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  1. Article ; Online: Updates in Cutaneous T-cell Lymphomas at ASH 2022

    Emmanuella Guenova

    healthbook TIMES. Oncology Hematology (2023)

    2023  

    Keywords Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher THE HEALTHBOOK COMPANY LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Harnessing the Power of Existing Therapeutic Strategies to Treat Cutaneous T-cell Lymphomas

    Emmanuella Guenova

    healthbook TIMES. Oncology Hematology, Vol 16, Iss

    2023  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher THE HEALTHBOOK COMPANY LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: EORTC-CLTG 2022

    Emmanuella Guenova

    healthbook TIMES. Oncology Hematology (2022)

    Vital Platform to Discuss the Recent Advances in Cutaneous Lymphomas

    2022  

    Keywords Medicine ; R
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher THE HEALTHBOOK COMPANY LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Mycosis fungoides and Sézary syndrome

    Ieva Saulite / Antonio Cozzio / Emmanuella Guenova

    healthbook TIMES. Oncology Hematology, Vol 2, Iss

    2021  Volume 8

    Abstract: Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood. Regarding pathogenesis, ... ...

    Abstract Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood. Regarding pathogenesis, mycosis fungoides and Sézary syndrome derive from different T-helper cell types and are therefore considered two separate entities according to the current concept. Mycosis fungoides is clinically characterized by patch, plaque and tumor stages, although the disease can also manifest as erythroderma. Sézary syndrome is characterized by the presence of erythroderma, defined as redness of the skin covering >80% of the total body surface area. In the blood count of patients with mycosis fungoides, a T-lymphocytosis, especially with CD4-positive cells, can only be observed in advanced stage IV. One of the typical histological findings is an epidermotropic infiltrate of atypical, CD4-positive T-cells. Characteristic features of Sézary syndrome include atypical T lymphocytes (Sézary cells) in the blood and skin infiltrate. The diagnosis of both mycosis fungoides and Sézary syndrome is based on clinical, histological and hematological examinations as well as imaging techniques. Staging is based on the tumor-node-metastasis-blood (TNMB) classification and is a crucial factor in determining the prognosis. The treatment of mycosis fungoides and Sézary syndrome is carried out according to the stage, whereby local therapies such as UVB phototherapy are used as well as systemic forms of treatment, and in addition, in recent years, targeted therapies have increasingly become part of everyday clinical practice.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher THE HEALTHBOOK COMPANY LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mycosis fungoides and Sézary syndrome

    Ieva Saulite / Antonio Cozzio / Emmanuella Guenova

    healthbook TIMES. Oncology Hematology, Vol 2, Iss 8, Pp 22-

    2021  Volume 31

    Abstract: Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood. Regarding pathogenesis, ... ...

    Abstract Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood. Regarding pathogenesis, mycosis fungoides and Sézary syndrome derive from different T-helper cell types and are therefore considered two separate entities according to the current concept. Mycosis fungoides is clinically characterized by patch, plaque and tumor stages, although the disease can also manifest as erythroderma. Sézary syndrome is characterized by the presence of erythroderma, defined as redness of the skin covering >80% of the total body surface area. In the blood count of patients with mycosis fungoides, a T-lymphocytosis, especially with CD4-positive cells, can only be observed in advanced stage IV. One of the typical histological findings is an epidermotropic infiltrate of atypical, CD4-positive T-cells. Characteristic features of Sézary syndrome include atypical T lymphocytes (Sézary cells) in the blood and skin infiltrate. The diagnosis of both mycosis fungoides and Sézary syndrome is based on clinical, histological and hematological examinations as well as imaging techniques. Staging is based on the tumor-node-metastasis-blood (TNMB) classification and is a crucial factor in determining the prognosis. The treatment of mycosis fungoides and Sézary syndrome is carried out according to the stage, whereby local therapies such as UVB phototherapy are used as well as systemic forms of treatment, and in addition, in recent years, targeted therapies have increasingly become part of everyday clinical practice.
    Keywords sézary syndrome ; mycosis fungoides ; extranodal non-hodgkin’s lymphoma ; cutaneous t-cell lymphoma ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher THE HEALTHBOOK COMPANY LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Epidemiology of Dermatophytoses in Switzerland According to a Survey of Dermatophytes Isolated in Lausanne between 2001 and 2018

    Olympia Bontems / Marina Fratti / Karine Salamin / Emmanuella Guenova / Michel Monod

    Journal of Fungi, Vol 6, Iss 95, p

    2020  Volume 95

    Abstract: Dermatophytes are the most common pathogenic agents of superficial mycoses in humans and animals. Knowledge of their epidemiology can facilitate the prevention of dermatophytosis and improve prophylactic measures. We sought to determine the incidence of ... ...

    Abstract Dermatophytes are the most common pathogenic agents of superficial mycoses in humans and animals. Knowledge of their epidemiology can facilitate the prevention of dermatophytosis and improve prophylactic measures. We sought to determine the incidence of the different dermatophyte species diagnosed in Lausanne (Switzerland) from 2001 to 2018. In total, 10,958 dermatophytes were isolated from patients and 459 from pets. Overall, 99% of tinea unguium and tinea pedis were caused by Trichophyton rubrum and Trichophyton interdigitale with a prevalence ratio of 3:1. Trichophyton violaceum and Trichophyton soudanense were mainly found in tinea capitis in patients of African and Mediterranean origin. Interestingly, while Epidermophyton floccosum and Trichophyton verrucosum were prevalent 50 years ago in an epidemiological analysis carried out in the same laboratory from 1967 to 1970, these two species were rarely detected from 2001 to 2018. Trichophyton mentagrophytes , Trichophyton benhamiae and Microsporum canis were the prevalent zoophilic pathogenic species in children and young adults. Our investigation of animal samples revealed the main reservoirs of these zoophilic species to be cats and dogs for T. mentagrophytes and M. canis , and Guinea pigs for T. benhamiae . This study provides an epidemiological overview of dermatophytoses in Switzerland to improve their surveillance.
    Keywords Trichophyton ; Microsporum ; Epidermophyton ; epidemiology ; dermatophytosis onychomycosis ; tinea pedis ; Biology (General) ; QH301-705.5
    Subject code 590
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: MFS1, a Pleiotropic Transporter in Dermatophytes That Plays a Key Role in Their Intrinsic Resistance to Chloramphenicol and Fluconazole

    Tsuyoshi Yamada / Takashi Yaguchi / Karine Salamin / Emmanuella Guenova / Marc Feuermann / Michel Monod

    Journal of Fungi, Vol 7, Iss 542, p

    2021  Volume 542

    Abstract: A recently identified Trichophyton rubrum major facilitator superfamily (MFS)-type transporter (TruMFS1) has been shown to give resistance to azole compounds and cycloheximide (CYH) when overexpressed in Saccharomyces cerevisiae . We investigated the ... ...

    Abstract A recently identified Trichophyton rubrum major facilitator superfamily (MFS)-type transporter (TruMFS1) has been shown to give resistance to azole compounds and cycloheximide (CYH) when overexpressed in Saccharomyces cerevisiae . We investigated the roles of MFS1 in the intrinsic resistance of dermatophytes to CYH and chloramphenicol (CHL), which are commonly used to isolate these fungi, and to what extent MFS1 affects the susceptibility to azole antifungals. Susceptibility to antibiotics and azoles was tested in S. cerevisiae overexpressing MFS1 and ΔMFS1 mutants of Trichophyton benhamiae , a dermatophyte that is closely related to T. rubrum . We found that TruMFS1 functions as an efflux pump for CHL in addition to CYH and azoles in S. cerevisiae . In contrast, the growth of T. benhamiae ΔMFS1 mutants was not reduced in the presence of CYH but was severely impaired in the presence of CHL and thiamphenicol, a CHL analog. The suppression of MFS1 in T. benhamiae also increased the sensitivity of the fungus to fluconazole and miconazole. Our experiments revealed a key role of MFS1 in the resistance of dermatophytes to CHL and their high minimum inhibitory concentration for fluconazole. Suppression of MFS1 did not affect the sensitivity to CYH, suggesting that another mechanism was involved in resistance to CYH in dermatophytes.
    Keywords dermatophytes ; Trichophyton benhamiae ; chloramphenicol ; cycloheximide ; intrinsic resistance ; azole resistance ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Cutaneous Oncology

    Ieva Saulite / Elisabeth Roider / Razvigor Darlenksi / Ahmad Jalili / Emmanuella Guenova

    BioMed Research International, Vol

    From Research to Diagnosis and Management

    2016  Volume 2016

    Keywords Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Sézary Syndrome and Atopic Dermatitis

    Ieva Saulite / Wolfram Hoetzenecker / Stephan Weidinger / Antonio Cozzio / Emmanuella Guenova / Ulrike Wehkamp

    BioMed Research International, Vol

    Comparison of Immunological Aspects and Targets

    2016  Volume 2016

    Abstract: Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the ... ...

    Abstract Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.
    Keywords Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Long–Term Disease Control After Allogeneic Hematopoietic Stem Cell Transplantation in Primary Cutaneous T–Cell Lymphoma; Results From a Single Institution Analysis

    Florentia Dimitriou / Urs Schanz / Gayathri Nair / Susanne Kimeswenger / Marie-Charlotte Brüggen / Wolfram Hoetzenecker / Lars E. French / Reinhard Dummer / Antonio Cozzio / Emmanuella Guenova

    Frontiers in Medicine, Vol

    2020  Volume 7

    Abstract: Background: Allogeneic hematopoietic stem cell transplantation (alloHSCT) has been proposed as curative approach for advanced cutaneous T–cell lymphomas (CTCL). Currently, there is no established consensus for the management of disease relapse after ... ...

    Abstract Background: Allogeneic hematopoietic stem cell transplantation (alloHSCT) has been proposed as curative approach for advanced cutaneous T–cell lymphomas (CTCL). Currently, there is no established consensus for the management of disease relapse after alloHSCT.Results: Ten patients, previously treated with multiple lines of systemic treatment, received alloHSCT. Six patients had achieved partial response (PR, N = 5) and complete response (CR, N = 1) prior to HSCT. Post—HSCT, seven patients (N = 7) relapsed after a median time of 3.3 months (0.5–7.4 months) and were subsequently treated with radiotherapy (RT, N = 1), RT and adoptive T-cell transfer with EBV specific cells (N = 1), R-CHOP (N = 1) and interferon alpha−2a combined either with donor lymphocyte infusion (N = 1) or with brentuximab—vedotin (N = 1). One patient (N = 1) achieved PR only after reducing the immunosuppression. Two patients relapsed again and received interferon alpha−2a and brentuximab—vedotin, respectively. After a median follow-up time of 12.6 months (3.5–73.7 months) six patients were alive (60%) and four had deceased, three (N = 3) due to CTCL and one (N = 1) due to GVHD.Conclusion: Disease relapse after alloHSCT can be controlled with available treatments. For most patients who ultimately relapsed, reduction of immunosuppression and interferon alpha−2a either administered alone or in combination with another systemic agent were preferred. Although interferon alpha−2a, similarly to immunosuppression reduction, may be beneficial for the achievement of graft–vs.–lymphoma effect, the risk of simultaneous worsening of GVHD must be carefully evaluated and taken into consideration.
    Keywords allogeneic stem cell transplantation ; cutaneous T-cell lymphoma ; Sézary syndrome ; mycosis fungoides ; interferon alpha-2a ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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