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  1. Book ; Online ; E-Book: Trends in Counterfeit Drugs

    Elkins, Kelly M.

    (Counterfeit Drugs Series)

    2024  

    Abstract: This book addresses trends in counterfeit drugs over the past 5-10 years, and discusses approaches to reducing counterfeit medicines in the market. The text shows perspectives from both crime lab and toxicology lab personnel, as well as academic ... ...

    Author's details edited by Kelly M. Elkins
    Series title Counterfeit Drugs Series
    Abstract This book addresses trends in counterfeit drugs over the past 5-10 years, and discusses approaches to reducing counterfeit medicines in the market. The text shows perspectives from both crime lab and toxicology lab personnel, as well as academic researchers.
    Keywords Drug adulteration ; Drug traffic ; Pharmaceutical industry/Corrupt practices ; Product counterfeiting ; United States
    Subject code 615.1901
    Language English
    Size 1 online resource (279 pages)
    Publisher CRC Press
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-318332-8 ; 1-000-87553-9 ; 1-003-18332-8 ; 9781032024271 ; 978-1-00-318332-7 ; 978-1-000-87553-9 ; 978-1-003-18332-7 ; 1032024275
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Next Generation Sequencing (NGS) Technology in DNA Analysis

    Dash, Hirak Ranjan / Elkins, Kelly M. / Al-Snan, Noora Rashid

    2024  

    Author's details Hirak Ranjan Dash, Kelly M. Elkins, and Noora Rashid Al-Snan, editors
    MeSH term(s) High-Throughput Nucleotide Sequencing ; Sequence Analysis, DNA
    Keywords High-throughput nucleotide sequencing ; DNA/Data processing
    Subject code 572.8/633
    Language English
    Size 1 online resource (614 pages)
    Edition First edition.
    Publisher Stacy Masucci
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-99380-X ; 0-323-99144-0 ; 978-0-323-99380-7 ; 978-0-323-99144-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Advancements in Forensic DNA Analysis

    Dash, Hirak Ranjan / Al-Snan, Noora Rashid / Elkins, Kelly M.

    2023  

    Author's details Dr. Hirak Ranjan Dash is an Assistant Professor of Forensic Biology and Biotechnology at National Forensic Sciences University, India. Before joining academics, he has worked as a Forensic DNA expert at Forensic Science Laboratory, Madhya Pradesh, India. He has examined more than 1000 cases by DNA fingerprinting technique. His research interests include DNA fingerprinting, Microbial forensics, microbiome analysis, Next Generation Sequencing, and mtDNA analysis. He has published more than 40 research papers in various peer-reviewed journals. He has written 10 books in various fields of Biotechnology. He is a life member and served as reviewer for various International journals. He is the pioneer worker from India on NGS based forensic DNA analysis. He is featured in the list of top 2% scientists of the world for 2021, 2022, and 2023. Dr. Kelly M. Elkins is a Professor of Chemistry at Towson University, USA, founding co-editor-in-chief of an international journal, and former Director
    Keywords DNAFingerprinting ; NGSTechnology ; ForensicDNAanalysis ; ethicalissues ; Genotypinganalyses ; DNA Fingerprinting ; NGS technology ; Forensic DNA analysis ; Ethical issues ; Genotyping analyses
    Language English
    Size 172 p.
    Edition 1
    Publisher Springer Nature Singapore
    Document type Book
    Note PDA Manuell_25
    Format 183 x 260 x 16
    ISBN 9789819961948 ; 9819961947
    Database PDA

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  4. Book: Forensic DNA biology

    Elkins, Kelly M.

    a laboratory manual

    2013  

    Abstract: A collection of forensic DNA typing laboratory experiments designed for academic and training courses at the collegiate ... ...

    Author's details Kelly M. Elkins
    Abstract A collection of forensic DNA typing laboratory experiments designed for academic and training courses at the collegiate level
    Subject code 614.1
    Language English
    Size XXVI, 198 S. : Ill., graph. Darst., 24 cm
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017462586
    ISBN 978-0-12-394585-3 ; 0-12-394585-2
    Database Catalogue ZB MED Medicine, Health

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    2012 A 5782 order for loan Magazin

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  5. Article ; Online: Pyrosequencing Primer Design for Forensic Biology Applications.

    Elkins, Kelly M

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2392, Page(s) 247–259

    Abstract: The polymerase chain reaction (PCR) is used to copy DNA in vitro for a variety of applications including amplifying a target DNA, mutating a base, adding tags, and sequencing by synthesis applications. Next-generation sequencing (NGS) is a DNA sequencing ...

    Abstract The polymerase chain reaction (PCR) is used to copy DNA in vitro for a variety of applications including amplifying a target DNA, mutating a base, adding tags, and sequencing by synthesis applications. Next-generation sequencing (NGS) is a DNA sequencing technology that has been applied to screening cancer and tissue variants, deep sequencing, and gene expression analysis, and more recently, it has been applied to DNA typing for human identification, estimating age, and detecting and differentiating body fluids. Body fluids are normally identified using color tests, microscopy, and immunochromatographic assays. Pyrosequencing is an NGS approach that has been applied to body fluid analysis. The pyrosequencing assays can detect one or several mixed body fluids by analysis of their tissue-specific differentially methylated regions (tDMRs). Here, the process of designing pyrosequencing primers for forensic biology applications is described.
    MeSH term(s) Biology ; DNA ; DNA Fingerprinting ; DNA Methylation ; High-Throughput Nucleotide Sequencing ; Humans ; Sequence Analysis, DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2021-11-13
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1799-1_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Authors' response.

    Elkins, Kelly M / Garloff, Alexis / Zeller, Cynthia B

    Journal of forensic sciences

    2023  Volume 68, Issue 3, Page(s) 1092

    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Letter
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/1556-4029.15252
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  7. Article ; Online: Additional predictions for forensic DNA phenotyping of externally visible characteristics using the ForenSeq and Imagen kits.

    Elkins, Kelly M / Garloff, Alexis T / Zeller, Cynthia B

    Journal of forensic sciences

    2023  Volume 68, Issue 2, Page(s) 608–613

    Abstract: Multiplex DNA typing methods using massively parallel sequencing can be used to predict externally visible characteristics (EVCs) in forensic DNA phenotyping through the analysis of single-nucleotide polymorphisms. The focus of EVC determination has ... ...

    Abstract Multiplex DNA typing methods using massively parallel sequencing can be used to predict externally visible characteristics (EVCs) in forensic DNA phenotyping through the analysis of single-nucleotide polymorphisms. The focus of EVC determination has focused on hair color, eye color, and skin tone as well as visible biogeographical ancestry features. In this study, we researched off-label applications beyond what is currently marketed by the manufacturer of the Verogen ForenSeq kit primer set B and Imagen primer set E SNP loci. We investigated additional EVC predictions by examining published genome wide sequencing studies and reported allele-specific gene expression and predictive values. We have identified 15 SNPs included in the ForenSeq kit panel and Imagen kits that have additional EVC prediction capabilities beyond what is published in the Verogen manuals. The additional EVCs that can be predicted include hair graying, ephelides hyperpigmented spots, dermatoheliosis, facial pigmented spots, standing height, pattern balding, helix-rolling ear morphology, hair shape, hair thickness, facial morphology, eyebrow thickness, sarcoidosis, obesity, vitiligo, and tanning propensity. The loci can be used to augment and refine phenotype predictions with software such as MetaHuman for missing persons, cold case, and historic case investigations.
    MeSH term(s) Phenotype ; DNA/genetics ; DNA Fingerprinting ; Skin Pigmentation ; Hair ; Polymorphism, Single Nucleotide ; Forensic Genetics/methods ; High-Throughput Nucleotide Sequencing/methods ; Eye Color
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/1556-4029.15215
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  8. Article ; Online: Authors' response.

    Elkins, Kelly M / Garloff, Alexis T / Zeller, Cynthia B

    Journal of forensic sciences

    2023  Volume 69, Issue 2, Page(s) 741–742

    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Letter
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/1556-4029.15435
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  9. Article ; Online: Primer design for PCR reactions in forensic biology.

    Elkins, Kelly M

    Methods in molecular biology (Clifton, N.J.)

    2015  Volume 1275, Page(s) 17–30

    Abstract: The polymerase chain reaction (PCR) is a popular method to copy DNA in vitro. Its invention revolutionized fields ranging from clinical medicine to anthropology, molecular biology, and forensic biology. The method employs one of many available heat- ... ...

    Abstract The polymerase chain reaction (PCR) is a popular method to copy DNA in vitro. Its invention revolutionized fields ranging from clinical medicine to anthropology, molecular biology, and forensic biology. The method employs one of many available heat-stable DNA polymerases in a reaction that is repeated many times in situ. The DNA polymerase reads a template DNA strand and using the components of the reaction mix, catalyzes the addition of free 2'-deoxynucleotide triphosphate nitrogenous bases to short segment of DNA that forms a complement with the template via Watson-Crick base pairing. This short segment of DNA is referred to as a PCR primer and it is essential to the success of the reaction. The most widely used application of PCR in forensic labs is the amplification of short tandem repeat (STR) loci used in DNA typing. The STRs are routinely evaluated in concert with 16 or more reactions, a multiplex, run in one test tube simultaneously. In a multiplex, it is essential that the primers work specifically and accurately on the intended reactions without hindering the other reactions. The primers, which are very specific, also can be used to probe single nucleotide polymorphisms (SNPs) in a DNA sequence of interest by single base extension. Primers are often designed using one of many available automated software packages. Here the process of manually designing PCR primers for forensic biology using no-cost software is described.
    MeSH term(s) DNA/genetics ; DNA Fingerprinting/methods ; DNA Primers/genetics ; Forensic Sciences/methods ; Microsatellite Repeats/genetics ; Polymerase Chain Reaction/methods ; Polymorphism, Single Nucleotide/genetics ; Software
    Chemical Substances DNA Primers ; DNA (9007-49-2)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-2365-6_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Development of a PCR High-Resolution Melt Assay for Artemisia absinthium (Wormwood) and a Triplex Assay with Two Additional "Unregulated Legal High" Species Datura stramonium (Jimson Weed) and Merremia tuberosa (Hawaiian Woodrose).

    Kiesel, Brianna D / Elkins, Kelly M

    Journal of forensic sciences

    2019  Volume 64, Issue 6, Page(s) 1817–1822

    Abstract: Artemisia absinthium (wormwood), a common ingredient in absinthe, contains the compound thujone, which is unregulated by the U.S. Drug Enforcement Agency. Thujone can cause an "unregulated legal high" in higher concentrations. The European Union limits ... ...

    Abstract Artemisia absinthium (wormwood), a common ingredient in absinthe, contains the compound thujone, which is unregulated by the U.S. Drug Enforcement Agency. Thujone can cause an "unregulated legal high" in higher concentrations. The European Union limits thujone from Artemisia species to 35 mg/kg while the U.S. Food and Drug Administration requires less than 10 ppm to be "thujone-free." However, individuals can smoke or ingest A. absinthium in different forms. This study developed a polymerase chain reaction (PCR) high-resolution melt (HRM) assay to detect and identify A. absinthium based on primer specificity, sensitivity, repeatability, and robustness. A triplex assay was performed with three "unregulated legal high" species: Datura stramonium, Merremia tuberosa, and A. absinthium; the PCR HRM assay detected and identified each plant at melt temperatures 77.42 ± 0.20°C, 83.88 ± 0.22°C, and 87.77 ± 0.15°C, respectively. The primer set developed distinguished A. absinthium from a variety of plant species and was successfully triplexed.
    MeSH term(s) Artemisia absinthium/genetics ; Convolvulaceae/genetics ; DNA Primers ; Datura stramonium/genetics ; Humans ; Plant Extracts/genetics ; Polymerase Chain Reaction/methods ; Substance-Related Disorders ; Transition Temperature
    Chemical Substances DNA Primers ; Plant Extracts
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/1556-4029.14093
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