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  1. AU="Emanuele Dilaghi"
  2. AU="Sabetghadam, Shadi"
  3. AU="Tijssen, Henk J"
  4. AU="Hodges, Scott D"
  5. AU="Kose, Abdulkadir"
  6. AU=Matsumoto Kunio AU=Matsumoto Kunio
  7. AU="Mutus, Bulent"
  8. AU="Yu-Shan Gao"
  9. AU="Afza Gardner, Qurratulann"
  10. AU="Madan, Arina"
  11. AU="Cutshaw, Kaiyel A"
  12. AU="Al-Khazraji, Ahmed"
  13. AU="Mukherjee, Geetashree"
  14. AU="DeGraff, David J"
  15. AU="Schmoellerl, Johannes"
  16. AU="Henderson, S"
  17. AU="Carvalheiro, Tiago"
  18. AU="Bastos Soares, Taís Cristina"
  19. AU="Yin, Guo-Qing"
  20. AU="Sharber, Brian"
  21. AU="Goyaux, Nathalie"
  22. AU="Rauch, Geraldine"
  23. AU="Ekoh, Okwukwe Faith"
  24. AU="A Rahim, Haslinda"
  25. AU="Richard Stahl"
  26. AU=Vazquez-Iglesias J L
  27. AU="Amundsen, David S"
  28. AU="Konios, Dimitrios"
  29. AU="Lindh, Ingrid"
  30. AU=Zhao Chunyan
  31. AU="Scalia, Jennifer B"
  32. AU="Balint, Lajos"
  33. AU="Liang, Siping"
  34. AU="Wong, Anthony"
  35. AU="Müjdat YENİCESU"
  36. AU="Brooks, M L"
  37. AU="Garcia-Gutierrez, Ania" AU="Garcia-Gutierrez, Ania"
  38. AU="Marina Paola Gardiman"
  39. AU="Labarthe, Simon"
  40. AU="Jiahui Li"
  41. AU="Geier, Johannes"
  42. AU=Thangaraju Pugazhenthan
  43. AU="Tapio, Joona"
  44. AU="Navaratnam, Dhasakumar"
  45. AU="Blank, Marissa Cathleen"
  46. AU="Sadeghi, Yasaman"
  47. AU=Ye Keqiang
  48. AU="Huda, Walter"
  49. AU="Petrova, Polina E"
  50. AU="Pond, Gregory"
  51. AU=Krzewski Konrad
  52. AU="Feng, Yuquan"
  53. AU="Schmermund, Ben Niklas"
  54. AU="Soni, Payal D"
  55. AU="Romero-García, Carolina"
  56. AU="Petty, Lloyd"
  57. AU="James E. Posey"

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  1. Artikel ; Online: No Danger for Medical Interest and Awareness towards Celiac Disease. Reply to Greenaway et al. Why Is There Medical Inertia and Nihilism to Celiac Disease? Comment on “Pivetta et al. In Elderly Anemic Patients without Endoscopic Signs of Bleeding Are Duodenal Biopsies Always Necessary to Rule Out Celiac Disease? Diagnostics 2022, 12 , 678”

    Giulia Pivetta / Emanuele Dilaghi / Edith Lahner

    Diagnostics, Vol 12, Iss 1511, p

    2022  Band 1511

    Abstract: We would like to thank Greenaway et al. [.] ...

    Abstract We would like to thank Greenaway et al. [.]
    Schlagwörter n/a ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Applications of Artificial Intelligence for the Diagnosis of Gastrointestinal Diseases

    Silvia Pecere / Sebastian Manuel Milluzzo / Gianluca Esposito / Emanuele Dilaghi / Andrea Telese / Leonardo Henry Eusebi

    Diagnostics, Vol 11, Iss 1575, p

    2021  Band 1575

    Abstract: The development of convolutional neural networks has achieved impressive advances of machine learning in recent years, leading to an increasing use of artificial intelligence (AI) in the field of gastrointestinal (GI) diseases. AI networks have been ... ...

    Abstract The development of convolutional neural networks has achieved impressive advances of machine learning in recent years, leading to an increasing use of artificial intelligence (AI) in the field of gastrointestinal (GI) diseases. AI networks have been trained to differentiate benign from malignant lesions, analyze endoscopic and radiological GI images, and assess histological diagnoses, obtaining excellent results and high overall diagnostic accuracy. Nevertheless, there data are lacking on side effects of AI in the gastroenterology field, and high-quality studies comparing the performance of AI networks to health care professionals are still limited. Thus, large, controlled trials in real-time clinical settings are warranted to assess the role of AI in daily clinical practice. This narrative review gives an overview of some of the most relevant potential applications of AI for gastrointestinal diseases, highlighting advantages and main limitations and providing considerations for future development.
    Schlagwörter artificial intelligence ; radiomics ; deep learning ; gastrointestinal lesions ; gastrointestinal cancers ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: In Elderly Anemic Patients without Endoscopic Signs of Bleeding Are Duodenal Biopsies Always Necessary to Rule Out Celiac Disease?

    Giulia Pivetta / Chiara Coluccio / Emanuele Dilaghi / Edith Lahner / Emanuela Pilozzi / Marilia Carabotti / Vito Domenico Corleto

    Diagnostics, Vol 12, Iss 678, p

    2022  Band 678

    Abstract: Iron-deficiency anemia in the elderly may be due to numerous gastrointestinal conditions. Anemia is frequent in celiac disease (CD); however, the use of routine duodenal biopsies, independently of age or serology, is debated. To determine the diagnostic ... ...

    Abstract Iron-deficiency anemia in the elderly may be due to numerous gastrointestinal conditions. Anemia is frequent in celiac disease (CD); however, the use of routine duodenal biopsies, independently of age or serology, is debated. To determine the diagnostic yield of routine duodenal biopsies in adult and elderly patients with no bleeding anemia, a cross-sectional study analyzing 7968 gastroscopies (2017–2020) was performed; 744 were for anemia and 275 were excluded (GI bleeding or without duodenal biopsies). Of the 469 included patients, clinical, endoscopic, and histological features were analyzed in groups with or without histopathological changes in the duodenal mucosa (DM). Univariate/multivariate analyses were performed. Of the 469 patients, 41 (8.7%) had DM histopathological changes, 12 (2.6%) had CD, 26 (5.5%) had duodenal intraepithelial lymphocytosis (DIL), and 3 had (0.6%) other conditions. They were younger compared to patients with normal DM. DM histopathology was significantly inversely correlated with age group, with prevalences of 27%, 20%, 12.5%, 10%, and 2.5%, in the <40–50, 51–60, 61–70, 71–80, and >80-year age groups, respectively ( p = 0.0010). Logistic-regression models showed that anemic patients aged >60, >70, or >80 years with endoscopically normal DM had a progressively three- to four-fold higher probability of having normal duodenal histology. In adults, anemic patients without bleeding, age and endoscopically normal DM are predictors of normal DM histology. In >70-year anemic patients, negligible DM pathology was found. The results suggest that routine duodenal biopsies are questionable in elderly anemic patients
    Schlagwörter anemia ; celiac disease ; duodenal biopsies ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Prevalence of Sars-Cov-2 Infection in Health Workers (HWs) and Diagnostic Test Performance

    Edith Lahner / Emanuele Dilaghi / Claudio Prestigiacomo / Giuliano Alessio / Laura Marcellini / Maurizio Simmaco / Iolanda Santino / Giovanni Battista Orsi / Paolo Anibaldi / Adriano Marcolongo / Bruno Annibale / Christian Napoli

    International Journal of Environmental Research and Public Health, Vol 17, Iss 4417, p

    The Experience of a Teaching Hospital in Central Italy

    2020  Band 4417

    Abstract: 1) Background: Health workers (HWs) are at high risk of acquiring SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections. Therefore, health authorities further recommend screening strategies for SARS-CoV-2 infection in exposed or high- ... ...

    Abstract (1) Background: Health workers (HWs) are at high risk of acquiring SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections. Therefore, health authorities further recommend screening strategies for SARS-CoV-2 infection in exposed or high-risk HWs. Nevertheless, to date, the best/optimal method to screen HWs for SARS-CoV-2 infection is still under debate, and data on the prevalence of SARS-CoV-2 infection in HWs are still scarce. The present study aims to assess the SARS-CoV-2 infection rate amongst HWs in a teaching hospital in Central Italy and the diagnostic performance of SARS-CoV-2 serology (index test) in comparison with the SARS-CoV-2 RNA PCR assay (reference standard). (2) Methods: A cross-sectional study on the retrospective data of HWs tested for SARS-CoV-2 by RNA-RT-PCR on nasopharyngeal swabs and by an IgM/IgG serology assay on venous blood samples, irrespective of exposure and/or symptoms, was carried out. (3) Results: A total of 2057 HWs (median age 46, 19–69 years, females 60.2%) were assessed by the RNA RT-PCR assay and 58 (2.7%) tested positive for SARS-CoV-2 infection. Compared with negative HWs, SARS-CoV-2-positives were younger (mean age 41.7 versus 45.2, p < 0.01; 50% versus 31% under or equal to 40 years old, p < 0.002) and had a shorter duration of employment (64 versus 125 months, p = 0.02). Exposure to SARS-CoV-2 was more frequent in positive HWs than in negatives (55.2% versus 27.5%, p < 0.0001). In 44.8% of positive HWs, no exposure was traced. None of the positive HWs had a fatal outcome, none of them had acute respiratory distress syndrome, and only one required hospitalization for mild/moderate pneumonia. In 1084 (51.2%) HWs, nasopharyngeal swabs and an IgM/IgG serology assay were performed. With regard to IgM serology, sensitivity was 0% at a specificity of 98.99% (positive predictive value, PPV 0%, negative predictive value, NPV 99.2%). Concerning IgG serology and irrespective of the time interval between nasopharyngeal swab and serology, sensitivity was 50% at a specificity of 99.1% (PPV 28.6%, NPV 99.6%). IgG serology showed a higher diagnostic performance when performed at least two weeks after testing SARS-CoV-2-positive at the RNA RT-PCR assay by a nasopharyngeal swab. (4) Conclusions: Our experience in Central Italy demonstrated a low prevalence of SARS-CoV-2 infection amongst HWs, but higher than in the general population. Nearly half of the positive HWs reported no previous exposure to SARS-CoV-2-infected subjects and were diagnosed thanks to the proactive screening strategy implemented. IgG serology seems useful when performed at least two weeks after an RNA RT-PCR assay. IgM serology does not seem to be a useful test for the diagnosis of active SARS-CoV-2 infection. High awareness of SARS-CoV-2 infection is mandatory for all people, but especially for HWs, irrespective of symptoms, to safeguard their health and that of patients.
    Schlagwörter CoViD-19 ; health workers (HWs) ; screening ; Medicine ; R ; covid19
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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