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  1. Article: Scientometric analyses of studies on the role of innate variation in athletic performance.

    Lombardo, Michael P / Emiah, Shadie

    SpringerPlus

    2014  Volume 3, Page(s) 307

    Abstract: Historical events have produced an ideologically charged atmosphere in the USA surrounding the potential influences of innate variation on athletic performance. We tested the hypothesis that scientific studies of the role of innate variation in athletic ... ...

    Abstract Historical events have produced an ideologically charged atmosphere in the USA surrounding the potential influences of innate variation on athletic performance. We tested the hypothesis that scientific studies of the role of innate variation in athletic performance were less likely to have authors with USA addresses than addresses elsewhere because of this cultural milieu. Using scientometric data collected from 290 scientific papers published in peer-reviewed journals from 2000-2012, we compared the proportions of authors with USA addresses with those that listed addresses elsewhere that studied the relationships between athletic performance and (a) prenatal exposure to androgens, as indicated by the ratio between digits 2 and 4, and (b) the genotypes for angiotensin converting enzyme, α-actinin-3, and myostatin; traits often associated with athletic performance. Authors with USA addresses were disproportionately underrepresented on papers about the role of innate variation in athletic performance. We searched NIH and NSF databases for grant proposals solicited or funded from 2000-2012 to determine if the proportion of authors that listed USA addresses was associated with funding patterns. NIH did not solicit grant proposals designed to examine these factors in the context of athletic performance and neither NIH nor NSF funded grants designed to study these topics. We think the combined effects of a lack of government funding and the avoidance of studying controversial or non-fundable topics by USA based scientists are responsible for the observation that authors with USA addresses were underrepresented on scientific papers examining the relationships between athletic performance and innate variation.
    Language English
    Publishing date 2014-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661116-8
    ISSN 2193-1801
    ISSN 2193-1801
    DOI 10.1186/2193-1801-3-307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.

    Leung, Wilson / Shaffer, Christopher D / Reed, Laura K / Smith, Sheryl T / Barshop, William / Dirkes, William / Dothager, Matthew / Lee, Paul / Wong, Jeannette / Xiong, David / Yuan, Han / Bedard, James E J / Machone, Joshua F / Patterson, Seantay D / Price, Amber L / Turner, Bryce A / Robic, Srebrenka / Luippold, Erin K / McCartha, Shannon R /
    Walji, Tezin A / Walker, Chelsea A / Saville, Kenneth / Abrams, Marita K / Armstrong, Andrew R / Armstrong, William / Bailey, Robert J / Barberi, Chelsea R / Beck, Lauren R / Blaker, Amanda L / Blunden, Christopher E / Brand, Jordan P / Brock, Ethan J / Brooks, Dana W / Brown, Marie / Butzler, Sarah C / Clark, Eric M / Clark, Nicole B / Collins, Ashley A / Cotteleer, Rebecca J / Cullimore, Peterson R / Dawson, Seth G / Docking, Carter T / Dorsett, Sasha L / Dougherty, Grace A / Downey, Kaitlyn A / Drake, Andrew P / Earl, Erica K / Floyd, Trevor G / Forsyth, Joshua D / Foust, Jonathan D / Franchi, Spencer L / Geary, James F / Hanson, Cynthia K / Harding, Taylor S / Harris, Cameron B / Heckman, Jonathan M / Holderness, Heather L / Howey, Nicole A / Jacobs, Dontae A / Jewell, Elizabeth S / Kaisler, Maria / Karaska, Elizabeth A / Kehoe, James L / Koaches, Hannah C / Koehler, Jessica / Koenig, Dana / Kujawski, Alexander J / Kus, Jordan E / Lammers, Jennifer A / Leads, Rachel R / Leatherman, Emily C / Lippert, Rachel N / Messenger, Gregory S / Morrow, Adam T / Newcomb, Victoria / Plasman, Haley J / Potocny, Stephanie J / Powers, Michelle K / Reem, Rachel M / Rennhack, Jonathan P / Reynolds, Katherine R / Reynolds, Lyndsey A / Rhee, Dong K / Rivard, Allyson B / Ronk, Adam J / Rooney, Meghan B / Rubin, Lainey S / Salbert, Luke R / Saluja, Rasleen K / Schauder, Taylor / Schneiter, Allison R / Schulz, Robert W / Smith, Karl E / Spencer, Sarah / Swanson, Bryant R / Tache, Melissa A / Tewilliager, Ashley A / Tilot, Amanda K / VanEck, Eve / Villerot, Matthew M / Vylonis, Megan B / Watson, David T / Wurzler, Juliana A / Wysocki, Lauren M / Yalamanchili, Monica / Zaborowicz, Matthew A / Emerson, Julia A / Ortiz, Carlos / Deuschle, Frederic J / DiLorenzo, Lauren A / Goeller, Katie L / Macchi, Christopher R / Muller, Sarah E / Pasierb, Brittany D / Sable, Joseph E / Tucci, Jessica M / Tynon, Marykathryn / Dunbar, David A / Beken, Levent H / Conturso, Alaina C / Danner, Benjamin L / DeMichele, Gabriella A / Gonzales, Justin A / Hammond, Maureen S / Kelley, Colleen V / Kelly, Elisabeth A / Kulich, Danielle / Mageeney, Catherine M / McCabe, Nikie L / Newman, Alyssa M / Spaeder, Lindsay A / Tumminello, Richard A / Revie, Dennis / Benson, Jonathon M / Cristostomo, Michael C / DaSilva, Paolo A / Harker, Katherine S / Jarrell, Jenifer N / Jimenez, Luis A / Katz, Brandon M / Kennedy, William R / Kolibas, Kimberly S / LeBlanc, Mark T / Nguyen, Trung T / Nicolas, Daniel S / Patao, Melissa D / Patao, Shane M / Rupley, Bryan J / Sessions, Bridget J / Weaver, Jennifer A / Goodman, Anya L / Alvendia, Erica L / Baldassari, Shana M / Brown, Ashley S / Chase, Ian O / Chen, Maida / Chiang, Scott / Cromwell, Avery B / Custer, Ashley F / DiTommaso, Tia M / El-Adaimi, Jad / Goscinski, Nora C / Grove, Ryan A / Gutierrez, Nestor / Harnoto, Raechel S / Hedeen, Heather / Hong, Emily L / Hopkins, Barbara L / Huerta, Vilma F / Khoshabian, Colin / LaForge, Kristin M / Lee, Cassidy T / Lewis, Benjamin M / Lydon, Anniken M / Maniaci, Brian J / Mitchell, Ryan D / Morlock, Elaine V / Morris, William M / Naik, Priyanka / Olson, Nicole C / Osterloh, Jeannette M / Perez, Marcos A / Presley, Jonathan D / Randazzo, Matt J / Regan, Melanie K / Rossi, Franca G / Smith, Melanie A / Soliterman, Eugenia A / Sparks, Ciani J / Tran, Danny L / Wan, Tiffany / Welker, Anne A / Wong, Jeremy N / Sreenivasan, Aparna / Youngblom, Jim / Adams, Andrew / Alldredge, Justin / Bryant, Ashley / Carranza, David / Cifelli, Alyssa / Coulson, Kevin / Debow, Calise / Delacruz, Noelle / Emerson, Charlene / Farrar, Cassandra / Foret, Don / Garibay, Edgar / Gooch, John / Heslop, Michelle / Kaur, Sukhjit / Khan, Ambreen / Kim, Van / Lamb, Travis / Lindbeck, Peter / Lucas, Gabi / Macias, Elizabeth / Martiniuc, Daniela / Mayorga, Lissett / Medina, Joseph / Membreno, Nelson / Messiah, Shady / Neufeld, Lacey / Nguyen, San Francisco / Nichols, Zachary / Odisho, George / Peterson, Daymon / Rodela, Laura / Rodriguez, Priscilla / Rodriguez, Vanessa / Ruiz, Jorge / Sherrill, Will / Silva, Valeria / Sparks, Jeri / Statton, Geeta / Townsend, Ashley / Valdez, Isabel / Waters, Mary / Westphal, Kyle / Winkler, Stacey / Zumkehr, Joannee / DeJong, Randall J / Hoogewerf, Arlene J / Ackerman, Cheri M / Armistead, Isaac O / Baatenburg, Lara / Borr, Matthew J / Brouwer, Lindsay K / Burkhart, Brandon J / Bushhouse, Kelsey T / Cesko, Lejla / Choi, Tiffany Y Y / Cohen, Heather / Damsteegt, Amanda M / Darusz, Jess M / Dauphin, Cory M / Davis, Yelena P / Diekema, Emily J / Drewry, Melissa / Eisen, Michelle E M / Faber, Hayley M / Faber, Katherine J / Feenstra, Elizabeth / Felzer-Kim, Isabella T / Hammond, Brandy L / Hendriksma, Jesse / Herrold, Milton R / Hilbrands, Julia A / Howell, Emily J / Jelgerhuis, Sarah A / Jelsema, Timothy R / Johnson, Benjamin K / Jones, Kelly K / Kim, Anna / Kooienga, Ross D / Menyes, Erika E / Nollet, Eric A / Plescher, Brittany E / Rios, Lindsay / Rose, Jenny L / Schepers, Allison J / Scott, Geoff / Smith, Joshua R / Sterling, Allison M / Tenney, Jenna C / Uitvlugt, Chris / VanDyken, Rachel E / VanderVennen, Marielle / Vue, Samantha / Kokan, Nighat P / Agbley, Kwabea / Boham, Sampson K / Broomfield, Daniel / Chapman, Kayla / Dobbe, Ali / Dobbe, Ian / Harrington, William / Ibrahem, Marwan / Kennedy, Andre / Koplinsky, Chad A / Kubricky, Cassandra / Ladzekpo, Danielle / Pattison, Claire / Ramirez, Roman E / Wande, Lucia / Woehlke, Sarah / Wawersik, Matthew / Kiernan, Elizabeth / Thompson, Jeffrey S / Banker, Roxanne / Bartling, Justina R / Bhatiya, Chinmoy I / Boudoures, Anna L / Christiansen, Lena / Fosselman, Daniel S / French, Kristin M / Gill, Ishwar S / Havill, Jessen T / Johnson, Jaelyn L / Keny, Lauren J / Kerber, John M / Klett, Bethany M / Kufel, Christina N / May, Francis J / Mecoli, Jonathan P / Merry, Callie R / Meyer, Lauren R / Miller, Emily G / Mullen, Gregory J / Palozola, Katherine C / Pfeil, Jacob J / Thomas, Jessica G / Verbofsky, Evan M / Spana, Eric P / Agarwalla, Anant / Chapman, Julia / Chlebina, Ben / Chong, Insun / Falk, I N / Fitzgibbons, John D / Friedman, Harrison / Ighile, Osagie / Kim, Andrew J / Knouse, Kristin A / Kung, Faith / Mammo, Danny / Ng, Chun Leung / Nikam, Vinayak S / Norton, Diana / Pham, Philip / Polk, Jessica W / Prasad, Shreya / Rankin, Helen / Ratliff, Camille D / Scala, Victoria / Schwartz, Nicholas U / Shuen, Jessica A / Xu, Amy / Xu, Thomas Q / Zhang, Yi / Rosenwald, Anne G / Burg, Martin G / Adams, Stephanie J / Baker, Morgan / Botsford, Bobbi / Brinkley, Briana / Brown, Carter / Emiah, Shadie / Enoch, Erica / Gier, Chad / Greenwell, Alyson / Hoogenboom, Lindsay / Matthews, Jordan E / McDonald, Mitchell / Mercer, Amanda / Monsma, Nicholaus / Ostby, Kristine / Ramic, Alen / Shallman, Devon / Simon, Matthew / Spencer, Eric / Tomkins, Trisha / Wendland, Pete / Wylie, Anna / Wolyniak, Michael J / Robertson, Gregory M / Smith, Samuel I / DiAngelo, Justin R / Sassu, Eric D / Bhalla, Satish C / Sharif, Karim A / Choeying, Tenzin / Macias, Jason S / Sanusi, Fareed / Torchon, Karvyn / Bednarski, April E / Alvarez, Consuelo J / Davis, Kristen C / Dunham, Carrie A / Grantham, Alaina J / Hare, Amber N / Schottler, Jennifer / Scott, Zackary W / Kuleck, Gary A / Yu, Nicole S / Kaehler, Marian M / Jipp, Jacob / Overvoorde, Paul J / Shoop, Elizabeth / Cyrankowski, Olivia / Hoover, Betsy / Kusner, Matt / Lin, Devry / Martinov, Tijana / Misch, Jonathan / Salzman, Garrett / Schiedermayer, Holly / Snavely, Michael / Zarrasola, Stephanie / Parrish, Susan / Baker, Atlee / Beckett, Alissa / Belella, Carissa / Bryant, Julie / Conrad, Turner / Fearnow, Adam / Gomez, Carolina / Herbstsomer, Robert A / Hirsch, Sarah / Johnson, Christen / Jones, Melissa / Kabaso, Rita / Lemmon, Eric / Vieira, Carolina Marques Dos Santos / McFarland, Darryl / McLaughlin, Christopher / Morgan, Abbie / Musokotwane, Sepo / Neutzling, William / Nietmann, Jana / Paluskievicz, Christina / Penn, Jessica / Peoples, Emily / Pozmanter, Caitlin / Reed, Emily / Rigby, Nichole / Schmidt, Lasse / Shelton, Micah / Shuford, Rebecca / Tirasawasdichai, Tiara / Undem, Blair / Urick, Damian / Vondy, Kayla / Yarrington, Bryan / Eckdahl, Todd T / Poet, Jeffrey L / Allen, Alica B / Anderson, John E / Barnett, Jason M / Baumgardner, Jordan S / Brown, Adam D / Carney, Jordan E / Chavez, Ramiro A / Christgen, Shelbi L / Christie, Jordan S / Clary, Andrea N / Conn, Michel A / Cooper, Kristen M / Crowley, Matt J / Crowley, Samuel T / Doty, Jennifer S / Dow, Brian A / Edwards, Curtis R / Elder, Darcie D / Fanning, John P / Janssen, Bridget M / Lambright, Anthony K / Lane, Curtiss E / Limle, Austin B / Mazur, Tammy / McCracken, Marly R / McDonough, Alexa M / Melton, Amy D / Minnick, Phillip J / Musick, Adam E / Newhart, William H / Noynaert, Joseph W / Ogden, Bradley J / Sandusky, Michael W / Schmuecker, Samantha M / Shipman, Anna L / Smith, Anna L / Thomsen, Kristen M / Unzicker, Matthew R / Vernon, William B / Winn, Wesley W / Woyski, Dustin S / Zhu, Xiao / Du, Chunguang / Ament, Caitlin / Aso, Soham / Bisogno, Laura Simone / Caronna, Jason / Fefelova, Nadezhda / Lopez, Lenin / Malkowitz, Lorraine / Marra, Jonathan / Menillo, Daniella / Obiorah, Ifeanyi / Onsarigo, Eric Nyabeta / Primus, Shekerah / Soos, Mahdi / Tare, Archana / Zidan, Ameer / Jones, Christopher J / Aronhalt, Todd / Bellush, James M / Burke, Christa / DeFazio, Steve / Does, Benjamin R / Johnson, Todd D / Keysock, Nicholas / Knudsen, Nelson H / Messler, James / Myirski, Kevin / Rekai, Jade Lea / Rempe, Ryan Michael / Salgado, Michael S / Stagaard, Erica / Starcher, Justin R / Waggoner, Andrew W / Yemelyanova, Anastasia K / Hark, Amy T / Bertolet, Anne / Kuschner, Cyrus E / Parry, Kesley / Quach, Michael / Shantzer, Lindsey / Shaw, Mary E / Smith, Mary A / Glenn, Omolara / Mason, Portia / Williams, Charlotte / Key, S Catherine Silver / Henry, Tyneshia C P / Johnson, Ashlee G / White, Jackie X / Haberman, Adam / Asinof, Sam / Drumm, Kelly / Freeburg, Trip / Safa, Nadia / Schultz, Darrin / Shevin, Yakov / Svoronos, Petros / Vuong, Tam / Wellinghoff, Jules / Hoopes, Laura L M / Chau, Kim M / Ward, Alyssa / Regisford, E Gloria C / Augustine, LaJerald / Davis-Reyes, Brionna / Echendu, Vivienne / Hales, Jasmine / Ibarra, Sharon / Johnson, Lauriaun / Ovu, Steven / Braverman, John M / Bahr, Thomas J / Caesar, Nicole M / Campana, Christopher / Cassidy, Daniel W / Cognetti, Peter A / English, Johnathan D / Fadus, Matthew C / Fick, Cameron N / Freda, Philip J / Hennessy, Bryan M / Hockenberger, Kelsey / Jones, Jennifer K / King, Jessica E / Knob, Christopher R / Kraftmann, Karen J / Li, Linghui / Lupey, Lena N / Minniti, Carl J / Minton, Thomas F / Moran, Joseph V / Mudumbi, Krishna / Nordman, Elizabeth C / Puetz, William J / Robinson, Lauren M / Rose, Thomas J / Sweeney, Edward P / Timko, Ashley S / Paetkau, Don W / Eisler, Heather L / Aldrup, Megan E / Bodenberg, Jessica M / Cole, Mara G / Deranek, Kelly M / DeShetler, Megan / Dowd, Rose M / Eckardt, Alexandra K / Ehret, Sharon C / Fese, Jessica / Garrett, Amanda D / Kammrath, Anna / Kappes, Michelle L / Light, Morgan R / Meier, Anne C / O'Rouke, Allison / Perella, Mallory / Ramsey, Kimberley / Ramthun, Jennifer R / Reilly, Mary T / Robinett, Deirdre / Rossi, Nadine L / Schueler, Mary Grace / Shoemaker, Emma / Starkey, Kristin M / Vetor, Ashley / Vrable, Abby / Chandrasekaran, Vidya / Beck, Christopher / Hatfield, Kristen R / Herrick, Douglas A / Khoury, Christopher B / Lea, Charlotte / Louie, Christopher A / Lowell, Shannon M / Reynolds, Thomas J / Schibler, Jeanine / Scoma, Alexandra H / Smith-Gee, Maxwell T / Tuberty, Sarah / Smith, Christopher D / Lopilato, Jane E / Hauke, Jeanette / Roecklein-Canfield, Jennifer A / Corrielus, Maureen / Gilman, Hannah / Intriago, Stephanie / Maffa, Amanda / Rauf, Sabya A / Thistle, Katrina / Trieu, Melissa / Winters, Jenifer / Yang, Bib / Hauser, Charles R / Abusheikh, Tariq / Ashrawi, Yara / Benitez, Pedro / Boudreaux, Lauren R / Bourland, Megan / Chavez, Miranda / Cruz, Samantha / Elliott, GiNell / Farek, Jesse R / Flohr, Sarah / Flores, Amanda H / Friedrichs, Chelsey / Fusco, Zach / Goodwin, Zane / Helmreich, Eric / Kiley, John / Knepper, John Mark / Langner, Christine / Martinez, Megan / Mendoza, Carlos / Naik, Monal / Ochoa, Andrea / Ragland, Nicolas / Raimey, England / Rathore, Sunil / Reza, Evangelina / Sadovsky, Griffin / Seydoux, Marie-Isabelle B / Smith, Jonathan E / Unruh, Anna K / Velasquez, Vicente / Wolski, Matthew W / Gosser, Yuying / Govind, Shubha / Clarke-Medley, Nicole / Guadron, Leslie / Lau, Dawn / Lu, Alvin / Mazzeo, Cheryl / Meghdari, Mariam / Ng, Simon / Pamnani, Brad / Plante, Olivia / Shum, Yuki Kwan Wa / Song, Roy / Johnson, Diana E / Abdelnabi, Mai / Archambault, Alexi / Chamma, Norma / Gaur, Shailly / Hammett, Deborah / Kandahari, Adrese / Khayrullina, Guzal / Kumar, Sonali / Lawrence, Samantha / Madden, Nigel / Mandelbaum, Max / Milnthorp, Heather / Mohini, Shiv / Patel, Roshni / Peacock, Sarah J / Perling, Emily / Quintana, Amber / Rahimi, Michael / Ramirez, Kristen / Singhal, Rishi / Weeks, Corinne / Wong, Tiffany / Gillis, Aubree T / Moore, Zachary D / Savell, Christopher D / Watson, Reece / Mel, Stephanie F / Anilkumar, Arjun A / Bilinski, Paul / Castillo, Rostislav / Closser, Michael / Cruz, Nathalia M / Dai, Tiffany / Garbagnati, Giancarlo F / Horton, Lanor S / Kim, Dongyeon / Lau, Joyce H / Liu, James Z / Mach, Sandy D / Phan, Thu A / Ren, Yi / Stapleton, Kenneth E / Strelitz, Jean M / Sunjed, Ray / Stamm, Joyce / Anderson, Morgan C / Bonifield, Bethany Grace / Coomes, Daniel / Dillman, Adam / Durchholz, Elaine J / Fafara-Thompson, Antoinette E / Gross, Meleah J / Gygi, Amber M / Jackson, Lesley E / Johnson, Amy / Kocsisova, Zuzana / Manghelli, Joshua L / McNeil, Kylie / Murillo, Michael / Naylor, Kierstin L / Neely, Jessica / Ogawa, Emmy E / Rich, Ashley / Rogers, Anna / Spencer, J Devin / Stemler, Kristina M / Throm, Allison A / Van Camp, Matt / Weihbrecht, Katie / Wiles, T Aaron / Williams, Mallory A / Williams, Matthew / Zoll, Kyle / Bailey, Cheryl / Zhou, Leming / Balthaser, Darla M / Bashiri, Azita / Bower, Mindy E / Florian, Kayla A / Ghavam, Nazanin / Greiner-Sosanko, Elizabeth S / Karim, Helmet / Mullen, Victor W / Pelchen, Carly E / Yenerall, Paul M / Zhang, Jiayu / Rubin, Michael R / Arias-Mejias, Suzette M / Bermudez-Capo, Armando G / Bernal-Vega, Gabriela V / Colon-Vazquez, Mariela / Flores-Vazquez, Arelys / Gines-Rosario, Mariela / Llavona-Cartagena, Ivan G / Martinez-Rodriguez, Javier O / Ortiz-Fuentes, Lionel / Perez-Colomba, Eliezer O / Perez-Otero, Joseph / Rivera, Elisandra / Rodriguez-Giron, Luke J / Santiago-Sanabria, Arnaldo J / Senquiz-Gonzalez, Andrea M / delValle, Frank R Soto / Vargas-Franco, Dorianmarie / Velázquez-Soto, Karla I / Zambrana-Burgos, Joan D / Martinez-Cruzado, Juan Carlos / Asencio-Zayas, Lillyann / Babilonia-Figueroa, Kevin / Beauchamp-Pérez, Francis D / Belén-Rodríguez, Juliana / Bracero-Quiñones, Luciann / Burgos-Bula, Andrea P / Collado-Méndez, Xavier A / Colón-Cruz, Luis R / Correa-Muller, Ana I / Crooke-Rosado, Jonathan L / Cruz-García, José M / Defendini-Ávila, Marianna / Delgado-Peraza, Francheska M / Feliciano-Cancela, Alex J / Gónzalez-Pérez, Valerie M / Guiblet, Wilfried / Heredia-Negrón, Aldo / Hernández-Muñiz, Jennifer / Irizarry-González, Lourdes N / Laboy-Corales, Ángel L / Llaurador-Caraballo, Gabriela A / Marín-Maldonado, Frances / Marrero-Llerena, Ulises / Martell-Martínez, Héctor A / Martínez-Traverso, Idaliz M / Medina-Ortega, Kiara N / Méndez-Castellanos, Sonya G / Menéndez-Serrano, Krizia C / Morales-Caraballo, Carol I / Ortiz-DeChoudens, Saryleine / Ortiz-Ortiz, Patricia / Pagán-Torres, Hendrick / Pérez-Afanador, Diana / Quintana-Torres, Enid M / Ramírez-Aponte, Edwin G / Riascos-Cuero, Carolina / Rivera-Llovet, Michelle S / Rivera-Pagán, Ingrid T / Rivera-Vicéns, Ramón E / Robles-Juarbe, Fabiola / Rodríguez-Bonilla, Lorraine / Rodríguez-Echevarría, Brian O / Rodríguez-García, Priscila M / Rodríguez-Laboy, Abneris E / Rodríguez-Santiago, Susana / Rojas-Vargas, Michael L / Rubio-Marrero, Eva N / Santiago-Colón, Albeliz / Santiago-Ortiz, Jorge L / Santos-Ramos, Carlos E / Serrano-González, Joseline / Tamayo-Figueroa, Alina M / Tascón-Peñaranda, Edna P / Torres-Castillo, José L / Valentín-Feliciano, Nelson A / Valentín-Feliciano, Yashira M / Vargas-Barreto, Nadyan M / Vélez-Vázquez, Miguel / Vilanova-Vélez, Luis R / Zambrana-Echevarría, Cristina / MacKinnon, Christy / Chung, Hui-Min / Kay, Chris / Pinto, Anthony / Kopp, Olga R / Burkhardt, Joshua / Harward, Chris / Allen, Robert / Bhat, Pavan / Chang, Jimmy Hsiang-Chun / Chen, York / Chesley, Christopher / Cohn, Dara / DuPuis, David / Fasano, Michael / Fazzio, Nicholas / Gavinski, Katherine / Gebreyesus, Heran / Giarla, Thomas / Gostelow, Marcus / Greenstein, Rachel / Gunasinghe, Hashini / Hanson, Casey / Hay, Amanda / He, Tao Jian / Homa, Katie / Howe, Ruth / Howenstein, Jeff / Huang, Henry / Khatri, Aaditya / Kim, Young Lu / Knowles, Olivia / Kong, Sarah / Krock, Rebecca / Kroll, Matt / Kuhn, Julia / Kwong, Matthew / Lee, Brandon / Lee, Ryan / Levine, Kevin / Li, Yedda / Liu, Bo / Liu, Lucy / Liu, Max / Lousararian, Adam / Ma, Jimmy / Mallya, Allyson / Manchee, Charlie / Marcus, Joseph / McDaniel, Stephen / Miller, Michelle L / Molleston, Jerome M / Diez, Cristina Montero / Ng, Patrick / Ngai, Natalie / Nguyen, Hien / Nylander, Andrew / Pollack, Jason / Rastogi, Suchita / Reddy, Himabindu / Regenold, Nathaniel / Sarezky, Jon / Schultz, Michael / Shim, Jien / Skorupa, Tara / Smith, Kenneth / Spencer, Sarah J / Srikanth, Priya / Stancu, Gabriel / Stein, Andrew P / Strother, Marshall / Sudmeier, Lisa / Sun, Mengyang / Sundaram, Varun / Tazudeen, Noor / Tseng, Alan / Tzeng, Albert / Venkat, Rohit / Venkataram, Sandeep / Waldman, Leah / Wang, Tracy / Yang, Hao / Yu, Jack Y / Zheng, Yin / Preuss, Mary L / Garcia, Angelica / Juergens, Matt / Morris, Robert W / Nagengast, Alexis A / Azarewicz, Julie / Carr, Thomas J / Chichearo, Nicole / Colgan, Mike / Donegan, Megan / Gardner, Bob / Kolba, Nik / Krumm, Janice L / Lytle, Stacey / MacMillian, Laurell / Miller, Mary / Montgomery, Andrew / Moretti, Alysha / Offenbacker, Brittney / Polen, Mike / Toth, John / Woytanowski, John / Kadlec, Lisa / Crawford, Justin / Spratt, Mary L / Adams, Ashley L / Barnard, Brianna K / Cheramie, Martin N / Eime, Anne M / Golden, Kathryn L / Hawkins, Allyson P / Hill, Jessica E / Kampmeier, Jessica A / Kern, Cody D / Magnuson, Emily E / Miller, Ashley R / Morrow, Cody M / Peairs, Julia C / Pickett, Gentry L / Popelka, Sarah A / Scott, Alexis J / Teepe, Emily J / TerMeer, Katie A / Watchinski, Carmen A / Watson, Lucas A / Weber, Rachel E / Woodard, Kate A / Barnard, Daron C / Appiah, Isaac / Giddens, Michelle M / McNeil, Gerard P / Adebayo, Adeola / Bagaeva, Kate / Chinwong, Justina / Dol, Chrystel / George, Eunice / Haltaufderhyde, Kirk / Haye, Joanna / Kaur, Manpreet / Semon, Max / Serjanov, Dmitri / Toorie, Anika / Wilson, Christopher / Riddle, Nicole C / Buhler, Jeremy / Mardis, Elaine R / Elgin, Sarah C R

    G3 (Bethesda, Md.)

    2015  Volume 5, Issue 5, Page(s) 719–740

    Abstract: The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we ... ...

    Abstract The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25-50%) than euchromatic reference regions (3-11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11-27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4-3.6 vs. 8.4-8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu.
    MeSH term(s) Animals ; Codon ; Computational Biology ; DNA Transposable Elements ; Drosophila/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Evolution, Molecular ; Exons ; Gene Rearrangement ; Genome ; Genomics ; Heterochromatin ; Introns ; Molecular Sequence Annotation ; Polytene Chromosomes ; Repetitive Sequences, Nucleic Acid ; Selection, Genetic ; Species Specificity
    Chemical Substances Codon ; DNA Transposable Elements ; Drosophila Proteins ; Heterochromatin
    Language English
    Publishing date 2015-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1534/g3.114.015966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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