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Article ; Online: Biomarkers in heart failure: a focus on natriuretic peptides.

Eltayeb, Mohamed / Squire, Iain / Sze, Shirley

2023

Abstract: While progress has been made in the management of most aspects of cardiovascular disease, the incidence and prevalence of heart failure (HF) remains high. HF affects around a million people in the UK and has a worse prognosis than most cancers. Patients ... ...

Abstract	While progress has been made in the management of most aspects of cardiovascular disease, the incidence and prevalence of heart failure (HF) remains high. HF affects around a million people in the UK and has a worse prognosis than most cancers. Patients with HF are often elderly with complex comorbidities, making accurate assessment of HF challenging. A timely diagnosis and initiation of evidence-based treatments are key to prevent hospitalisation and improve outcomes in this population. Biomarkers have dramatically impacted the way patients with HF are evaluated and managed. The most studied biomarkers in HF are natriuretic peptides (NPs). Since their discovery in the 1980s, there has been an explosion of work in the field of NPs and they have become an important clinical tool used in everyday practice to guide diagnosis and prognostic assessment of patients with HF. In this article, we will review the physiology of NPs and study their biological effects. Then, we will discuss the role of NPs in the diagnosis, management and prognostication of patients with HF. We will also explore the role of NPs as a potential therapeutic agent.
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2020-318553
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Article ; Online: Concurrent management of HIV and malaria: A comprehensive review of strategies to enhance quality of life.

Obeagu, Emmanuel Ifeanyi / Obeagu, Getrude Uzoma / Ubosi, Nwanganga Ihuoma / Uzoma, Ijeoma Chinwe / Tayrab, Eltayeb Mohamed Ahmed

Medicine

2024 Volume 103, Issue 14, Page(s) e37649

Abstract: The co-occurrence of human immunodeficiency virus and malaria presents a complex medical scenario, significantly impacting the quality of life for affected individuals. This comprehensive review synthesizes current knowledge, challenges, and strategies ... ...

Abstract	The co-occurrence of human immunodeficiency virus and malaria presents a complex medical scenario, significantly impacting the quality of life for affected individuals. This comprehensive review synthesizes current knowledge, challenges, and strategies concerning the concurrent management of these infections to improve overall well-being. Epidemiological insights reveal the prevalence and demographic trends, highlighting geographical areas of concern and socioeconomic factors contributing to the burden of co-infection. Pathophysiological interactions elucidate the compounding effects, altering disease progression and treatment outcomes. Healthcare challenges underscore the necessity for integrated care models, evaluating existing healthcare frameworks and their efficacy in addressing dual infections. In-depth analysis of interventions explores pharmacological, behavioral, and preventive measures, evaluating their efficacy and safety in co-infected individuals. Additionally, the review assesses psychosocial support mechanisms, emphasizing community-based interventions and peer networks in enhancing holistic care. Consideration is given to the role of antiretroviral therapy, malaria prevention strategies, and the evolving landscape of healthcare delivery in optimizing outcomes for this vulnerable population. The paper concludes by emphasizing the significance of multidisciplinary approaches and integrated care models, stressing the need for continued research and collaborative efforts to advance interventions and improve the quality of life for those navigating the complexities of human immunodeficiency virus and malaria co-infection.
MeSH term(s)	Humans ; HIV ; Quality of Life ; Coinfection/epidemiology ; Malaria/drug therapy ; Malaria/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037649
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Article ; Online: Surgical management of anterior sacral meningoceles: an illustrated case series and review of the literature.

Kamal, Muhmmad Ahmad / Eltayeb, Mohamed / Coulter, Ian / Jenkins, Alistair

British journal of neurosurgery

2023 , Page(s) 1–7

Abstract: Background: Anterior sacral meningocele (ASM) is an uncommon variant of spinal dysraphism. Surgical correction for this condition is challenging and optimal corrective approaches are uncertain.: Objective: To share our experience of managing this ... ...

Abstract	Background: Anterior sacral meningocele (ASM) is an uncommon variant of spinal dysraphism. Surgical correction for this condition is challenging and optimal corrective approaches are uncertain. Objective: To share our experience of managing this rare condition using the posterior trans-sacral approach and provide a contemporary review of the literature. Methods: Retrospective review of case notes, operative records, and imaging of eligible patients treated via the posterior trans-sacral approach between 2006 and 2020 at our regional neurosciences centre. Results: Three patients, two females and one male with a mean age of 30 years (range 16-38), were treated. Presenting symptoms included lower abdominal pain and recurrent miscarriages. Patients underwent corrective surgery using the posterior approach involving a sacral laminectomy, durotomy and closure of the communicating fistula. A single patient required reoperation due to early recurrence. Another patient proved challenging because of a very large sacral fistula and required two procedures due to the development of high-pressure headaches secondary to a recurrence. All patients improved symptomatically postoperatively and remained symptom free at the last clinic follow-up and have been discharged. Following review of the literature, only two other non-syndromic cases have been described. Conclusions: ASM is an uncommon congenital abnormality, typically presenting with mass effect symptoms secondary to a presacral cystic mass. Surgical management using a posterior approach to close the meningeal sac is feasible and less invasive than an anterior approach. Long term clinical outcomes in our series were satisfactory.
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2022.2162852
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Book ; Thesis: Development of a granular mycoherbicidal formulation of Fusarium oxysporum "Foxy 2" for the biological control of Striga hermonthica (Del.) Benth

Elzein, Abuelgasim Eltayeb Mohamed

(Tropical Agriculture ; 12 ; Tropical agriculture : Advances in crop research ; 2)

2003

Author's details	Abuelgasim Eltayeb Mohamed Elzein
Series title	Tropical Agriculture ; 12 Tropical agriculture : Advances in crop research ; 2 Tropical agriculture Tropical agriculture Tropical agriculture ; Advances in crop research
Collection	Tropical agriculture Tropical agriculture Tropical agriculture ; Advances in crop research
Keywords	Striga hermonthica ; Schädlingsbekämpfung ; Fusarium oxysporum ; Mykoherbizid
Subject	Fusarium augustum ; Fusarium bulbigenum
Language	English
Size	XI, 172 S., Ill., graph. Darst., 210 mm x 210 mm
Publisher	Margraf
Publishing place	Weikersheim
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hohenheim, Univ., Diss., 2003
Note	Zsfassung in dt. Sprache
HBZ-ID	HT013849010
ISBN	3-8236-1405-3 ; 978-3-8236-1405-0
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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048/247	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Decompressive craniectomy for intracranial hypertension in vaccine-induced immune thrombotic thrombocytopaenia: a case series.

Eltayeb, Mohamed / Jayakumar, Nithish / Coulter, Ian / Johnson, Christopher / Crossman, John

British journal of neurosurgery

2022 , Page(s) 1–4

Abstract: Background: Vaccines have been key in preventing COVID-19 infections and the AstraZeneca (AZ) vaccine has been widely used. However, increased rates of thromboembolic events were identified in recipients and, subsequently, a syndrome of vaccine-induced ... ...

Abstract	Background: Vaccines have been key in preventing COVID-19 infections and the AstraZeneca (AZ) vaccine has been widely used. However, increased rates of thromboembolic events were identified in recipients and, subsequently, a syndrome of vaccine-induced immune thrombotic thrombocytopaenia (VITT) was described whereby recipients presented with venous sinus thromboses, haemorrhagic infarctions, and - consequently - raised intracranial pressure. National guidance recommended decompressive craniectomies for refractory intracranial hypertension. We describe our neurosurgical experience in managing a cohort of patients with VITT. Clinical presentation: Four patients were included (three females and one male); median age was 46 years. All patients presented with a constellation of headache, focal neurological deficit(s), altered consciousness, and/or seizure at a median 11 d post-vaccine. Pre-operatively, median GCS was 7 and the median platelet count was 28 × 10 Conclusions: VITT-related sinus thromboses and associated infarcts are rare complications of the AZ vaccine. Neurosurgical management involves treating intracranial hypertension however survival outcomes in our cohort were poor. In our series, decompression was performed in deteriorating patients however prophylactic decompression, in the presence of extensive venous sinus thrombosis, should be considered on a case-by-case basis. As vaccination programmes accelerate across the world, neurosurgeons are likely to be increasingly involved in managing intracranial hypertension in patients with VITT-related sinus thromboses.
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2022.2115007
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Article: In-hospital outcomes predictors and trends of redo sternotomy aortic root replacements: insights from a UK registry analysis.

Fudulu, Daniel P / Dong, Tim / Kota, Rahul / Sinha, Shubhra / Chan, Jeremy / Rajakaruna, Cha / Dimagli, Arnaldo / Angelini, Gianni D / Ahmed, Eltayeb Mohamed

Frontiers in cardiovascular medicine

2024 Volume 10, Page(s) 1295968

Abstract: Background: Redo sternotomy aortic root surgery is technically demanding, and the evidence on outcomes is mostly from retrospective, small sample, single-centre studies. We report the trend, early clinical results and outcome predictors of redo aortic ... ...

Abstract	Background: Redo sternotomy aortic root surgery is technically demanding, and the evidence on outcomes is mostly from retrospective, small sample, single-centre studies. We report the trend, early clinical results and outcome predictors of redo aortic root replacement over 20 years in the United Kingdom. Methods: We retrospectively analysed collected data from the UK National Adult Cardiac Surgery Audit (NACSA) on all redo sternotomy aortic root replacements performed between 30th January 1998 and 19th March 2019. We analysed trends in the volume of operations, characteristics of hospital survivors vs. non-survivors, and predictors of in-hospital outcomes. Results: During the study period, 1,107 redo sternotomy aortic root replacements were performed (median age 59, 26% of patients were females). Eighty-four per cent of cases ( Conclusions: Redo sternotomy aortic root replacement still carries significant morbidity and mortality and is sporadically performed across surgeons and centres in the UK.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1295968
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Article ; Online: Incidence and outcomes of surgical pulmonary embolectomy in the UK.

Argyriou, Amerikos / Vohra, Hunaid / Chan, Jeremy / Ahmed, Eltayeb Mohamed / Rajakaruna, Cha / Angelini, Gianni Davide / Fudulu, Daniel Paul

The British journal of surgery

2024 Volume 111, Issue 1

Abstract: Background: Surgical pulmonary embolectomy is rarely used for the treatment of massive acute pulmonary embolism. The aim of this study was to assess the incidence and outcomes of this operation by undertaking a retrospective analysis of a large national ...

Abstract	Background: Surgical pulmonary embolectomy is rarely used for the treatment of massive acute pulmonary embolism. The aim of this study was to assess the incidence and outcomes of this operation by undertaking a retrospective analysis of a large national registry in the UK. Methods: All acute pulmonary embolectomies performed between 1996 and 2018 were captured in the National Institute of Cardiovascular Outcomes Research central database. Trends in the number of operations performed during this interval and reported in-hospital outcomes were analysed retrospectively. Multivariable logistic regression was used to identify independent risk factors for in-hospital death. Results: All 256 patients treated surgically for acute pulmonary embolism during the study interval were included in the analysis. Median age at presentation was 54 years, 55.9% of the patients were men, 48.0% had class IV heart failure symptoms, and 37.5% had preoperative cardiogenic shock. The median duration of bypass was 73 min, and median cross-clamp time was 19 min. Cardioplegic arrest was used in 53.1% of patients. The median duration of hospital stay was 11 days. The in-hospital mortality rate was 25%, postoperative stroke occurred in 5.4%, postoperative dialysis was required in 16%, and the reoperation rate for bleeding was 7.5%. Risk-adjusted multivariable analysis revealed cardiogenic shock (OR 2.54, 95% c.i. 1.05 to 6.21; P = 0.038), preoperative ventilation (OR 5.85, 2.22 to 16.35; P < 0.001), and duration of cardiopulmonary bypass exceeding 89 min (OR 7.82, 3.25 to 20.42; P < 0.001) as significant independent risk factors for in-hospital death. Conclusion: Surgical pulmonary embolectomy is rarely performed in the UK, and is associated with significant mortality and morbidity. Preoperative ventilation, cardiogenic shock, and increased duration of bypass were significant predictors of in-hospital death.
MeSH term(s)	Male ; Humans ; Female ; Retrospective Studies ; Shock, Cardiogenic/epidemiology ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/surgery ; Treatment Outcome ; Incidence ; Hospital Mortality ; Embolectomy/adverse effects ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/surgery ; Pulmonary Embolism/complications ; Acute Disease ; United Kingdom/epidemiology
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znae003
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Article ; Online: Innovative approach for predicting daily reference evapotranspiration using improved shallow and deep learning models in a coastal region: A comparative study.

Elzain, Hussam Eldin / Abdalla, Osman A / Abdallah, Mohammed / Al-Maktoumi, Ali / Eltayeb, Mohamed / Abba, Sani I

Journal of environmental management

2024 Volume 354, Page(s) 120246

Abstract: Accurate and reliable estimation of Reference Evapotranspiration (ETo) is crucial for water resources management, hydrological processes, and agricultural production. The FAO-56 Penman-Monteith (FAO-56PM) approach is recommended as the standard model for ...

Abstract	Accurate and reliable estimation of Reference Evapotranspiration (ETo) is crucial for water resources management, hydrological processes, and agricultural production. The FAO-56 Penman-Monteith (FAO-56PM) approach is recommended as the standard model for ETo estimation; nevertheless, the absence of comprehensive meteorological variables at many global locations frequently restricts its implementation. This study compares shallow learning (SL) and deep learning (DL) models for estimating daily ETo against the FAO-56PM approach based on various statistic metrics and graphic tool over a coastal Red Sea region, Sudan. A novel approach of the SL model, the Catboost Regressor (CBR) and three DL models: 1D-Convolutional Neural Networks (1D-CNN), Long Short-Term Memory (LSTM), and Gated Recurrent Unit (GRU) were adopted and coupled with a semi-supervised pseudo-labeling (PL) technique. Six scenarios were developed regarding different input combinations of meteorological variables such as air temperature (Tmin, Tmax, and Tmean), wind speed (U2), relative humidity (RH), sunshine hours duration (SSH), net radiation (Rn), and saturation vapor pressure deficit (es-ea). The results showed that the PL technique reduced the systematic error of SL and DL models during training for all the scenarios. The input combination of Tmin, Tmax, Tmean, and RH reflected higher performance than other combinations for all employed models. The CBR-PL model demonstrated good generalization abilities to predict daily ETo and was the overall superior model in the testing phase according to prediction accuracy, stability analysis, and less computation cost compared to DL models. Thus, the relatively simple CBR-PL model is highly recommended as a promising tool for predicting daily ETo in coastal regions worldwide which have limited climate data.
MeSH term(s)	Deep Learning ; Neural Networks, Computer ; Climate ; Wind ; Temperature
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120246
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Article ; Online: Left ventricular pseudoaneurysm in Lemierre's syndrome: a case report.

Gall, Alexander / Sandhu, Manraj Singh / Ahmed, Eltayeb Mohamed / McAloon, Christopher James

European heart journal. Case reports

2023 Volume 7, Issue 3, Page(s) ytad109

Abstract: Background: Lemierre's syndrome is an infectious phenomenon characterized by oropharyngeal infection with bacteraemia, thrombophlebitis, and distant septic emboli. Septic emboli are a recognized cause of a Type 2 myocardial infarction, with a left ... ...

Abstract	Background: Lemierre's syndrome is an infectious phenomenon characterized by oropharyngeal infection with bacteraemia, thrombophlebitis, and distant septic emboli. Septic emboli are a recognized cause of a Type 2 myocardial infarction, with a left ventricular pseudoaneurysm being a rare but important complication of this. Case summary: A 19-year-old male presented with acute confusion, fevers, and a cough. Blood cultures were positive for Discussion: This is the first case described of left ventricular pseudoaneurysm as a complication of Lemierre's syndrome. It highlights not only the importance of serial, multimodality imaging in both diagnostic workup and identification of complications, but also the importance of a multidisciplinary team in the management of patients with complex and rare presentations.
Language	English
Publishing date	2023-03-03
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad109
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Article ; Online: Ten-year survival in glioblastoma. A systematic review.

Tykocki, Tomasz / Eltayeb, Mohamed

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2018 Volume 54, Page(s) 7–13

Abstract: Glioblastoma (GBM) is among the most deadly neoplasms associated with one of the worst 5-year overall survival (OS) rates among all human cancers. The aim of this systematic review is to present all cases with OS of a decade or more and to perform a ... ...

Abstract	Glioblastoma (GBM) is among the most deadly neoplasms associated with one of the worst 5-year overall survival (OS) rates among all human cancers. The aim of this systematic review is to present all cases with OS of a decade or more and to perform a descriptive analysis of the group. This systematic review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. A comprehensive search for relevant articles was performed on PubMed, Embase and Google Scholar for a period until June 10, 2016, using the following search words: glioblastoma multiforme, glioblastoma, GBM, long-term survival/survivors. Reports containing cases with the long-term survival of 10 years or longer were included in the review. The search produced 36 studies with 162 cases published in the years 1950-2014. The rate of long survivors in the cohort studied was established 0.76%. Mean age at diagnosis, OS and PFS were 31.1 ± 11.1, 15.9 ± 6.3, 11.9 ± 5.6 years respectively. Total and subtotal resections were found in 82 and 58 patients respectively. Nine cases received a biopsy alone. No statistical differences were found in a comparison of PFS, OS and age between total and subtotal resection groups. A regression analysis showed a significant correlation between PFS and OS, with an inverse relationship stated between age at diagnosis and OS. The 10-year survival rate in the cohort studied with GBM was estimated 0.71%. OS was positively correlated with the length of PFS and inversely related with age at diagnosis.
MeSH term(s)	Brain Neoplasms/mortality ; Brain Neoplasms/surgery ; Disease-Free Survival ; Glioblastoma/mortality ; Glioblastoma/surgery ; Humans ; Survival Rate ; Time Factors
Language	English
Publishing date	2018-05-23
Publishing country	Scotland
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2018.05.002
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