified as T1N0) have been rarely studied, as their prognosis is generally favorable. ... ...

Abstract	Background: Early luminal breast cancer (BC) represents 70% of newly diagnosed BC cases. Among them, small (under 2 cm) BC without lymph node metastasis (classified as T1N0) have been rarely studied, as their prognosis is generally favorable. Nevertheless, up to 5% of luminal T1N0 BC patients relapse with distant metastases that ultimately prove fatal. The aim of our work was to identify the mechanisms involved in metastatic recurrence in these patients. Methods: Our study addresses the role that autonomous and non-autonomous tumor cell features play with regard to distant recurrence in early luminal BC patients. We created a cohort of T1N0 luminal BC patients (tumors between 0.5-2 cm without lymph node metastasis) with metastatic recurrence ("cases") and corresponding "controls" (without relapse) matched 1:1 on main prognostic factors: age, grade, and proliferation. We deciphered different characteristics of cancer cells and their tumor micro-environment (TME) by deep analyses using immunohistochemistry. We performed in vitro functional assays and highlighted a new mechanism of cooperation between cancer cells and one particular subset of cancer-associated fibroblasts (CAF). Results: We found that specific TME features are indicative of relapse in early luminal BC. Indeed, quantitative histological analyses reveal that "cases" are characterized by significant accumulation of a particular CAF subset (CAF-S1) and decrease in CD4 Conclusions: This study shows that distant recurrence in T1N0 BC is strongly associated with the presence of CAF-S1 fibroblasts. Moreover, we identify CDH11 as a key player in CAF-S1-mediated pro-metastatic activity. This is independent of tumor cells and represents a new prognostic factor. These results could assist clinicians in identifying luminal BC patients with high risk of relapse. Targeted therapies against CAF-S1 using anti-FAP antibody or CDH11-targeting compounds might help in preventing relapse for such patients with activated stroma.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cancer-Associated Fibroblasts/immunology ; Cancer-Associated Fibroblasts/pathology ; Carcinoma, Ductal, Breast/immunology ; Carcinoma, Ductal, Breast/metabolism ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/therapy ; Carcinoma, Lobular/immunology ; Carcinoma, Lobular/metabolism ; Carcinoma, Lobular/pathology ; Carcinoma, Lobular/therapy ; Case-Control Studies ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/pathology ; Middle Aged ; Neoplasm Recurrence, Local/immunology ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Prognosis ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Survival Rate ; Tumor Microenvironment/immunology
Chemical Substances	Biomarkers, Tumor ; Receptors, Estrogen ; Receptors, Progesterone ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2020-07-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/s13058-020-01311-9
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