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  1. Book ; Online: Gluten-Free Diet

    Elli, Luca

    2019  

    Abstract: In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high ... ...

    Abstract In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed
    Keywords Medicine (General) ; Nutritional diseases. Deficiency diseases
    Size 1 electronic resource (318 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020103076
    ISBN 9783038977360 ; 9783038977377 ; 3038977365 ; 3038977373
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Author's reply: "Time is over: step back to reusable and step forward to recyclable!"

    Sorge, Andrea / Elli, Luca

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 55, Issue 8, Page(s) 1152

    Language English
    Publishing date 2023-06-09
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.05.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical practices and adherence to guidelines for eosinophilic esophagitis: A European survey.

    Sorge, Andrea / Coletta, Marina / Elli, Luca / Bredenoord, Albert J

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2024  

    Abstract: Background: We aimed to assess the clinical practices and adherence to guidelines for adult Eosinophilic Esophagitis (EoE) patients in Europe.: Methods: A cross-sectional web survey containing 23 questions was distributed to members of the European ... ...

    Abstract Background: We aimed to assess the clinical practices and adherence to guidelines for adult Eosinophilic Esophagitis (EoE) patients in Europe.
    Methods: A cross-sectional web survey containing 23 questions was distributed to members of the European Consortium for Eosinophilic Diseases of the Gastrointestinal Tract (EUREOS) and the Italian Association of Hospital Gastroenterologists and digestive endoscopists (AIGO). We conducted a subgroup analysis to assess the impact of EoE expertise and practice setting on clinical practices.
    Results: 228 physicians from 18 European countries participated. Adherence to guidelines varied from 72% to 98.6%. 83.4% of total respondents obtained ≥ 6 esophageal biopsies in suspected EoE. 42% of total respondents, 82.5% of EoE experts (vs. non-experts 33%; P < 0.0001), and 55% of academics (vs. 29.1 non-academics; P < 0.0001) routinely used the EREFS score. Regarding first-line therapy, 82.9% of total respondents prescribed proton pump inhibitors, 41.6% topical steroids, 20.6% elimination diets, and 9.2% combination therapies. Only 72% of respondents used symptoms and endoscopy with <15 Eosinophils/HPF to define treatment response. 21.5% of all respondents did not prescribe maintenance therapies and 12.7% discontinued therapy before response evaluation endoscopy.
    Conclusion: Our findings revealed significant heterogeneity in practice patterns and suboptimal adherence to EoE guidelines across Europe. Expertise in EoE and working in an academic hospital positively influenced clinical practices and adherence to guidelines.
    Language English
    Publishing date 2024-01-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Past, Present, and Future of Noninvasive Tests to Assess Gluten Exposure, Celiac Disease Activity, and End-Organ Damage.

    Silvester, Jocelyn A / Elli, Luca / Khosla, Chaitan / Tye-Din, Jason A

    Gastroenterology

    2024  

    Abstract: Although many biomarkers have been proposed, and several are in widespread clinical use, there is no single readout or combination of readouts that correlates tightly with gluten exposure, disease activity, or end-organ damage in treated patients with ... ...

    Abstract Although many biomarkers have been proposed, and several are in widespread clinical use, there is no single readout or combination of readouts that correlates tightly with gluten exposure, disease activity, or end-organ damage in treated patients with celiac disease. Challenges to developing and evaluating better biomarkers include significant interindividual variability-related to immune amplification of gluten exposure and how effects of immune activation are manifest. Furthermore, the current "gold standard" for assessment of end-organ damage, small intestinal biopsy, is itself highly imperfect, such that a marker that is a better reflection of the "ground truth" may indeed appear to perform poorly. The goal of this review was to analyze past and present efforts to establish robust noninvasive tools for monitoring treated patients with celiac disease and to highlight emerging tools that may prove to be useful in clinical practice.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.01.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Thalidomide for Bleeding from Small-Intestinal Angiodysplasia.

    Topa, Matilde / Pessarelli, Tommaso / Elli, Luca

    The New England journal of medicine

    2023  Volume 390, Issue 5, Page(s) 479

    MeSH term(s) Humans ; Thalidomide/adverse effects ; Hemorrhage/chemically induced ; Angiogenesis Inhibitors/therapeutic use ; Intestine, Small/diagnostic imaging ; Angiodysplasia/complications ; Angiodysplasia/drug therapy
    Chemical Substances Thalidomide (4Z8R6ORS6L) ; Angiogenesis Inhibitors
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2314599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The low-FODMAP diet and the gluten-free diet in the management of functional abdominal bloating and distension.

    Pessarelli, Tommaso / Sorge, Andrea / Elli, Luca / Costantino, Andrea

    Frontiers in nutrition

    2022  Volume 9, Page(s) 1007716

    Abstract: This review summarizes current knowledge on the role of low-FODMAP diet and gluten-free diet in functional abdominal bloating and distension, an emerging disorder of gut-brain interaction characterized by remarkable costs for healthcare systems and a ... ...

    Abstract This review summarizes current knowledge on the role of low-FODMAP diet and gluten-free diet in functional abdominal bloating and distension, an emerging disorder of gut-brain interaction characterized by remarkable costs for healthcare systems and a significant impact on the patient's quality of life. Ingested food plays a key role in the pathophysiology of disorders of gut-brain interaction as up to 84% of patients with irritable bowel syndrome (IBS) report food-triggered symptoms. Potential pathogenetic mechanisms of food-related symptoms in these patients are discussed, focusing on bloating and abdominal distension. These mechanisms provide the rationale for dietary treatment in patients with functional abdominal bloating and distension. The role of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and gluten in functional abdominal bloating and distension is examined. Current literature evaluating the efficacy of the low-FODMAP diet and the gluten-free diet in abdominal bloating and distension is analyzed. Available evidence originates mainly from studies on patients with IBS, since clinical studies on selected cohorts of patients with only functional abdominal bloating and distension have been missing to date. Promising evidence on the potential efficacy of the low-FODMAP diet in functional abdominal bloating and distension is provided by the reduction of the bloating observed in patients with IBS. Regarding the gluten-free diet, there is insufficient evidence to recommend it to reduce bloating and abdominal distension. In conclusion, this review asserts the need for a close collaboration with experts in nutrition to optimize the management of these patients and reduce the risks associated with elimination diets.
    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.1007716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biomarkers for the diagnosis and monitoring of celiac disease: can you count on me?

    Topa, Matilde / Sanders, David Surendran / Elli, Luca

    Current opinion in gastroenterology

    2022  Volume 38, Issue 3, Page(s) 263–269

    Abstract: Purpose of review: Different markers are available to diagnose and monitor celiac disease (CeD); however, the concordance among them and their efficacy are still controversial. We aim at defining the efficacy of CeD biomarkers, their advantages and ... ...

    Abstract Purpose of review: Different markers are available to diagnose and monitor celiac disease (CeD); however, the concordance among them and their efficacy are still controversial. We aim at defining the efficacy of CeD biomarkers, their advantages and limits.
    Recent findings: CeD diagnostic criteria are widely accepted, being a positive serology and duodenal atrophy (according to the Marsh-Oberhuber score) the main hallmarks. Flow cytometry and other molecular biomarkers support the diagnosis of refractory CeD. On the other side, CeD monitoring is less defined, as the biomarkers are not always reliable. To date, the reference standard to detect mucosal healing is represented by duodenal histology, but its timing and significance are debated. Novel scores may better define the trend of mucosal damage and MicroRNAs are among the innovative noninvasive biomarkers. The assessment of a correct gluten-free diet (GFD) is another aspect of CeD monitoring, based upon questionnaires and recently developed tools such as dosage of urinary or faecal gluten immunogenic peptides.
    Summary: Clinicians lack of a widely acknowledged tools to monitor CeD and GFD. Here, we present the efficacy of the most used markers.
    MeSH term(s) Biomarkers ; Celiac Disease/diagnosis ; Diet, Gluten-Free/methods ; Duodenum/pathology ; Glutens ; Humans
    Chemical Substances Biomarkers ; Glutens (8002-80-0)
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Gluten Rhapsody.

    Elli, Luca / Marinoni, Beatrice

    Nutrients

    2019  Volume 11, Issue 3

    Abstract: For decades, gluten-free dieting (GFD) has been accepted as the only therapeutic approach to coeliac disease (CD) and, more recently, for non-coeliac gluten sensitivity (NCGS), a term to refer to the so-called gluten-related disorders (GRD) [ ... ]. ...

    Abstract For decades, gluten-free dieting (GFD) has been accepted as the only therapeutic approach to coeliac disease (CD) and, more recently, for non-coeliac gluten sensitivity (NCGS), a term to refer to the so-called gluten-related disorders (GRD) [...].
    MeSH term(s) Celiac Disease/diet therapy ; Diet, Gluten-Free ; Humans
    Language English
    Publishing date 2019-03-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11030589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Band-on-band endoscopic variceal ligation: a technique for the treatment of esophageal varices in case of band misplacement.

    Sorge, Andrea / Pessarelli, Tommaso / Elli, Luca / Nandi, Nicoletta / Tosetti, Giulia / Primignani, Massimo / Tontini, Gian Eugenio

    Endoscopy

    2024  Volume 56, Issue S 01, Page(s) E211–E212

    MeSH term(s) Humans ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/surgery ; Hypertension, Portal ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/surgery ; Ligation/methods ; Sclerotherapy/methods ; Liver Cirrhosis
    Language English
    Publishing date 2024-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2268-5513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Persisting Villous Atrophy and Adherence in Celiac Disease: What Does the Patient Want? What Should a Clinician Advise?

    Rej, Anupam / Elli, Luca / Sanders, David Surendran

    The American journal of gastroenterology

    2021  Volume 116, Issue 5, Page(s) 946–948

    Abstract: Abstract: Adherence to a gluten-free diet in celiac disease remains challenging. Clinicians may view mucosal healing as crucial. From the patient's perspective, avoidance of an invasive upper endoscopy may be desirable. A fundamental misconception is ... ...

    Abstract Abstract: Adherence to a gluten-free diet in celiac disease remains challenging. Clinicians may view mucosal healing as crucial. From the patient's perspective, avoidance of an invasive upper endoscopy may be desirable. A fundamental misconception is that noninvasive tools including symptoms, serology, dietary adherence questionnaires, and novel gluten immunogenic peptides may detect ongoing villous atrophy rather than assess adherence. Duodenal biopsies are the only reliable method for assessment of mucosal healing-however, we as clinicians should provide patients with the uncertainties of this approach allowing them to make an informed decision on an individual basis.
    MeSH term(s) Adult ; Atrophy/pathology ; Biopsy ; Celiac Disease/pathology ; Diet, Gluten-Free ; Humans ; Intestinal Mucosa/pathology ; Prospective Studies
    Language English
    Publishing date 2021-03-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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