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  1. Article ; Online: Immunotherapy advances: One year on.

    Elliott, Tim

    Immunotherapy advances

    2022  Volume 2, Issue 1, Page(s) ltac001

    Language English
    Publishing date 2022-01-11
    Publishing country England
    Document type Editorial
    ISSN 2732-4303
    ISSN (online) 2732-4303
    DOI 10.1093/immadv/ltac001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Introducing

    Elliott, Tim

    Immunotherapy advances

    2020  Volume 1, Issue 1, Page(s) ltaa009

    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Editorial
    ISSN 2732-4303
    ISSN (online) 2732-4303
    DOI 10.1093/immadv/ltaa009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: STAT5A antagonizes TOX in CD8

    Arcia-Anaya, David / Elliott, Tim

    Nature reviews. Immunology

    2023  Volume 23, Issue 2, Page(s) 73

    MeSH term(s) Humans ; T-Cell Exhaustion ; CD8-Positive T-Lymphocytes ; Tumor Suppressor Proteins ; STAT5 Transcription Factor
    Chemical Substances STAT5A protein, human ; Tumor Suppressor Proteins ; STAT5 Transcription Factor
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-022-00833-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MG 34: Show issues

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  4. Article ; Online: Visualising tapasin- and TAPBPR-assisted editing of major histocompatibility complex class-I immunopeptidomes.

    van Hateren, Andy / Elliott, Tim

    Current opinion in immunology

    2023  Volume 83, Page(s) 102340

    Abstract: Which peptides are selected for presentation by major histocompatibility complex class-I (MHC-I) molecules is a key determinant of successful immune responses. Peptide selection is co-ordinated by the tapasin and TAP Binding PRotein (TAPBPR) proteins, ... ...

    Abstract Which peptides are selected for presentation by major histocompatibility complex class-I (MHC-I) molecules is a key determinant of successful immune responses. Peptide selection is co-ordinated by the tapasin and TAP Binding PRotein (TAPBPR) proteins, which ensure MHC-I molecules preferentially acquire high-affinity-binding peptides. New structural analyses have offered insight into how tapasin achieves this function within the peptide-loading complex (PLC) (comprising the Transporter associated with Antigen Presentation (TAP) peptide transporter, tapasin-ERp57, MHC-I and calreticulin), and how TAPBPR performs a peptide editing function independently of other molecules. The new structures reveal nuances in how tapasin and TAPBPR interact with MHC-I, and how calreticulin and ERp57 complement tapasin to exploit the plasticity of MHC-I molecules to achieve peptide editing.
    MeSH term(s) Humans ; Calreticulin/metabolism ; Carrier Proteins ; Histocompatibility Antigens Class I ; Antigen Presentation ; Peptides ; HLA Antigens ; Major Histocompatibility Complex ; Immunoglobulins/metabolism
    Chemical Substances tapasin ; Calreticulin ; Carrier Proteins ; Histocompatibility Antigens Class I ; Peptides ; HLA Antigens ; Immunoglobulins
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2023.102340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 13: Show issues

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  5. Article ; Online: CasPR and the Unfriendly Host?

    Elliott, Tim

    The CRISPR journal

    2019  Volume 1, Page(s) 20–22

    Language English
    Publishing date 2019-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3017891-5
    ISSN 2573-1602 ; 2573-1599
    ISSN (online) 2573-1602
    ISSN 2573-1599
    DOI 10.1089/crispr.2018.29004.tel
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    Zs.A 7195: Show issues Location:
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    Zs.MG 119: Show issues

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  6. Article ; Online: Antigen processing movers and shakers.

    Elliott, Tim

    Nature chemical biology

    2018  Volume 14, Issue 8, Page(s) 747–748

    MeSH term(s) Antigen Presentation
    Language English
    Publishing date 2018-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-018-0106-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6251: Show issues Location:
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    Zs.MG 90: Show issues

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  7. Article ; Online: Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology.

    Turner, Steven / Essex, Jonathan W / Elliott, Tim

    Biochemical Society transactions

    2023  Volume 51, Issue 1, Page(s) 275–285

    Abstract: Antigen processing is an immunological mechanism by which intracellular peptides are transported to the cell surface while bound to Major Histocompatibility Complex molecules, where they can be surveyed by circulating CD8+ or CD4+ T-cells, potentially ... ...

    Abstract Antigen processing is an immunological mechanism by which intracellular peptides are transported to the cell surface while bound to Major Histocompatibility Complex molecules, where they can be surveyed by circulating CD8+ or CD4+ T-cells, potentially triggering an immunological response. The antigen processing pathway is a complex multistage filter that refines a huge pool of potential peptide ligands derived from protein degradation into a smaller ensemble for surface presentation. Each stage presents unique challenges due to the number of ligands, the polymorphic nature of MHC and other protein constituents of the pathway and the nature of the interactions between them. Predicting the ensemble of displayed peptide antigens, as well as their immunogenicity, is critical for improving T cell vaccines against pathogens and cancer. Our predictive abilities have always been hindered by an incomplete empirical understanding of the antigen processing pathway. In this review, we highlight the role of computational and structural approaches in improving our understanding of antigen processing, including structural biology, computer simulation, and machine learning techniques, with a particular focus on the MHC-I pathway.
    MeSH term(s) Antigen Presentation ; Ligands ; Computer Simulation ; Peptides/metabolism ; Biology
    Chemical Substances Ligands ; Peptides
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20220782
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 944: Show issues Location:
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  8. Book ; Conference proceedings: Science and cultivation of edible fungi / 1

    Elliott, Tim J.

    proceedings of the 14th International Congress on the Science and Cultivation of Edible Fungi, Oxford, 17 - 22 September 1995

    1995  

    Institution Mushroom Growers' Association
    Event/congress International Congress on the Science and Cultivation of Edible Fungi (14, 1995, Oxford)
    Author's details [jointly organised by the Mushroom Growers' Association of Great Britain (MGA) ...] Ed. by T. J. Elliott
    Collection Science and cultivation of edible fungi
    Size XXIV, 472 S. : Ill., graph. Darst.
    Publisher Balkema
    Publishing place Rotterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT007095032
    ISBN 90-5410-571-2 ; 978-90-5410-571-8
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    968/905 available for loan (reading room) Freihandmagazin (U1)

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  9. Book ; Conference proceedings: Science and cultivation of edible fungi / 2

    Elliott, Tim J.

    proceedings of the 14th International Congress on the Science and Cultivation of Edible Fungi, Oxford, 17 - 22 September 1995

    1995  

    Institution Mushroom Growers' Association
    Event/congress International Congress on the Science and Cultivation of Edible Fungi (14, 1995, Oxford)
    Author's details [jointly organised by the Mushroom Growers' Association of Great Britain (MGA) ...] Ed. by T. J. Elliott
    Collection Science and cultivation of edible fungi
    Size IX, S. 475 - 926 : Ill., graph. Darst.
    Publisher Balkema
    Publishing place Rotterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT007095039
    ISBN 90-5410-572-0 ; 978-90-5410-572-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    968/906 available for loan (reading room) Freihandmagazin (U1)

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  10. Article ; Online: The role of MHC I protein dynamics in tapasin and TAPBPR-assisted immunopeptidome editing.

    van Hateren, Andy / Elliott, Tim

    Current opinion in immunology

    2021  Volume 70, Page(s) 138–143

    Abstract: Major Histocompatibility Complex class I (MHC I) molecules are highly polymorphic, with allotypes differing in peptide binding preferences, and in their dependence upon tapasin for optimal peptide selection. The tapasin dependence of MHC allotypes is ... ...

    Abstract Major Histocompatibility Complex class I (MHC I) molecules are highly polymorphic, with allotypes differing in peptide binding preferences, and in their dependence upon tapasin for optimal peptide selection. The tapasin dependence of MHC allotypes is inversely correlated with their self-editing ability, and underpinned by conformational plasticity. Recently, TAPBPR has been shown to enhance MHC I assembly via a chaperone-like function, and by editing the peptide repertoire of some MHC I allotypes. Structural analysis has shown TAPBPR binding changes the conformation and dynamics of MHC I, with MHC protein dynamics likely to determine the prevailing TAPBPR function: generically enhancing MHC I assembly by stabilising highly dynamic peptide-empty MHC I; and by editing the peptide repertoire of highly dynamic MHC I allotypes.
    MeSH term(s) Histocompatibility Antigens Class I/immunology ; Humans ; Immunoglobulins/immunology ; Membrane Proteins/immunology ; Membrane Transport Proteins/immunology ; Peptides/immunology
    Chemical Substances Histocompatibility Antigens Class I ; Immunoglobulins ; Membrane Proteins ; Membrane Transport Proteins ; Peptides ; TAPBPL protein, human ; tapasin
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2021.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
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    Zs.MG 13: Show issues

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