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  1. Article ; Online: Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins.

    Desai, Aamod V / Vornholt, Simon M / Major, Louise L / Ettlinger, Romy / Jansen, Christian / Rainer, Daniel N / de Rome, Richard / So, Venus / Wheatley, Paul S / Edward, Ailsa K / Elliott, Caroline G / Pramanik, Atin / Karmakar, Avishek / Armstrong, A Robert / Janiak, Christoph / Smith, Terry K / Morris, Russell E

    ACS applied materials & interfaces

    2023  

    Abstract: Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in ... ...

    Abstract Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in the form of deactivating coronavirus particles through selective binding onto the surface of metal-organic frameworks (MOFs) to further the fight against the transmission of respiratory viruses. MOFs are attractive materials in this regard, as their rich pore and surface chemistry can easily be modified on demand. The surfaces of three MOFs, UiO-66(Zr), UiO-66-NH
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c21187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins

    Desai, Aamod V. / Vornholt, Simon M. / Major, Louise L. / Ettlinger, Romy / Jansen, C. E. C. / Rainer, Daniel N. / de Rome, Richard / So, Venus / Wheatley, Paul S. / Edward, Ailsa K. / Elliott, Caroline G. / Pramanik, Atin / Karmakar, Avishek / Armstrong, A. Robert / Janiak, Christoph / Smith, Terry K. / Morris, Russell E.

    ACS Applied Materials & Interfaces. 2023 Feb. 14, v. 15, no. 7 p.9058-9065

    2023  

    Abstract: Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in ... ...

    Abstract Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in the form of deactivating coronavirus particles through selective binding onto the surface of metal-organic frameworks (MOFs) to further the fight against the transmission of respiratory viruses. MOFs are attractive materials in this regard, as their rich pore and surface chemistry can easily be modified on demand. The surfaces of three MOFs, UiO-66­(Zr), UiO-66-NH₂(Zr), and UiO-66-NO₂(Zr), have been functionalized with repurposed antiviral agents, namely, folic acid, nystatin, and tenofovir, to enable specific interactions with the external spike protein of the SARS virus. Protein binding studies revealed that this surface modification significantly improved the binding affinity toward glycosylated and non-glycosylated proteins for all three MOFs. Additionally, the pores for the surface-functionalized MOFs can adsorb water, making them suitable for locally dehydrating microbial aerosols. Our findings highlight the immense potential of MOFs in deactivating respiratory coronaviruses to be better equipped to fight future pandemics.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; equipment ; filtration ; folic acid ; glycosylation ; nystatin ; viruses ; SARS-CoV-2 ; antiviral drugs ; metal−organic framework ; protein binding ; water adsorption
    Language English
    Dates of publication 2023-0214
    Size p. 9058-9065.
    Publishing place American Chemical Society
    Document type Article ; Online
    ISSN 1944-8252
    DOI 10.1021/acsami.2c21187
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Controlled Synthesis of Large Single Crystals of Metal-Organic Framework CPO-27-Ni Prepared by a Modulation Approach: In situ Single-Crystal X-ray Diffraction Studies.

    Vornholt, Simon M / Elliott, Caroline G / Rice, Cameron M / Russell, Samantha E / Kerr, Peter J / Rainer, Daniel N / Mazur, Michal / Warren, Mark R / Wheatley, Paul S / Morris, Russell E

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Volume 27, Issue 33, Page(s) 8537–8546

    Abstract: The size of single crystals of the metal-organic framework CPO-27-Ni was incrementally increased through a series of modulated syntheses. A novel linker modulated synthesis using 2,5-dihydroxyterephthalic acid and the isomeric ligand 4,6- ... ...

    Abstract The size of single crystals of the metal-organic framework CPO-27-Ni was incrementally increased through a series of modulated syntheses. A novel linker modulated synthesis using 2,5-dihydroxyterephthalic acid and the isomeric ligand 4,6-dihydroxyisophthalic acid yielded large single crystals of CPO-27-Ni (∼70 μm). All materials were shown to have high crystallinity and phase purity through powder X-ray diffraction, electron microscopy methods, thermogravimetry, and compositional analysis. For the first time single-crystal structure analyses were carried out on CPO-27-Ni. High BET surface areas and nitric oxide (NO) release efficiencies were recorded for all materials. Large single crystals of CPO-27-Ni showed a prolonged NO release and proved suitable for in situ single-crystal diffraction experiments to follow the NO adsorption. An efficient activation protocol was developed, leading to a dehydrated structure after just 4 h, which subsequently was NO-loaded, leading to a first NO loaded single-crystal structural model of CPO-27-Ni.
    Language English
    Publishing date 2021-05-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202100528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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