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Article: Biological Bone Plate and Iliac Bone Autograft for Proximal Tibial Slope Changing Osteotomy in Genu Recurvatum.

Zein, Assem Mohamed Noureldin / Mahmoud Hassan, Alaa Zenhom / Saleh Elsaid, Ahmed Nady

2022 Volume 11, Issue 6, Page(s) e989–e998

Abstract: Genu recurvatum (GR) is defined as knee hyperextension greater than 5°, with the normal physiological accepted limits of up to 10 to 15° of extension. Physiological GR is commonly bilateral, symmetrical, and mostly asymptomatic. Pathologic GR is usually ... ...

Abstract	Genu recurvatum (GR) is defined as knee hyperextension greater than 5°, with the normal physiological accepted limits of up to 10 to 15° of extension. Physiological GR is commonly bilateral, symmetrical, and mostly asymptomatic. Pathologic GR is usually asymmetric, symptomatic, and can be congenital or acquired. Acquired GR can be classified according to the origin of the deformity into pure osseous, soft tissue, and combined types. Symptomatic GR can present with anterior knee pain and/or instability. Surgery is generally indicated in symptomatic (pain, instability), pathologic GR with an associated causative correctible deformity (bony, soft tissue, or a combination of both). Tibial slope-reversing osteotomy is indicated for the osseous or mixed types where there is inverted tibial slope. Varu-correcting osteotomy is indicated in the posttraumatic soft-tissue type (posterior and lateral soft-tissue injury as in knee dislocation), the aim of osteotomy is to protect the reconstructed ligaments. No role for osteotomy in the nontraumatic soft tissue type (gradual stretching of the posterior structures). In this article, we describe a technique to correct a unilateral genu recurvatum deformity with inverted tibial slope, mostly due to Osgood-Schlatter disease. Correction is done by performing an anterior open-wedge osteotomy of the proximal tibia and impaction of 2 wedges of autogenous iliac bone grafts within the osteotomy. The proximal portion of the tibia is cut in the coronal plan and is used as a biologic plate for fixation with no need for additional hardware (e.g., plate or staples) for fixation of the osteotomy.
Language	English
Publishing date	2022-05-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2653101-X
ISSN	2212-6287
ISSN	2212-6287
DOI	10.1016/j.eats.2022.02.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Machine learning approach for hemorrhagic transformation prediction: Capturing predictors' interaction.

Elsaid, Ahmed F / Fahmi, Rasha M / Shehta, Nahed / Ramadan, Bothina M

Frontiers in neurology

2022 Volume 13, Page(s) 951401

Abstract: Background and purpose: Patients with ischemic stroke frequently develop hemorrhagic transformation (HT), which could potentially worsen the prognosis. The objectives of the current study were to determine the incidence and predictors of HT, to evaluate ...

Abstract	Background and purpose: Patients with ischemic stroke frequently develop hemorrhagic transformation (HT), which could potentially worsen the prognosis. The objectives of the current study were to determine the incidence and predictors of HT, to evaluate predictor interaction, and to identify the optimal predicting models. Methods: A prospective study included 360 patients with ischemic stroke, of whom 354 successfully continued the study. Patients were subjected to thorough general and neurological examination and T2 diffusion-weighted MRI, at admission and 1 week later to determine the incidence of HT. HT predictors were selected by a filter-based minimum redundancy maximum relevance (mRMR) algorithm independent of model performance. Several machine learning algorithms including multivariable logistic regression classifier (LRC), support vector classifier (SVC), random forest classifier (RFC), gradient boosting classifier (GBC), and multilayer perceptron classifier (MLPC) were optimized for HT prediction in a randomly selected half of the sample (training set) and tested in the other half of the sample (testing set). The model predictive performance was evaluated using receiver operator characteristic (ROC) and visualized by observing case distribution relative to the models' predicted three-dimensional (3D) hypothesis spaces within the testing dataset true feature space. The interaction between predictors was investigated using generalized additive modeling (GAM). Results: The incidence of HT in patients with ischemic stroke was 19.8%. Infarction size, cerebral microbleeds (CMB), and the National Institute of Health stroke scale (NIHSS) were identified as the best HT predictors. RFC (AUC: 0.91, 95% CI: 0.85-0.95) and GBC (AUC: 0.91, 95% CI: 0.86-0.95) demonstrated significantly superior performance compared to LRC (AUC: 0.85, 95% CI: 0.79-0.91) and MLPC (AUC: 0.85, 95% CI: 0.78-0.92). SVC (AUC: 0.90, 95% CI: 0.85-0.94) outperformed LRC and MLPC but did not reach statistical significance. LRC and MLPC did not show significant differences. The best models' 3D hypothesis spaces demonstrated non-linear decision boundaries suggesting an interaction between predictor variables. GAM analysis demonstrated a linear and non-linear significant interaction between NIHSS and CMB and between NIHSS and infarction size, respectively. Conclusion: Cerebral microbleeds, NIHSS, and infarction size were identified as HT predictors. The best predicting models were RFC and GBC capable of capturing nonlinear interaction between predictors. Predictor interaction suggests a dynamic, rather than, fixed cutoff risk value for any of these predictors.
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.951401
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Article ; Online: Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial.

Elsaid, Ahmed F / Agrawal, Sudhanshu / Agrawal, Anshu / Ghoneum, Mamdooh

Nutrients

2021 Volume 13, Issue 11

Abstract: Influenza-like illness (ILI) remains a major cause of severe mortality and morbidity in the elderly. Aging is associated with a decreased ability to sense pathogens and mount effective innate and adaptive immune responses, thus mandating the development ... ...

Abstract	Influenza-like illness (ILI) remains a major cause of severe mortality and morbidity in the elderly. Aging is associated with a decreased ability to sense pathogens and mount effective innate and adaptive immune responses, thus mandating the development of protective nutraceuticals. Biobran/MGN-3, an arabinoxylan from rice bran, has potent anti-aging and immunomodulatory effects, suggesting that it may be effective against ILI. The objective of the current study was to investigate the effect of Biobran/MGN-3 on ILI incidence, natural killer (NK) cell activity, and the expressions of RIG-1 (retinoic acid-inducible gene 1), MDA5 (melanoma differentiation-associated protein 5), and their downstream signaling genes ISG-15 (interferon-stimulated genes 15) and MX1 (myxovirus (influenza) resistance 1, interferon-inducible). A double-blind, placebo-controlled clinical trial included eighty healthy older adults over 55 years old, 40 males and 40 females, who received either a placebo or Biobran/MGN-3 (500 mg/day) for 3 months during known ILI seasonality (peak incidence) in Egypt. The incidence of ILI was confirmed clinically according to the WHO case definition criteria. Hematological, hepatic, and renal parameters were assessed in all subjects, while the activity of NK and NKT (natural killer T) cells was assessed in six randomly chosen subjects in each group by the degranulation assay. The effect of Biobran/MGN-3 on RIG-1 and MDA5, as well as downstream ISG15 and MX1, was assessed in BEAS-2B pulmonary epithelial cells using flow cytometry. The incidence rate and incidence density of ILI in the Biobran/MGN-3 group were 5.0% and 0.57 cases per 1000 person-days, respectively, compared to 22.5% and 2.95 cases per 1000 person-days in the placebo group. Furthermore, Biobran/MGN-3 ingestion significantly enhanced NK activity compared to the basal levels and to the placebo group. In addition, Biobran/MGN-3 significantly upregulated the expression levels of RIG-1, MDA5, ISG15, and MX1 in the human pulmonary epithelial BEAS-2B cell lines. No side effects were observed. Taken together, Biobran/MGN-3 supplementation enhanced the innate immune response of elderly subjects by upregulating the NK activity associated with reduction of ILI incidence. It also upregulated the intracellular RIG-1, MDA5, ISG15, and MX1 expression in pulmonary epithelial tissue cultures. Biobran/MGN-3 could be a novel agent with prophylactic effects against a wide spectrum of respiratory viral infections that warrants further investigation.
MeSH term(s)	Aged ; Cell Line ; Cytokines/metabolism ; Dietary Supplements ; Double-Blind Method ; Egypt/epidemiology ; Epithelial Cells/drug effects ; Female ; Flow Cytometry ; Humans ; Immunity, Innate/drug effects ; Immunomodulating Agents/administration & dosage ; Incidence ; Interferon-Induced Helicase, IFIH1/metabolism ; Killer Cells, Natural/drug effects ; Lung/cytology ; Lung/immunology ; Male ; Middle Aged ; Myxovirus Resistance Proteins/metabolism ; Pilot Projects ; Receptors, Retinoic Acid/metabolism ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Respiratory Tract Infections/virology ; Seasons ; Ubiquitins/metabolism ; Up-Regulation/drug effects ; Xylans/administration & dosage
Chemical Substances	Cytokines ; Immunomodulating Agents ; MX1 protein, human ; Myxovirus Resistance Proteins ; PLAAT4 protein, human ; Receptors, Retinoic Acid ; Ubiquitins ; Xylans ; polysaccharide MGN3 ; ISG15 protein, human (60267-61-0) ; IFIH1 protein, human (EC 3.6.1.-) ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
Language	English
Publishing date	2021-11-19
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13114133
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Book ; Online: COVID - 19 infection Statistical analysis

Elsaid, Ahmed Samy / Elsaid, Iman Samy

gender and Age may explain mortality with covid – 19 infection.

2020

Abstract: Since March 11, 2020 and the World Health Organization announced that Covid -19 has become a pandemic and health organizations in the world have been racing to make statistics for the diseased and the dead to try to find out how the virus works. In ... ...

Abstract	Since March 11, 2020 and the World Health Organization announced that Covid -19 has become a pandemic and health organizations in the world have been racing to make statistics for the diseased and the dead to try to find out how the virus works. In addition, why males have higher mortality rates than females? In addition, the elderly for young people. In this paper, we will try to present an explanation of these statistics.We concluded that RAS system play a role in the mortality rate. We may suggest a further study on the covid – 19 effect on the nitric oxide / Ang II balance and if the treatment with low dose inhaled Nitric oxide and angiotensin (1, 7) may be beneficial.
Keywords	covid19
Publisher	Center for Open Science
Publishing country	us
Document type	Book ; Online
DOI	10.31219/osf.io/ja3tz
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: COVID - 19 infection

Elsaid, Ahmed Samy / Elsaid, Iman Samy

Angiotensin II has a major role in the mortality rate. Low dose of inhaled Nitric oxide may be the treatment.

2020

Abstract: Since who characterized COVID-19 as a pandemic, all scientists and clinicians studied the viral effects on the various organs and tissues of the infected patients. The virus irreversible binding to the ACE2 in the target cell in the lungs is the first ... ...

Abstract	Since who characterized COVID-19 as a pandemic, all scientists and clinicians studied the viral effects on the various organs and tissues of the infected patients. The virus irreversible binding to the ACE2 in the target cell in the lungs is the first step of the viral deleterious pathway to invade the target tissues. As the virus replicates and its number increase, the ACE2 in lung type II alveolar cells become inactive. ACE2 is also located in the arterial and venous endothelial cells and arterial smooth muscle cells in most organs. ACE2 is the enzyme catalyzing the conversion of angiotensin II to angiotensin (1–7). The accumulated angiotensin II has a paracrine effect in the pulmonary system in increasing the mean pulmonary pressure and vasoconstriction affect the lungs. One of the suggested treatments is the use of low dose inhaled nitric oxide, which has minimal systemic effects. Treatment with low dose inhaled Nitric oxide can be done first to preserve the patient's condition and as a quick solution at first, and then inject him with angiotensin (1,7) for varying periods to maintain the rate of angiotensin II / angiotensin (1,7) which will provide two antagonists to the angiotensin II to decrease its effect on the infected tissue. In addition, this will increase the blood flow to the infected tissue, which will decrease the virus effect and will enhance the immune response. The nitric oxide usage will also increase the immune response, which will lower the infection period. Angiotensin (1,7) has anti - angiotensin II effect and should be used as a potential treatment.
Keywords	covid19
Publisher	Center for Open Science
Publishing country	us
Document type	Book ; Online
DOI	10.31219/osf.io/znq6h
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: COVID - 19 infection

Elsaid, Ahmed Samy / Elsaid, Iman Samy

the perspectives on Angiotensin II role

2020

Abstract	Since who characterized COVID-19 as a pandemic, all scientists and clinicians studied the viral effects on the various organs and tissues of the infected patients. The virus irreversible binding to the ACE2 in the target cell in the lungs is the first step of the viral deleterious pathway to invade the target tissues. As the virus replicates and its number increase, the ACE2 in lung type II alveolar cells become inactive. ACE2 is also located in the arterial and venous endothelial cells and arterial smooth muscle cells in most organs. ACE2 is the enzyme catalyzing the conversion of angiotensin II to angiotensin (1–7). Nitric oxide Should be tested as a potential treatment.
Keywords	covid19
Publisher	Center for Open Science
Publishing country	us
Document type	Book ; Online
DOI	10.31219/osf.io/8pvra
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial

Elsaid, Ahmed F. / Agrawal, Sudhanshu / Agrawal, Anshu / Ghoneum, Mamdooh

Nutrients. 2021 Nov. 19, v. 13, no. 11

2021

Abstract	Influenza-like illness (ILI) remains a major cause of severe mortality and morbidity in the elderly. Aging is associated with a decreased ability to sense pathogens and mount effective innate and adaptive immune responses, thus mandating the development of protective nutraceuticals. Biobran/MGN-3, an arabinoxylan from rice bran, has potent anti-aging and immunomodulatory effects, suggesting that it may be effective against ILI. The objective of the current study was to investigate the effect of Biobran/MGN-3 on ILI incidence, natural killer (NK) cell activity, and the expressions of RIG-1 (retinoic acid-inducible gene 1), MDA5 (melanoma differentiation-associated protein 5), and their downstream signaling genes ISG-15 (interferon-stimulated genes 15) and MX1 (myxovirus (influenza) resistance 1, interferon-inducible). A double-blind, placebo-controlled clinical trial included eighty healthy older adults over 55 years old, 40 males and 40 females, who received either a placebo or Biobran/MGN-3 (500 mg/day) for 3 months during known ILI seasonality (peak incidence) in Egypt. The incidence of ILI was confirmed clinically according to the WHO case definition criteria. Hematological, hepatic, and renal parameters were assessed in all subjects, while the activity of NK and NKT (natural killer T) cells was assessed in six randomly chosen subjects in each group by the degranulation assay. The effect of Biobran/MGN-3 on RIG-1 and MDA5, as well as downstream ISG15 and MX1, was assessed in BEAS-2B pulmonary epithelial cells using flow cytometry. The incidence rate and incidence density of ILI in the Biobran/MGN-3 group were 5.0% and 0.57 cases per 1000 person-days, respectively, compared to 22.5% and 2.95 cases per 1000 person-days in the placebo group. Furthermore, Biobran/MGN-3 ingestion significantly enhanced NK activity compared to the basal levels and to the placebo group. In addition, Biobran/MGN-3 significantly upregulated the expression levels of RIG-1, MDA5, ISG15, and MX1 in the human pulmonary epithelial BEAS-2B cell lines. No side effects were observed. Taken together, Biobran/MGN-3 supplementation enhanced the innate immune response of elderly subjects by upregulating the NK activity associated with reduction of ILI incidence. It also upregulated the intracellular RIG-1, MDA5, ISG15, and MX1 expression in pulmonary epithelial tissue cultures. Biobran/MGN-3 could be a novel agent with prophylactic effects against a wide spectrum of respiratory viral infections that warrants further investigation.
Keywords	arabinoxylan ; clinical trials ; dietary supplements ; elderly ; epithelium ; flow cytometry ; genes ; humans ; influenza ; ingestion ; innate immunity ; melanoma ; morbidity ; mortality ; placebos ; rice bran ; Egypt
Language	English
Dates of publication	2021-1119
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13114133
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Sequent of Gram-Negative Co-Infectome-Induced Acute Respiratory Distress Syndrome Are Potentially Subtle Aggravators Associated to the SARS-CoV-2 Evolution of Virulence

Kamaleldin B. Said / Ahmed Alsolami / Khalid F. Alshammari / Fawaz Alshammari / Sulaf A. Alhallabi / Shahad F. Alafnan / Safia Moussa / Abdelhafiz I. Bashir / Kareemah S. Alshurtan / Rana Aboras / Ehab K. Sogeir / Alfatih M. A. Alnajib / Abdullah D. Alotaibi / Ruba M. Elsaid Ahmed

Diagnostics, Vol 14, Iss 1, p

2024 Volume 120

Abstract: Acute respiratory distress syndrome (ARDS) is one of the major problems in COVID-19 that is not well understood. ARDS is usually complicated by co-infections in hospitals. Although ARDS is inherited by Europeans and Africans, this is not clear for those ... ...

Abstract	Acute respiratory distress syndrome (ARDS) is one of the major problems in COVID-19 that is not well understood. ARDS is usually complicated by co-infections in hospitals. Although ARDS is inherited by Europeans and Africans, this is not clear for those from the Middle East. There are severe limitations in correlations made between COVID-19, ARDS, co-infectome, and patient demographics. We investigated 298 patients for associations of ARDS, coinfections, and patient demographics on COVID-19 patients’ outcomes. Of the 149 patients examined for ARDS during COVID-19, 16 had an incidence with a higher case fatality rate (CFR) of 75.0% compared to those without ARDS (27.0%) ( p value = 0.0001). The co-infectome association showed a CFR of 31.3% in co-infected patients; meanwhile, only 4.8% of those without co-infections ( p value = 0.01) died. The major bacteria were Acinetobacter baumannii and Escherichia coli , either alone or in a mixed infection with Klebsiella pneumoniae . Kaplan–Meier survival analysis of COVID-19 patients with and without ARDS revealed a significant difference in the survival time of patients with ARDS (58.8 +/− 2.7 days) and without ARDS (41.9 +/− 1.8 days) ( p value = 0.0002). These findings prove that increased hospital time was risky for co-infectome-induced SDRS later on. This also explained that while empiric therapy and lethal ventilations delayed the mortality in 75% of patients, they potentially did not help those without co-infection or ARDS who stayed for shorter times. In addition, the age of patients ( n = 298) was significantly associated with ARDS (72.9 +/− 8.9) compared to those without it (56.2 +/− 15.1) and was irrespective of gender. However, there were no significant differences neither in the age of admitted patients before COVID-19 (58.5 +/− 15.3) and during COVID-19 (57.2 +/− 15.5) nor in the gender and COVID-19 fatality ( p value 0.546). Thus, Gram-negative co-infectome potentially induced fatal ARDS, aggravating the COVID-19 outcome. These findings are important for ...
Keywords	ARDS ; co-infections ; COVID-19 fatality ; co-evolution of virulence ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Infarction Size, Interleukin-6, and Their Interaction Are Predictors of Short-Term Stroke Outcome in Young Egyptian Adults.

Fahmi, Rasha M / Elsaid, Ahmed F

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2016 Volume 25, Issue 10, Page(s) 2475–2481

Abstract: Background: A trend of increasing incidence of first-ever cerebral ischemic stroke in young adults has been recently reported. The current study was conducted with the objective of identifying independent predictors of short-term outcome of first-ever ... ...

Abstract	Background: A trend of increasing incidence of first-ever cerebral ischemic stroke in young adults has been recently reported. The current study was conducted with the objective of identifying independent predictors of short-term outcome of first-ever cerebral ischemic stroke affecting young Egyptian adults. Methods: The present hospital-based study included 50 patients, 23 males and 27 females, aged 18-45 years, with first-ever ischemic stroke confirmed by computed tomography (CT) and magnetic resonance imaging. Twenty healthy age- and sex-matched random control subjects were included to set the reference laboratory values. Detailed medical, neurological, and laboratory data were collected. Stroke severity and short-term stroke outcome were assessed using the Canadian Neurological Scale and the National Institutes of Health Stroke Scale (NIHSS), respectively. Results: High prevalence of modifiable risk factors was observed in young Egyptian adults affected with first-ever ischemic cerebral stroke. Although all studied risk factors were significantly correlated with NIHSS score, multiple regression analysis revealed that only infarction size (CT size), interleukin-6 (IL-6), and their synergistic interaction were the most important predictors of NIHSS stroke outcome. Conclusions: IL-6 and infarction size were independent predictors of short-term stroke outcome in young Egyptian adults. Synergistic interaction of IL-6 with infarction size suggests an investigative value for assessing serum IL-6 level and a therapeutic benefit for its reduction during the course of early ischemic stroke treatment.
MeSH term(s)	Adolescent ; Adult ; Age of Onset ; Bayes Theorem ; Biomarkers/blood ; Brain/diagnostic imaging ; Brain Infarction/blood ; Brain Infarction/diagnostic imaging ; Brain Infarction/epidemiology ; Brain Infarction/therapy ; Case-Control Studies ; Disability Evaluation ; Egypt/epidemiology ; Female ; Humans ; Interleukin-6/blood ; Likelihood Functions ; Linear Models ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prevalence ; Prognosis ; Risk Factors ; Time Factors ; Tomography, X-Ray Computed ; Young Adult
Chemical Substances	Biomarkers ; IL6 protein, human ; Interleukin-6
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2016.06.021
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Article ; Online: Neutrophil-lymphocyte ratio as a marker for disability and activity in multiple sclerosis.

Fahmi, Rasha M / Ramadan, Bothina M / Salah, Hanan / Elsaid, Ahmed F / Shehta, Nahed

Multiple sclerosis and related disorders

2021 Volume 51, Page(s) 102921

Abstract: Background: There is limited data regarding the association of Neutrophil-lymphocyte ratio (NLR) inflammatory marker with multiple sclerosis (MS) disability and activity.: Objective: The aim of the present study was to evaluate validity of NLR as an ... ...

Abstract	Background: There is limited data regarding the association of Neutrophil-lymphocyte ratio (NLR) inflammatory marker with multiple sclerosis (MS) disability and activity. Objective: The aim of the present study was to evaluate validity of NLR as an inflammatory marker for MS disability and activity. Methods: A case-control study including 140 MS patients and 140 age, sex and body mass index matched healthy controls was performed. All participants were subjected to detailed history taking, complete general and neurological examination, laboratory and radiological investigations. Assessment of disease disability was performed using Expanded Disability Status Scale. Results: The NLR levels was significantly higher in MS patients compared to the controls and in patients with relapse compared to remission. Logistic regression analyses showed that NLR was significantly associated with disease disability (odds ratio (OR): 2.568; confidence interval (CI): 1.377 - 4.788; P: 0.003) and activity (OR: 3.603; CI: 2.086 - 6.226; P: 0.02). The cutoff value for the NLR to predict MS disability and activity was 3.12. Conclusion: NLR was significantly increased in MS patients compared to controls. The significant association of NLR with MS disability and activity suggest that it could be utilized as a simple, rapid and inexpensive inflammatory marker.
MeSH term(s)	Biomarkers ; Case-Control Studies ; Humans ; Lymphocytes ; Multiple Sclerosis/diagnosis ; Neutrophils
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2021.102921
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