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Article ; Online: Estimation of Right Atrial Pressure Using a Portable Handheld Ultrasound Device.

Elzeneini, Mohammed / Gupta, Shishir / Li, Yujia / Guo, Yi / Hamburger, Robert

2022 Volume 135, Issue 11, Page(s) 1378–1381

Abstract: Background: Handheld ultrasound devices are increasingly used by clinicians for their ease of use and portability. Their utility for estimating right atrial pressure (RAP) is poorly described.: Methods: This prospective study enrolled 50 consecutive ... ...

Abstract	Background: Handheld ultrasound devices are increasingly used by clinicians for their ease of use and portability. Their utility for estimating right atrial pressure (RAP) is poorly described. Methods: This prospective study enrolled 50 consecutive patients presenting for outpatient right heart catheterization (RHC). A handheld ultrasound device was used to measure inferior vena cava size and collapsibility and estimate RAP to be 3, 8, or 15 mmHg according to American Society of Echocardiography recommendations for cardiac chamber quantification. Invasive pressure measurements were then performed using RHC. Spearman's correlation and linear regression analysis were used to evaluate the association between estimated RAP using ultrasound and invasive RAP. Results: Fifty patients were enrolled (mean age 68 ± 8 years). Estimated RAP by ultrasound was significantly associated with invasive RAP (r 0.80; R Conclusions: Handheld ultrasonography is a useful tool that can accurately estimate RAP at the bedside.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Atrial Pressure ; Atrial Function, Right ; Prospective Studies ; Echocardiography ; Cardiac Catheterization
Language	English
Publishing date	2022-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.05.018
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Article ; Online: Chronic Limb-Threatening Ischemia Is Associated With Higher Mortality and Limb Revascularization After Transcatheter Aortic Valve Replacement.

Shah, Khanjan B / Elzeneini, Mohammed / Neal, Dan / Kamisetty, Sujay / Winchester, David / Shah, Samir K

The American journal of cardiology

2023 Volume 207, Page(s) 202–205

Abstract: Peripheral arterial disease (PAD) is common in patients with symptomatic aortic stenosis. PAD exists as a spectrum, and patients with chronic limb-threatening ischemia (CLTI), the most severe form of PAD, are at high risk for limb loss and death. We seek ...

Abstract	Peripheral arterial disease (PAD) is common in patients with symptomatic aortic stenosis. PAD exists as a spectrum, and patients with chronic limb-threatening ischemia (CLTI), the most severe form of PAD, are at high risk for limb loss and death. We seek to determine patient characteristics and clinical outcomes among patients who underwent TAVR with or without CLTI. We identified all hospitalizations for TAVR from October 2015 to December 2018 using the National Inpatient Sample database. Patients with any diagnosis of CLTI were identified using the International Classification of Diseases 10th Revision codes. The primary outcome was in-hospital mortality, and secondary outcomes were major complications, open revascularization, and endovascular revascularization after TAVR. During the study period, a total of 31,335 hospitalizations for TAVR procedures were included, including 7,048 (22.5%) in patients with CLTI. CLTI was associated with higher in-hospital mortality (odds ratio [OR] 1.4, 95% confidence interval [CI] 1.13 to 1.74, p = 0.002) and major complications (OR 1.2, 95% CI 1.09 to 1.25, p <0.001). CLTI was also associated with a significantly higher rate of open limb revascularization (OR 5.1, 95% CI 3.94 to 6.48, p <0.001) and endovascular revascularization (OR 4.0, 95% CI 3.54 to 4.59, p <0.001). CLTI among patients who underwent TAVR is associated with higher in-hospital mortality, major complications, and longer lengths of stay compared with patients without CLTI. However, the overall rates of adverse events remain low. Further studies are needed to optimize the multidisciplinary care of these patients before TAVR with a focus on shared decision-making.
MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Chronic Limb-Threatening Ischemia ; Risk Factors ; Ischemia/epidemiology ; Ischemia/etiology ; Ischemia/surgery ; Vascular Surgical Procedures ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/epidemiology ; Peripheral Arterial Disease/surgery ; Treatment Outcome ; Endovascular Procedures/methods ; Chronic Disease ; Retrospective Studies
Language	English
Publishing date	2023-09-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.08.114
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Article ; Online: Dementia is associated with worse procedural outcomes after mitral valve transcatheter edge-to-edge repair.

Elzeneini, Mohammed / Nassereddin, Ali T / Li, Yujia / Shah, Samir K / Winchester, David / Li, Ang / Guo, Yi / Shah, Khanjan B

Cardiovascular revascularization medicine : including molecular interventions

2024

Abstract: Background: Patients with dementia are at increased risk for adverse events following valvular surgery. Outcomes after mitral transcatheter edge-to-edge repair (TEER) for mitral regurgitation in this vulnerable population are not well understood.: ... ...

Abstract	Background: Patients with dementia are at increased risk for adverse events following valvular surgery. Outcomes after mitral transcatheter edge-to-edge repair (TEER) for mitral regurgitation in this vulnerable population are not well understood. Methods: We queried the National Inpatient Sample database for all hospitalizations for mitral TEER between 2016 and 2019. Patients with a validated diagnosis code for dementia were identified by ICD-10 codes and compared to a matched cohort of non-dementia patients using multivariable regression analysis. The primary outcome was in-hospital mortality. Secondary outcomes were hospital length of stay, discharge to nursing facility, total hospital charges, and in-hospital adverse events. Results: 24,550 hospitalizations for mitral TEER were identified, including 880 patients (3.6 %) with dementia. Dementia was associated with higher in-hospital mortality (OR 4.31, 95 % CI 2.65 to 6.99, p < 0.001), prolonged length of hospital stay (OR 1.33, 95 % CI 1.12 to 1.57, p 0.001), higher discharge rate to nursing facility (OR 2.71, 95 % CI 2.13-3.44, p < 0.001), and higher rate of in-hospital adverse events including delirium (OR 5.88, 95 % CI 4.06 to 8.52, p < 0.001) and acute stroke (OR 8.87, 95 % CI 5.01 to 15.70, p < 0.001). Conclusions: Dementia is associated with worse post-procedural outcomes after mitral TEER. Further investigation is needed to elucidate mechanisms of poor clinical outcomes and guide shared decision-making in this vulnerable population.
Language	English
Publishing date	2024-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2024.03.031
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Article ; Online: The left atrial appendage morphology and gender differences by multi-detector computed tomography in an Egyptian population.

Elzeneini, Mohammed / Elshazly, Ahmed / Nayel, Ahmed El Mahmoudy

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

2020 Volume 72, Issue 1, Page(s) 38

Abstract: Background: The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation. Unique LAA morphologies have been associated with the risk of thromboembolism. This study investigates the LAA anatomy ... ...

Abstract	Background: The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation. Unique LAA morphologies have been associated with the risk of thromboembolism. This study investigates the LAA anatomy in the Egyptian population using cardiac multi-detector computed tomography (MDCT). Results: We included 252 consecutive patients presenting for coronary computed tomography angiography in 2 tertiary centers in Egypt in the period from January to July 2017. Patients with atrial fibrillation, valvular affection, or left ventricular dysfunction were excluded. Two and three-dimensional cardiac MDCT images were assessed for LAA morphology, volume, length, and orifice position. The distribution of LAA morphologies was windsock (32.5%), chicken wing (25.4%), cauliflower (22.6%), and cactus (19.4%). Differences in the LAA dimensions in the 4 morphological variants were described. Females were less likely to have a chicken wing LAA morphology compared to males (7.9% vs 34.7%, p value < 0.01), and had a larger LAA volume, smaller LAA length, and a higher prevalence of high LAA orifice position. Conclusions: The most common LAA morphology in our study population is windsock, which may represent the Egyptian population or patients in sinus rhythm. Females were less likely to have a chicken wing LAA morphology, and had a larger LAA volume, smaller length, and higher incidence of high orifice position. Clinical correlation into the translation of these differences into thromboembolic risk is required.
Language	English
Publishing date	2020-07-02
Publishing country	Germany
Document type	Journal Article
ISSN	2090-911X
ISSN (online)	2090-911X
DOI	10.1186/s43044-020-00072-2
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Article ; Online: Recurrent Lethal Allergic Coronary Vasospasm.

Elzeneini, Mohammed / Aalaei-Andabili, Seyed Hossein / Keeley, Ellen C

The American journal of medicine

2020 Volume 133, Issue 12, Page(s) e731–e732

MeSH term(s)	Aged ; Contrast Media/adverse effects ; Coronary Vasospasm/chemically induced ; Echocardiography ; Fatal Outcome ; Fluorocarbons/adverse effects ; Hemorrhage/complications ; Humans ; Kounis Syndrome/pathology ; Lung Diseases/complications ; Lung Diseases/pathology ; Male
Chemical Substances	Contrast Media ; Definity ; Fluorocarbons
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2020.04.037
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Article ; Online: Utilization rate and outcomes of intravascular imaging in elderly patients presenting with ST-elevation myocardial infarction.

Elzeneini, Mohammed / Betageri, Omkar / Kamisetty, Sujay R / Assaf, Yazan / Elgendy, Islam Y / Shah, Khanjan B

Cardiovascular revascularization medicine : including molecular interventions

2022

Abstract: Background: Elderly patients presenting with ST-elevation myocardial infarction (STEMI) represent a vulnerable population with comorbid conditions and complex coronary anatomy. We aimed to describe the utilization rate and outcomes of intravascular ... ...

Abstract	Background: Elderly patients presenting with ST-elevation myocardial infarction (STEMI) represent a vulnerable population with comorbid conditions and complex coronary anatomy. We aimed to describe the utilization rate and outcomes of intravascular imaging to guide percutaneous coronary intervention (PCI) in this population. Methods: The Nationwide Readmissions Database was queried for all hospitalizations for STEMI involving PCI from 2018 to 2019. Hospitalizations were stratified by patient age into a younger cohort <75 years (mean age 58.7 ± 9.5 years) and an older cohort ≥75 years. Propensity score-weighed regression analysis was used to identify the association of intravascular imaging with in-hospital mortality, 90-day all-cause readmission, and readmission for myocardial infarction (MI). Results: A total of 299,619 STEMI PCI hospitalizations were included. Intravascular imaging was utilized less frequently in the older cohort (6.8 % vs 7.8 %, odds ratio [OR] 0.87, 95 % CI 0.82-0.92, p < 0.001). In both cohorts, intravascular imaging was more likely to be used with anterior STEMI, complex PCI, mechanical support, and thrombectomy. Propensity score analysis showed the use of intravascular imaging was associated with lower in-hospital mortality in both cohorts (OR 0.60, 95 % CI 0.52-0.68, p < 0.001 in the younger cohort and OR 0.61, 95 % CI 0.51-0.72, p < 0.001 in the older cohort). There was no difference in 90-day all-cause readmission or readmission for MI with intravascular imaging. Conclusions: Intravascular imaging during STEMI PCI is associated with lower in-hospital mortality regardless of age. Further studies are needed to understand the low utilization rates especially among elderly patients.
Language	English
Publishing date	2022-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2022.08.004
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Article ; Online: Outcomes of Percutaneous Coronary Intervention for In-Stent Restenosis Versus De Novo Lesions: A Meta-Analysis.

Elbadawi, Ayman / Dang, Alexander T / Mahana, Ingy / Elzeneini, Mohammed / Alonso, Fernando / Banerjee, Subhash / Kumbhani, Dharam J / Elgendy, Islam Y / Mintz, Gary S

Journal of the American Heart Association

2023 Volume 12, Issue 13, Page(s) e029300

Abstract: Background In-stent restenosis (ISR) is commonly encountered even in the era of contemporary percutaneous coronary intervention (PCI). There is a paucity of data on the comparative outcomes of PCI for ISR lesions versus de novo lesions. Methods and ... ...

Abstract	Background In-stent restenosis (ISR) is commonly encountered even in the era of contemporary percutaneous coronary intervention (PCI). There is a paucity of data on the comparative outcomes of PCI for ISR lesions versus de novo lesions. Methods and Results An electronic search was conducted for MEDLINE, Cochrane, and Embase through August 2022 for studies comparing the clinical outcomes after PCI for ISR versus de novo lesions. The primary outcome was major adverse cardiac events. Data were pooled using a random-effects model. The final analysis included 12 studies, with a total of 708 391 patients, of whom 71 353 (10.3%) underwent PCI for ISR. The weighted follow-up duration was 29.1 months. Compared with de novo lesions, PCI for ISR was associated with a higher incidence of major adverse cardiac events (odds ratio [OR], 1.31 [95% CI, 1.18-1.46]). There was no difference on a subgroup analysis of chronic total occlusion lesions versus none (
MeSH term(s)	Humans ; Percutaneous Coronary Intervention ; Coronary Restenosis/epidemiology ; Coronary Restenosis/etiology ; Coronary Restenosis/therapy ; Drug-Eluting Stents/adverse effects ; Risk Factors ; Myocardial Infarction/epidemiology ; Stents/adverse effects ; Constriction, Pathologic ; Treatment Outcome ; Coronary Angiography/adverse effects
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.029300
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Article ; Online: Caregiver Stress Is Improved and Sustained Following Transcatheter Aortic Valve Replacement.

Elzeneini, Mohammed / Osman, Alfaroug / Bright, Khadija / Yang, Shuang / Guo, Yi / Jeng, Eric / Shah, Khanjan B

Palliative medicine reports

2023 Volume 4, Issue 1, Page(s) 56–58

Abstract: Background: Little is known about the impact of symptomatic aortic stenosis and subsequent transcatheter aortic valve replacement (TAVR) on stress and health for the caregiver. In this prospective cohort study, we measured caregiver stress before and ... ...

Abstract	Background: Little is known about the impact of symptomatic aortic stenosis and subsequent transcatheter aortic valve replacement (TAVR) on stress and health for the caregiver. In this prospective cohort study, we measured caregiver stress before and after TAVR. Methods: We interviewed 34 primary caregivers for patients undergoing outpatient TAVR at an academic institution. Caregiver stress was measured using the Kingston Caregiver Stress Scale (KCSS) and the Caregiver Self-Assessment Questionnaire (CSAQ) before TAVR and at one and six months after. Mean scores were compared pre- and post-TAVR using the Wilcoxon signed-rank test. Results: There was significant improvement in KCSS caregiver stress at one month that was sustained at six months post-TAVR (mean change -1.91 ± 2.50 for six months, Conclusions: Our findings support further investigation of caregiver outcomes in shared decision making before TAVR.
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ISSN	2689-2820
ISSN (online)	2689-2820
DOI	10.1089/pmr.2022.0064
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Article ; Online: Outcomes of Mitral Transcatheter Edge-to-Edge Repair in Patients With Rheumatic Heart Disease.

Elzeneini, Mohammed / Ashraf, Hassan / Mahmoud, Ahmad / Elgendy, Islam Y / Elbadawi, Ayman / Assaf, Yazan / Anderson, R David / Jneid, Hani

The American journal of cardiology

2023 Volume 192, Page(s) 166–173

Abstract: Mitral transcatheter edge-to-edge repair (TEER) in patients with rheumatic heart disease (RHD) is challenging owing to leaflet thickening and calcification but is performed in select cases. Limited data exist on its outcomes. The aim of this analysis was ...

Abstract	Mitral transcatheter edge-to-edge repair (TEER) in patients with rheumatic heart disease (RHD) is challenging owing to leaflet thickening and calcification but is performed in select cases. Limited data exist on its outcomes. The aim of this analysis was to investigate the safety and efficacy of mitral TEER in patients with severe symptomatic rheumatic mitral regurgitation. We queried the Nationwide Readmissions Database for hospitalizations for mitral TEER between 2016 and 2018. Propensity score-weighted regression analysis was conducted to evaluate the association of RHD with in-hospital outcomes and 90-day readmissions after mitral TEER. A total of 18,240 procedures were included in the analysis, including 1,779 in patients with RHD. Mitral TEER in patients with RHD was associated with similar in-hospital mortality to that in patients without RHD (odds ratio [OR] 1.47, 95% confidence interval [CI] 0.94 to 2.30, p = 0.089). However, RHD was associated with higher acute myocardial infarction (OR 1.65, 95% CI 1.07 to 2.56), acute kidney injury (OR 1.58, 95% CI 1.30 to 1.94), ventricular arrhythmia (OR 1.50, 95% CI 1.12 to 2.01), high-degree heart block (OR 1.67, 95% CI 1.25 to 2.23), and conversion to open surgical repair/replacement (OR 2.53, 95% CI 1.02 to 6.30). Mitral TEER in RHD was also associated with higher 90-day all-cause readmission (hazard ratio [HR] 1.19, 95% CI 1.04 to 1.47, p = 0.012). In conclusion, mitral TEER in patients with RHD is associated with higher rates of hospital complications, crossover to surgery, and readmissions but could be performed selectively in patients at high surgical risk who have favorable anatomy.
MeSH term(s)	Humans ; Acute Kidney Injury ; Calcinosis ; Databases, Factual ; Heart Block ; Heart Valve Prosthesis Implantation ; Mitral Valve Insufficiency/surgery ; Rheumatic Heart Disease ; Treatment Outcome
Language	English
Publishing date	2023-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.01.034
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Article ; Online: Circulating Biomarkers in Hypertrophic Cardiomyopathy.

Matthia, Eldon L / Setteducato, Michael L / Elzeneini, Mohammed / Vernace, Nicholas / Salerno, Michael / Kramer, Christopher M / Keeley, Ellen C

Journal of the American Heart Association

2022 Volume 11, Issue 23, Page(s) e027618

Abstract: Hypertrophic cardiomyopathy is the most common genetic heart disease. Biomarkers, molecules measurable in the blood, could inform the clinician by aiding in diagnosis, directing treatment, and predicting outcomes. We present an updated review of ... ...

Abstract	Hypertrophic cardiomyopathy is the most common genetic heart disease. Biomarkers, molecules measurable in the blood, could inform the clinician by aiding in diagnosis, directing treatment, and predicting outcomes. We present an updated review of circulating biomarkers in hypertrophic cardiomyopathy representing key pathologic processes including wall stretch, myocardial necrosis, fibrosis, inflammation, hypertrophy, and endothelial dysfunction, in addition to their clinical significance.
MeSH term(s)	Humans ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/physiopathology ; Biomarkers/blood
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-11-16
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.027618
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