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  1. AU="Emanuela Ricciotti"
  2. AU="Wani, Willayat Yousuf"
  3. AU="Luan, Xiaoyang"
  4. AU="Goberdhan, Sankalp"
  5. AU="Krammer, Sandy"
  6. AU="Whitehorne-Smith, Patrice"
  7. AU="Witek, M." AU="Witek, M."
  8. AU="Steiner, Luzius A"
  9. AU=Williams Kirryn
  10. AU="Rossi, Simone"
  11. AU="Bryan, Nathan S."
  12. AU="Sodhi, Sohail"
  13. AU="Sotiropoulos, Thodoris"
  14. AU="Osborne, Cameron"
  15. AU="Seira, Jordan"
  16. AU="Komiya, Ryota"
  17. AU="Yeonsoo Joe"
  18. AU="Christina Drake"
  19. AU="Rosenbloom, E Scott"
  20. AU="Clémentine Schilte"
  21. AU="Montanari, Andrea"
  22. AU="Salehi Karizmeh, Mojtaba"
  23. AU="Svanberg Frisinger, Frida"
  24. AU="Iyappan, Petchi"
  25. AU="Naomi Nakagata"
  26. AU="Marianne A. van der Sande"
  27. AU="Reno, Chiara"

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  1. Artikel ; Online: Mechanistic and Pharmacological Issues of Aspirin as an Anticancer Agent

    Paola Patrignani / Emanuela Ricciotti / Stefania Tacconelli / Carlos Sostres / Melania Dovizio

    Pharmaceuticals, Vol 5, Iss 12, Pp 1346-

    2012  Band 1371

    Abstract: Recent findings have shown that aspirin, taken for several years, reduces the long-term risk of some cancers, particularly colorectal cancer. The result that aspirin benefit is detectable at daily low-doses (at least 75mg), the same used for the ... ...

    Abstract Recent findings have shown that aspirin, taken for several years, reduces the long-term risk of some cancers, particularly colorectal cancer. The result that aspirin benefit is detectable at daily low-doses (at least 75mg), the same used for the prevention of cardiovascular disease, positions the antiplatelet action of aspirin at the center of its antitumor efficacy. At low-doses given every 24 h, aspirin is acting by a complete and persistent inhibition of cyclooxygenase (COX)-1 in platelets (in the pre-systemic circulation) while causing a limited and rapidly reversible inhibitory effect on COX-2 and/or COX-1 expressed in nucleated cells. Aspirin has a short half-life in human circulation (approximately 20 min); nucleated cells have the ability to resynthesize the acetylated COX-isozymes within a few hours, while platelets do not. COX-independent mechanisms of aspirin, such as the inhibition of Wnt/ b-catenin and NF-kB signaling and the acetylation of extra-COX proteins, have been suggested to play a role in its chemo-preventive effects, but their relevance remains to be demonstrated in vivo at clinical doses. In conclusion, the results of clinical pharmacology and the analysis of randomized and epidemiological studies suggest that colorectal cancer and atherothrombosis share a common mechanism of disease, i.e. enhanced platelet activation in response to injury at distinct sites.
    Schlagwörter aspirin ; colorectal cancer ; platelet ; cycloooxygenase-1 ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2012-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input

    Dimitra Sarantopoulou / Soon Yew Tang / Emanuela Ricciotti / Nicholas F. Lahens / Damien Lekkas / Jonathan Schug / Xiaofeng S. Guo / Georgios K. Paschos / Garret A. FitzGerald / Allan I. Pack / Gregory R. Grant

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 10

    Abstract: Abstract Library preparation is a key step in sequencing. For RNA sequencing there are advantages to both strand specificity and working with minute starting material, yet until recently there was no kit available enabling both. The Illumina TruSeq ... ...

    Abstract Abstract Library preparation is a key step in sequencing. For RNA sequencing there are advantages to both strand specificity and working with minute starting material, yet until recently there was no kit available enabling both. The Illumina TruSeq stranded mRNA Sample Preparation kit (TruSeq) requires abundant starting material while the Takara Bio SMART-Seq v4 Ultra Low Input RNA kit (V4) sacrifices strand specificity. The SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian (Pico) by Takara Bio claims to overcome these limitations. Comparative evaluation of these kits is important for selecting the appropriate protocol. We compared the three kits in a realistic differential expression analysis. We prepared and sequenced samples from two experimental conditions of biological interest with each of the three kits. We report differences between the kits at the level of differential gene expression; for example, the Pico kit results in 55% fewer differentially expressed genes than TruSeq. Nevertheless, the agreement of the observed enriched pathways suggests that comparable functional results can be obtained. In summary we conclude that the Pico kit sufficiently reproduces the results of the other kits at the level of pathway analysis while providing a combination of options that is not available in the other kits.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-09-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Distinct vascular genomic response of proton and gamma radiation-A pilot investigation.

    Emanuela Ricciotti / Dimitra Sarantopoulou / Gregory R Grant / Jenine K Sanzari / Gabriel S Krigsfeld / Amber J Kiliti / Ann R Kennedy / Tilo Grosser

    PLoS ONE, Vol 14, Iss 2, p e

    2019  Band 0207503

    Abstract: The cardiovascular biology of proton radiotherapy is not well understood. We aimed to compare the genomic dose-response to proton and gamma radiation of the mouse aorta to assess whether their vascular effects may diverge. We performed comparative RNA ... ...

    Abstract The cardiovascular biology of proton radiotherapy is not well understood. We aimed to compare the genomic dose-response to proton and gamma radiation of the mouse aorta to assess whether their vascular effects may diverge. We performed comparative RNA sequencing of the aorta following (4 hrs) total-body proton and gamma irradiation (0.5-200 cGy whole body dose, 10 dose levels) of conscious mice. A trend analysis identified genes that showed a dose response. While fewer genes were dose-responsive to proton than gamma radiation (29 vs. 194 genes; q-value ≤ 0.1), the magnitude of the effect was greater. Highly responsive genes were enriched for radiation response pathways (DNA damage, apoptosis, cellular stress and inflammation; p-value ≤ 0.01). Gamma, but not proton radiation induced additionally genes in vasculature specific pathways. Genes responsive to both radiation types showed almost perfectly superimposable dose-response relationships. Despite the activation of canonical radiation response pathways by both radiation types, we detected marked differences in the genomic response of the murine aorta. Models of cardiovascular risk based on photon radiation may not accurately predict the risk associated with proton radiation.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Considerations for the Safe Operation of Schools During the Coronavirus Pandemic

    Ronan Lordan / Samantha Prior / Elizabeth Hennessy / Amruta Naik / Soumita Ghosh / Georgios K. Paschos / Carsten Skarke / Kayla Barekat / Taylor Hollingsworth / Sydney Juska / Liudmila L. Mazaleuskaya / Sarah Teegarden / Abigail L. Glascock / Sean Anderson / Hu Meng / Soon-Yew Tang / Aalim Weljie / Lisa Bottalico / Emanuela Ricciotti /
    Perla Cherfane / Antonijo Mrcela / Gregory Grant / Kristen Poole / Natalie Mayer / Michael Waring / Laura Adang / Julie Becker / Susanne Fries / Garret A. FitzGerald / Tilo Grosser

    Frontiers in Public Health, Vol

    2021  Band 9

    Abstract: During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, providing safe in-person schooling has been a dynamic process balancing evolving community disease burden, scientific information, and local regulatory requirements with ... ...

    Abstract During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, providing safe in-person schooling has been a dynamic process balancing evolving community disease burden, scientific information, and local regulatory requirements with the mandate for education. Considerations include the health risks of SARS-CoV-2 infection and its post-acute sequelae, the impact of remote learning or periods of quarantine on education and well-being of children, and the contribution of schools to viral circulation in the community. The risk for infections that may occur within schools is related to the incidence of SARS-CoV-2 infections within the local community. Thus, persistent suppression of viral circulation in the community through effective public health measures including vaccination is critical to in-person schooling. Evidence suggests that the likelihood of transmission of SARS-CoV-2 within schools can be minimized if mitigation strategies are rationally combined. This article reviews evidence-based approaches and practices for the continual operation of in-person schooling.
    Schlagwörter COVID-19 ; SARS-CoV-2 ; education ; vaccination ; post-acute sequelae of SARS-CoV-2 infection (PASC) ; pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 306
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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