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  1. Article ; Online: Natural mineral fibers: conducting inhalation toxicology studies - part A: Libby Amphibole aerosol generation and characterization method development.

    Wang, Anbo / Gupta, Amit / Grimm, Michael D / Pressburger, David T / Sparrow, Barney R / Richey, Jamie S / Shaw, John R / Elsass, Karen E / Roberts, Georgia K / Yao, Pei-Li / Stout, Matthew D / Ellis, Benjamin J / Ray, Robyn L

    Inhalation toxicology

    2023  Volume 35, Issue 7-8, Page(s) 201–213

    Abstract: Background: Asbestos has been classified as a human carcinogen, and exposure may increase the risk of diseases associated with impaired respiratory function. As the range of health effects and airborne concentrations that result in health effects across ...

    Abstract Background: Asbestos has been classified as a human carcinogen, and exposure may increase the risk of diseases associated with impaired respiratory function. As the range of health effects and airborne concentrations that result in health effects across asbestos-related natural mineral fiber types are not fully understood, the National Institute of Environmental Health Sciences has established a series of research studies to characterize hazards of natural mineral fibers after inhalation exposure. This paper presents the method development work of this research project.
    Results: A prototype nose-only exposure system was fabricated to explore the feasibility of generating natural mineral fiber aerosol for
    Conclusions: Characterization of the prototype system demonstrated feasibility of generating LA 2007 fiber aerosols appropriate for
    MeSH term(s) Humans ; Rats ; Animals ; Asbestos, Amphibole/toxicity ; Mineral Fibers ; Asbestos/analysis ; Carcinogens/toxicity ; Aerosols
    Chemical Substances Asbestos, Amphibole ; Mineral Fibers ; Asbestos (1332-21-4) ; Carcinogens ; Aerosols
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 1038809-6
    ISSN 1091-7691 ; 0895-8378
    ISSN (online) 1091-7691
    ISSN 0895-8378
    DOI 10.1080/08958378.2023.2220737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2618: Show issues Location:
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  2. Article ; Online: Natural mineral fibers: conducting inhalation toxicology studies-part B: development of a nose-only exposure system for repeat-exposure

    Wang, Anbo / Gupta, Amit / Grimm, Michael D / Pressburger, David T / Sparrow, Barney R / Richey, Jamie S / Shaw, John R / Elsass, Karen E / Roberts, Georgia K / Yao, Pei-Li / Stout, Matthew D / Ellis, Benjamin J / Ray, Robyn L

    Inhalation toxicology

    2023  Volume 35, Issue 7-8, Page(s) 214–229

    Abstract: Background: Exposure to asbestos is associated with malignant and nonmalignant respiratory disease. To strengthen the scientific basis for risk assessment on fibers, the National Institute of Environmental Health Sciences (NIEHS) has initiated a series ... ...

    Abstract Background: Exposure to asbestos is associated with malignant and nonmalignant respiratory disease. To strengthen the scientific basis for risk assessment on fibers, the National Institute of Environmental Health Sciences (NIEHS) has initiated a series of studies to address fundamental questions on the toxicology of naturally occurring asbestos and related mineral fibers after inhalation exposure. A prototype nose-only exposure system was previously developed and validated. The prototype system was expanded to a large-scale exposure system in this study for conducting subsequent
    Results: The exposure system consisting of six exposure carousels was able to independently deliver stable LA 2007 aerosol to individual carousels at target concentrations of 0 (control group), 0.1, 0.3, 1, 3, or 10 mg/m
    Conclusion: The exposure system developed is ready for use in conducting nose-only inhalation toxicity studies of LA 2007 in rats. The exposure system is anticipated to have applicability for the inhalation toxicity evaluation of other natural mineral fibers of concern.
    MeSH term(s) Rats ; Animals ; Asbestos, Amphibole/toxicity ; Mineral Fibers ; Asbestos ; Aerosols ; Inhalation Exposure/adverse effects
    Chemical Substances Asbestos, Amphibole ; Mineral Fibers ; Asbestos (1332-21-4) ; Aerosols
    Language English
    Publishing date 2023-06-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 1038809-6
    ISSN 1091-7691 ; 0895-8378
    ISSN (online) 1091-7691
    ISSN 0895-8378
    DOI 10.1080/08958378.2023.2220735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2618: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Safety and Immunogenicity of a 4-Component Toxoid-Based

    Venkatasubramaniam, Arundhathi / Liao, Grant / Cho, Eunice / Adhikari, Rajan P / Kort, Tom / Holtsberg, Frederick W / Elsass, Karen E / Kobs, Dean J / Rudge, Thomas L / Kauffman, Keith D / Lora, Nickiana E / Barber, Daniel L / Aman, M Javad / Karauzum, Hatice

    Frontiers in immunology

    2021  Volume 12, Page(s) 621754

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    MeSH term(s) Animals ; Antibodies, Bacterial/blood ; Antibody Formation ; Broadly Neutralizing Antibodies/blood ; CD4-Positive T-Lymphocytes/immunology ; Immunity, Heterologous ; Immunogenicity, Vaccine ; Lymphocyte Activation ; Macaca mulatta ; Methicillin-Resistant Staphylococcus aureus/physiology ; Staphylococcal Infections/immunology ; Staphylococcal Toxoid/immunology ; Staphylococcal Vaccines/immunology ; Superantigens/immunology ; Vaccination
    Chemical Substances Antibodies, Bacterial ; Broadly Neutralizing Antibodies ; Staphylococcal Toxoid ; Staphylococcal Vaccines ; Superantigens
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.621754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Characterization of acute biliary hyperplasia in Fisher 344 rats administered the indole-3-carbinol analog, NSC-743380.

    Eldridge, Sandy R / Covey, Joseph / Morris, Joel / Fang, Bingliang / Horn, Thomas L / Elsass, Karen E / Hamre, John R / McCormick, David L / Davis, Myrtle A

    Toxicology and applied pharmacology

    2014  Volume 281, Issue 3, Page(s) 303–309

    Abstract: NSC-743380 (1-[(3-chlorophenyl)-methyl]-1H-indole-3-carbinol) is in early stages of development as an anticancer agent. Two metabolites reflect sequential conversion of the carbinol functionality to a carboxaldehyde and the major metabolite, 1-[(3- ... ...

    Abstract NSC-743380 (1-[(3-chlorophenyl)-methyl]-1H-indole-3-carbinol) is in early stages of development as an anticancer agent. Two metabolites reflect sequential conversion of the carbinol functionality to a carboxaldehyde and the major metabolite, 1-[(3-chlorophenyl)-methyl]-1H-indole-3-carboxylic acid. In an exploratory toxicity study in rats, NSC-743380 induced elevations in liver-associated serum enzymes and biliary hyperplasia. Biliary hyperplasia was observed 2 days after dosing orally for 2 consecutive days at 100mg/kg/day. Notably, hepatotoxicity and biliary hyperplasia were observed after oral administration of the parent compound, but not when major metabolites were administered. The toxicities of a structurally similar but pharmacologically inactive molecule and a structurally diverse molecule with a similar efficacy profile in killing cancer cells in vitro were compared to NSC-743380 to explore scaffold versus target-mediated toxicity. Following two oral doses of 100mg/kg/day given once daily on two consecutive days, the structurally unrelated active compound produced hepatic toxicity similar to NSC-743380. The structurally similar inactive compound did not, but, lower exposures were achieved. The weight of evidence implies that the hepatotoxicity associated with NSC-743380 is related to the anticancer activity of the parent molecule. Furthermore, because biliary hyperplasia represents an unmanageable and non-monitorable adverse effect in clinical settings, this model may provide an opportunity for investigators to use a short-duration study design to explore biomarkers of biliary hyperplasia.
    MeSH term(s) Acute Disease ; Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacokinetics ; Biliary Tract/drug effects ; Biliary Tract/metabolism ; Biliary Tract/pathology ; Biliary Tract Diseases/blood ; Biliary Tract Diseases/chemically induced ; Biliary Tract Diseases/metabolism ; Biliary Tract Diseases/pathology ; Biomarkers/blood ; Biotransformation ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/physiopathology ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/methods ; Drugs, Investigational/administration & dosage ; Drugs, Investigational/adverse effects ; Drugs, Investigational/metabolism ; Drugs, Investigational/pharmacokinetics ; Hyperplasia ; Indoles/administration & dosage ; Indoles/adverse effects ; Indoles/blood ; Indoles/metabolism ; Indoles/pharmacokinetics ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver/physiopathology ; Male ; Random Allocation ; Rats, Inbred F344 ; Structure-Activity Relationship
    Chemical Substances 1-((3-chlorophenyl)methyl)-1H-indole-3-carbinol ; Antineoplastic Agents ; Biomarkers ; Drugs, Investigational ; Indoles ; NSC-741908 ; NSC-751172
    Language English
    Publishing date 2014-10-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2014.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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