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  1. Book ; Online: Neurons

    Emiliano Aranda Abreu, Gonzalo / Elena Hernández Aguilar, María

    Dendrites and Axons

    2019  

    Keywords Neurosciences ; neurodegeneration, extracellular matrix, pain, neurodegenerative diseases, interface, stem cell
    Language English
    Size 1 electronic resource (128 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030645270
    ISBN 9781839620393 ; 1839620390
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Mechanisms of Neuroinflammation

    Emiliano Aranda Abreu, Gonzalo

    2017  

    Keywords Neurosciences ; alzheimer's disease, cytokines, neurodegeneration, traumatic brain injury, psychiatric disorders, stroke
    Language English
    Size 1 electronic resource (318 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030646203
    ISBN 9789535147022 ; 9535147021
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: A strategy focused on MAPT, APP, NCSTN and BACE1 to build blood classifiers for Alzheimer's disease.

    Herrera-Rivero, Marisol / Elena Hernández-Aguilar, María / Emiliano Aranda-Abreu, Gonzalo

    Journal of theoretical biology

    2015  Volume 376, Page(s) 32–38

    Abstract: Background: Although Alzheimer's disease (AD) is a brain disorder, a number of peripheral alterations have been found in these patients, including differences in leukocyte gene expression; however, the key genes involved in plaque and tangle formation ... ...

    Abstract Background: Although Alzheimer's disease (AD) is a brain disorder, a number of peripheral alterations have been found in these patients, including differences in leukocyte gene expression; however, the key genes involved in plaque and tangle formation have shown a relatively small potential as diagnostic markers. We focused on MAPT, APP, NCSTN and BACE1 as the basis to build and compare blood classifiers for AD.
    Methods: We used a combined model to build disease classifiers, using measures of blood pressure and serum glucose, cholesterol and triglyceride levels as well as RT-PCR expression levels of APP, NCSTN and BACE1 in peripheral blood mononuclear cells (PBMCs) from an independent cohort of 36 individuals of cognitively-normal controls, AD and other neuropathologies. Also, a set of genes was carefully selected by molecular interactions with MAPT, APP, NCSTN and BACE1 to test an expression-based classifier in a public microarray dataset of 40 samples (AD and controls). A series of discriminant analyses and classification and regression trees (C&RTs) were used to perform classification tasks.
    Results: Using C&RTs, the combined model showed potential to differentially diagnose AD with up to 94.4% accuracy and 100% specificity for our independent sample. Furthermore, a subset of 16 genes showed the best diagnostic potential using a minimum number of expression variables, correctly classifying up to 100% of samples in the public dataset.
    Conclusions: Our unique method of variable selection proves that even elements showing no significant differences between controls and AD, but that have somehow been linked to AD or AD-related elements, still hold a potential to be used in its diagnosis. Sample size and inherent methodological limitations of this study need to be kept in mind. Our classifiers require careful further testing in larger cohorts. Nonetheless, we believe these results provide evidence for the utility of our innovative method, which contributes a different approach to generate promising diagnostic tools for neuropsychiatric disorders.
    MeSH term(s) Alzheimer Disease/blood ; Amyloid Precursor Protein Secretases/biosynthesis ; Amyloid beta-Protein Precursor/biosynthesis ; Aspartic Acid Endopeptidases/biosynthesis ; Databases, Genetic ; Female ; Gene Expression Regulation ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Membrane Glycoproteins/biosynthesis ; tau Proteins/biosynthesis
    Chemical Substances APP protein, human ; Amyloid beta-Protein Precursor ; MAPT protein, human ; Membrane Glycoproteins ; nicastrin protein ; tau Proteins ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; BACE1 protein, human (EC 3.4.23.46)
    Language English
    Publishing date 2015-07-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2972-5
    ISSN 1095-8541 ; 0022-5193
    ISSN (online) 1095-8541
    ISSN 0022-5193
    DOI 10.1016/j.jtbi.2015.03.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 923: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online: Topics in Autonomic Nervous System

    Elena Hernández-Aguilar, María / Emiliano Aranda-Abreu, Gonzalo

    (Physiology ; 22)

    720  

    Series title Physiology ; 22
    Keywords Neurosciences ; physiology ; pain ; cancer ; diabetes mellitus ; melatonin ; autism
    Language 0|e d
    Dates of publication 720-23
    Size 1 electronic resource (168 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030720632
    ISBN 9781837683475 ; 1837683476
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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