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  1. Article ; Online: The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes.

    Alkholy, Usama M / Abdalmonem, Nermin / Zaki, Ahmed / Elkoumi, Mohamed A / Hashim, Mustafa I Abu / Basset, Maha A A / Salah, Hossam E

    Jornal de pediatria

    2018  Volume 95, Issue 2, Page(s) 224–230

    Abstract: Objective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes.: Method: This case-control study was conducted on 72 children with type 1 ... ...

    Abstract Objective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes.
    Method: This case-control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets.
    Results: Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low-density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high-density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p<0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p<0.05). The platelet redox status showed a negative correlation with the A1c % levels (r=-0.31; p=0.022) and the duration of type 1 diabetes (r=-0.35, p=0.012).
    Conclusion: Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress.
    MeSH term(s) Adolescent ; Biomarkers/blood ; Case-Control Studies ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/blood ; Female ; Humans ; Male ; Oxidation-Reduction ; Oxidative Stress ; Ubiquinone/analogs & derivatives ; Ubiquinone/blood ; Vitamin E/blood
    Chemical Substances Biomarkers ; Ubiquinone (1339-63-5) ; Vitamin E (1406-18-4) ; coenzyme Q10 (EJ27X76M46)
    Language English
    Publishing date 2018-02-07
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.1016/j.jped.2017.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1265: Show issues Location:
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  2. Article ; Online: Interleukin-4 -590C/T gene polymorphism in Egyptian children with acute lower respiratory infection: A multicenter study.

    Emam, Ahmed A / Shehab, Mohamed M M / Allah, Mayy A N / Elkoumi, Mohamed A / Abdelaal, NourEldin M / Mosabah, Amira A A / Zakaria, Mervat T / Sherif, Ashraf M / Soliman, Mohammed M / El-Kaffas, Rania M H / Abouzeid, Heba / Abdou, Mohammed A / Abdalmonem, Nermin / Abdelbaset, Heba R / Mohamed, Soma A / Soliman, Attia A / Elashkar, Shaimaa S A / Hegab, Mohamed S / Khalil, Atef M /
    Abdel-Aziz, Alsayed / Anany, Heba G / Salah, Hossam E / Abdou, Adel M / Elshehawy, Naglaa A / Elbasyouni, Hany A A / Hafez, Sahbaa F M / Abo-Alella, Doaa A / Fawzi, Maggie M / Morsi, Samar S

    Pediatric pulmonology

    2019  Volume 54, Issue 3, Page(s) 297–302

    Abstract: Background: Acute lower respiratory infection (ALRI) is the leading cause of child mortality, especially in the developing world. Polymorphisms in the interleukin 4 (IL-4) gene have been linked to a variety of human diseases.: Objectives: To ... ...

    Abstract Background: Acute lower respiratory infection (ALRI) is the leading cause of child mortality, especially in the developing world. Polymorphisms in the interleukin 4 (IL-4) gene have been linked to a variety of human diseases.
    Objectives: To investigate whether the IL-4 -590C/T (rs2243250) polymorphism could be a genetic marker for susceptibility to ALRIs in young Egyptian children.
    Methods: This was a multicenter study conducted on 480 children diagnosed with pneumonia or bronchiolitis, and 480 well-matched healthy control children. Using PCR-RFLP analysis, we genotyped a -590C/T (rs2243250) single nucleotide polymorphism of the IL-4 gene promoter, meanwhile the serum IL-4concentration was measured by ELISA.
    Results: The frequency of the IL-4 -590 T/T genotype and T allele were overrepresented in patients with ALRIs in comparison to the control group (OR = 2.0; [95% confidence interval [CI]: 1.38-2.96]; for the T/T genotype) and (OR: 1.3; [95%CI: 1.07-1.56]; for the T allele; P < 0.01). The IL-4 -590 T/T genotype was associated with significantly higher mean serum IL-4 concentration (58.7 ± 13.4 pg/mL) compared to the C/T genotype (47.6 ± 11 pg/mL) and the C/C genotype (34.8 ± 9.6 pg/mL); P < 0.01.
    Conclusion: The IL-4 -590C/T (rs2243250) polymorphism may contribute to susceptibility to ALRIs in young Egyptian children.
    MeSH term(s) Alleles ; Bronchiolitis/blood ; Bronchiolitis/genetics ; Child, Preschool ; Egypt ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Infant ; Interleukin-4/blood ; Interleukin-4/genetics ; Male ; Pneumonia/blood ; Pneumonia/genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Respiratory Tract Infections/blood ; Respiratory Tract Infections/genetics
    Chemical Substances Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2019-01-06
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Association of interleukin-17A gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multi-centre study.

    Elkoumi, Mohamed A / Allah, Mayy An / Mohamed, Faisal Y / Boraey, Naglaa F / Abdellatif, Sawsan H / Shehab, Mohamed Mm / Sherif, Ahmed H / Akeel, Nagwa E / Saleh, Rabab M / Elshreif, Anas M / Abdelrahman, Hind M / Soliman, Attia A / Emam, Ahmed A / Youssef, Manal Aa / Fahmy, Dalia S / Sallam, Mohammad M / Nawara, Abdalla M / Elgohary, Elsayed A / Ismael, Ali /
    El-Kaffas, Sameh Mh / Sobeih, Alaa A / Ibrahim, Lamya M / Ibrahim, Mohamed Am / Abdou, Adel M / Yousry, Sherif M / Osman, Sherif F / El-Deeb, Fatma M / Elhewala, Ahmed A / Hafez, Sahbaa Fm / Waked, Nevin M / Elbasyouni, Hany Aa / Fouad, Rania A / Zeidan, Nancy Ms / Nashat, Mohamed / Farghaly, Mohsen Aa

    Lupus

    2020  Volume 29, Issue 7, Page(s) 767–775

    Abstract: Background: Recently, the interleukin-17A (: Objectives: This study aimed to investigate whether IL-17A polymorphisms at rs2275913 G/A, rs8193036 C/T and rs3748067 C/T could be susceptibility markers for juvenile-onset SLE (JSLE) and lupus nephritis ( ...

    Abstract Background: Recently, the interleukin-17A (
    Objectives: This study aimed to investigate whether IL-17A polymorphisms at rs2275913 G/A, rs8193036 C/T and rs3748067 C/T could be susceptibility markers for juvenile-onset SLE (JSLE) and lupus nephritis (LN) in Egyptian children and adolescents.
    Methods: In this multi-centre study, we genotyped 320 patients diagnosed with JSLE and 320 matched control children for three IL-17A polymorphisms at rs2275913 G/A, rs8193036 C/T and rs3748067 C/T using TaqMan probe-based real-time polymerase chain reaction. Meanwhile, IL-17A serum levels were assessed using ELISA.
    Results: The IL-17 rs2275913 A/A genotype and A allele were more represented in JSLE patients compared to the control group (21% vs. 7%, odds ratio (OR) = 3.8, 95% confidence interval (CI) 1.78-5.5,
    Conclusion: The IL-17 rs2275913 A allele and A/A genotype were associated with high IL-17 serum levels and may contribute to susceptibility to JSLE and the development of LN in Egyptian children and adolescents. However, no significant association was evident between the studied IL-17A SNPs and other clinical phenotypes, disease activity scores or laboratory profile of JSLE.
    MeSH term(s) Adolescent ; Alleles ; Case-Control Studies ; Child ; Egypt ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Interleukin-17/genetics ; Logistic Models ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/pathology ; Lupus Nephritis/genetics ; Lupus Nephritis/pathology ; Male ; Polymorphism, Single Nucleotide ; Prospective Studies ; Risk Factors
    Chemical Substances IL17A protein, human ; Interleukin-17
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/0961203320922305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3717: Show issues Location:
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  4. Article ; Online: Ficolin-1 gene (FCN1) -144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under-five Egyptian children: A multicenter study.

    Elkoumi, Mohamed A / Abdellatif, Sawsan H / Mohamed, Faisal Y / Sherif, Ahmed H / Elashkar, Shaimaa S A / Saleh, Rabab M / Boraey, Naglaa F / Abdelaal, NourEldin M / Akeel, Nagwa E / Elhewala, Ahmed A / Mosbah, Amira A / Zakaria, Mervat T / Soliman, Mohammed M / Salah, Ahmed / Sedky, Yasser M / Sobieh, Alaa A / Mashali, Mohamed H / Waked, Nevin M / Elshreif, Anas M /
    Hafez, Sahbaa F / Hashem, Mustafa I A / Shehab, Mohamed M / Soliman, Attia A / Emam, Ahmed A / Ahmed, Abdelrahman A A / Fahim, Mohamed S / Elshehawy, Naglaa A / Abdel-Aziz, Marwa M / Abdou, Adel M / El-Shehawy, Ahmed A / Youssef, Manal A A / Fahmy, Dalia S / Malek, Mai M / Osman, Sherif F / Ibrahim, Mohamed A M / Alanwar, Mohamed I / Zeidan, Nancy M S

    Pediatric pulmonology

    2020  Volume 55, Issue 5, Page(s) 1175–1183

    Abstract: Background: Pneumonia is the foremost cause of child death worldwide. M-ficolin is encoded by the FCN1 gene and represents a novel link between innate and adaptive immunity.: Objectives: To investigate the FCN1 -144 C/A (rs10117466) polymorphism as a ...

    Abstract Background: Pneumonia is the foremost cause of child death worldwide. M-ficolin is encoded by the FCN1 gene and represents a novel link between innate and adaptive immunity.
    Objectives: To investigate the FCN1 -144 C/A (rs10117466) polymorphism as a potential marker for pneumonia severity and adverse outcome namely complications or mortality in the under-five Egyptian children.
    Methods: This was a prospective multicenter study that included 620 children hospitalized with World Health Organization-defined severe pneumonia and 620 matched healthy control children. Polymorphism rs10117466 of the FCN1 gene promoter was analyzed by PCR-SSP, while serum M-ficolin levels were assessed by ELISA.
    Results: The FCN1 A/A genotype and A allele at the -144 position were more frequently observed in patients compared to the control children (43.4% vs 27.6%; odds ratio [OR]: 1.62; [95% confidence interval {CI}: 1.18-2.2]; for the A/A genotype) and (60.8% vs 52.5%; OR: 1.4; [95% CI: 1.19-1.65]; for the A allele); P < .01. The FCN1 -144 A/A homozygous patients had significantly higher serum M-ficolin concentrations (mean: 1844 ± 396 ng/mL) compared with those carrying the C/C or C/A genotype (mean: 857 ± 278 and 1073 ± 323 ng/mL, respectively; P = .002). FCN1 -144 A/A genotype was an independent risk factor for adverse outcomes in children with severe pneumonia (adjusted OR = 4.85, [95% CI: 2.96-10.25]; P = .01).
    Conclusion: The FCN1 A/A genotype at the -144 position was associated with high M-ficolin serum levels and possibly contributes to enhanced inflammatory response resulting in the adverse outcome of pneumonia in the under-five Egyptian children.
    MeSH term(s) Child, Preschool ; Egypt/epidemiology ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Infant ; Lectins/blood ; Lectins/genetics ; Male ; Odds Ratio ; Pneumonia/blood ; Pneumonia/epidemiology ; Pneumonia/genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Prospective Studies ; Risk Factors ; Ficolins
    Chemical Substances Lectins
    Language English
    Publishing date 2020-03-06
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2143: Show issues Location:
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