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  1. Article ; Online: Matérialisations du souvenir en montagne les enjeux identitaires des places et des placements

    Emmanuelle Petit

    Carnets de Géographes, Vol

    2013  Volume 5

    Keywords Geography (General) ; G1-922
    Language French
    Publishing date 2013-01-01T00:00:00Z
    Publisher UMR 245 - CESSMA
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Matérialisations du souvenir en montagne les enjeux identitaires des places et des placements

    Emmanuelle Petit

    Carnets de Géographes, Vol

    2013  Volume 5

    Keywords Geography (General) ; G1-922
    Language French
    Publishing date 2013-01-01T00:00:00Z
    Publisher UMR 245 - CESSMA
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Matérialisations du souvenir en montagne les enjeux identitaires des places et des placements

    Emmanuelle Petit

    Carnets de Géographes, Vol

    2013  Volume 5

    Keywords Geography (General) ; G1-922
    Language French
    Publishing date 2013-01-01T00:00:00Z
    Publisher UMR 245 - CESSMA
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Les usagers d’une plage péri-urbaine face à la contamination microbiologique des eaux de baignade

    Maëlig Le Béguec / Emmanuelle Petit / Luc Vacher / Hélène Agogué / Mery Ndione

    VertigO, Vol 23, Iss

    2023  Volume 1

    Abstract: This paper deals with the case of a long-term swimming ban on a beach in the urban area of La Rochelle on the French Atlantic coast due to recurring exceedances of sanitary standards regarding water quality. It questions the confrontation of a coastal ... ...

    Abstract This paper deals with the case of a long-term swimming ban on a beach in the urban area of La Rochelle on the French Atlantic coast due to recurring exceedances of sanitary standards regarding water quality. It questions the confrontation of a coastal urban population with an environmental contamination issue in a space usually practiced for leisure activities. This analysis is presented through an environmental geography approach considering nature-society interactions and focusing on the perception of environmental quality in the attractiveness of coastal areas. Through the presentation of a survey’s results conducted among the local population, the aim is to analyze the way in which the user population perceives the alteration of the environmental quality of the beach and the bathing water and whether their understanding is homogeneous. The ways in which the origin of the contamination and the prevention dimension of the prohibition measures affect the population's understanding are presented. The changes in the practice of the beach and in the perception of this leisure space are related to the mode of information reception on the environment’s contamination. The roles of memory effect and place attachment that lead to the maintenance of certain practices will also be presented.
    Keywords contamination ; beach ; swimming ; Atlantic ; littoral ; recreational practices ; Environmental sciences ; GE1-350
    Subject code 710
    Language French
    Publishing date 2023-04-01T00:00:00Z
    Publisher Éditions en environnement VertigO
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Analysis of a Combined HBHA and ESAT-6-Interferon-γ-Release Assay for the Diagnosis of Tuberculous Lymphadenopathies

    Françoise Mascart / Maya Hites / Emmanuelle Watelet / Gil Verschelden / Christelle Meuris / Jean-Luc Doyen / Anne Van Praet / Audrey Godefroid / Emmanuelle Petit / Mahavir Singh / Camille Locht / Véronique Corbière

    Journal of Clinical Medicine, Vol 12, Iss 2127, p

    2023  Volume 2127

    Abstract: Background and Objectives: The incidence of tuberculosis lymphadenopathy (TBLA) is increasing, and diagnostic procedures lack sensitivity and are often highly invasive. TBLA may be asymptomatic, and differential diagnosis with other adenopathies (ADPs) ... ...

    Abstract Background and Objectives: The incidence of tuberculosis lymphadenopathy (TBLA) is increasing, and diagnostic procedures lack sensitivity and are often highly invasive. TBLA may be asymptomatic, and differential diagnosis with other adenopathies (ADPs) is difficult. We evaluated a blood-cell interferon-γ release assay (IGRA) with two different stage-specific mycobacterial antigens for the differential diagnosis of ADP suspected of mycobacterial origin. Methods: Twenty-one patients were included and divided into three groups: (1) cervical/axillar ADP ( n = 8), (2) mediastinal ADP ( n = 10), and (3) disseminated ADP ( n = 3). The mycobacterial antigens used for the IGRA were the heparin-binding haemagglutinin (HBHA) and the early-secreted antigenic target-6 (ESAT-6), a latency-associated antigen and a bacterial replication-related antigen, respectively. Diagnosis of TBLA based on microbiological results and/or response to anti-TB treatment was obtained for 15 patients. Results: An IGRA profile highly suggestive of active TB (higher IFN-γ response to ESAT-6 compared to HBHA) was found for 3/6 TBLA patients from group 1, and for all the TBLA patients from groups 2 and 3, whereas this profile was not noticed in patients with a final alternative diagnosis. Conclusion: These results highlight the potential value of this combined HBHA/ESAT-6 IGRA as a triage test for the differential diagnosis of ADP.
    Keywords tuberculous lymphadenopathy ; IGRA ; HBHA ; ESAT-6 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Male Differentiation in the Marine Copepod Oithona nana Reveals the Development of a New Nervous Ganglion and Lin12-Notch-Repeat Protein-Associated Proteolysis

    Kevin Sugier / Romuald Laso-Jadart / Benoît Vacherie / Jos Käfer / Laurie Bertrand / Karine Labadie / Nathalie Martins / Céline Orvain / Emmanuelle Petit / Patrick Wincker / Jean-Louis Jamet / Adriana Alberti / Mohammed-Amin Madoui

    Biology, Vol 10, Iss 657, p

    2021  Volume 657

    Abstract: Copepods are among the most numerous animals, and they play an essential role in the marine trophic web and biogeochemical cycles. The genus Oithona is described as having the highest density of copepods. The Oithona male paradox describes the activity ... ...

    Abstract Copepods are among the most numerous animals, and they play an essential role in the marine trophic web and biogeochemical cycles. The genus Oithona is described as having the highest density of copepods. The Oithona male paradox describes the activity states of males, which are obliged to alternate between immobile and mobile phases for ambush feeding and mate searching, respectively, while the female is less mobile and feeds less. To characterize the molecular basis of this sexual dimorphism, we combined immunofluorescence, genomics, transcriptomics, and protein–protein interaction approaches and revealed the presence of a male-specific nervous ganglion. Transcriptomic analysis showed male-specific enrichment for nervous system development-related transcripts. Twenty-seven Lin12-Notch Repeat domain-containing protein coding genes (LDPGs) of the 75 LDPGs identified in the genome were specifically expressed in males. Furthermore, some LDPGs coded for proteins with predicted proteolytic activity, and proteases-associated transcripts showed a male-specific enrichment. Using yeast double–hybrid assays, we constructed a protein–protein interaction network involving two LDPs with proteases, extracellular matrix proteins, and neurogenesis-related proteins. We also hypothesized possible roles of the LDPGs in the development of the lateral ganglia through helping in extracellular matrix lysis, neurites growth guidance, and synapses genesis.
    Keywords copepods ; sexual differentiation ; nervous system ; Lin12-Notch-Repeat ; Oithona ; protein–protein interaction ; Biology (General) ; QH301-705.5
    Subject code 590
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Investigating population‐scale allelic differential expression in wild populations of Oithona similis (Cyclopoida, Claus, 1866)

    Romuald Laso‐Jadart / Kevin Sugier / Emmanuelle Petit / Karine Labadie / Pierre Peterlongo / Christophe Ambroise / Patrick Wincker / Jean‐Louis Jamet / Mohammed‐Amin Madoui

    Ecology and Evolution, Vol 10, Iss 16, Pp 8894-

    2020  Volume 8905

    Abstract: Abstract Acclimation allowed by variation in gene or allele expression in natural populations is increasingly understood as a decisive mechanism, as much as adaptation, for species evolution. However, for small eukaryotic organisms, as species from ... ...

    Abstract Abstract Acclimation allowed by variation in gene or allele expression in natural populations is increasingly understood as a decisive mechanism, as much as adaptation, for species evolution. However, for small eukaryotic organisms, as species from zooplankton, classical methods face numerous challenges. Here, we propose the concept of allelic differential expression at the population‐scale (psADE) to investigate the variation in allele expression in natural populations. We developed a novel approach to detect psADE based on metagenomic and metatranscriptomic data from environmental samples. This approach was applied on the widespread marine copepod, Oithona similis, by combining samples collected during the Tara Oceans expedition (2009–2013) and de novo transcriptome assemblies. Among a total of 25,768 single nucleotide variants (SNVs) of O. similis, 572 (2.2%) were affected by psADE in at least one population (FDR < 0.05). The distribution of SNVs under psADE in different populations is significantly shaped by population genomic differentiation (Pearson r = 0.87, p = 5.6 × 10−30), supporting a partial genetic control of psADE. Moreover, a significant amount of SNVs (0.6%) were under both selection and psADE (p < .05), supporting the hypothesis that natural selection and psADE tends to impact common loci. Population‐scale allelic differential expression offers new insights into the gene regulation control in populations and its link with natural selection.
    Keywords allelic expression ; Arctic seas ; copepod ; metagenomics ; metatranscriptomics ; selection ; Ecology ; QH540-549.5
    Subject code 612
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Proportions of interferon-γ-producing ascites lymphocytes in response to mycobacterial antigens

    Sophie Henrard / Véronique Corbière / Liliane Schandené / Martine Ducarme / Anne Van Praet / Emmanuelle Petit / Mahavir Singh / Camille Locht / Violette Dirix / Françoise Mascart

    PLoS ONE, Vol 14, Iss 4, p e

    A help for early diagnosis of peritoneal tuberculosis in a low TB incidence country.

    2019  Volume 0214333

    Abstract: Background Peritoneal tuberculosis (TB) remains difficult to diagnose because of its non-specific clinical features and the lack of efficient microbiological tests. As delayed diagnosis is associated with high mortality rates, new diagnostic tools are ... ...

    Abstract Background Peritoneal tuberculosis (TB) remains difficult to diagnose because of its non-specific clinical features and the lack of efficient microbiological tests. As delayed diagnosis is associated with high mortality rates, new diagnostic tools are needed. Methods and findings We investigated for 24 patients prospectively enrolled with a possible diagnosis of peritoneal TB, the diagnostic value of the analysis of IFN-γ production by peritoneal fluid lymphocytes in response to a short in vitro stimulation with mycobacterial antigens. The patients were classified in two groups: non-TB and confirmed or highly probable TB. Diagnosis of TB was based on microbiological and histopathological criteria and/or a favorable response to anti-TB treatment. The IFN-γ production by peritoneal CD4+ T lymphocytes was analyzed by flow cytometry after an overnight in vitro stimulation with three different mycobacterial antigens, purified protein derivative (PPD), heparin-binding haemagglutinin (HBHA) or early-secreted-antigen-target-6 (ESAT-6). The percentages of PPD-, HBHA- or ESAT-6-induced IFN-γ-producing peritoneal fluid CD4+ T lymphocytes were higher in the TB group than in the non-TB group (p = 0.0007, p = 0.0004, and p = 0.0002 respectively). Based on cut-off values determined by ROC curve analysis of the results from TB and highly probable TB compared to those of non-TB patients, the sensitivity of these three tests was 100% with a specificity of 92%. Conclusions The analysis of mycobacterial-induced IFN-γ production by peritoneal lymphocytes is a promising tool to reliably and rapidly diagnose peritoneal TB. Further studies should be performed on larger cohorts of patients in high-TB-incidence countries to confirm the clinical value of this new diagnostic approach for peritoneal TB.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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