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  1. Article: Can the robot overcome technical challenges of thoracoscopic bronchial anastomosis?

    Elliott, Irmina A / Yanagawa, Jane

    Journal of thoracic disease

    2019  Volume 11, Issue Suppl 9, Page(s) S1123–S1125

    Language English
    Publishing date 2019-06-05
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.04.100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Social Disparities in Lung Cancer.

    Elliott, Irmina / Gonzalez, Cayo / Backhus, Leah / Lui, Natalie

    Thoracic surgery clinics

    2021  Volume 32, Issue 1, Page(s) 33–42

    Abstract: Social disparities in lung cancer diagnosis, treatment, and survival have been studied using national databases, statewide registries, and institution-level data. Some disparities emerge consistently, such as lower adherence to treatment guidelines and ... ...

    Abstract Social disparities in lung cancer diagnosis, treatment, and survival have been studied using national databases, statewide registries, and institution-level data. Some disparities emerge consistently, such as lower adherence to treatment guidelines and worse survival by race and socioeconomic status, whereas other disparities are less well studied. A critical appraisal of current data is essential to increasing equity in lung cancer care.
    MeSH term(s) Guideline Adherence ; Healthcare Disparities ; Humans ; Lung Neoplasms/epidemiology ; Lung Neoplasms/therapy ; Registries ; Social Class
    Language English
    Publishing date 2021-11-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2149218-9
    ISSN 1558-5069 ; 1547-4127
    ISSN (online) 1558-5069
    ISSN 1547-4127
    DOI 10.1016/j.thorsurg.2021.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Smooth Muscle Operator: Robotic-Assisted Enucleation of an Esophageal Leiomyoma.

    Elliott, Irmina A / Forgó, Erna / Lui, Natalie S

    Digestive diseases and sciences

    2021  Volume 66, Issue 8, Page(s) 2538–2541

    MeSH term(s) Aged ; Esophageal Neoplasms/surgery ; Humans ; Leiomyoma/surgery ; Male ; Robotic Surgical Procedures/methods
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06703-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Outcomes of surgery for catastrophic hiatal hernia presentations.

    Wong, Lye-Yeng / Leipzig, Matthew / Elliott, Irmina A / Liou, Douglas Z / Backhus, Leah M / Shrager, Joseph B / Berry, Mark F

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2024  Volume 28, Issue 3, Page(s) 285–286

    MeSH term(s) Humans ; Hernia, Hiatal/surgery
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1016/j.gassur.2023.12.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lepidic-Type Lung Adenocarcinomas: Is It Safe to Observe for Growth Before Treating?

    Wong, Lye-Yeng / Elliott, Irmina A / Liou, Douglas Z / Backhus, Leah M / Lui, Natalie S / Shrager, Joseph B / Berry, Mark F

    The Annals of thoracic surgery

    2024  

    Abstract: Background: Lepidic-type adenocarcinomas (LPAs) can be multifocal, and treatment is often deferred until growth is observed. This study investigated the potential downside of that strategy by evaluating the relationship of nodal involvement with tumor ... ...

    Abstract Background: Lepidic-type adenocarcinomas (LPAs) can be multifocal, and treatment is often deferred until growth is observed. This study investigated the potential downside of that strategy by evaluating the relationship of nodal involvement with tumor size and survival.
    Methods: The impact of tumor size on lymph node involvement and survival was evaluated for National Cancer Database patients who underwent surgery without induction therapy as primary treatment for cT1-3 N0 M0 histologically confirmed LPA from 2006 to 2019 by using logistic regression, Kaplan-Meier, and Cox analyses.
    Results: Positive nodes occurred in 442 of 8286 patients (5.3%). The incidence of having positive nodes approximately doubled with each 1-cm increment increase in size. Patients with positive nodes were more likely to have larger tumors (27 mm vs 20 mm, P < .001) and clinical ≥T2 disease (40.7% vs 26.8%, P < .001) compared with node-negative patients. However, tumor size was the only significant independent predictor of having positive nodal disease in logistic regression analysis, and this association grew stronger with each incremental centimeter increase in size. Patients with positive nodes were more likely to undergo adjuvant radiotherapy (23.5% vs 1.1%, P < .001) and chemotherapy (72.9% vs 7.9%, P < .001), and expectedly, had worse survival compared with the node-negative group in univariate (5-year overall survival, 50.9% vs 81.1%, P < .001) and multivariable (hazard ratio, 2.56; 95% CI, 2.14-3.05; P < .001) analyses.
    Conclusions: Nodal involvement is relatively uncommon in early-stage LPAs but steadily increases with tumor size and is associated with dramatically worse survival. These data can be used to inform treatment decisions when evaluating LPA patients.
    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2024.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Impact of Immunotherapy Use in Stage IIIA (T1-2N2) NSCLC: A Nationwide Analysis.

    Wong, Lye-Yeng / Liou, Douglas Z / Roy, Mohana / Elliott, Irmina A / Backhus, Leah M / Lui, Natalie S / Shrager, Joseph B / Berry, Mark F

    JTO clinical and research reports

    2024  Volume 5, Issue 3, Page(s) 100654

    Abstract: Introduction: Multiple clinical trials have revealed the benefit of immunotherapy (IO) for NSCLC, including unresectable stage III disease. Our aim was to investigate the impact of IO use on treatment and outcomes of potentially resectable stage IIIA ... ...

    Abstract Introduction: Multiple clinical trials have revealed the benefit of immunotherapy (IO) for NSCLC, including unresectable stage III disease. Our aim was to investigate the impact of IO use on treatment and outcomes of potentially resectable stage IIIA NSCLC in a broader nationwide patient cohort.
    Methods: We queried the National Cancer Database (2004-2019) for patients with stage IIIA (T1-2N2) NSCLC. Treatment and survival were evaluated with descriptive statistics, logistic regression, Kaplan-Meier analysis, and Cox proportional hazards modeling.
    Results: Overall, 5.5% (3777 of 68,335) of patients received IO. IO use was uncommon until 2017, but by 2019, it was given to 40.1% (1544 of 2308) of stage IIIA patients. The increased use of IO after 2017 was associated with increased definitive chemoradiation treatment (54.2% [6800 of 12,535] from years 2017 to 2019 versus 46.9% [26,251 of 55,914] from 2004 to 2016,
    Conclusions: Increased use of IO was associated with a change in treatment patterns and improved survival for patients with stage IIIA(N2) NSCLC.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2024.100654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Randomized controlled trials in lung cancer surgery: How are we doing?

    Wong, Lye-Yeng / Li, Yanli / Elliott, Irmina A / Backhus, Leah M / Berry, Mark F / Shrager, Joseph B / Oh, Daniel S

    JTCVS open

    2024  Volume 18, Page(s) 234–252

    Abstract: Objective: Randomized control trials are considered the highest level of evidence, yet the scalability and practicality of implementing randomized control trials in the thoracic surgical oncology space are not well described. The aim of this study is to ...

    Abstract Objective: Randomized control trials are considered the highest level of evidence, yet the scalability and practicality of implementing randomized control trials in the thoracic surgical oncology space are not well described. The aim of this study is to understand what types of randomized control trials have been conducted in thoracic surgical oncology and ascertain their success rate in completing them as originally planned.
    Methods: The ClinicalTrials.gov database was queried in April 2023 to identify registered randomized control trials performed in patients with lung cancer who underwent surgery (by any technique) as part of their treatment.
    Results: There were 68 eligible randomized control trials; 33 (48.5%) were intended to examine different perioperative patient management strategies (eg, analgesia, ventilation, drainage) or to examine different intraoperative technical aspects (eg, stapling, number of ports, port placement, ligation). The number of randomized control trials was relatively stable over time until a large increase in randomized control trials starting in 2016. Forty-four of the randomized control trials (64.7%) were open-label studies, 43 (63.2%) were conducted in a single facility, 66 (97.1%) had 2 arms, and the mean number of patients enrolled per randomized control trial was 236 (SD, 187). Of 21 completed randomized control trials (31%), the average time to complete accrual was 1605 days (4.4 years) and average time to complete primary/secondary outcomes and adverse events collection was 2125 days (5.82 years).
    Conclusions: Given the immense investment of resources that randomized control trials require, these findings suggest the need to scrutinize future randomized control trial proposals to assess the likelihood of successful completion. Future study is needed to understand the various contributing factors to randomized control trial success or failure.
    Language English
    Publishing date 2024-01-20
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2024.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Commentary: An innovative, minimally-invasive approach to post-pneumonectomy bronchopleural fistula.

    Elliott, Irmina A / Bedi, Harmeet S / Lui, Natalie S

    JTCVS techniques

    2020  Volume 4, Page(s) 351–352

    Language English
    Publishing date 2020-08-15
    Publishing country United States
    Document type Editorial
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2020.08.032
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  9. Article: Impact of hyperthermic intrathoracic chemotherapy (HITHOC) during resection of pleural mesothelioma on patient survival.

    Elliott, Irmina A / He, Hao / Lui, Natalie S / Liou, Douglas Z / Guenthart, Brandon A / Shrager, Joseph B / Berry, Mark F / Backhus, Leah M

    Journal of thoracic disease

    2023  Volume 15, Issue 11, Page(s) 6140–6150

    Abstract: Background: Pleural mesothelioma (PM) is rare but portends a poor prognosis. Multimodal treatment, including aggressive surgical resection, may offer the best chance of treatment response and improved survival. Single-center studies suggest that ... ...

    Abstract Background: Pleural mesothelioma (PM) is rare but portends a poor prognosis. Multimodal treatment, including aggressive surgical resection, may offer the best chance of treatment response and improved survival. Single-center studies suggest that hyperthermic intrathoracic chemotherapy (HITHOC) during surgical resection improves outcomes, but the impact of HITHOC on postoperative morbidity and survival has not been examined on a larger scale.
    Methods: The National Cancer Database was queried for patients undergoing resection for PM from 2006-2017. Patients were excluded if staging or survival data was incomplete. After propensity-score matching, patients who underwent HITHOC were compared to patients who did not (case-control study). Perioperative outcomes and survival were analyzed.
    Results: The final cohort consisted of 3,232 patients; of these, 365 patients underwent HITHOC. After propensity-score matching, receipt of HITHOC was associated with increased length of stay (12
    Conclusions: Using a large national database, we describe the impact of HITHOC on survival in patients with PM. Despite observed increased short-term morbidity, in multivariable analysis HITHOC was associated with an overall survival advantage for patients undergoing surgical resection of PM.
    Language English
    Publishing date 2023-11-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-466
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  10. Article ; Online: The impact of refusing esophagectomy for treatment of locally advanced esophageal adenocarcinoma.

    Wong, Lye-Yeng / Elliott, Irmina A / Liou, Douglas Z / Backhus, Leah M / Lui, Natalie S / Shrager, Joseph B / Berry, Mark F

    JTCVS open

    2023  Volume 16, Page(s) 987–995

    Abstract: Objective: Patients with esophageal cancer may be reluctant to proceed with surgery due to high complication rates. This study aims to compare outcomes between eligible surgical candidates who proceeded with surgery versus those who refused surgery.: ... ...

    Abstract Objective: Patients with esophageal cancer may be reluctant to proceed with surgery due to high complication rates. This study aims to compare outcomes between eligible surgical candidates who proceeded with surgery versus those who refused surgery.
    Methods: Characteristics and survival of patients with locally advanced (cT3N0M0, cT1-3N+M0) mid-/distal esophageal adenocarcinoma in the National Cancer Database (2006-2019) who either proceeded with or refused surgery after chemoradiotherapy were evaluated with logistic regression, Kaplan-Meier curves, and Cox proportional hazards methods.
    Results: Of the 13,594 patients included in the analysis, 595 (4.4%) patients refused esophagectomy. Patients who refused surgery were older, had less distance to travel to their treatment facility, were more likely to have cN0 disease, and were more likely to be treated at a community rather than academic or integrated network program, but did not have significantly different comorbid disease distributions. On multivariable analysis, refusing surgery was independently associated with older age, uninsured, lower income, less distance to a hospital, and treatment in a community program versus an academic/research or integrated network program. Esophagectomy was associated with better survival (5-year survival 40.1% [39.2-41] vs 23.6% [19.9-27.9],
    Conclusions: The results of this study can inform selected patients with resectable esophageal adenocarcinoma that their survival will be significantly diminished if surgery is not pursued. Many factors associated with refusing surgery are non-clinical and suggest that access to or support for care could influence patient decisions.
    Language English
    Publishing date 2023-09-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2023.09.006
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