Article ; Online: Characterization of an
2023 Volume 34, Issue 12, Page(s) 2358–2365
Abstract: Aldehydes are attractive bioorthogonal coupling partners. The ease of manipulation of aldehydes and their orthogonality to other classes of bioorthogonal reactions have inspired the exploration of chemistries, which generate irreversible conjugates. ... ...
| Abstract | Aldehydes are attractive bioorthogonal coupling partners. The ease of manipulation of aldehydes and their orthogonality to other classes of bioorthogonal reactions have inspired the exploration of chemistries, which generate irreversible conjugates. Similarly, nitrones have been shown to be potent 1,3-dipoles in bioorthogonal reactions when paired with strained alkynes. Here, we combine the reactivity of nitrones with the simplicity of aldehydes using an |
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| MeSH term(s) | Humans ; HEK293 Cells ; Proteins/chemistry ; Nitrogen Oxides/chemistry ; Alkynes/chemistry ; Aldehydes ; Azides/chemistry ; Cycloaddition Reaction | |||||
| Chemical Substances | nitrones ; Proteins ; Nitrogen Oxides ; Alkynes ; Aldehydes ; Azides | |||||
| Language | English | |||||
| Publishing date | 2023-12-05 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1024041-x | |||||
| ISSN | 1520-4812 ; 1043-1802 | |||||
| ISSN (online) | 1520-4812 | |||||
| ISSN | 1043-1802 | |||||
| DOI | 10.1021/acs.bioconjchem.3c00463 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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