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Article ; Online: Masse anévrysmale de la cuisse chez un sportif.

Jira, Mohamed / Elomri, Naoual / Fatihi, Jamal / Sekkach, Youssef / Amezyane, Taoufik

Presse medicale (Paris, France : 1983)

2019 Volume 48, Issue 10, Page(s) 1194–1195

Title translation	Aneurysmal mass of the thigh in an athlete.
MeSH term(s)	Aneurysm/diagnostic imaging ; Aneurysm/etiology ; Athletes ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Femoral Artery/diagnostic imaging ; Femur/blood supply ; Femur/diagnostic imaging ; Humans ; Magnetic Resonance Angiography ; Male ; Middle Aged
Language	French
Publishing date	2019-10-23
Publishing country	France
Document type	Case Reports
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2019.09.032
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Article: Significant Association of Polymorphisms in the TCF7L2 Gene with a Higher Risk of Type 2 Diabetes in a Moroccan Population.

Elhourch, Sarah / Arrouchi, Housna / Mekkaoui, Nour / Allou, Younes / Ghrifi, Fatima / Allam, Loubna / Elhafidi, Naima / Belyamani, Lahcen / Ibrahimi, Azeddine / Elomri, Naoual / Eljaoudi, Rachid

Journal of personalized medicine

2021 Volume 11, Issue 6

Abstract: Background and aims: Several studies have shown that genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) are highly associated with the development of type 2 diabetes mellitus (T2DM) and its associated complications in several ... ...

Abstract	Background and aims: Several studies have shown that genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) are highly associated with the development of type 2 diabetes mellitus (T2DM) and its associated complications in several populations. The aim of our study was to investigate the association of the rs7903146 (C/T) and rs12255372 (G/T) polymorphism in the TCF7L2 gene with the risk of developing T2DM in the Moroccan population. Material and methods: A total of 150 T2DM patients and 100 healthy controls were recruited for various anthropometric, biochemical and genetic parameters. Genotyping was performed by using Real Time-PCR. The frequency of genotypes, alleles, anthropometric measures, glycemia, glycated hemoglobin (HbA1c) were evaluated in patients and control, while lipid profile was available only for T2DM group. Results: Glycemia, HbA1c and body mass index (BMI) were significantly higher in T2DM group than control. Analysis of the distribution of the TCF7L2 rs7903146 genotype and allele revealed that the TT genotype was more frequent in T2DM group (24.0%) than in healthy controls (5%) (OR = 4.08, 95% confidence interval (CI = 1.95-11.80, Conclusion: The present study confirmed a significant association of the TCF7L2 gene (rs7903146 (C/T) and rs12255372 (G/T) polymorphisms with a higher risk to T2DM in the Moroccan population. No significant difference in respect to anthropometric and metabolic parameters between different genotypes.
Language	English
Publishing date	2021-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11060461
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Article: Antioxidants status in type 2 diabetic patients in Morocco.

Eljaoudi, Rachid / Elomri, Naoual / Laamarti, Meryem / Cherrah, Yahia / Amezyane, Taoufik / Ghafir, Driss / Ibrahimi, Azeddine

Turkish journal of medical sciences

2017 Volume 47, Issue 3, Page(s) 782–788

Abstract: Background/aim: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the ... ...

Abstract	Background/aim: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes. Materials and methods: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se). Results: CRP and triglycerides were higher in the diabetic group while high-density lipoprotein levels were significantly lower compared to the control group. Plasma MDA, Cu concentrations, and Cu/Zn ratio were found to be higher in diabetic patients compared to healthy subjects, while vitamin E, Zn, and Se concentrations were lower compared to the control group. No significant difference was found in vitamin C levels between the two groups. Plasma HbA1c was positively correlated to MDA levels. Conclusion: This study shows that antioxidant status is impaired in diabetics compared to healthy controls.
MeSH term(s)	Adult ; Aged ; Antioxidants/analysis ; C-Reactive Protein/analysis ; Copper/blood ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/metabolism ; Female ; Humans ; Lipid Peroxidation ; Male ; Malondialdehyde/blood ; Middle Aged ; Morocco/epidemiology ; Oxidative Stress ; Trace Elements/blood ; Vitamin E/blood
Chemical Substances	Antioxidants ; Trace Elements ; Vitamin E (1406-18-4) ; Malondialdehyde (4Y8F71G49Q) ; Copper (789U1901C5) ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2017-06-12
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-1512-110
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Zs.A 3242: Show issues

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Article ; Online: Bullous systemic lupus erythematosus.

Mekouar, Fadwa / Hammi, Salaheddine / Elomri, Naoual / Ghafir, Driss

Internal medicine (Tokyo, Japan)

2011 Volume 50, Issue 13, Page(s) 1445

MeSH term(s)	Female ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Skin Diseases, Vesiculobullous/complications ; Skin Diseases, Vesiculobullous/diagnosis ; Young Adult
Language	English
Publishing date	2011-07-01
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.50.4887
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Article ; Online: Rupture d'anévrismes des artères rénales dans la polyangéite microscopique.

Jira, Mohamed / Sekkach, Youssef / Elomri, Naoual / Elqatni, Mohamed / Amezyane, Taoufik / Abouzahir, Ali / Ghafir, Driss

Nephrologie & therapeutique

2013 Volume 9, Issue 7, Page(s) 501–503

Abstract: Introduction: Renal artery aneurysms are unusual manifestations of microscopic polyangiitis.: Observation: We report the case of a 55 years old male patient, with a microscopic polyangiitis, which was revealed by a demyelinating ... ...

Title translation	Ruptured renal artery aneurysms in microscopic polyangiitis.
Abstract	Introduction: Renal artery aneurysms are unusual manifestations of microscopic polyangiitis. Observation: We report the case of a 55 years old male patient, with a microscopic polyangiitis, which was revealed by a demyelinating polyradiculoneuropathy, the diagnosis was made with association of alveolar hemorrhage, peripheral neuropathy and glomerulonephritis with positive antineutrophil cytoplasmic antibodies (antimyeloperoxidase antibodies). The evolution was marked by a state of shock by rupture of aneurysms of intrarenal arteries. Conclusion: This case emphasizes the importance of looking for complications of unusual type of intrarenal aneurysms in patients with microscopic polyngiitis.
MeSH term(s)	Aneurysm, Ruptured/etiology ; Humans ; Male ; Microscopic Polyangiitis/complications ; Middle Aged ; Renal Artery
Language	French
Publishing date	2013-12
Publishing country	France
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/j.nephro.2013.07.365
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Zs.A 6298: Show issues

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Article: Chimioprophylaxie de longue durée à la méfloquine : étude des effets indésirables.

El Jaoudi, Rachid / Benziane, Hamid / Khabbal, Youssef / Elomri, Naoual / Lamsaouri, Jamal / Cherrah, Yahia

Therapie

2010 Volume 65, Issue 5, Page(s) 439–445

Abstract: Purpose: To estimate the relative frequency of reported adverse drug reactions during the malaria chemoprophylactic period of the Moroccan contingent in Democratic Republic of Congo (DRC).: Methods: The transversal survey involved all military ... ...

Title translation	Long-term malaria prophylaxis with mefloquine: a study of adverse drug reactions.
Abstract	Purpose: To estimate the relative frequency of reported adverse drug reactions during the malaria chemoprophylactic period of the Moroccan contingent in Democratic Republic of Congo (DRC). Methods: The transversal survey involved all military personnel of the Moroccan contingent and was carried out using a questionnaire to be filled out by a multidisciplinary medical team. It was performed in all the military sites and the advanced posts accessible during the period of the study. Results: The study involved 362 male military subjects. Ninety-four adverse drug reactions were described: neuropsychiatric (anxiety, irritability, dizziness...) [n=76], digestive (anorexia, diarrhea, nausea...) [n=42], cardiovascular (tachycardia, palpitation, precordialgia...) [n=5], musculoskeletal (arthralgia, cramps) [n=4], cutaneous (redness, purpura) [n=2], and other (n=13). No "unexpected" or "serious" adverse drug reaction was reported. The causality assessment score was determined in 94 cases. Two of these reports were rated "likely", 12 "possible" and 80 doubtful. More adverse drug reactions were reported by subjects having medical and paramedical functions. Conclusion: During our study, mefloquine induced adverse drug reactions in a quarter of the treated subjects. Most of the adverse drug reactions were neuropsychiatric. No "serious" adverse drug reactions were reported underlying the interest of its use, even for long-term chemoprophylaxis.
MeSH term(s)	Adult ; Antimalarials/administration & dosage ; Antimalarials/adverse effects ; Democratic Republic of the Congo/epidemiology ; Humans ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/prevention & control ; Male ; Mefloquine/administration & dosage ; Mefloquine/adverse effects ; Middle Aged ; Military Personnel ; Morocco/ethnology ; Plasmodium falciparum/isolation & purification ; Surveys and Questionnaires ; Time Factors ; Young Adult
Chemical Substances	Antimalarials ; Mefloquine (TML814419R)
Language	French
Publishing date	2010-09
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.2515/therapie/2010049
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Article ; Online: Unusual human poisoning with Delphinium peregrinum.

El Jaoudi, Rachid / Yahia, Cherrah / Satté, Amal / Mounach, Jamal / Ouhabi, Hamid / Elomri, Naoual / Makouar, Fadoua

Clinical toxicology (Philadelphia, Pa.)

2011 Volume 49, Issue 10, Page(s) 949–950

MeSH term(s)	Adolescent ; Delphinium/poisoning ; Female ; Glasgow Coma Scale ; Humans ; Morocco ; Recovery of Function ; Reflex, Abnormal/drug effects ; Respiratory Insufficiency/chemically induced
Language	English
Publishing date	2011-12
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.3109/15563650.2011.630321
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Article ; Online: Maladie de Behçet: trente observations avec atteintes vasculaires pulmonaires et des vaisseaux péripheriques.

Sekkach, Youssef / Elomri, Naoual / Jira, Mohamed / Elqatni, Mohamed / Fatihi, Jamal / Mekouar, Fadwa / Smaali, Jihane / Badaoui, Mohamed / Hammi, Salaheddine / Amezyane, Taoufik / Abouzahir, Ali / Khattabi, Abdessadek El / Ghafir, Driss

Presse medicale (Paris, France : 1983)

2012 Volume 41, Issue 2, Page(s) e52–62

Abstract: Introduction: Behcet's disease is a systematic vasculitis of unknown cause, characterized essentially by eye, cutaneous, articular, neurological and vascular manifestations.: Methods: We retrospectively analysed the Behcet's disease cases that were ... ...

Title translation	Behcet syndrome: thirty comments with lung and vascular injury of peripheral vessels.
Abstract	Introduction: Behcet's disease is a systematic vasculitis of unknown cause, characterized essentially by eye, cutaneous, articular, neurological and vascular manifestations. Methods: We retrospectively analysed the Behcet's disease cases that were followed up in our ward from January 2000 to January 2009. The inclusion criteria were those of International Study Group on Behçet's disease (aphthosis mouth was required). Data were retrieved and analysed with two softwares (Access(®) and Epi Info(®)). Results: We observed 30 cases with vascular lesions on a series of 92 patients with Behcet's disease. Most patients were male, with an average age around 40. The venous manifestations, concerning essentially the lower limbs (deep and superficial thrombosis) were found at 27 patients (90 %), and the average of age during the appearance of the venous lesions was 40 years. Arterial lesions appear more late in 13 patients (43 %) (average of age 43 years). We noted, on the other hand, 11 cases of aneurysms and five cases of arterial thrombosis. The use of corticosteroids was necessary in all cases in association with the others drugs (anticoagulants, colchicine, immunosuppressors). Among the patients having had aneurysms, six were treated surgically. The outcome was favorable for most patients. Two patients had pulmonary embolism and two post-surgery complications. One patient died in the consequences of an intragastric break of an aneurysm of the abdominal aorta. Conclusion: The vascular involvement in Behcet's disease is manifested primarily by thrombophlebitis. Achieving blood pressure, less common, is problematic therapeutic because of the recurrent and life threatening.
MeSH term(s)	Adolescent ; Adult ; Behcet Syndrome/complications ; Female ; Humans ; Male ; Middle Aged ; Peripheral Vascular Diseases/etiology ; Pulmonary Artery ; Pulmonary Embolism/etiology ; Retrospective Studies ; Vascular Diseases/etiology ; Young Adult
Language	French
Publishing date	2012-02
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2011.05.018
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Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.87: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Les antagonistes de l'interleukine-6 (tocilizumab) dans la maladie de still réfractaire de l'adulte.

Sekkach, Youssef / Elqatni, Mohamed / Khattabi, Abdessadek El / Fatihi, Jamal / Hammi, Salaheddine / Badaoui, Mohamed / Elomri, Naoual / Mekouar, Fadoua / Amezyane, Taoufik / Abouzahir, Ali / Ghafir, Driss

Presse medicale (Paris, France : 1983)

2011 Volume 40, Issue 7-8, Page(s) e333–7

Abstract: Introduction: The pathogenesis of Still's disease is best elucidated for the better recognition of the involvement of Many pro-inflammatory cytokines in the genesis of this condition. Publications have reported the contribution beneficial for certain ... ...

Title translation	Antagonists of interleukin-6 (tocilizumab), in adult refractory still disease.
Abstract	Introduction: The pathogenesis of Still's disease is best elucidated for the better recognition of the involvement of Many pro-inflammatory cytokines in the genesis of this condition. Publications have reported the contribution beneficial for certain biotherapeutics, such as anti-TNFa, the anti-CD20 or antagonists of interleukine1 (IL-1) tested successfully in the treatment of systemic Juvenile idiopathic arthritis (Still's disease the child), the tocilizumab is a humanized monoclonal antibody directed against the receptor for interleukin-6 and is beginning to be reported as effective in some refractory cases of Still's disease in adults. Patients: We report two young patients with Still's disease in adults with refractory early and prolonged remission after the first infusion tocilizumab. Conclusion: The tocilizumab can be used in patients MSA with refractory after failure or intolerance conventional treatments.
MeSH term(s)	Adolescent ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Humans ; Interleukin-6/antagonists & inhibitors ; Male ; Remission Induction ; Still's Disease, Adult-Onset/drug therapy ; Young Adult
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Interleukin-6 ; tocilizumab (I031V2H011)
Language	French
Publishing date	2011-07
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2011.03.012
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