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Article: Peripheral Vascular Disease: The Beneficial Effect of Exercise in Peripheral Vascular Diseases Based on Clinical Trials.

Elnady, Basant M / Saeed, Ayman

Advances in experimental medicine and biology

2017 Volume 1000, Page(s) 173–183

Abstract: Intermittent claudication (IC) due to peripheral artery diseases (PAD) is one of the disabling disease that can affect quality of life (QOL) and functional status of capacity. It is characterized by cramping pain which develops with exercise and ... ...

Abstract	Intermittent claudication (IC) due to peripheral artery diseases (PAD) is one of the disabling disease that can affect quality of life (QOL) and functional status of capacity. It is characterized by cramping pain which develops with exercise and eliminated by rest secondary to decrease blood flow to the muscles. The annual incidence rate is increased with age. Exercise rehabilitation has a great impact in improving the functional capacity and prevent the functional disability. The available evidences from current studies have showed that exercise therapy is considered the primary treatment in PAD, which in consequently improves the QOL. In this chapter we will illustrate the current available evidences which support exercise benefit and outcomes in PAD with IC.
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-10-4304-8_11
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Article: Adverse Impact of Systemic Lupus Erythematosus on Pregnancy Outcomes: A Saudi Arabia Retrospective Multi-Center Study.

Al Rayes, Hanan / AlOudah, Norah / Alsolaimani, Roaa / Alharthi, Abdulrahman / Attar, Mohammed / Daghasi, Hassan / Albeity, Abdurahman / Afifi, Afnan M / AlQahtani, Abdulelah / Alkaff, Alya / Alkhamesi, Sultan M / Elnady, Basant

Open access rheumatology : research and reviews

2024 Volume 16, Page(s) 31–41

Abstract: Objective: The current study aimed to determine the pregnancy outcomes complications in patients with SLE and its association with clinical, laboratory variables, disease activity, and medication use in the Saudi population, as well as pregnancy effect ... ...

Abstract	Objective: The current study aimed to determine the pregnancy outcomes complications in patients with SLE and its association with clinical, laboratory variables, disease activity, and medication use in the Saudi population, as well as pregnancy effect on disease activity. Methods: A multicenter study included pregnant female patients with Systemic Lupus Erythematosus (SLE) from three tertiary centers in Saudi Arabia. The demographics, clinical, and laboratory variables, SLE disease activity index (SLEDAI), medication before, during, and after pregnancy, planned pregnancy, pregnancy-related outcomes, and complications in comparison to age-matched healthy female controls were noted. Results: A total of 66 pregnant patients with SLE and 93 healthy age-matched pregnant controls were included in the study. A total of 77.3% had SLEDAI-2K ≤ 4 before conception, and 84.85% of pregnancies were planned. Age of conception, cesarean section, miscarriage, and low birth weight were statistically significant (p <0.05) higher in SLE patients than in healthy controls. Among all clinical and laboratory variables, SLEDAI-2K > 4 and active lupus nephritis during pregnancy were statistically associated with adverse outcomes (p <0.05), history of lupus nephritis was not associated with statistically adverse pregnancy outcomes. Higher SLEDAI-2K > 4 was an independent risk at least 4.87 times higher association with adverse pregnancy outcomes. (p <0.05). Conclusion: SLE is intricately connected with unfavorable pregnancy outcomes. The preconception of high disease activity stands as a pivotal risk factor for adverse outcomes. Despite the disease remission and meticulous planning, SLE patients frequently grapple with disease exacerbations during pregnancy, culminating in unexpected and unfavorable pregnancy-related outcomes. This underscores the intricate and multifaceted nature of managing SLE during gestation.
Language	English
Publishing date	2024-02-01
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508169-X
ISSN	1179-156X
ISSN	1179-156X
DOI	10.2147/OARRR.S448186
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Article ; Online: Correction to: New onset of axial spondyloarthropathy in patients treated with isotretinoin for acne vulgaris: incidence, follow-up, and MRI findings.

Elnady, Basant / Elkhouly, Tohamy / Dawoud, Noha M / Desouky, Dalia E / Kewan, Hanady H / Dawoud, Dalia M / Ritchlin, Christopher

Clinical rheumatology

2022 Volume 41, Issue 8, Page(s) 2615

Language	English
Publishing date	2022-04-13
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-022-06178-z
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Article: Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life.

Mahgoub, Marwa Yahia / Elnady, Basant Mohamed / Abdelkader, Haytham Sayed / Abdelhalem, Raghdaa Abdelkhaleq / Hassan, Waleed Ahmed

Open access rheumatology : research and reviews

2020 Volume 12, Page(s) 55–63

Abstract: Background: Knee osteoarthritis (OA) is a painful condition with peripheral and central pain transmission. Fibromyalgia (FM) is the role model of central sensitization of pain perception.: Aim: To assess the frequency of FM in knee OA patients and ... ...

Abstract	Background: Knee osteoarthritis (OA) is a painful condition with peripheral and central pain transmission. Fibromyalgia (FM) is the role model of central sensitization of pain perception. Aim: To assess the frequency of FM in knee OA patients and evaluate the impact of FM on mental health and the quality of life in knee OA patients. Patients and methods: A total of 121 female patients were recruited and divided into 3 groups: group I of 59 patients with knee OA only, group II of 32 patients with knee OA and FM, and group III of 30 FM patients. Patients underwent history taking, examination, investigations, and radiological evaluation of both knees. The assessment of visual analog scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Pain Anxiety Symptom Scale Short Form 20 (PASS20), Beck Depression Inventory (BDI-II), and PCASEE questionnaire were done for all patients. Lequesne index of knee OA and radiological Kellgren and Lawrence score severity were done for all OA patients. Fibromyalgia Impact Questionnaire (FIQ) was assessed for all FM patients. Results: FM was diagnosed in 35.5% of knee OA patients. Group II patients had higher VAS, PASS-20, PSQI, and lower quality of life than either groups I and III, elevated Lequesne index score than group I, significant correlation between VAS and BMI (p=0.002), Lequesne index score (p<0.001), PASS20 (p=0.006), BDI-II score (p=0.002), and FIQ (P<0.001), and a negative correlation was found between VAS and physical (p<0.001), anxiety (p=0.046), and social (p=0.026) QoL parameters. Univariable regression analysis showed a higher age, VAS, PSQI, PASS20, and FIQ were associated with lower QoL in group II. A higher PASS20 was the only predictor of lower QoL in multivariable analysis. Conclusion: Fibromyalgia coexists frequently in knee OA patients and has implications on their mental health, functional activity, and quality of life.
Language	English
Publishing date	2020-05-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508169-X
ISSN	1179-156X
ISSN	1179-156X
DOI	10.2147/OARRR.S252748
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Article ; Online: Serum uric acid as a sensitive concordant marker with lupus nephritis and new onset of renal damage: a prospective cohort study.

Elnady, Basant / Almalki, Abdulaziz / Abdel-Fattah, Moataz M / Desouky, Dalia El-Sayed / Attar, Mohammed

Clinical rheumatology

2020 Volume 40, Issue 5, Page(s) 1827–1834

Abstract: Objective: The objectives of this study are to assess serum different uric acid levels among systemic lupus erythematosus patients with or without active lupus nephritis in comparison to healthy controls and to study the relation of baseline uric acid ... ...

Abstract	Objective: The objectives of this study are to assess serum different uric acid levels among systemic lupus erythematosus patients with or without active lupus nephritis in comparison to healthy controls and to study the relation of baseline uric acid levels to the development of new-onset renal damage in lupus nephritis. Methods: This is a case-control study followed by a prospective cohort of systemic lupus erythematosus (SLE) patients. Three groups were included; all were having normal kidney function, 25 SLE patients with recently diagnosed active lupus nephritis (LN), 26 SLE patients without LN, and 38 healthy controls. Serum uric acid (SUA)and serum creatinine were done for all groups; for SLE patients, 24-h protein in the urine, urinalysis, C3, C4 levels, anti-DNA, anti-ENA antibodies, SLE Disease Activity Index (SLEDAI), and SLICC/ACR damage index (SDI) evaluation were also calculated. Follow-up was done with clinical and laboratory assessment including SUA, with SLEDAI and SDI evaluation. Results: Serum uric acid was significantly higher in SLE patients with active LN than the other two groups (p < 0.05), a cutoff value of serum uric acid associated with lupus nephritis onset was 0.41 mmol/L with a sensitivity of 58% and specificity of 100%, however, C3 and C4 showed very low sensitivity and specificity. During follow-up, all patients with LN with baseline serum uric acid ≥ 0.52 mmol/L were associated with new-onset renal damage within 43 months. Conclusions: High-serum uric acid levels showed a significant association with lupus nephritis onset and new onset of renal damage. Key Points • Serum uric acid is a cheap, rapid, and popular test available in most of the worldwide laboratories; its higher levels showed a significant association with lupus nephritis onset and new onset of renal damage • The current work is the largest study done on lupus nephritis with strict control to the confound risk factors that are associated with the increase of the uric acid levels; moreover, it is the first study to assess such relation in Saudi population • Uric acid could have a role in the pathogenesis of lupus nephritis patients and consequent renal damage.
MeSH term(s)	Biomarkers ; Case-Control Studies ; Humans ; Kidney ; Lupus Erythematosus, Systemic/complications ; Lupus Nephritis ; Prospective Studies ; Severity of Illness Index ; Uric Acid
Chemical Substances	Biomarkers ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2020-10-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-020-05473-x
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Article ; Online: Adalimumab as a successful treatment for acne fulminans and bilateral acute sacroiliitis with hip synovitis complicating isotretinoin therapy.

Dawoud, Noha Mohammed / Elnady, Basant Mohammed / Elkhouly, Tohamy / Yosef, Ayman

Indian journal of dermatology, venereology and leprology

2017 Volume 84, Issue 1, Page(s) 104–107

MeSH term(s)	Acne Vulgaris/chemically induced ; Acne Vulgaris/diagnosis ; Acne Vulgaris/drug therapy ; Acute Disease ; Adalimumab/therapeutic use ; Adolescent ; Anti-Inflammatory Agents/adverse effects ; Dermatologic Agents/therapeutic use ; Hip/diagnostic imaging ; Humans ; Isotretinoin/adverse effects ; Male ; Sacroiliitis/chemically induced ; Sacroiliitis/diagnosis ; Sacroiliitis/drug therapy ; Synovitis/chemically induced ; Synovitis/diagnosis ; Synovitis/drug therapy ; Treatment Outcome
Chemical Substances	Anti-Inflammatory Agents ; Dermatologic Agents ; Isotretinoin (EH28UP18IF) ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2017-12-29
Publishing country	India
Document type	Case Reports ; Letter
ZDB-ID	416068-x
ISSN	0973-3922 ; 0019-5162 ; 0378-6323
ISSN (online)	0973-3922
ISSN	0019-5162 ; 0378-6323
DOI	10.4103/ijdvl.IJDVL_834_16
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Article ; Online: In shoulder adhesive capsulitis, ultrasound-guided anterior hydrodilatation in rotator interval is more effective than posterior approach: a randomized controlled study.

Elnady, Basant / Rageh, Elsayed M / Hussein, Manal Shawky / Abu-Zaid, Mohammed Hassan / Desouky, Dalia El-Sayed / Ekhouly, Tohamy / Rasker, Johannes J

Clinical rheumatology

2020 Volume 39, Issue 12, Page(s) 3805–3814

Abstract: Shoulder adhesive capsulitis, also called frozen shoulder, is a musculoskeletal disorder associated with pain and functional disability. This study aimed to compare the effectiveness of shoulder ultrasound-guided hydrodilatation with corticosteroid, via ... ...

Abstract	Shoulder adhesive capsulitis, also called frozen shoulder, is a musculoskeletal disorder associated with pain and functional disability. This study aimed to compare the effectiveness of shoulder ultrasound-guided hydrodilatation with corticosteroid, via rotator interval (RI) anteriorly, versus posterior approach, in adhesive capsulitis patients. All patients received exercise program following injection. Patients and methods: A prospective randomized controlled study among 60 consecutive adhesive capsulitis patients was randomized into two equal groups. Group I received ultrasound-guided hydrodilatation with corticosteroid, saline, and local anesthetic via posterior intra-articular approach; group II received the same ultrasound-guided hydrodilatation via anterior rotator interval approach. Both groups received guided stretching exercises for 3 months after injection. Baseline and 3 months evaluation of pain by visual analogue scale (VAS), shoulder pain and disability index (SPADI), and range of motion (ROM) had been recorded for all patients. Results: Both groups showed significant improvement 3 months after hydrodilatation regarding VAS pain, external rotation, and SPADI. Only in group II (RI anterior approach) improvement was observed regarding flexion and abduction. There was no improvement regarding extension or internal rotation in either group. When comparing the improvement in both groups after hydrodilatation, group II (anterior approach) showed a statistically significant higher level of improvement regarding VAS pain (p = 0.003), SPADI, flexion, abduction, and external rotation, compared to group I (p < 0.001). Extension, internal rotation, and adduction were not different. Conclusions: Ultrasound-guided anterior rotator interval hydrodilatation for adhesive capsulitis, followed by guided exercise, is clinically and functionally more effective than the conventional posterior approach.
MeSH term(s)	Bursitis/drug therapy ; Bursitis/therapy ; Humans ; Injections, Intra-Articular ; Prospective Studies ; Range of Motion, Articular ; Shoulder Joint/diagnostic imaging ; Shoulder Pain/drug therapy ; Shoulder Pain/therapy ; Treatment Outcome ; Ultrasonography, Interventional
Language	English
Publishing date	2020-05-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-020-05131-2
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Article ; Online: New onset of axial spondyloarthropathy in patients treated with isotretinoin for acne vulgaris: incidence, follow-up, and MRI findings.

Elnady, Basant / Elkhouly, Tohamy / Dawoud, Noha M / Desouky, Dalia E / Kewan, Hanady H / Dawoud, Dalia M / Ritchlin, Christopher

Clinical rheumatology

2020 Volume 39, Issue 6, Page(s) 1829–1838

Abstract: Introduction: Oral isotretinoin is commonly prescribed for acne vulgaris. Several case reports and observational studies have reported serious musculoskeletal side effects; however, the incidence, imaging findings, and longitudinal follow-up data are ... ...

Abstract	Introduction: Oral isotretinoin is commonly prescribed for acne vulgaris. Several case reports and observational studies have reported serious musculoskeletal side effects; however, the incidence, imaging findings, and longitudinal follow-up data are limited for patients who develop inflammatory back pain (IBP). Objective: To assess the incidence of isotretinoin-triggered axial spondyloarthropathy (SpA) in acne vulgaris patients based on clinical features and MRI findings and to examine clinical and radiological outcomes following drug withdrawal. Methods: Five hundred thirteen acne patients receiving isotretinoin were screened for IBP; IBP patients were assessed for CRP, plain radiographs, and MRI of the sacroiliac joint. MRI-proven sacroiliitis was scored semi-quantitatively. Patients were followed longitudinally to assess SpA clinical course and longitudinal MRI sacroiliac joints, and CRP levels were reassessed 3 weeks after patients were symptom-free, following isotretinoin discontinuation. Results: Of the 513 patients, 23.98% developed IBP. MRI-proven sacroiliitis was detected in 42.3% of the symptomatic patients or 10.1% of the cohort. Among MRI-proven sacroiliitis cases, 51.9% fulfilled the Assessment of Spondyloarthritis International Society criteria for axial SpA. Mean CRP level was 32.05 ± 17.23 mg/L at pain onset and 3.4 ± 2.7 mg/L after symptom resolution. MRI findings completely resolved within 9 months (mean 6.27 ± 1.7) after isotretinoin discontinuation. MRI scores positively correlated with baseline CRP levels and global acne grading system score, pain, and the Ankylosing Spondylitis Disease Activity Score. Conclusion: Isotretinoin-induced axial SpA is a prevalent side effect in acne vulgaris patients. Early detection and follow-up of isotretinoin-induced sacroiliitis can be facilitated by MRI. Cessation of isotretinoin resulted in complete resolution in all affected patients.Key Points• Detection of underdiagnosed isotretinoin side effects which are common but not always correctly diagnosed and managed.• Incidence, diagnosis, and management of these side effects in a real-world setting.• This is the first large prospective longitudinal cohort study to report on axial manifestations in patients treated with isotretinoin as well as the effect of drug cessation upon the clinical, laboratory, and radiological findings.
MeSH term(s)	Acne Vulgaris/drug therapy ; Adolescent ; Adult ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/adverse effects ; Female ; Follow-Up Studies ; Humans ; Incidence ; Isotretinoin/administration & dosage ; Isotretinoin/adverse effects ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Pain Measurement ; Prospective Studies ; Radiography ; Sacroiliitis/chemically induced ; Sacroiliitis/diagnostic imaging ; Sacroiliitis/epidemiology ; Severity of Illness Index ; Spondylarthropathies/chemically induced ; Spondylarthropathies/diagnostic imaging ; Spondylarthropathies/epidemiology ; Young Adult
Chemical Substances	Dermatologic Agents ; Isotretinoin (EH28UP18IF)
Language	English
Publishing date	2020-02-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-020-04957-0
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Article ; Online: Correction to: In shoulder adhesive capsulitis, ultrasound-guided anterior hydrodilatation in rotator interval is more effective than posterior approach: a randomized controlled study.

Elnady, Basant / Rageh, Elsayed M / Hussein, Manal Shawky / Abu-Zaid, Mohammed Hassan / Desouky, Dalia El-Sayed / Ekhouly, Tohamy / Rasker, Johannes J

Clinical rheumatology

2020 Volume 39, Issue 12, Page(s) 3815

Abstract: The authors of the original version of the above article requested to add the name of the instrument that was used in the Intervention section. ...

Abstract	The authors of the original version of the above article requested to add the name of the instrument that was used in the Intervention section.
Language	English
Publishing date	2020-10-14
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-020-05461-1
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Article: Adverse Impact of Rheumatoid Arthritis on Pregnancy Outcomes: A Saudi Arabia Prospective Multicenter Study.

Al Rayes, Hanan / Abdulaziz, Sultana / Alotaibi, Asma Mohammed / Alaithan, Mufaddal Adil / Attar, Mohammed / Daghasi, Hassan / Melibari, Rand / Althagafi, Ali H / Elnady, Basant

Open access rheumatology : research and reviews

2021 Volume 13, Page(s) 167–175

Abstract: Background: Rheumatoid arthritis (RA) is associated with adverse pregnancy outcomes and postpartum complications, especially with severe disease activity.: Objective: The current study aimed to compare the pregnancy outcomes in patients with RA and ... ...

Abstract	Background: Rheumatoid arthritis (RA) is associated with adverse pregnancy outcomes and postpartum complications, especially with severe disease activity. Objective: The current study aimed to compare the pregnancy outcomes in patients with RA and healthy controls as well as to assess the impact of disease-related variables, medications and disease activity on pregnancy and neonatal-related outcomes in the Saudi population. Methods: This prospective multicenter study included pregnant female patients with RA from three tertiary centers in Saudi Arabia. The demographics, disease activity scoring (DAS28-CRP), medication before and during pregnancy, pregnancy-related outcomes, and complications in comparison to age-matched healthy female controls were noted. Results: A total of 77 pregnant patients with RA and 250 healthy age-matched pregnant controls were included in the study. A total of 67.53% were in remission before conception (DAS28CRP ≤2.6), and 81.8% of pregnancies were planned. Age of conception, preterm labor, neonatal intensive care unit (NICU) admission and low birth weight were statistically significant (p <0.05) and higher in RA patients than in healthy controls. Longer disease duration (p <0.001), and high C-reactive protein and erythrocyte sedimentation rate levels before conception (p ≤0.001) were statistically associated with preterm NICU admission. There was statistically significant association between mild (p = 0.015) or moderate to severe DAS28-CRP (p = 0.001) and RA patients regarding pregnancy outcomes. The classification table obtained from the logistic model showed patients with mild and moderate-severe DAS28-CRP have significantly high chances of having an adverse pregnancy outcome. Conclusion: RA has a negative impact on pregnancy-related outcomes. Higher disease activity is considered a major risk; thus, tight disease control should be aimed. Planned pregnancy follow-up is associated with better pregnancy outcomes.
Language	English
Publishing date	2021-06-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508169-X
ISSN	1179-156X
ISSN	1179-156X
DOI	10.2147/OARRR.S315867
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