LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Ceruloplasmin Reduces the Lactoferrin/Oleic Acid Antitumor Complex-Mediated Release of Heme-Containing Proteins from Blood Cells.

    Elizarova, Anna Yu / Sokolov, Alexey V / Vasilyev, Vadim B

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Our previous study showed that not only bovine lactoferrin (LF), the protein of milk and neutrophils, but also the human species forms complexes with oleic acid (OA) that inhibit tumor growth. Repeated injections of human LF in complex with OA (LF/8OA) ... ...

    Abstract Our previous study showed that not only bovine lactoferrin (LF), the protein of milk and neutrophils, but also the human species forms complexes with oleic acid (OA) that inhibit tumor growth. Repeated injections of human LF in complex with OA (LF/8OA) to hepatoma-carrying mice decelerated tumor growth and increased animals' longevity. However, whether the effect of the LF/8OA complex is directed exclusively against malignant cells was not studied. Hence, its effect on normal blood cells was assayed, along with its possible modulation of ceruloplasmin (CP), the preferred partner of LF among plasma proteins. The complex LF/8OA (6 μM) caused hemolysis, unlike LF alone or BSA/8OA (250 μM). The activation of neutrophils with exocytosis of myeloperoxidase (MPO), a potent oxidant, was induced by 1 μM LF/8OA, whereas BSA/8OA had a similar effect at a concentration increased by an order. The egress of heme-containing proteins, i.e., MPO and hemoglobin, from blood cells affected by LF/8OA was followed by a pronounced oxidative/halogenating stress. CP, which is the natural inhibitor of MPO, added at a concentration of 2 mol per 1 mol of LF/8OA abrogated its cytotoxic effect. It seems likely that CP can be used effectively in regulating the LF/8OA complex's antitumor activity.
    MeSH term(s) Mice ; Humans ; Animals ; Ceruloplasmin/metabolism ; Oleic Acid/pharmacology ; Lactoferrin/pharmacology ; Lactoferrin/metabolism ; Hemeproteins/metabolism ; Carcinoma, Hepatocellular ; Heme/metabolism
    Chemical Substances Ceruloplasmin (EC 1.16.3.1) ; Oleic Acid (2UMI9U37CP) ; Lactoferrin (EC 3.4.21.-) ; Hemeproteins ; Heme (42VZT0U6YR)
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316711
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Effect of alpha-lactalbumin and lactoferrin oleic acid complexes on chromatin structural organization

    Lebedev, Dmitry V / Zabrodskaya, Yana A / Pipich, Vitaly / Kuklin, Alexander I / Ramsay, Edward / Sokolov, Alexey V / Elizarova, Anna Yu / Shaldzhyan, Aram A / Grudinina, Natalia A / Pantina, Rimma A / Wu, Baohu / Shtam, Tatiana A / Volnitskiy, Andrey V / Schmidt, Alexander E / Shvetsov, Alexey V / Vasilyev, Vadim B / Isaev-Ivanov, Vladimir V / Egorov, Vladimir V

    Biochemical and biophysical research communications. 2019 Nov. 26, v. 520, no. 1

    2019  

    Abstract: This work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. ... ...

    Abstract This work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. Complexes featuring oleic acid (OA) with human alpha-lactalbumin (hAl) or with bovine alpha-lactalbumin (bAl), and human lactoferrin (hLf) were investigated using small-angle neutron scattering (SANS). It was shown that while alpha-lactalbumin protein complexes were formed on the surface of polydisperse OA micelles, the lactoferrin complexes comprised a monodisperse system of nanoscale particles. Both hAl and hLf complexes appeared to interact with the chromatin of isolated nuclei affecting chromatin structural organization. The possible roles of these processes in the specific anti-tumor activity of these complexes are discussed.
    Keywords antineoplastic activity ; apoptosis ; cattle ; chromatin ; humans ; lactalbumin ; lactoferrin ; micelles ; neoplasm cells ; neutrons ; oleic acid ; research
    Language English
    Dates of publication 2019-1126
    Size p. 136-139.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2019.09.116
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 71/706: Show issues
    Z 3.8: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Effect of alpha-lactalbumin and lactoferrin oleic acid complexes on chromatin structural organization.

    Lebedev, Dmitry V / Zabrodskaya, Yana A / Pipich, Vitaly / Kuklin, Alexander I / Ramsay, Edward / Sokolov, Alexey V / Elizarova, Anna Yu / Shaldzhyan, Aram A / Grudinina, Natalia A / Pantina, Rimma A / Wu, Baohu / Shtam, Tatiana A / Volnitskiy, Andrey V / Schmidt, Alexander E / Shvetsov, Alexey V / Vasilyev, Vadim B / Isaev-Ivanov, Vladimir V / Egorov, Vladimir V

    Biochemical and biophysical research communications

    2019  Volume 520, Issue 1, Page(s) 136–139

    Abstract: This work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. ... ...

    Abstract This work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. Complexes featuring oleic acid (OA) with human alpha-lactalbumin (hAl) or with bovine alpha-lactalbumin (bAl), and human lactoferrin (hLf) were investigated using small-angle neutron scattering (SANS). It was shown that while alpha-lactalbumin protein complexes were formed on the surface of polydisperse OA micelles, the lactoferrin complexes comprised a monodisperse system of nanoscale particles. Both hAl and hLf complexes appeared to interact with the chromatin of isolated nuclei affecting chromatin structural organization. The possible roles of these processes in the specific anti-tumor activity of these complexes are discussed.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cattle ; Cell Nucleus/chemistry ; Chromatin/chemistry ; HeLa Cells ; Humans ; Lactalbumin/chemistry ; Lactoferrin/chemistry ; Micelles ; Oleic Acid/chemistry ; Oleic Acids/chemistry ; Scattering, Small Angle
    Chemical Substances Antineoplastic Agents ; Chromatin ; LTF protein, human ; Micelles ; Oleic Acids ; Oleic Acid (2UMI9U37CP) ; Lactalbumin (9013-90-5) ; Lactoferrin (EC 3.4.21.-)
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2019.09.116
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top