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  1. Article ; Online: Expanding the role of chromosomal microarray analysis in the evaluation of recurrent pregnancy loss.

    Eliwa, Jasmine / Papas, Ralph S / Kutteh, William H

    Journal of reproductive immunology

    2023  Volume 161, Page(s) 104188

    Abstract: Multiple factors contribute to recurrent pregnancy loss (RPL). This review highlights the latest international guidelines for RPL workup, including immunological testing, by the American Society for Reproductive Medicine (ASRM), the European Society of ... ...

    Abstract Multiple factors contribute to recurrent pregnancy loss (RPL). This review highlights the latest international guidelines for RPL workup, including immunological testing, by the American Society for Reproductive Medicine (ASRM), the European Society of Human Reproduction and Embryology (ESHRE), and the Royal College of Obstetricians and Gynaecologists (RCOG). These three societies recommend testing for antiphospholipid syndrome. ESHRE and RCOG also recommend thyroid peroxidase antibody testing, whereas ASRM does not. All guidelines advise against testing of natural killer cells, cytokines, antinuclear antibodies, human leukocyte antigen (HLA) compatibility, anti-HLA antibodies, and anti-sperm antibodies. However, when following ASRM, ESHRE or RCOG diagnostic guidelines, over 50% of cases have no identifiable cause. Genetic testing of products of conception (POC) can improve our understanding of unexplained RPL as aneuploidy is a common cause of RPL. Based on studies reporting results from chromosomal microarray analysis (CMA) of POC, we propose a novel algorithm for RPL evaluation. The algorithm involves following evidence-based societal guidelines (published by ASRM, ESHRE, or RCOG), excluding parental karyotyping, in combination with CMA testing of miscarriage tissue. When utilizing this new evaluation algorithm, the number of unexplained cases of RPL decreases from over 50% to less than 10%. As a result, most patients are provided an explanation for their loss and healthcare costs are potentially reduced. Patients with an otherwise negative workup with euploid POC, are classified as "truly unexplained RPL". These patients are excellent candidates for enrollment in randomized, controlled trials examining novel immunological testing and treatment protocols.
    MeSH term(s) Pregnancy ; Female ; Humans ; Abortion, Habitual/diagnosis ; Abortion, Habitual/genetics ; Aneuploidy ; Microarray Analysis ; Antiphospholipid Syndrome/complications ; Antibodies, Antinuclear
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2023-12-28
    Publishing country Ireland
    Document type Review ; Journal Article
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2023.104188
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The barriers and future directions of interspecialty collaboration in reproductive surgery.

    Eliwa, Jasmine / Carugno, Jose / Flyckt, Rebecca

    Fertility and sterility

    2023  Volume 120, Issue 6, Page(s) 1266

    MeSH term(s) Humans ; Urogenital Surgical Procedures ; Specialization
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2023.10.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Risk Factors, Subtypes, and Outcome of Ischemic Stroke in Kuwait: A National Study.

    Al-Hashel, Jasem Y / Al-Sabah, Al-Alya / Ahmed, Samar F / Al-Enezi, Maha / Al-Tawheid, Nour / Al Mesailekh, Zainab / Eliwa, Jasmine / Alroughani, Raed

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2016  Volume 25, Issue 9, Page(s) 2145–2152

    Abstract: Background and purpose: Epidemiological studies of stroke burden in Kuwait are scarce. We aimed to identify the risk factors, subtypes, and outcome of ischemic stroke in the 6 major hospitals in Kuwait between 2008 and 2013.: Methods: A cross- ... ...

    Abstract Background and purpose: Epidemiological studies of stroke burden in Kuwait are scarce. We aimed to identify the risk factors, subtypes, and outcome of ischemic stroke in the 6 major hospitals in Kuwait between 2008 and 2013.
    Methods: A cross-sectional survey was carried out using randomly selected ischemic stroke patients. It included data of sociodemographic status, stroke risk factors, stroke subtypes, treatment, and outcomes.
    Results: A total of 1257 ischemic stroke patients (811 men and 446 women; mean age 60.2 ± 13.1) were included. Small-artery ischemic stroke was the most common stroke subgroup (69.8%) whereas hypertension was the most prevalent risk factor (80.9%). History of heart disease was significantly associated (P < .001) with cardioembolic strokes (58.3%) compared to large-artery stroke (37.5%) and small-artery stroke (32.5%). Atrial fibrillation was significantly prevalent (P < .001) in cardioembolic stroke (54.2%) compared to large-artery stroke (13%) and small-artery stroke (7.6%). Presentation at ages less than 45 years was significantly (P < .001) associated with improved neurological status at discharge (82.6%) when compared to patients aged 45-70 years (78.5%) and more than 70 years (63.8%). Similar findings were observed at 6 months follow-up (78.4% versus 72.8% and 46%; P < .001). Cardioembolic stroke was significantly associated with higher mortality rates (25% versus 12.4% and 6.8%; P < .061) in large-vessel and small-vessel strokes, respectively.
    Conclusions: Small-artery ischemic stroke was the most common stroke subgroup, and hypertension was the most common risk factor. The outcome was better in younger patients. Cardioembolic stroke was associated with worse outcome.
    MeSH term(s) Adult ; Age Distribution ; Aged ; Brain Ischemia/complications ; Brain Ischemia/epidemiology ; Chi-Square Distribution ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Kuwait/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Stroke/classification ; Stroke/epidemiology ; Stroke/etiology ; Stroke/therapy ; Treatment Outcome
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2016.05.038
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    Zs.A 3519: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Abstinence Time and Its Impact on Basic and Advanced Semen Parameters.

    Agarwal, Ashok / Gupta, Sajal / Du Plessis, Stefan / Sharma, Rakesh / Esteves, Sandro C / Cirenza, Caroline / Eliwa, Jasmine / Al-Najjar, Wedad / Kumaresan, Deepika / Haroun, Namariq / Philby, Sara / Sabanegh, Edmund

    Urology

    2016  Volume 94, Page(s) 102–110

    Abstract: Objective: To assess the effect of ejaculatory abstinence (EA) periods on routine and advanced sperm tests.: Methods: Men with normozoospermia provided semen samples after 1, 2, 5, 7, 9, and 11 days of abstinence. A standard semen analysis was ... ...

    Abstract Objective: To assess the effect of ejaculatory abstinence (EA) periods on routine and advanced sperm tests.
    Methods: Men with normozoospermia provided semen samples after 1, 2, 5, 7, 9, and 11 days of abstinence. A standard semen analysis was performed on all samples. Each specimen was assessed for levels of reactive oxygen species (ROS) and sperm DNA fragmentation. Comparison was also made by grouping EA periods into short (1 day), recommended by World Health Organization (WHO) (2-7 days), and long (9-11 days).
    Results: Semen volume (P < .001), sperm concentration (P < .001), and total sperm count (P < .001) increased significantly with abstinence length. Sperm DNA fragmentation was associated with the length of EA (P < .001). Both 1 and 2 days of EA had the least amount of DNA fragmentation (P < .001). Significant increase was seen in volume, pH, viscosity, total count, total motile sperm, and DNA fragmentation between short and recommended EA (P < .05), and between recommended and long EA (P < .05). Short EA had no detrimental impact on semen characteristics according to the 2010 WHO thresholds.
    Conclusion: Shortening of EA time is not detrimental to sperm quality in men with normozoospermia and is proposed as a method for reducing sperm DNA fragmentation. This strategy could help optimize sperm quality and the chances of natural and assisted conception. Accurate abstinence time should be considered when managing men with infertility problems with semen analyses even when it is within the recommended range.
    MeSH term(s) Adult ; Ejaculation ; Humans ; Male ; Middle Aged ; Semen Analysis ; Sexual Abstinence ; Time Factors ; Young Adult
    Language English
    Publishing date 2016-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2016.03.059
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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