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Article ; Online: Biology, Epidemiology, Clinical Features, Diagnosis, and Treatment of Selected Fish-borne Parasitic Zoonoses.

Cong, Wei / Elsheikha, Hany M

The Yale journal of biology and medicine

2021 Volume 94, Issue 2, Page(s) 297–309

Abstract: Fish-borne parasites have been part of the global landscape of food-borne zoonotic diseases for many decades and are often endemic in certain regions of the world. The past 20 years or so have seen the expansion of the range of fish-borne parasitic ... ...

Abstract	Fish-borne parasites have been part of the global landscape of food-borne zoonotic diseases for many decades and are often endemic in certain regions of the world. The past 20 years or so have seen the expansion of the range of fish-borne parasitic zoonoses to new geographic regions leading to a substantial public health burden. In this article, we summarize current knowledge about the biology, epidemiology, clinical characteristics, diagnosis, treatment and control of selected fish-borne helminthic diseases caused by parasitic roundworm (
MeSH term(s)	Animals ; Biology ; Fishes ; Foodborne Diseases/diagnosis ; Foodborne Diseases/epidemiology ; Humans ; Parasites ; Zoonoses/diagnosis ; Zoonoses/epidemiology
Language	English
Publishing date	2021-06-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	200515-3
ISSN	1551-4056 ; 0044-0086
ISSN (online)	1551-4056
ISSN	0044-0086
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Article: An In Silico and In Vitro Assessment of the Neurotoxicity of Mefloquine.

El Sharazly, Basma M / Ahmed, Abrar / Elsheikha, Hany M / Carter, Wayne G

Biomedicines

2024 Volume 12, Issue 3

Abstract: Mefloquine (MQ) is a quinoline-based anti-malarial drug used for chemoprophylaxis or as a treatment in combination with artesunate. Although MQ has clear anti- ...

Abstract	Mefloquine (MQ) is a quinoline-based anti-malarial drug used for chemoprophylaxis or as a treatment in combination with artesunate. Although MQ has clear anti-
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12030505
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Article ; Online: Global prevalence and risk factors associated with Toxoplasma gondii infection in wild birds: A systematic review and meta-analysis.

Chen, Chao / Qin, Si-Yuan / Yang, Xing / Li, Xiao-Man / Cai, Yanan / Lei, Cong-Cong / Zhao, Quan / Elsheikha, Hany M / Cao, Hongwei

Preventive veterinary medicine

2024 Volume 226, Page(s) 106187

Abstract: A systematic review and meta-analysis were performed to identify the global prevalence and factors associated with Toxoplasma gondii infection in wild birds. Six bibliographic databases (Chinese National Knowledge Infrastructure, VIP Chinese Journal ... ...

Abstract	A systematic review and meta-analysis were performed to identify the global prevalence and factors associated with Toxoplasma gondii infection in wild birds. Six bibliographic databases (Chinese National Knowledge Infrastructure, VIP Chinese Journal Database, Wanfang Data, PubMed, Web of science and ScienceDirect) were searched from inception to February 2023. The search yielded 1220 records of which 659 articles underwent full-text evaluation, which identified 49 eligible articles and 16,030 wild bird samples that were included in the meta-analysis. The estimated pooled global prevalence of T. gondii infection in wild birds was 16.6%. Out of the variables tested, publication year after 2020 and climate type were significantly associated with T. gondii infection (P<0.01). Our data indicate that the prevalence of T. gondii in wild birds can be influenced by epidemiological variables. Further research is needed to identify the biological, environmental, anthropogenic, and geographical risk factors which impact the ecology and prevalence of T. gondii in wild birds.
MeSH term(s)	Animals ; Toxoplasma ; Prevalence ; Toxoplasmosis, Animal/epidemiology ; Animals, Wild ; Risk Factors ; Birds ; Seroepidemiologic Studies
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	43399-8
ISSN	1873-1716 ; 0167-5877
ISSN (online)	1873-1716
ISSN	0167-5877
DOI	10.1016/j.prevetmed.2024.106187
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Article ; Online: Global prevalence of Plasmodium infection in wild birds: A systematic review and meta-analysis.

Yan, Wei-Lan / Sun, He-Ting / Zhao, Yi-Chen / Hou, Xin-Wen / Zhang, Miao / Zhao, Quan / Elsheikha, Hany M / Ni, Hong-Bo

Research in veterinary science

2024 Volume 168, Page(s) 105136

Abstract: Avian malaria is a vector-borne parasitic disease caused by Plasmodium infection transmitted to birds by mosquitoes. The aim of this systematic review was to analyze the global prevalence of malaria and risk factors associated with infection in wild ... ...

Abstract	Avian malaria is a vector-borne parasitic disease caused by Plasmodium infection transmitted to birds by mosquitoes. The aim of this systematic review was to analyze the global prevalence of malaria and risk factors associated with infection in wild birds. A systematic search of the databases CNKI, WanFang, VIP, PubMed, and ScienceDirect was performed from database inception to 24 February 2023. The search identified 3181 retrieved articles, of which 52 articles met predetermined inclusion criteria. Meta-analysis was performed using the random-effects model. The estimated pooled global prevalence of Plasmodium infection in wild birds was 16%. Sub-group analysis showed that the highest prevalence was associated with adult birds, migrant birds, North America, tropical rainforest climate, birds captured by mist nets, detection of infection by microscopy, medium quality studies, and studies published after 2016. Our study highlights the need for more understanding of Plasmodium prevalence in wild birds and identifying risk factors associated with infection to inform future infection control measures.
MeSH term(s)	Animals ; Prevalence ; Mosquito Vectors/parasitology ; Animals, Wild ; Plasmodium ; Malaria, Avian/epidemiology ; Malaria, Avian/parasitology ; Birds/parasitology
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2024.105136
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Article ; Online: Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle.

Wang, Sha-Sha / Wang, Xiangwei / He, Jun-Jun / Zheng, Wen-Bin / Zhu, Xing-Quan / Elsheikha, Hany M / Zhou, Chun-Xue

Parasitology research

2024 Volume 123, Issue 2, Page(s) 145

Abstract: Toxoplasma gondii is an opportunistic protozoan parasite that is highly prevalent in the human population and can lead to adverse health consequences in immunocompromised patients and pregnant women. Noncoding RNAs, such as microRNAs (miRNAs) and ... ...

Abstract	Toxoplasma gondii is an opportunistic protozoan parasite that is highly prevalent in the human population and can lead to adverse health consequences in immunocompromised patients and pregnant women. Noncoding RNAs, such as microRNAs (miRNAs) and circular RNAs (circRNAs), play important regulatory roles in the pathogenesis of many infections. However, the differentially expressed (DE) miRNAs and circRNAs implicated in the host cell response during the lytic cycle of T. gondii are unknown. In this study, we profiled the expression of miRNAs and circRNAs in human foreskin fibroblasts (HFFs) at different time points after T. gondii infection using RNA sequencing (RNA-seq). We identified a total of 7, 7, 27, 45, 70, 148, 203, and 217 DEmiRNAs and 276, 355, 782, 1863, 1738, 6336, 1229, and 1680 DEcircRNAs at 1.5, 3, 6, 9, 12, 24, 36, and 48 h post infection (hpi), respectively. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses revealed that the DE transcripts were enriched in immune response, apoptosis, signal transduction, and metabolism-related pathways. These findings provide new insight into the involvement of miRNAs and circRNAs in the host response to T. gondii infection.
MeSH term(s)	Pregnancy ; Humans ; Female ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/genetics ; RNA, Competitive Endogenous ; Toxoplasma ; Gene Expression Profiling ; Gene Regulatory Networks
Chemical Substances	MicroRNAs ; RNA, Circular ; RNA, Competitive Endogenous
Language	English
Publishing date	2024-02-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-024-08152-x
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Article: A systematic review, meta‐analysis and meta‐regression of the global prevalence of Toxoplasma gondii infection in wild marine mammals and associations with epidemiological variables

Li, Man‐Yao / Gao, Xiao‐Nan / Ma, Jun‐Yang / Elsheikha, Hany M. / Cong, Wei

Transboundary and emerging diseases. 2022 Sept., v. 69, no. 5

2022

Abstract: Toxoplasma gondii infection in wild marine mammals is a growing problem and is associated with adverse impacts on marine animal and public health. This systematic review, meta‐analysis and meta‐regression estimates the global prevalence of T. gondii ... ...

Abstract	Toxoplasma gondii infection in wild marine mammals is a growing problem and is associated with adverse impacts on marine animal and public health. This systematic review, meta‐analysis and meta‐regression estimates the global prevalence of T. gondii infection in wild marine mammals and analyses the association between T. gondii infection and epidemiological variables. PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure, and Wanfang Data databases were searched until 30 May 2021. Eighty‐four studies (n = 14,931 wild marine mammals from 15 families) were identified from literature. The overall pooled prevalence of T. gondii infection was 22.44% [3848/14,931; 95% confidence interval (CI): 17.29–28.04]. The prevalence in adult animals 21.88% (798/3119; 95% CI: 13.40–31.59) was higher than in the younger age groups. North America had a higher prevalence 29.92% (2756/9243; 95% CI: 21.77–38.77) compared with other continents. At the country level, the highest prevalence was found in Spain 44.26% (19/88; 95%CI: 5.21–88.54). Regarding climatic variables, the highest prevalence was found in areas with a mean annual temperature >20°C 36.28% (171/562; 95% CI: 6.36–73.61) and areas with an annual precipitation > 800 mm 26.92% (1341/5042; 95% CI: 18.20–36.59). The subgroup and meta‐regression analyses showed that study‐level covariates, including age, country, continent, and mean temperature, partly explained the between‐study heterogeneity. Further studies are needed to investigate the source of terrestrial to aquatic dissemination of T. gondii oocysts, the fate of this parasite in marine habitat and its effects on wild marine mammals.
Keywords	Toxoplasma gondii ; adults ; animals ; atmospheric precipitation ; confidence interval ; habitats ; meta-analysis ; oocysts ; parasites ; public health ; systematic review ; temperature ; North America ; Spain
Language	English
Dates of publication	2022-09
Size	p. e1213-e1230.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	REVIEW
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.14493
Database	NAL-Catalogue (AGRICOLA)

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Article: The Future of Parasitology: Challenges and Opportunities.

Elsheikha, Hany M

Frontiers in veterinary science

2014 Volume 1, Page(s) 25

Language	English
Publishing date	2014-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2014.00025
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Article: Drug Discovery against Acanthamoeba Infections: Present Knowledge and Unmet Needs

Elsheikha, Hany M / Siddiqui, Ruqaiyyah / Khan, Naveed Ahmed

Pathogens. 2020 May 22, v. 9, no. 5

2020

Abstract: Although major strides have been made in developing and testing various anti-acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health complications, and side effects associated with the use of currently available drugs necessitate ...

Abstract	Although major strides have been made in developing and testing various anti-acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health complications, and side effects associated with the use of currently available drugs necessitate the development of more effective and safe therapeutic regimens. For any new anti-acanthamoebic drugs to be more effective, they must have either superior potency and safety or at least comparable potency and an improved safety profile compared to the existing drugs. The development of the so-called ‘next-generation’ anti-acanthamoebic agents to address this challenge is an active area of research. Here, we review the current status of anti-acanthamoebic drugs and discuss recent progress in identifying novel pharmacological targets and new approaches, such as drug repurposing, development of small interfering RNA (siRNA)-based therapies and testing natural products and their derivatives. Some of the discussed approaches have the potential to change the therapeutic landscape of Acanthamoeba infections.
Keywords	Acanthamoeba ; adverse effects ; area ; drugs ; knowledge ; landscapes ; pathogens ; research ; small interfering RNA ; testing ; therapeutics
Language	English
Dates of publication	2020-0522
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9050405
Database	NAL-Catalogue (AGRICOLA)

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Article: Assessment of bioaccumulation of cu and Pb in experimentally exposed spiders, Lycosa terrestris and Pardosa birmanica, using different exposure routes

Aziz, Nida / Butt, Abida / Elsheikha, Hany M

Environmental science and pollution research international. 2020 Jan., v. 27, no. 3

2020

Abstract: Major concerns exist regarding the environmental and human health risks caused by exposure to heavy metals. Spiders are often used as a model in ecotoxicological studies to assess soil pollution. Here, we measured the bioaccumulation of copper (Cu) and ... ...

Abstract	Major concerns exist regarding the environmental and human health risks caused by exposure to heavy metals. Spiders are often used as a model in ecotoxicological studies to assess soil pollution. Here, we measured the bioaccumulation of copper (Cu) and lead (Pb) in spiders, Lycosa terrestris and Pardosa birmanica, by inductively coupled plasma mass spectrometry (ICP-MS). We investigated whether Cu and Pb accumulation differs according to different spider species, single versus combined metal exposure, and routes of exposure. Spiders were exposed to 10 mM CuSO4 and 10 mM PbCl2 solutions separately or in combination (10 mM + 10 mM) through different exposure routes (spiked soil and food) for 6 weeks. The effect of metals on the survival and body mass of exposed and unexposed (control) spiders was determined. We found that in both spider species, accumulation of metals increased with exposure time. In single metal exposure, Cu accumulation from food was higher than soil exposure in both spider species, whereas the opposite was observed for Pb. The simultaneous uptake of Cu and Pb significantly decreased from food and soil, respectively. Soil exposure caused more accumulation of metals in L. terrestris than P. birmanica. Metal exposure via contaminated food caused higher mortality compared to soil exposure. Body mass of both spider species was significantly decreased and negatively correlated with metal’s concentration. Overall, our results show that bioaccumulation efficiency of Cu and Pb differs significantly in spiders exposed to metal’s mixture compared to single metal exposure and is dependent on the exposure route, the type of metal, and spider species. More understanding of the effects of exposure to metal mixture and exposure routes is essential for designing and supporting risk assessment and ecological monitoring programs.
Keywords	atomic absorption spectrometry ; bioaccumulation ; copper ; copper sulfate ; ecotoxicology ; exposure duration ; exposure pathways ; food contamination ; heavy metals ; human health ; lead ; Lycosa ; models ; mortality ; Pardosa ; risk ; risk assessment ; soil ; soil pollution
Language	English
Dates of publication	2020-01
Size	p. 3309-3319.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-019-07055-0
Database	NAL-Catalogue (AGRICOLA)

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Article: Drug Discovery against

Elsheikha, Hany M / Siddiqui, Ruqaiyyah / Khan, Naveed Ahmed

Pathogens (Basel, Switzerland)

2020 Volume 9, Issue 5

Abstract	Although major strides have been made in developing and testing various anti-acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health complications, and side effects associated with the use of currently available drugs necessitate the development of more effective and safe therapeutic regimens. For any new anti-acanthamoebic drugs to be more effective, they must have either superior potency and safety or at least comparable potency and an improved safety profile compared to the existing drugs. The development of the so-called 'next-generation' anti-acanthamoebic agents to address this challenge is an active area of research. Here, we review the current status of anti-acanthamoebic drugs and discuss recent progress in identifying novel pharmacological targets and new approaches, such as drug repurposing, development of small interfering RNA (siRNA)-based therapies and testing natural products and their derivatives. Some of the discussed approaches have the potential to change the therapeutic landscape of
Language	English
Publishing date	2020-05-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9050405
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