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  1. Article ; Online: Effect of Saponin on Cerebral Edema Rate in An Animal Model of Stroke

    Elmira Shiri / Mohammad Reza Bigdeli / Akram Eidi / Seyed Pejman Mortazavi

    Journal of Mazandaran University of Medical Sciences, Vol 32, Iss 214, Pp 43-

    2022  Volume 54

    Abstract: Background and purpose: Oxidative stress and neuroinflammation are the main causes of cerebral ischemia. Saponin with steroid or triterpenoid compounds with a sugar part has strong antioxidant and anti-inflammatory properties. The aim of this study was ... ...

    Abstract Background and purpose: Oxidative stress and neuroinflammation are the main causes of cerebral ischemia. Saponin with steroid or triterpenoid compounds with a sugar part has strong antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effect of saponin on cerebral edema, Bax gene expression level, and ischemic neurological defects. Materials and methods: In this experimental study, 24 male Wistar rats were divided into three groups: sham, stroke, and stroke+saponin. Rats in the stroke+saponin group received intravenous injection of saponin (3mg/kg) 30 minutes before cerebral ischemia. Each group was divided into two subgroups: brain edema (n=5) and gene expression level investigation (n=3). Cerebral ischemia was induced by middle cerebral artery occlusion model. After 24 hrs, we investigated neurological deficits resulting from ischemia (Kruskal-Wallis test), the degree of brain edema, and Bax gene expression levels in the cortex, piriform cortex-amygdala, striatum, and hippocampus (one-way ANOVA). Results: Findings indicated a significant decrease in the score of neurological defects resulting from ischemia, the amount of cerebral edema, and the level of Bax gene expression in stroke+saponin group (P<0.05). Conclusion: This study showed that saponin pretreatment in rats with ischemia-reperfusion injury can be effective in reducing the damage caused by cerebral ischemia.
    Keywords stroke ; cerebral edema ; saponin ; bax ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Mazandaran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: An Evaluation of the Effects of Cucurbita moschata on Cerebrovascular ‎Accident and Neurological Disorders in an Animal Model of Rats

    elmira shiri / M rahnema / MR Bigdeli

    Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 17, Iss 12, Pp 19-

    2015  Volume 25

    Abstract: BACKGROUND AND OBJECTIVE: Cerebral ischemia is a common cause of mortality, which can be described as a focal brain defect secondary to trauma. This study aimed to determine the relationship between consumption of Cucurbita moschata seed oil and stroke ... ...

    Abstract BACKGROUND AND OBJECTIVE: Cerebral ischemia is a common cause of mortality, which can be described as a focal brain defect secondary to trauma. This study aimed to determine the relationship between consumption of Cucurbita moschata seed oil and stroke volume, as well as the neurological disorders in a cerebrovascular model of rats. METHODS: In this empirical study, 28 mature male Wistar rats weighing between 250 and 350 gr were divided into four groups. The control group was gavaged with distilled water, and the other three groups received 0.25, 0.50, and 0.75 ml/kg Cucurbita moschata seed oil orally for 30 days. At the end of the thirty-day period, the animals underwent middle cerebral artery occlusion in order to induce stroke. Twenty-four hours after reperfusion, lesion volume and neurological disorders were evaluated. FINDINGS: It was found that 0.50 and 0.75 ml/kg doses of Cucurbita moschata seed oil reduced neurological disorders (p<0.021 and p<0.000, respectively). In addition, stroke volume decreased in the cortical area at doses 0.50 (55.02±7.6) and 0.75 (30.05±9.06) ml/kg, as compared to the control group (133.02±9.11 p<0.000 and p<0.000). CONCLUSION: Consumption of Cucurbita moschata seed oil can reduce symptoms of ischemic stroke
    Keywords Cerebral Ischemia ; Neurological Disorders ; Cucurbita moschata Seed Oil‎ ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 150
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Babol University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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