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  1. Article ; Online: The potential role of chronic pain and the polytrauma clinical triad in predicting prodromal PD: A cross-sectional study of U.S. Veterans.

    Neilson, Lee E / Balba, Nadir M / Elliott, Jonathan E / Scott, Gregory D / Mist, Scott D / Butler, Matthew P / Heinricher, Mary M / Lim, Miranda M

    Clinical parkinsonism & related disorders

    2024  Volume 10, Page(s) 100253

    Abstract: Introduction: The research criteria for prodromal Parkinson disease (pPD) depends on prospectively validated clinical inputs with large effect sizes and/or high prevalence. Neither traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), nor ...

    Abstract Introduction: The research criteria for prodromal Parkinson disease (pPD) depends on prospectively validated clinical inputs with large effect sizes and/or high prevalence. Neither traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), nor chronic pain are currently included in the calculator, despite recent evidence of association with pPD. These conditions are widely prevalent, co-occurring, and already known to confer risk of REM behavior disorder (RBD) and PD. Few studies have examined PD risk in the context of TBI and PTSD; none have examined chronic pain. This study aimed to measure the risk of pPD caused by TBI, PTSD, and chronic pain.
    Methods: 216 US Veterans were enrolled who had self-reported recurrent or persistent pain for at least three months. Of these, 44 met criteria for PTSD, 39 for TBI, and 41 for all three conditions. Several pain, sleep, affective, and trauma questionnaires were administered. Participants' history of RBD was determined via self-report, with a subset undergoing confirmatory video polysomnography.
    Results: A greater proportion of Veterans with chronic pain met criteria for RBD (36 % vs. 10 %) and pPD (18.0 % vs. 8.3 %) compared to controls. Proportions were increased in RBD (70 %) and pPD (27 %) when chronic pain co-occurred with TBI and PTSD. Partial effects were seen with just TBI or PTSD alone. When analyzed as continuous variables, polytrauma symptom severity correlated with pPD probability (r = 0.28,
    Conclusion: These data demonstrate the potential utility of chronic pain, TBI, and PTSD in the prediction of pPD, and the importance of trauma-related factors in the pathogenesis of PD.
    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Journal Article
    ISSN 2590-1125
    ISSN (online) 2590-1125
    DOI 10.1016/j.prdoa.2024.100253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hyperoxia-induced stepwise reduction in blood flow through intrapulmonary, but not intracardiac, shunt during exercise.

    Davis, James T / Elliott, Jonathan E / Duke, Joseph W / Cristobal, Alberto / Lovering, Andrew T

    American journal of physiology. Regulatory, integrative and comparative physiology

    2023  Volume 325, Issue 1, Page(s) R96–R105

    Abstract: Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) ( ...

    Abstract Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) (
    MeSH term(s) Male ; Female ; Humans ; Hyperoxia ; Hemodynamics/physiology ; Oxygen ; Heart ; Pulmonary Circulation/physiology ; Foramen Ovale, Patent
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00014.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: AltitudeOmics: effects of 16 days acclimatization to hypobaric hypoxia on muscle oxygen extraction during incremental exercise.

    Bourdillon, Nicolas / Subudhi, Andrew W / Fan, Jui-Lin / Evero, Oghenero / Elliott, Jonathan E / Lovering, Andrew T / Roach, Robert C / Kayser, Bengt

    Journal of applied physiology (Bethesda, Md. : 1985)

    2023  Volume 135, Issue 4, Page(s) 823–832

    Abstract: Acute altitude exposure lowers arterial oxygen content ([Formula: see text]) and cardiac output ([Formula: see text]) at peak exercise, whereas ... ...

    Abstract Acute altitude exposure lowers arterial oxygen content ([Formula: see text]) and cardiac output ([Formula: see text]) at peak exercise, whereas O
    MeSH term(s) Humans ; Oxygen/metabolism ; Hypoxia/metabolism ; Exercise/physiology ; Quadriceps Muscle/physiology ; Acclimatization/physiology ; Oxygen Consumption/physiology ; Altitude ; Muscle, Skeletal/physiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00100.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Remote Spectral Light Sensing in the Home Environment: Further Development of the TWLITE Study Concept.

    Reynolds, Christina L / Tan, Aylmer / Elliott, Jonathan E / Tinsley, Carolyn E / Wall, Rachel / Kaye, Jeffrey A / Silbert, Lisa C / Lim, Miranda M

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 8

    Abstract: Aging is a significant contributor to changes in sleep patterns, which has compounding consequences on cognitive health. A modifiable factor contributing to poor sleep is inadequate and/or mistimed light exposure. However, methods to reliably and ... ...

    Abstract Aging is a significant contributor to changes in sleep patterns, which has compounding consequences on cognitive health. A modifiable factor contributing to poor sleep is inadequate and/or mistimed light exposure. However, methods to reliably and continuously collect light levels long-term in the home, a necessity for informing clinical guidance, are not well established. We explored the feasibility and acceptability of remote deployment and the fidelity of long-term data collection for both light levels and sleep within participants' homes. The original TWLITE study utilized a whole-home tunable lighting system, while the current project is an observational study of the light environment already existing in the home. This was a longitudinal, observational, prospective pilot study involving light sensors remotely deployed in the homes of healthy adults (
    MeSH term(s) Humans ; Aged ; Prospective Studies ; Pilot Projects ; Activities of Daily Living ; Independent Living ; Remote Sensing Technology/methods
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Observational Study ; Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23084134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Dietary Supplementation With Branched Chain Amino Acids to Improve Sleep in Veterans With Traumatic Brain Injury: A Randomized Double-Blind Placebo-Controlled Pilot and Feasibility Trial.

    Elliott, Jonathan E / Keil, Allison T / Mithani, Sara / Gill, Jessica M / O'Neil, Maya E / Cohen, Akiva S / Lim, Miranda M

    Frontiers in systems neuroscience

    2022  Volume 16, Page(s) 854874

    Abstract: Study objectives: Traumatic brain injury (TBI) is associated with chronic sleep disturbances and cognitive impairment. Our prior preclinical work demonstrated dietary supplementation with branched chain amino acids (BCAA: leucine, isoleucine, and valine) ...

    Abstract Study objectives: Traumatic brain injury (TBI) is associated with chronic sleep disturbances and cognitive impairment. Our prior preclinical work demonstrated dietary supplementation with branched chain amino acids (BCAA: leucine, isoleucine, and valine), precursors to
    Methods: Thirty-two Veterans with TBI were prospectively enrolled in a randomized, double-blinded, placebo-controlled trial comparing BCAA (30 g, b.i.d. for 21-days) with one of two placebo arms (microcrystalline cellulose or rice protein, both 30 g, b.i.d. for 21-days). Pre- and post-intervention outcomes included sleep measures (questionnaires, daily sleep/study diaries, and wrist actigraphy), neuropsychological testing, and blood-based biomarkers related to BCAA consumption.
    Results: Six subjects withdrew from the study (2/group), leaving 26 remaining subjects who were highly adherent to the protocol (BCAA, 93%; rice protein, 96%; microcrystalline, 95%; actigraphy 87%). BCAA were well-tolerated with few side effects and no adverse events. BCAA significantly improved subjective insomnia symptoms and objective sleep latency and wake after sleep onset on actigraphy.
    Conclusion: Dietary supplementation with BCAA is a mechanism-based, promising intervention that shows feasibility, acceptability, and preliminary efficacy to treat insomnia and objective sleep disruption in Veterans with TBI. A larger scale randomized clinical trial is warranted to further evaluate the efficacy, dosing, and duration of BCAA effects on sleep and other related outcome measures in individuals with TBI.
    Clinical trial registration: [http://clinicaltrials.gov/], identifier [NCT03990909].
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2022.854874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Head Injury Treatment With Healthy and Advanced Dietary Supplements: A Pilot Randomized Controlled Trial of the Tolerability, Safety, and Efficacy of Branched Chain Amino Acids in the Treatment of Concussion in Adolescents and Young Adults.

    Corwin, Daniel J / Myers, Sage R / Arbogast, Kristy B / Lim, Miranda M / Elliott, Jonathan E / Metzger, Kristina B / LeRoux, Peter / Elkind, Jaclynn / Metheny, Hannah / Berg, Jeffrey / Pettijohn, Kevin / Master, Christina L / Kirschen, Matthew P / Cohen, Akiva S

    Journal of neurotrauma

    2024  

    Abstract: Concussion is a common injury in the adolescent and young adult populations. Although branched chain amino acid (BCAA) supplementation has shown improvements in neurocognitive and sleep function in pre-clinical animal models of mild-to-moderate traumatic ...

    Abstract Concussion is a common injury in the adolescent and young adult populations. Although branched chain amino acid (BCAA) supplementation has shown improvements in neurocognitive and sleep function in pre-clinical animal models of mild-to-moderate traumatic brain injury (TBI), to date, no studies have been performed evaluating the efficacy of BCAAs in concussed adolescents and young adults. The goal of this pilot trial was to determine the efficacy, tolerability, and safety of varied doses of oral BCAA supplementation in a group of concussed adolescents and young adults. The study was conducted as a pilot, double-blind, randomized controlled trial of participants ages 11-34 presenting with concussion to outpatient clinics (sports medicine and primary care), urgent care, and emergency departments of a tertiary care pediatric children's hospital and an urban tertiary care adult hospital, between June 24, 2014 and December 5, 2020. Participants were randomized to one of five study arms (placebo and 15 g, 30 g, 45 g, and 54 g BCAA treatment daily) and followed for 21 days after enrollment. Outcome measures included daily computerized neurocognitive tests (processing speed, the
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2023.0433
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  7. Article ; Online: Categorizing Sleep in Older Adults with Wireless Activity Monitors Using LSTM Neural Networks.

    Yildiz, Selda / Opel, Ryan A / Elliott, Jonathan E / Kaye, Jeffrey / Cao, Hung / Lim, Miranda M

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2020  Volume 2019, Page(s) 3368–3372

    Abstract: Novel approaches are needed to accurately classify and monitor sleep patterns in older adults, particularly those with cognitive impairment and non-normative sleep. Traditional methods ignore underlying sleep architecture in these patient populations, ... ...

    Abstract Novel approaches are needed to accurately classify and monitor sleep patterns in older adults, particularly those with cognitive impairment and non-normative sleep. Traditional methods ignore underlying sleep architecture in these patient populations, and other modern approaches tend to focus on healthy, normative patient populations. In this paper, we developed a model using a long-short-term memory neural network (LSTM) and trained it on a sample of older, non-normative patients. The 22 nights of data collected were trained on gold-standard polysomnography (PSG) as ground truth and were compared against the clinical standard threshold-based method for sleep detection. The LSTM more than doubled the traditional method's ability to detect clinically-relevant wakefulness during sleep (37.7% vs. 15%) without significantly sacrificing accuracy (67.7% vs. 75%) or precision (90.7% vs. 94%) of sleep classification.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Machine Learning ; Male ; Middle Aged ; Neural Networks, Computer ; Polysomnography ; Sleep ; Wakefulness ; Wearable Electronic Devices ; Wireless Technology
    Language English
    Publishing date 2020-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2019.8857453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults.

    Keil, Samantha A / Schindler, Abigail G / Wang, Marie X / Piantino, Juan / Silbert, Lisa C / Elliott, Jonathan E / Werhane, Madeleine L / Thomas, Ronald G / Willis, Sherry / Lim, Miranda M / Iliff, Jeffrey J

    JAMA network open

    2023  Volume 6, Issue 12, Page(s) e2346006

    Abstract: Importance: Sleep disturbances and clinical sleep disorders are associated with all-cause dementia and neurodegenerative conditions, but it remains unclear how longitudinal changes in sleep impact the incidence of cognitive impairment.: Objective: To ...

    Abstract Importance: Sleep disturbances and clinical sleep disorders are associated with all-cause dementia and neurodegenerative conditions, but it remains unclear how longitudinal changes in sleep impact the incidence of cognitive impairment.
    Objective: To evaluate the association of longitudinal sleep patterns with age-related changes in cognitive function in healthy older adults.
    Design, setting, and participants: This cross-sectional study is a retrospective longitudinal analyses of the Seattle Longitudinal Study (SLS), which evaluated self-reported sleep duration (1993-2012) and cognitive performance (1997-2020) in older adults. Participants within the SLS were enrolled as part of a community-based cohort from the Group Health Cooperative of Puget Sound and Health Maintenance Organization of Washington between 1956 and 2020. Data analysis was performed from September 2020 to May 2023.
    Main outcomes and measures: The main outcome for this study was cognitive impairment, as defined by subthreshold performance on both the Mini-Mental State Examination and the Mattis Dementia Rating Scale. Sleep duration was defined by self-report of median nightly sleep duration over the last week and was assessed longitudinally over multiple time points. Median sleep duration, sleep phenotype (short sleep, median ≤7 hours; medium sleep, median = 7 hour; long sleep, median ≥7 hours), change in sleep duration (slope), and variability in sleep duration (SD of median sleep duration, or sleep variability) were evaluated.
    Results: Of the participants enrolled in SLS, only 1104 participants who were administered both the Health Behavior Questionnaire and the neuropsychologic battery were included for analysis in this study. A total of 826 individuals (mean [SD] age, 76.3 [11.8] years; 468 women [56.7%]; 217 apolipoprotein E ε4 allele carriers [26.3%]) had complete demographic information and were included in the study. Analysis using a Cox proportional hazard regression model (concordance, 0.76) showed that status as a short sleeper (hazard ratio, 3.67; 95% CI, 1.59-8.50) and higher sleep variability (hazard ratio, 3.06; 95% CI, 1.14-5.49) were significantly associated with the incidence of cognitive impairment.
    Conclusions and relevance: In this community-based longitudinal study of the association between sleep patterns and cognitive performance, the short sleep phenotype was significantly associated with impaired cognitive performance. Furthermore, high sleep variability in longitudinal sleep duration was significantly associated with the incidence of cognitive impairment, highlighting the possibility that instability in sleep duration over long periods of time may impact cognitive decline in older adults.
    MeSH term(s) Humans ; Female ; Aged ; Cross-Sectional Studies ; Longitudinal Studies ; Retrospective Studies ; Cognitive Dysfunction/epidemiology ; Sleep ; Sleep Wake Disorders/epidemiology
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.46006
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  9. Article: Instability in longitudinal sleep duration predicts cognitive impairment in aged participants of the Seattle Longitudinal Study.

    Keil, Samantha A / Schindler, Abigail G / Wang, Marie X / Piantino, Juan / Silbert, Lisa C / Elliott, Jonathan E / Thomas, Ronald G / Willis, Sherry / Lim, Miranda M / Iliff, Jeffrey J

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Importance: Sleep disturbances and clinical sleep disorders are associated with all-cause dementia and neurodegenerative conditions. It remains unclear how longitudinal changes in sleep impact the incidence of cognitive impairment.: Objective: To ... ...

    Abstract Importance: Sleep disturbances and clinical sleep disorders are associated with all-cause dementia and neurodegenerative conditions. It remains unclear how longitudinal changes in sleep impact the incidence of cognitive impairment.
    Objective: To evaluate how longitudinal sleep patterns contribute to age-related changes in cognitive function in healthy adults.
    Design setting participants: This study utilizes retrospective longitudinal analyses of a community-based study within Seattle, evaluating self-reported sleep (1993-2012) and cognitive performance (1997-2020) in aged adults.
    Main outcomes and measures: The main outcome is cognitive impairment as defined by sub-threshold performance on 2 of 4 neuropsychological batteries: Mini-Mental State Examination (MMSE), Mattis Dementia Rating Scale, Trail Making Test, and Wechsler Adult Intelligent Scale (Revised). Sleep duration was defined through self-report of 'average nightly sleep duration over the last week' and assessed longitudinally. Median sleep duration, change in sleep duration (slope), variability in sleep duration (standard deviation, Sleep Variability), and sleep phenotype ("Short Sleep" median ≤7hrs.; "Medium Sleep" median = 7hrs; "Long Sleep" median ≥7hrs.).
    Results: A total of 822 individuals (mean age of 76.2 years [11.8]; 466 women [56.7%]; 216
    Conclusions and relevance: High variability in longitudinal sleep duration was significantly associated with the incidence of cognitive impairment and predictive of decline in cognitive performance ten years later. These data highlight that instability in longitudinal sleep duration may contribute to age-related cognitive decline.
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.07.23291098
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  10. Article ; Online: Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies.

    Sandsmark, Danielle K / Elliott, Jonathan E / Lim, Miranda M

    Sleep

    2017  Volume 40, Issue 5

    Abstract: Sleep-wake disturbances following traumatic brain injury (TBI) are increasingly recognized as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep-wake disturbances can persist for years, often impairing quality of ... ...

    Abstract Sleep-wake disturbances following traumatic brain injury (TBI) are increasingly recognized as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep-wake disturbances can persist for years, often impairing quality of life. Recently, there has been a nearly exponential increase in the number of primary research articles published on the pathophysiology and mechanisms underlying sleep-wake disturbances after TBI, both in animal models and in humans, including in the pediatric population. In this review, we summarize over 200 articles on the topic, most of which were identified objectively using reproducible online search terms in PubMed. Although these studies differ in terms of methodology and detailed outcomes; overall, recent research describes a common phenotype of excessive daytime sleepiness, nighttime sleep fragmentation, insomnia, and electroencephalography spectral changes after TBI. Given the heterogeneity of the human disease phenotype, rigorous translation of animal models to the human condition is critical to our understanding of the mechanisms and of the temporal course of sleep-wake disturbances after injury. Arguably, this is most effectively accomplished when animal and human studies are performed by the same or collaborating research programs. Given the number of symptoms associated with TBI that are intimately related to, or directly stem from sleep dysfunction, sleep-wake disorders represent an important area in which mechanistic-based therapies may substantially impact recovery after TBI.
    MeSH term(s) Animals ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/physiopathology ; Brain Injuries, Traumatic/rehabilitation ; Brain Injuries, Traumatic/therapy ; Disease Models, Animal ; Electroencephalography ; Humans ; Phenotype ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Initiation and Maintenance Disorders/physiopathology ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/physiopathology ; Sleep Wake Disorders/therapy
    Language English
    Publishing date 2017-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsx044
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