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  1. Article ; Online: Author Correction

    Leticia Laura Niborski / Paul Gueguen / Mengliang Ye / Allan Thiolat / Rodrigo Nalio Ramos / Pamela Caudana / Jordan Denizeau / Ludovic Colombeau / Raphaël Rodriguez / Christel Goudot / Jean-Michel Luccarini / Anne Soudé / Bruno Bournique / Pierre Broqua / Luigia Pace / Sylvain Baulande / Christine Sedlik / Jean-Pierre Quivy / Geneviève Almouzni /
    José L. Cohen / Elina Zueva / Joshua J. Waterfall / Sebastian Amigorena / Eliane Piaggio

    Nature Communications, Vol 14, Iss 1, Pp 1-

    CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

    2023  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

    Leticia Laura Niborski / Paul Gueguen / Mengliang Ye / Allan Thiolat / Rodrigo Nalio Ramos / Pamela Caudana / Jordan Denizeau / Ludovic Colombeau / Raphaël Rodriguez / Christel Goudot / Jean-Michel Luccarini / Anne Soudé / Bruno Bournique / Pierre Broqua / Luigia Pace / Sylvain Baulande / Christine Sedlik / Jean-Pierre Quivy / Geneviève Almouzni /
    José L. Cohen / Elina Zueva / Joshua J. Waterfall / Sebastian Amigorena / Eliane Piaggio

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 16

    Abstract: Abstract Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint blockers are incompletely understood. We show here that genetic ablation or ... ...

    Abstract Abstract Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint blockers are incompletely understood. We show here that genetic ablation or pharmacological inhibition of histone lysine methyltransferase Suv39h1 delays tumor growth and potentiates tumor rejection by anti-PD-1. In the absence of Suv39h1, anti-PD-1 induces alternative activation pathways allowing survival and differentiation of IFNγ and Granzyme B producing effector cells that express negative checkpoint molecules, but do not reach final exhaustion. Their transcriptional program correlates with that of melanoma patients responding to immune-checkpoint blockade and identifies the emergence of cytolytic-effector tumor-infiltrating lymphocytes as a biomarker of clinical response. Anti-PD-1 favors chromatin opening in loci linked to T-cell activation, memory and pluripotency, but in the absence of Suv39h1, cells acquire accessibility in cytolytic effector loci. Overall, Suv39h1 inhibition enhances anti-tumor immune responses, alone or combined with anti-PD-1, suggesting that Suv39h1 is an “epigenetic checkpoint” for tumor immunity.
    Keywords Science ; Q
    Subject code 570
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients

    Cindy Neuzillet / Manon Marchais / Sophie Vacher / Marc Hilmi / Anne Schnitzler / Didier Meseure / Renaud Leclere / Charlotte Lecerf / Coraline Dubot / Emmanuelle Jeannot / Jerzy Klijanienko / Odette Mariani / Valentin Calugaru / Caroline Hoffmann / Maria Lesnik / Nathalie Badois / Edith Borcoman / Eliane Piaggio / Maud Kamal /
    Christophe Le Tourneau / Ivan Bieche

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 13

    Abstract: Abstract Changes in the oral microbiome, particularly Fusobacterium nucleatum, are associated with oral squamous cell carcinoma (OSCC). F. nucleatum has been reported to modulate local immunity in cancers. We aimed to assess the association between ... ...

    Abstract Abstract Changes in the oral microbiome, particularly Fusobacterium nucleatum, are associated with oral squamous cell carcinoma (OSCC). F. nucleatum has been reported to modulate local immunity in cancers. We aimed to assess the association between intratumoral F. nucleatum and clinico-pathological features, relapse, and overall survival (OS) in two independent cohorts of patients with OSCC, and to explore the interplay with immune-related genes. We retrospectively analyzed tissue samples from a first cohort of 122 patients with head and neck squamous cell carcinoma, including 61 OSCC (cohort #1), and a second cohort of 90 additional OSCC (cohort #2). We then performed a sensitivity analysis on the merged cohort of OSCC patients (N = 151). F. nucleatum 16S rRNA gene sequences were quantified using real-time quantitative PCR. The presence of gram-negative bacteria and macrophages was confirmed by LPS and CD163 immunostainings, respectively. F. nucleatum positivity was associated with older age, less alcohol and combined alcohol plus tobacco consumption, and less frequent lymph node invasion. There was a trend for a lower recurrence rate in F. nucleatum-positive cases, with less metastatic relapses compared to F. nucleatum-negative tumors, and significantly longer OS, relapse-free and metastasis-free survival. F. nucleatum status was independently associated with OS in multivariate analysis. Immune-related gene and immunohistochemistry analyses showed that gram-negative bacteria load inversely correlated with M2 macrophages. F. nucleatum-associated OSCC has a specific immune microenvironment, is more frequent in older, non-drinking patients, and associated with a favorable prognosis.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

    Ruby Alonso / Héloïse Flament / Sébastien Lemoine / Christine Sedlik / Emanuel Bottasso / Isabel Péguillet / Virginie Prémel / Jordan Denizeau / Marion Salou / Aurélie Darbois / Nicolás Gonzalo Núñez / Benoit Salomon / David Gross / Eliane Piaggio / Olivier Lantz

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 17

    Abstract: Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or ... ...

    Abstract Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity.
    Keywords Science ; Q
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

    Ruby Alonso / Héloïse Flament / Sébastien Lemoine / Christine Sedlik / Emanuel Bottasso / Isabel Péguillet / Virginie Prémel / Jordan Denizeau / Marion Salou / Aurélie Darbois / Nicolás Gonzalo Núñez / Benoit Salomon / David Gross / Eliane Piaggio / Olivier Lantz

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 17

    Abstract: Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or ... ...

    Abstract Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity.
    Keywords Science ; Q
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

    Nicolas Gonzalo Núñez / Jimena Tosello Boari / Rodrigo Nalio Ramos / Wilfrid Richer / Nicolas Cagnard / Cyrill Dimitri Anderfuhren / Leticia Laura Niborski / Jeremy Bigot / Didier Meseure / Philippe De La Rochere / Maud Milder / Sophie Viel / Delphine Loirat / Louis Pérol / Anne Vincent-Salomon / Xavier Sastre-Garau / Becher Burkhard / Christine Sedlik / Olivier Lantz /
    Sebastian Amigorena / Eliane Piaggio

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 15

    Abstract: Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to ... ...

    Abstract Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

    Nicolas Gonzalo Núñez / Jimena Tosello Boari / Rodrigo Nalio Ramos / Wilfrid Richer / Nicolas Cagnard / Cyrill Dimitri Anderfuhren / Leticia Laura Niborski / Jeremy Bigot / Didier Meseure / Philippe De La Rochere / Maud Milder / Sophie Viel / Delphine Loirat / Louis Pérol / Anne Vincent-Salomon / Xavier Sastre-Garau / Becher Burkhard / Christine Sedlik / Olivier Lantz /
    Sebastian Amigorena / Eliane Piaggio

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 15

    Abstract: Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to ... ...

    Abstract Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Heparan sulfates targeting increases MHC class I- and MHC class II-restricted antigen presentation and CD8+ T-cell response

    Knittel, Delphine / Adeline Gadzinski / Alexandra Savatier / Christine Sedlik / Eliane Piaggio / Jean-Claude Boulain / Jordan Denizeau / Michel Léonetti / Philippe de la Rochère / Sebastian Amigorena / Stéphane Hua

    Vaccine. 2016 June 08, v. 34, no. 27

    2016  

    Abstract: Heparan sulfates (HS) are carbohydrate moieties of HS proteoglycans (HSPGs). They often represent alternative attachment points for proteins or microorganisms targeting receptors. HSPGs, which are ubiquitously expressed, thereby participate in numerous ... ...

    Abstract Heparan sulfates (HS) are carbohydrate moieties of HS proteoglycans (HSPGs). They often represent alternative attachment points for proteins or microorganisms targeting receptors. HSPGs, which are ubiquitously expressed, thereby participate in numerous biological processes. We previously showed that MHC class II-restricted antigen presentation is increased when antigens are coupled to HS ligands, suggesting that HSPGs might contribute to adaptive immune responses. Here, we examined if HSPG targeting influences other aspects of immune responses. We found that coupling of an HS ligand to the antigen increases antigen presentation to CD4+ and CD8+ T-cells after antigen targeting to membrane immunoglobulins or to MHC-II molecules. Moreover, this increased stimulating capacity correlates with an enhanced CD8+ immune response in mice. Last, animals control more effectively the growth of Ova-expressing tumour cells when they are immunized with an Ova construct targeting HSPGs and MHC-II molecules. Our results indicate that ubiquitous molecules can influence both MHC class I- and MHC class II-restricted antigen presentation and behave as co-receptors during T-cell stimulation. Moreover, they suggest that tumour-antigens endowed with the ability to target both HSPGs and MHC-II molecules could be of value to increase CD8+ immune response and control tumour-growth, opening new perspectives for the design of highly immunogenic protein-based vaccines.
    Keywords antigen presentation ; antigens ; CD8-positive T-lymphocytes ; immune response ; immunoglobulins ; ligands ; mice ; microorganisms ; neoplasm cells ; proteoglycans ; receptors ; sulfates ; vaccines
    Language English
    Dates of publication 2016-0608
    Size p. 3093-3101.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2016.04.073
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ

    Cristian Gabriel Beccaria / María Carolina Amezcua Vesely / Facundo Fiocca Vernengo / Ricardo Carlos Gehrau / María Cecilia Ramello / Jimena Tosello Boari / Melisa Gorosito Serrán / Juan Mucci / Eliane Piaggio / Oscar Campetella / Eva Virginia Acosta Rodríguez / Carolina Lucía Montes / Adriana Gruppi

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that ... ...

    Abstract Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoimmune symptoms.
    Keywords Science ; Q
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ

    Cristian Gabriel Beccaria / María Carolina Amezcua Vesely / Facundo Fiocca Vernengo / Ricardo Carlos Gehrau / María Cecilia Ramello / Jimena Tosello Boari / Melisa Gorosito Serrán / Juan Mucci / Eliane Piaggio / Oscar Campetella / Eva Virginia Acosta Rodríguez / Carolina Lucía Montes / Adriana Gruppi

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that ... ...

    Abstract Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoimmune symptoms.
    Keywords Science ; Q
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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