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  1. Article ; Online: Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells

    Shweta Mahajan / Aria Alexander / Zachary Koenig / Nicholas Saba / Nina Prasanphanich / David A. Hildeman / Claire A. Chougnet / Emily DeFranco / Sandra Andorf / Tamara Tilburgs

    JCI Insight, Vol 8, Iss

    2023  Volume 17

    Abstract: Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. Human decidual CD8+ T cells were shown to be highly differentiated memory T ... ...

    Abstract Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. Human decidual CD8+ T cells were shown to be highly differentiated memory T cells with mixed signatures of dysfunction, activation, and effector function. However, no information is present on how specificity for microbial or fetal antigens relates to their function or dysfunction. In addition, a key question, whether decidual CD8+ T cells include unique tissue-resident memory T cells (Trm) or also effector memory T cell (Tem) types shared with peripheral blood populations, is unknown. Here, high-dimensional flow cytometry of decidual and blood CD8+ T cells identified 2 Tem populations shared in blood and decidua and 9 functionally distinct Trm clusters uniquely found in decidua. Interestingly, fetus- and virus-specific decidual CD8+ Trm cells had similar features of inhibition and cytotoxicity, with no significant differences in their expression of activation, inhibitory, and cytotoxic molecules, suggesting that not all fetus-specific CD8+ T cell responses are suppressed at the maternal-fetal interface. Understanding how decidual CD8+ T cell specificity relates to their function and tissue residency is crucial in advancing understanding of their contribution to placental inflammation and control of congenital infections.
    Keywords Immunology ; Reproductive biology ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque

    Pietro Presicce / Monica Cappelletti / Marco Morselli / Feiyang Ma / Paranthaman Senthamaraikannan / Giulia Protti / Brian B. Nadel / Laila Aryan / Mansoureh Eghbali / Lukasz Salwinski / Neema Pithia / Emily De Franco / Lisa A. Miller / Matteo Pellegrini / Alan H. Jobe / Claire A. Chougnet / Suhas G. Kallapur

    iScience, Vol 26, Iss 11, Pp 108118- (2023)

    2023  

    Abstract: Summary: Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion ...

    Abstract Summary: Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion (a fetal tissue in contact with amniotic fluid) in a preterm Rhesus macaque model of IUI induced by lipopolysaccharide with human cohorts of chorioamnionitis. Bulk RNA sequencing (RNA-seq) amnion transcriptomic profiles were remarkably similar in both Rhesus and human subjects and revealed that induction of key labor-mediating genes such as IL1 and IL6 was dependent on nuclear factor κB (NF-κB) signaling and reversed by the anti-tumor necrosis factor (TNF) antibody Adalimumab. Inhibition of collagen biosynthesis by IUI was partially restored by Adalimumab. Interestingly, single-cell transcriptomics, flow cytometry, and immunohistology demonstrated that a subset of amnion mesenchymal cells (AMCs) increase CD14 and other myeloid cell markers during IUI both in the human and Rhesus macaque. Our data suggest that CD14+ AMCs represent activated AMCs at the maternal-fetal interface.
    Keywords Immunology ; Bioinformatics ; Omics ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Air pollution and stillbirth risk

    Emily DeFranco / Eric Hall / Monir Hossain / Aimin Chen / Erin N Haynes / David Jones / Sheng Ren / Long Lu / Louis Muglia

    PLoS ONE, Vol 10, Iss 3, p e

    exposure to airborne particulate matter during pregnancy is associated with fetal death.

    2015  Volume 0120594

    Abstract: Objective To test the hypothesis that exposure to fine particulate air pollution (PM2.5) is associated with stillbirth. Study design Geo-spatial population-based cohort study using Ohio birth records (2006-2010) and local measures of PM2.5, recorded by ... ...

    Abstract Objective To test the hypothesis that exposure to fine particulate air pollution (PM2.5) is associated with stillbirth. Study design Geo-spatial population-based cohort study using Ohio birth records (2006-2010) and local measures of PM2.5, recorded by the EPA (2005-2010) via 57 monitoring stations across Ohio. Geographic coordinates of the mother's residence for each birth were linked to the nearest PM2.5 monitoring station and monthly exposure averages calculated. The association between stillbirth and increased PM2.5 levels was estimated, with adjustment for maternal age, race, education level, quantity of prenatal care, smoking, and season of conception. Results There were 349,188 live births and 1,848 stillbirths of non-anomalous singletons (20-42 weeks) with residence ≤10 km of a monitor station in Ohio during the study period. The mean PM2.5 level in Ohio was 13.3 μg/m3 [±1.8 SD, IQR(Q1: 12.1, Q3: 14.4, IQR: 2.3)], higher than the current EPA standard of 12 μg/m3. High average PM2.5 exposure through pregnancy was not associated with a significant increase in stillbirth risk, adjOR 1.21(95% CI 0.96,1.53), nor was it increased with high exposure in the 1st or 2nd trimester. However, exposure to high levels of PM2.5 in the third trimester of pregnancy was associated with 42% increased stillbirth risk, adjOR 1.42(1.06,1.91). Conclusions Exposure to high levels of fine particulate air pollution in the third trimester of pregnancy is associated with increased stillbirth risk. Although the risk increase associated with high PM2.5 levels is modest, the potential impact on overall stillbirth rates could be robust as all pregnant women are potentially at risk.
    Keywords Medicine ; R ; Science ; Q
    Subject code 333
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The SunBEAm birth cohort

    Corinne Keet, MD, PhD / Scott H. Sicherer, MD / Supinda Bunyavanich, MD, MPH, MPhil / Cynthia Visness, PhD, MPH / Patricia C. Fulkerson, MD, PhD / Alkis Togias, MD / Wendy Davidson, PhD / Susan Perry, RN / Sanaz Hamrah, PharmD, RPh / Agustin Calatroni, MS / Katina Robinson, MS / Lars Dunaway, PhD / Carla M. Davis, MD / Sara Anvari, MD / Susan M. Leong-Kee, MD / Gurjit Khurana Hershey, MD, PhD / Emily DeFranco, MD / Ashley Devonshire, MD / Haejin Kim, MD /
    Christine Joseph, PhD / Brent Davidson, MD / Noel K. Strong, MD / Angela J. Tsuang, MD, MSc / Marion Groetch, MS, RDN / Julie Wang, MD / Jennifer Dantzer, MD, MS / Kim Mudd, RN, MSN / Abimbola Aina, MD / Wayne Shreffler, MD, PhD / Qian Yuan, MD, PhD / Virginia Simmons, MD / Donald Y.M. Leung, MD, PhD / Jessica Hui-Beckman, MD / Jania Arcia Ramos, MD / Sharon Chinthrajah, MD / Virginia Winn, MD, PhD / Tina Sindher, MD / Stacie M. Jones, MD / Nirvana A. Manning, MD / Amy M. Scurlock, MD / Edwin Kim, MD, MS / Alison Stuebe, MD / James E. Gern, MD / Anne Marie Singh, MD / Jennifer Krupp, MD / Robert A. Wood, MD

    Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 3, Pp 100124- (2023)

    Protocol design

    2023  

    Abstract: Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement ... ...

    Abstract Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort. Methods: Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes. Results: Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs. Conclusions: The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.
    Keywords Food allergy ; atopic dermatitis ; eczema ; birth cohort ; systems biology ; multiomics ; Immunologic diseases. Allergy ; RC581-607
    Subject code 610
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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