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Article ; Online: Corticosteroid dosage for acute bacterial meningitis in children.

Emiroglu, M

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2016 Volume 22, Issue 7, Page(s) 651

MeSH term(s)	Adrenal Cortex Hormones/administration & dosage ; Anti-Inflammatory Agents/administration & dosage ; Child ; Child, Preschool ; Community-Acquired Infections/drug therapy ; Humans ; Meningitis, Bacterial/drug therapy
Chemical Substances	Adrenal Cortex Hormones ; Anti-Inflammatory Agents
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Letter
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2016.05.001
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Article ; Online: Hydraulic Performance of Sharp-Crested Side Slit Weirs

Kartal, Veysi / Emiroglu, M. Emin

Water Resour Manage. 2023 Feb., v. 37, no. 3 p.1297-1319

2023

Abstract: A rectangular slit weir is used to measure small discharges (Q < 5 L/s) and contraction ratios (b/B [Formula: see text] 0.25). Various discharge relationships were reported in the literature for calculating the discharge capacity of slit weirs in terms ... ...

Abstract	A rectangular slit weir is used to measure small discharges (Q < 5 L/s) and contraction ratios (b/B [Formula: see text] 0.25). Various discharge relationships were reported in the literature for calculating the discharge capacity of slit weirs in terms of frontal flow. However, this is not valid for lateral flow. In the current study, the side slit weir flow was investigated experimentally using piezometric heads over the weirs. The discharge coefficient was investigated for side slit weirs with different contraction ratios, which ranged from 0.075 to 0.25. Accordingly, the discharge coefficients were calculated using the Schmidt approach. Moreover, the outflow discharge of sharp-crested side slit weir was analyzed using the incomplete self-similarity theory (ISS) and dimensional analysis. The new discharge model was theoretically created based on the experimental results obtained from laboratory tests. The results of the current study indicated that the contraction ratio, dimensionless head over the weir, and Froude number were dominant parameters over the discharge of sharp-crested side slit weirs. Within this framework, slit weirs can be used laterally as water intake structures for small discharges. Furthermore, a nonlinear equation including all effective parameters is proposed to obtain the discharge capacity of sharp-crested side slit weirs with the highest accuracy.
Keywords	equations ; head ; models ; water
Language	English
Dates of publication	2023-02
Size	p. 1297-1319.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	59924-4
ISSN	1573-1650 ; 0920-4741
ISSN (online)	1573-1650
ISSN	0920-4741
DOI	10.1007/s11269-023-03433-z
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Article ; Online: Effect of Early Versus Delayed Laparoscopic Cholecystectomy on Postoperative Morbidity and Difficult Cholecystectomy in Patients With Grade II Cholecystitis According to Tokyo 2018 Guidelines: A Prospective Study.

Kilinc Tuncer, Gizem / Tuncer, Korhan / Sert, Ismail / Emiroglu, Mustafa

The American surgeon

2023 Volume 89, Issue 12, Page(s) 5775–5781

Abstract: Background: The timing of the cholecystectomy in patients with acute cholecystitis is still controversial. In our study, we aimed to investigate the effect of early and delayed cholecystectomy on difficult cholecystectomy, morbidity and mortality in ... ...

Abstract	Background: The timing of the cholecystectomy in patients with acute cholecystitis is still controversial. In our study, we aimed to investigate the effect of early and delayed cholecystectomy on difficult cholecystectomy, morbidity and mortality in patients diagnosed with Grade II acute cholecystitis according to Tokyo 2018 guidelines. Methods: Patients who presented to the emergency department and diagnosed with Grade II acute cholecystitis between December 2019 and June 2021 were included in this study. Cholecystectomy was performed within 7 days and 6 weeks after symptom onset. The effect of early and delayed cholecystectomy was observed. Results: A total of 92 patients were included in the study. The timing of cholecystectomy was not a risk factor for mortality, morbidity and difficult cholecystectomy. The conversion rate was higher in delayed group ( Conclusions: Delayed cholecystectomy does not facilitate cholecystectomy in patients with Grade II acute cholecystitis. Early cholecystectomy can be performed safely and high CRP levels can be used to determine difficult cholecystectomy in early period.
MeSH term(s)	Humans ; Cholecystectomy, Laparoscopic ; Prospective Studies ; Tokyo ; Cholecystectomy ; Cholecystitis/surgery ; Cholecystitis, Acute/surgery ; Cholecystitis, Acute/diagnosis
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348231175113
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Article: First report of human ehrlichiosis in Turkey.

Emiroğlu, Melike / Çelebi, Bekir

The Turkish journal of pediatrics

2020 Volume 61, Issue 2, Page(s) 267–270

Abstract: Emiroğlu M, Çelebi B. First report of human ehrlichiosis in Turkey. Turk J Pediatr 2019; 61: 267-270. Ehrlichiosis, a tick-borne infection, can cause severe and fatal disease. A 6-year-old boy was admitted with fever, chills, malaise, headache, anorexia, ...

Abstract	Emiroğlu M, Çelebi B. First report of human ehrlichiosis in Turkey. Turk J Pediatr 2019; 61: 267-270. Ehrlichiosis, a tick-borne infection, can cause severe and fatal disease. A 6-year-old boy was admitted with fever, chills, malaise, headache, anorexia, rhinorrhoea, and cough lasting two days. He had had contact with a dog 10 days prior, and a tick had been removed the day before. Fever, minimal conjunctival injection, oropharyngeal hyperemia and cracked, hyperemic lips were observed. Laboratory tests were normal except for lymphopenia and hyponatremia. Cytoplasmic morulae in the monocytes and granulocytes were seen on peripheral blood smear. Doxycycline was started immediately, and the fever subsided within 48 hours. Given the Ehrlichia was positive but Anaplasma negative by real-time PCR, he was diagnosed as ehrlichiosis, subspecies identification could not be performed. This is the first human ehrlichiosis case in Turkey.
MeSH term(s)	Animals ; Child ; Diagnosis, Differential ; Dogs ; Ehrlichia/isolation & purification ; Ehrlichiosis/complications ; Ehrlichiosis/diagnosis ; Fever/diagnosis ; Fever/etiology ; Granulocytes ; Headache/blood ; Headache/diagnosis ; Headache/etiology ; Humans ; Leukocyte Count ; Male ; Turkey
Language	English
Publishing date	2020-01-24
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	123487-0
ISSN	0041-4301
ISSN	0041-4301
DOI	10.24953/turkjped.2019.02.017
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Article ; Online: The relationship between helicobacter pylori infection and nodular antral gastritis in pediatric patients.

Yorulmaz, Alaaddin / Emiroğlu, Halil Haldun / Gümüş, Meltem Dorum / Emiroğlu, Melike

Journal of the National Medical Association

2022 Volume 114, Issue 4, Page(s) 440–450

Abstract: Background: Helicobacter pylori (H. pylori) is a spiral-shaped gram-negative bacterium that colonizes the gastric mucosa. It is a common infectious agent in children. In this study, we aim to evaluate the demographic data, and the clinical and ... ...

Abstract	Background: Helicobacter pylori (H. pylori) is a spiral-shaped gram-negative bacterium that colonizes the gastric mucosa. It is a common infectious agent in children. In this study, we aim to evaluate the demographic data, and the clinical and histopathological findings of pediatric patients that underwent upper gastrointestinal endoscopy (UGSE) in our clinic. Methods: Between July 2017 and February 2019, 636 patients applied to the Selcuk University Faculty of Medicine, Pediatric Gastroenterology outpatient clinic with complaints of epigastric abdominal pain and/or dyspeptic complaints. Patients who underwent upper gastrointestinal endoscopy were evaluated retrospectively. Data on age, gender, family history of peptic ulcer disease, and family history of H. pylori were recorded. Endoscopic and histopathological findings were collected from medical records. Results: 235 (36.9%) of the patients participating in the study were male, and 401 (63.1%) were female. H. pylori infection was detected in 277 (43.6%) patients as a result of histopathological examination of H. Pylori, urea breath tests and H. Pylori antigen tests in the stools of patients are included in the study. Nodular antral gastritis was detected in 282 (44.3%) of our patients endoscopically. H. pylori was detected in 83.7% (n: 236) of the 282 patients with nodular antral gastritis. Nodular antral gastritis was observed to be significantly higher in H. pylori-positive patients than in H. pylori-negative cases (odds ratio (OR), 39.16; 95% confidence interval (CI), 24.88-61.64; p: <0.001). Conclusion: Nodular antral gastritis is caused by chronic H. pylori infection. It is predicted that early detection of H. pylori infection in children is important and may decrease complications later in life. Our study shows that all the markers evaluated are very good predictors of H. pylori infection. Positive significant association was found between the prevalence of H. pylori infection and nodular antral gastritis.
MeSH term(s)	Child ; Endoscopy, Gastrointestinal ; Female ; Gastritis/diagnosis ; Gastritis/epidemiology ; Gastritis/microbiology ; Helicobacter Infections/complications ; Helicobacter Infections/diagnosis ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Male ; Retrospective Studies
Language	English
Publishing date	2022-06-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	419737-9
ISSN	1943-4693 ; 0027-9684
ISSN (online)	1943-4693
ISSN	0027-9684
DOI	10.1016/j.jnma.2022.05.011
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Article ; Online: The first human case of Rickettsia slovaca from Turkey.

Emiroglu, Melike / Celebi, Bekir / Alkan, Gulsum / Yilmaz, Yusuf

Ticks and tick-borne diseases

2021 Volume 12, Issue 5, Page(s) 101755

Abstract: A three year-old girl was admitted to our university hospital with fever, muscle and abdominal pain, and painful cervical lymph nodes after a tick bite on scalp. Rickettsia slovaca DNA was detected in eschar tissue taken from the bite site. This is the ... ...

Abstract	A three year-old girl was admitted to our university hospital with fever, muscle and abdominal pain, and painful cervical lymph nodes after a tick bite on scalp. Rickettsia slovaca DNA was detected in eschar tissue taken from the bite site. This is the first clinical case of a R. slovaca infection reported from Turkey.
MeSH term(s)	Animals ; Child, Preschool ; Dermacentor/microbiology ; Female ; Genes, Bacterial ; Humans ; Rickettsia/genetics ; Rickettsia/isolation & purification ; Rickettsia Infections/pathology ; Tick Bites/microbiology ; Tick-Borne Diseases/microbiology ; Turkey
Language	English
Publishing date	2021-06-03
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2541872-5
ISSN	1877-9603 ; 1877-959X
ISSN (online)	1877-9603
ISSN	1877-959X
DOI	10.1016/j.ttbdis.2021.101755
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Article: The Clinical and Pathological Characteristics That Differentiate Cases With "Low Estrogen Receptor Expression" From Triple-Negative Breast Cancer.

Karaali, Cem / Emiroğlu, Mümin / Değirmenci, Mustafa / Keser, Murat / Salimoğlu, Semra / Kelten Talu, Canan

European journal of breast health

2023 Volume 20, Issue 1, Page(s) 19–24

Abstract: Objective: Estrogen receptor (ER) expression is an immunohistochemical marker that is examined in all invasive breast cancers and has prognostic and predictive value. ER-positive breast cancers refer to those that show positivity for ER at 1% cellular ... ...

Abstract	Objective: Estrogen receptor (ER) expression is an immunohistochemical marker that is examined in all invasive breast cancers and has prognostic and predictive value. ER-positive breast cancers refer to those that show positivity for ER at 1% cellular expression or higher. The American Society of Clinical Oncology/College of American Pathologists guidelines suggest using the term "low ER-positive breast cancer" for tumors with ER expression between 1% and 10%. Low ER-positive breast cancers exhibit similarities, in terms of disease-free survival and overall survival rates, to triple-negative breast cancers (TNBCs) rather than ER-positive breast cancers. In this study, our aim was to compare the clinicopathological characteristics of low ER-positive breast cancer cases diagnosed and followed in our clinic with TNBCs. Materials and methods: A total of 26 cases of low ER-positive breast cancer diagnosed at University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital between 2010 and 2016 were retrieved from hospital records. The relevant histopathology slides and blocks were retrieved and re-evaluated retrospectively through microscopic examination. Thirteen cases that met the criteria were included in the study. Additionally, a consecutive series of 13 TNBC cases that did not receive neoadjuvant treatment within the same time period were identified. Results: In the low ER-positive group, the presence of tumor necrosis, as well as histological grade, nuclear grade and Ki-67 proliferation index were significantly lower compared to the TNBC group. Ductal carcinoma Conclusion: Although our study consisted of a small number of cases, some features showed significant differences between low ER-positive breast cancers and TNBCs. Histological and nuclear grades, as well as the presence of a DCIS component, were associated with low ER-positive breast cancer. In contrast, the presence of tumor necrosis, as well as Grade 3 features and a high Ki-67 proliferation index indicated TNBC.
Language	English
Publishing date	2023-12-27
Publishing country	Turkey
Document type	Journal Article
ISSN	2587-0831
ISSN	2587-0831
DOI	10.4274/ejbh.galenos.2023.2023-6-3
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Article ; Online: Effectiveness of laser hemorrhoidoplasty in the treatment of hemorrhoidal disease.

Dursun, Ayberk / Tuncer, Gizem Kilinc / Tuncer, Korhan / Karaali, Cem / Erdoğan, Gürsoy / Emiroglu, Mustafa

Cirugia y cirujanos

2023 Volume 91, Issue 2, Page(s) 179–185

Abstract: Introduction: Minimally invasive techniques still continue to maintain their popularity in hemorrhoidal disease. In this study, we aimed to present the symptomatic recovery and recurrence rates, post-operative pain levels, and complication rates of ... ...

Title translation	Eficacia de la hemorroidoplastia láser en el tratamıento de la enfermedad hemorroidal.
Abstract	Introduction: Minimally invasive techniques still continue to maintain their popularity in hemorrhoidal disease. In this study, we aimed to present the symptomatic recovery and recurrence rates, post-operative pain levels, and complication rates of patients treated with the laser hemorrhoidoplasty (LHP) method in our clinic. Methods: The data of patients who underwent LHP due to Grades 2, 3, and 4 internal hemorrhoidal disease in our clinic were reviewed retrospectively. The patients enrolled in the study were followed for at least 6 months (6 months, 1 year, and 2 years) and their results were analyzed. Results: A total of 103 patients were included in the study. Seventy-five (72.8%) of them were male and the mean age was 41.6 ± 13.6 years. The mean operation time was 17.9 ± 5.2 min and minor complications developed in 3 (2.9%) patients postoperatively. Mean time to return to normal daily life was 2.17 (1-11) days. Recurrence developed in 16 (17.6%) patients with Grades 2 and 3 disease and in 6 (50%) of 12 patients with Grade 4 disease (p = 0.019). Conclusion: LHP is a popular procedure which is effective in selected patient groups with acceptable recurrence rates.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Female ; Hemorrhoids/surgery ; Hemorrhoids/complications ; Hemorrhoidectomy/adverse effects ; Hemorrhoidectomy/methods ; Retrospective Studies ; Lasers ; Pain, Postoperative/epidemiology ; Pain, Postoperative/etiology ; Treatment Outcome ; Ligation
Language	English
Publishing date	2023-04-21
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.22000287
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Article ; Online: Diagnosis of Immunoglobulin G4-related disease in a child with ligneous conjunctivitis: a novel mutation in plasminogen gene and plasminogen activator inhibitor-1 polymorphism.

Emiroğlu, Melike / Bozkurt, Banu / Emiroğlu, Halil Haldun / Koplay, Mustafa / Koçak, Nadir / Karabağli, Pinar

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

2023 Volume 34, Issue 7, Page(s) 456–461

Abstract: Objectives: Ligneous conjunctivitis (LC) is a chronic conjunctivitis characterized by recurrent, firm, fibrin-rich, woody pseudomembranes on the palpebral conjunctiva. It is an ultrarare autosomal recessive disease associated with congenital plasminogen ...

Abstract	Objectives: Ligneous conjunctivitis (LC) is a chronic conjunctivitis characterized by recurrent, firm, fibrin-rich, woody pseudomembranes on the palpebral conjunctiva. It is an ultrarare autosomal recessive disease associated with congenital plasminogen (PLG) deficiency due to mutations in the PLG gene (6q26). Immunoglobulin G4-related disease (IgG4-RD) is an idiopathic, systemic fibroinflammatory disease characterized by elevated serum IgG4 concentration and tissue infiltration of IgG4-positive plasma cells leading to organ enlargement, fibrosis and damage. Case report: A 7-year-old girl with LC was hospitalized for recurrent pancreatitis and diagnosed as IgG4-RD. PLG activity level was 15% (normal range 55-145%). Co-segregation analysis indicated that the patient was homozygous for the c. NG_016200.1(NM_000301.5):c.1465 T>C mutation in PLG gene. c. NG_016200.1(NM_000301.5):c.1465 T>C PLG variant was found to be heterozygous by NGS analysis in both parents. She also had plasminogen activator inhibitor - 1 (PAI-1) NG_013213.1(NM_000602.5):c.-816A>G (4G/4G) homozygous polymorphism and a heterozygote NG_001333.2 (NM_002769.5):c.292_293insC mutation in the serine protease 1 (PRSS-1) gene. However, heterozygous PRSS-1NG_001333.2 (NM_002769.5):c.292_293insC variant was found in the mother of the patient. All detected variants are currently considered as a variant of uncertain (or unknown) significance (VUS) according to the American College of Medical Genetics and Genomics (ACMG) classification. Oral steroid, oral azathioprine, topical fresh frozen plasma, topical heparin, topical steroid and topical cyclosporine were given. After 3 years of follow-up, IgG4-RD is under partial remission and no pseudomembranes. Conclusion: She is the second case had both LC and IgG4-RD. We identified a NG_016200.1(NM_000301.5):c.1465 T>C novel homozygous mutation in PLG gene and a PAI-1 NG_016200.1(NM_000301.5):c.1465 T>C (4G/4G) homozygous polymorphism, which has been reported as a risk factor for thrombotic events.
MeSH term(s)	Female ; Humans ; Child ; Immunoglobulin G4-Related Disease ; Plasminogen Activator Inhibitor 1/genetics ; Conjunctivitis/diagnosis ; Conjunctivitis/genetics ; Plasminogen/genetics ; Mutation ; Immunoglobulin G ; Steroids
Chemical Substances	Plasminogen Activator Inhibitor 1 ; Plasminogen (9001-91-6) ; Immunoglobulin G ; Steroids
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1033551-1
ISSN	1473-5733 ; 0957-5235
ISSN (online)	1473-5733
ISSN	0957-5235
DOI	10.1097/MBC.0000000000001246
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Article: The first human case of Rickettsia slovaca from Turkey

Emiroglu, Melike / Celebi, Bekir / Alkan, Gulsum / Yilmaz, Yusuf

Ticks and tick-borne diseases. 2021 Sept., v. 12, no. 5

2021

Abstract	A three year-old girl was admitted to our university hospital with fever, muscle and abdominal pain, and painful cervical lymph nodes after a tick bite on scalp. Rickettsia slovaca DNA was detected in eschar tissue taken from the bite site. This is the first clinical case of a R. slovaca infection reported from Turkey.
Keywords	DNA ; Rickettsia slovaca ; fever ; girls ; hospitals ; humans ; lymph ; muscles ; pain ; ticks
Language	English
Dates of publication	2021-09
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	2541872-5
ISSN	1877-9603 ; 1877-959X
ISSN (online)	1877-9603
ISSN	1877-959X
DOI	10.1016/j.ttbdis.2021.101755
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