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Article ; Online: Comparative study of operative expenses: robotic vs. laparoscopic vs. open liver resections at a university hospital in the UK.

Elshaer, Mohamed / Askari, Alan / Pathanki, Adithya / Rajani, Jaimini / Ahmad, Jawad

2024 Volume 18, Issue 1, Page(s) 12

Abstract: Robotic liver resections (RLR) are increasingly being performed and has previously been considered more costly. The aim is to explore the cost of RLR compared with laparoscopic and open liver resection in a single National Health Service (NHS) hospital. ... ...

Abstract	Robotic liver resections (RLR) are increasingly being performed and has previously been considered more costly. The aim is to explore the cost of RLR compared with laparoscopic and open liver resection in a single National Health Service (NHS) hospital. A retrospective review of patients who underwent RLR, LLR, and OLR from April 2014 to December 2022 was conducted. The primary outcomes were the cost of consumables and median income, and the secondary outcomes were the overall length of stay and mortality at 90 days. Overall, 332 patients underwent liver resections. There were 204 males (61.4%) and 128 females (38.6%), with a median age of 62 years (IQR: 51-77 years). Of these, 60 patients (18.1%) underwent RLR, 21 patients (6.3%) underwent LLR, and 251 patients (75.6%) underwent OLR. Median consumables cost per case was £3863 (IQR: £3458-£5061) for RLR, £4326 (IQR: £4273-£4473) for LLR, and £4,084 (IQR: £3799-£5549) for the OLR cohort (p = 0.140). Median income per case was £7999 (IQR: £4509-£10,777) for RLR, £7497 (IQR: £2407-£14,576) for LLR, and £7493 (IQR: £2542-£14,121) for OLR. The median length of stay (LOS) for RLR was 3 days (IQR: 2-4.7 days) compared to 5 days for LLR (IQR: 4.5-7 days) and 6 days for OLR (IQR: 5-8 days, p < 0.001). Within the NHS, RLR has consumable costs comparable to OLR and LLR. It is also linked with a shorter LOS and generates similar income for patients undergoing OLR and LLR.
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Aged ; Liver Neoplasms/surgery ; Robotic Surgical Procedures/methods ; State Medicine ; Laparoscopy ; Hepatectomy ; Length of Stay ; Retrospective Studies ; Hospitals ; United Kingdom ; Carcinoma, Hepatocellular/surgery ; Postoperative Complications/surgery
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-023-01778-6
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Article ; Online: Improvised biliary cooling technique for radiofrequency ablation of liver tumours close to central bile ducts.

Elshaer, M / White, J / Liau, S S

Annals of the Royal College of Surgeons of England

2020 Volume 102, Issue 9, Page(s) 758

MeSH term(s)	Common Bile Duct/physiology ; Humans ; Hypothermia, Induced/methods ; Laparotomy ; Liver/surgery ; Liver Neoplasms/surgery ; Radiofrequency Ablation/methods
Language	English
Publishing date	2020-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2020.0187
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Article ; Online: Identification of potential biomarkers with colorectal cancer based on bioinformatics analysis and machine learning.

Hammad, Ahmed / Elshaer, Mohamed / Tang, Xiuwen

Mathematical biosciences and engineering : MBE

2021 Volume 18, Issue 6, Page(s) 8997–9015

Abstract: Colorectal cancer (CRC) is one of the most common malignancies worldwide. Biomarker discovery is critical to improve CRC diagnosis, however, machine learning offers a new platform to study the etiology of CRC for this purpose. Therefore, the current ... ...

Abstract	Colorectal cancer (CRC) is one of the most common malignancies worldwide. Biomarker discovery is critical to improve CRC diagnosis, however, machine learning offers a new platform to study the etiology of CRC for this purpose. Therefore, the current study aimed to perform an integrated bioinformatics and machine learning analyses to explore novel biomarkers for CRC prognosis. In this study, we acquired gene expression microarray data from Gene Expression Omnibus (GEO) database. The microarray expressions GSE103512 dataset was downloaded and integrated. Subsequently, differentially expressed genes (DEGs) were identified and functionally analyzed via Gene Ontology (GO) and Kyoto Enrichment of Genes and Genomes (KEGG). Furthermore, protein protein interaction (PPI) network analysis was conducted using the STRING database and Cytoscape software to identify hub genes; however, the hub genes were subjected to Support Vector Machine (SVM), Receiver operating characteristic curve (ROC) and survival analyses to explore their diagnostic values. Meanwhile, TCGA transcriptomics data in Gene Expression Profiling Interactive Analysis (GEPIA) database and the pathology data presented by in the human protein atlas (HPA) database were used to verify our transcriptomic analyses. A total of 105 DEGs were identified in this study. Functional enrichment analysis showed that these genes were significantly enriched in biological processes related to cancer progression. Thereafter, PPI network explored a total of 10 significant hub genes. The ROC curve was used to predict the potential application of biomarkers in CRC diagnosis, with an area under ROC curve (AUC) of these genes exceeding 0.92 suggesting that this risk classifier can discriminate between CRC patients and normal controls. Moreover, the prognostic values of these hub genes were confirmed by survival analyses using different CRC patient cohorts. Our results demonstrated that these 10 differentially expressed hub genes could be used as potential biomarkers for CRC diagnosis.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Computational Biology ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; Humans ; Protein Interaction Maps ; Support Vector Machine
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2021443
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Article ; Online: Antifungal Activity of Efinaconazole Compared to Fluconazole, Itraconazole, and Terbinafine against Terbinafine- and Itraconazole-Resistant and -Susceptible Clinical Isolates of Dermatophytes, Candida, and Mold.

Gamal, Ahmed / Elshaer, Mohammed / Long, Lisa / McCormick, Thomas S / Elewski, Boni / Ghannoum, Mahmoud A

Journal of the American Podiatric Medical Association

2023 , Page(s) 1–30

Abstract: Background: Recently, an increasing number of resistant-to-terbinafine dermatophytosis cases have been reported. Thus, identifying an alternative antifungal agent that possesses a broad-spectrum activity, including against resistant strains, is needed.!# ...

Abstract	Background: Recently, an increasing number of resistant-to-terbinafine dermatophytosis cases have been reported. Thus, identifying an alternative antifungal agent that possesses a broad-spectrum activity, including against resistant strains, is needed. Methods: In this study, we compared the antifungal activity of efinaconazole to fluconazole, itraconazole, and terbinafine against clinical isolates of dermatophyte, Candida, and molds using in vitro assays. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of each antifungal was quantified and compared. Both susceptible and resistant clinical isolates of Trichophyton mentagrophytes (n=16), T. rubrum (n=43), T. tonsurans (n=18), T. violaceum (n=4), Candida albicans (n=55), C. auris (n=30), Fusarium sp., Scedosporium sp., and Scopulariopsis sp. (n=15 for each) were tested. Results: Our data shows that efinaconazole was the most active antifungal, compared to the other agents tested, against dermatophytes with MIC50 and MIC90 (Concentration that inhibited 50% and 90% of strains tested, respectively) values of 0.002 and 0.03 μg/ml, respectively. Fluconazole, itraconazole and terbinafine showed MIC50 and MIC90 values of 1 and 8 μg/ml, 0.03 and 0.25 μg/ml, and 0.031 and 16 μg/ml, respectively. Against Candida isolates, efinaconazole MIC50 and MIC90 values were 0.016 and 0.25 μg/ml, respectively, whereas fluconazole, itraconazole and terbinafine had MIC50 and the MIC90 values of 1 and 16 μg/ml, 0.25 and 0.5 μg/ml, and 2 and 8 μg/ml, respectively. Against various mold species, efinaconazole MIC values ranged from 0.016 and 2 μg/ml, compared to 0.5 to greater than 64 μg/ml for the comparators. Conclusions: efinaconazole showed superior potent activity against a broad panel of susceptible and resistant dermatophyte, Candida, and mold isolates.
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	632622-5
ISSN	1930-8264 ; 0003-0538 ; 8750-7315
ISSN (online)	1930-8264
ISSN	0003-0538 ; 8750-7315
DOI	10.7547/22-132
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Zs.A 364: Show issues

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Article ; Online: Totally minimally invasive two-stage esophagectomy with intrathoracic hand-sewn anastomosis: short-term clinical and oncological outcomes.

Elshaer, M / Gravante, G / Tang, C-B / Jayanthi, N V

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

2018 Volume 31, Issue 3

Abstract: Several esophageal resection techniques have been reported in literature. The objective of this study is to assess postoperative and oncological outcomes of two-stage minimally invasive esophagectomy (MIE) in a prone position using thoracoscopic hand- ... ...

Abstract	Several esophageal resection techniques have been reported in literature. The objective of this study is to assess postoperative and oncological outcomes of two-stage minimally invasive esophagectomy (MIE) in a prone position using thoracoscopic hand-sewn anastomosis. Consecutive patients who underwent two-stage MIE in 2016 performed by the senior author were included. This was compared with the preceding cohort of consecutive patients who underwent two-stage hybrid esophagectomy (HE). The primary outcome was 30-day morbidity and mortality. The secondary outcomes were operation duration, length of stay (LOS), total nodes examined (TNE), number of positive nodes (NPN), and resection margin. Overall, 15 patients underwent MIE and 11 patients underwent HE. Respiratory complications occurred in three (20.0%) patients in the MIE group and in five (45.5%) patients in the HE group (P = 0.218). Cardiac complications occurred in two (18.2%) patients, and two other patients (18.2%) experienced anastomotic leak in the HE group. Mean operative duration was 349 ± 41.6 min in MIE and 309 ± 47.8 min in HE (P = 0.040). Median LOS was 10 days (range: 7-70) in MIE and 13 days (range: 10-116) in HE (P = 0.045). Median TNE was 23 (range: 12-36) in MIE and 20 (range: 14-47) in HE (P = 0.775). Longitudinal margin was involved in one patient (9.1%) in HE and no longitudinal margin was involved in the MIE group. Circumferential resection margin was involved in seven patients (46.7%) in MIE and in four patients (36.4%) in HE (P = 0.391). Two-stage MIE using hand-sewn technique is safe and feasible without compromising surgical and oncological outcomes. A multicenter large trial is recommended to confirm these results.
MeSH term(s)	Aged ; Anastomosis, Surgical/methods ; Esophageal Neoplasms/surgery ; Esophagectomy/methods ; Esophagus/surgery ; Feasibility Studies ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Operative Time ; Postoperative Complications/etiology ; Prone Position ; Prospective Studies ; Retrospective Studies ; Stomach/surgery ; Thoracoscopy/methods ; Treatment Outcome
Language	English
Publishing date	2018-02-12
Publishing country	United States
Document type	Evaluation Studies ; Journal Article
ZDB-ID	639470-x
ISSN	1442-2050 ; 1120-8694
ISSN (online)	1442-2050
ISSN	1120-8694
DOI	10.1093/dote/dox150
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Zs.A 2378: Show issues

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Article ; Online: Comprehensive classification of anatomical variants of the main biliary ducts.

Janssen, B V / van Laarhoven, S / Elshaer, M / Cai, H / Praseedom, R / Wang, T / Liau, S-S

The British journal of surgery

2021 Volume 108, Issue 5, Page(s) 458–462

MeSH term(s)	Bile Ducts/abnormalities ; Classification ; Humans
Language	English
Publishing date	2021-03-15
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znaa147
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Article: The Mycobiome: Cancer Pathogenesis, Diagnosis, and Therapy.

Gamal, Ahmed / Elshaer, Mohammed / Alabdely, Mayyadah / Kadry, Ahmed / McCormick, Thomas S / Ghannoum, Mahmoud

Cancers

2022 Volume 14, Issue 12

Abstract: Cancer is among the leading causes of death globally. Despite advances in cancer research, a full understanding of the exact cause has not been established. Recent data have shown that the microbiome has an important relationship with cancer on various ... ...

Abstract	Cancer is among the leading causes of death globally. Despite advances in cancer research, a full understanding of the exact cause has not been established. Recent data have shown that the microbiome has an important relationship with cancer on various levels, including cancer pathogenesis, diagnosis and prognosis, and treatment. Since most studies have focused only on the role of bacteria in this process, in this article we review the role of fungi-another important group of the microbiome, the totality of which is referred to as the "mycobiome"-in the development of cancer and how it can impact responses to anticancer medications. Furthermore, we provide recent evidence that shows how the different microbial communities interact and affect each other at gastrointestinal and non-gastrointestinal sites, including the skin, thereby emphasizing the importance of investigating the microbiome beyond bacteria.
Language	English
Publishing date	2022-06-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14122875
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Article ; Online: Efficacy of chlorhexidine in advanced performance technology formulation in decolonizing the skin using Candida auris skin colonization mouse model.

Elshaer, Mohammed / Herrada, Janet / Gamal, Ahmed / McCormick, Thomas S / Ghannoum, Mahmoud

American journal of infection control

2022 Volume 51, Issue 7, Page(s) 836–837

Abstract: The incidence of Candida auris, an emerging multidrug resistant fungal species, is increasing. The ability of this yeast to colonize the human skin could lead to infections. Identifying agents to reduce the skin fungal burden is critical. Chlorhexidine ... ...

Abstract	The incidence of Candida auris, an emerging multidrug resistant fungal species, is increasing. The ability of this yeast to colonize the human skin could lead to infections. Identifying agents to reduce the skin fungal burden is critical. Chlorhexidine formulated in a new Advanced Performance Technology formulation (APT-CH) was significantly more effective than untreated controls. Additional studies are warranted.
MeSH term(s)	Animals ; Mice ; Humans ; Candida ; Candidiasis/drug therapy ; Candidiasis/prevention & control ; Candidiasis/microbiology ; Candida auris ; Chlorhexidine/pharmacology ; Skin/microbiology ; Antifungal Agents/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	Chlorhexidine (R4KO0DY52L) ; Antifungal Agents
Language	English
Publishing date	2022-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2022.11.010
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Article ; Online: Analysis of Gut Microbiome Using Fecal Samples.

Gamal, Ahmed / Alabdely, Mayyadah / Steller, Kelly / Al-Shakhir, Hilmi / Elshaer, Mohammed / Ghannoum, Mahmoud

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2542, Page(s) 287–299

Abstract: With the gut microbiome being implicated in many diseases and even offering the potential for future therapies, its study has been gaining interest over the years. However, to gain more in-depth insight and understanding of the impact of the microbiome ... ...

Abstract	With the gut microbiome being implicated in many diseases and even offering the potential for future therapies, its study has been gaining interest over the years. However, to gain more in-depth insight and understanding of the impact of the microbiome on our health, it is critical to have accurate microbial data that is reproducible and comparable across studies. Variation in experimental techniques, particularly DNA extraction and sequencing methods, may result in variability and the inability to compare results. In this chapter, we describe in detail our microbiome analysis methodology focusing on stool samples.
MeSH term(s)	Feces ; Gastrointestinal Microbiome/genetics ; Microbiota ; RNA, Ribosomal, 16S/genetics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2549-1_21
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Article ; Online: Carbapenem Resistance in Gram-Negative Bacteria: A Hospital-Based Study in Egypt.

Elrahem, Amira Abd / El-Mashad, Noha / Elshaer, Mohammed / Ramadan, Hazem / Damiani, Giovanni / Bahgat, Monir / Mercuri, Santo Raffaele / Elemshaty, Wafaa

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 2

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Humans ; Anti-Bacterial Agents ; beta-Lactamases/genetics ; Carbapenems ; Cross-Sectional Studies ; Egypt ; Escherichia coli ; Gram-Negative Bacteria ; Hospitals, University ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Drug Resistance, Bacterial
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; Carbapenems
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59020285
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