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  1. Article ; Online: Repurposing Platinum(IV) Prodrugs to Modulate Mitochondrial Metabolism

    Emmanouil Zacharioudakis / Raphaël Rodriguez

    ACS Central Science, Vol 9, Iss 7, Pp 1257-

    2023  Volume 1259

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Eltrombopag directly inhibits BAX and prevents cell death

    Adam Z. Spitz / Emmanouil Zacharioudakis / Denis E. Reyna / Thomas P. Garner / Evripidis Gavathiotis

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 15

    Abstract: The BCL-2 family protein BAX functions to regulate mitochondria-driven cell death. Here the authors show that the drug Eltrombopag inhibits BAX and prevents apoptosis induced by cytotoxic stimuli. ...

    Abstract The BCL-2 family protein BAX functions to regulate mitochondria-driven cell death. Here the authors show that the drug Eltrombopag inhibits BAX and prevents apoptosis induced by cytotoxic stimuli.
    Keywords Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Inhibitors of BRAF dimers using an allosteric site

    Xiomaris M. Cotto-Rios / Bogos Agianian / Nadege Gitego / Emmanouil Zacharioudakis / Orsi Giricz / Yang Wu / Yiyu Zou / Amit Verma / Poulikos I. Poulikakos / Evripidis Gavathiotis

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 16

    Abstract: FDA-approved RAF inhibitors poorly inhibit BRAF dimers, which limits their clinical efficacy in tumors expressing BRAFV600E mutant monomers. Here the authors identify FDA-approved Ponatinib as an effective inhibitor of BRAF monomers and dimers and ... ...

    Abstract FDA-approved RAF inhibitors poorly inhibit BRAF dimers, which limits their clinical efficacy in tumors expressing BRAFV600E mutant monomers. Here the authors identify FDA-approved Ponatinib as an effective inhibitor of BRAF monomers and dimers and designed PHI1, an inhibitor with a unique mode of action and selectivity for oncogenic BRAF dimers.
    Keywords Science ; Q
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Inhibitors of BRAF dimers using an allosteric site

    Xiomaris M. Cotto-Rios / Bogos Agianian / Nadege Gitego / Emmanouil Zacharioudakis / Orsi Giricz / Yang Wu / Yiyu Zou / Amit Verma / Poulikos I. Poulikakos / Evripidis Gavathiotis

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 16

    Abstract: FDA-approved RAF inhibitors poorly inhibit BRAF dimers, which limits their clinical efficacy in tumors expressing BRAFV600E mutant monomers. Here the authors identify FDA-approved Ponatinib as an effective inhibitor of BRAF monomers and dimers and ... ...

    Abstract FDA-approved RAF inhibitors poorly inhibit BRAF dimers, which limits their clinical efficacy in tumors expressing BRAFV600E mutant monomers. Here the authors identify FDA-approved Ponatinib as an effective inhibitor of BRAF monomers and dimers and designed PHI1, an inhibitor with a unique mode of action and selectivity for oncogenic BRAF dimers.
    Keywords Science ; Q
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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