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  1. Article ; Online: CONCISE REVIEW

    Umay Çelik / Özge Sezin Somuncu / Büşra Ergün / Emre Arpalı

    Trakya University Journal of Natural Sciences, Vol 20, Pp 45-

    β CELL REPLACEMENT THERAPIES IN TREATMENT OF DIABETES MELLITUS

    2019  Volume 54

    Abstract: Metabolic rate of glucose uptake is generally controlled by a feedback mechanism covering islet β cells and insulin-sensitive tissues, wherein tissue sensitivity to insulin influences the level of β-cell comeback. In case of insulin presence, β cells ... ...

    Abstract Metabolic rate of glucose uptake is generally controlled by a feedback mechanism covering islet β cells and insulin-sensitive tissues, wherein tissue sensitivity to insulin influences the level of β-cell comeback. In case of insulin presence, β cells preserve standard glucose tolerance via enhancing insulin production. Even though β-cell dysfunction has a strong hereditary component, environmental alterations carry an important part as well. Current research methods have facilitated to establish the important part of hexoses, amino acids, and fatty acids in the development of insulin resistance and β-cell dysfunction, therefore more operative treatments to slow the progressive loss of β-cell function are required. Latest discoveries from clinical research deliver significant information about approaches to stop and treat diabetes and some of the adversative properties of these interferences. Generation of satisfactory numbers of pancreatic endocrine cells that work in the same way as primary islets is of supreme prominence for the expansion of cell treatments to cure. In this study, we focused on different techniques starting from islet and pancreas transplantations individually and ending on new therapies such as stem cell technology and bioengineering. We aimed to establish a comprehensive and detailed explanation of treatment perspectives for islet cell loss. This review is carrying a novel potential for enlightening the current treatments and future-based therapies.
    Keywords stem cell therapy ; islet cells ; pancreas ; Science (General) ; Q1-390
    Subject code 571
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Trakya University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The efficacy of radiographic anatomical measurement methods in predicting success after extracorporeal shockwave lithotripsy for lower pole kidney stones

    Emre Arpali / Mert Altinel / Semih Yasar Sargin

    International Brazilian Journal of Urology, Vol 40, Iss 3, Pp 337-

    2014  Volume 345

    Abstract: Objectives To assess the impact of lower pole calyceal anatomy on clearace of lower pole stones after extracorporeal shockwave lithotripsy (ESWL) by means of a new and previously defined radiographic measurement method. Materials and Methods Sixty-four ... ...

    Abstract Objectives To assess the impact of lower pole calyceal anatomy on clearace of lower pole stones after extracorporeal shockwave lithotripsy (ESWL) by means of a new and previously defined radiographic measurement method. Materials and Methods Sixty-four patients with solitary radiopaque lower pole kidney stones were enrolled in the study. Infundibulopelvic angle (IPA), infundibulotransverse angle (ITA), infundibular lenght(IL), and infundibular width (IW) were measured on the intravenous urographies which were taken before the procedure. Results 48 of 64 patients (75%) were stone-free after a follow-up period of 3 months. The IPA,ITA,IL and IW were determined as statistically significant factors, while age,gender and stone area were found to have no impact on clearance. Conclusion By the help of radiographic measurement methods related to lower pole kidney anatomy, appropriate patient selection and increment in success after ESWL may be achieved.
    Keywords Lithotripsy ; Calculi ; Kidney ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2014-06-01T00:00:00Z
    Publisher Sociedade Brasileira de Urologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The antibiotic sensitivity of bacteria isolated from urine cultures

    Kemal Tolga Saraçoğlu / Vural Fidan / Özgür Pekel / Ayten Saraçoğlu / Sadettin Kalkandelen / Emre Arpalı

    Journal of Clinical and Experimental Investigations, Vol 4, Iss 3, Pp 356-

    2013  Volume 359

    Abstract: Objective: Urinary tract infections (UTI) come upon acommon infection disease in hospital. Empiric antibiotictherapy for patients with suspected UTI is commonly usedbecause obtaining antibiogram result is usually time consuming.Aim of the study was to ... ...

    Abstract Objective: Urinary tract infections (UTI) come upon acommon infection disease in hospital. Empiric antibiotictherapy for patients with suspected UTI is commonly usedbecause obtaining antibiogram result is usually time consuming.Aim of the study was to investigate urine cultureand antibiogram results of patients who were admitted toour hospital.Methods: Urine cultures were investigated between November2008 and June 2010 in database of laboratoryinformation system. Samples of isolated microorganismand antibiogram results were evaluated.Results: Microorganisms were isolated in 691 of 1342urine cultures. Polymicrobial infection was determined in46 patients. Most common identified microorganism wasE. coli (71.3%). If all samples considered, bacteria resistancewas detected against to ampicilline, trimethoprim/sulfamethoxazole (TMP/SMX) ampicilline/sulbactam(AMS) and ciprofloxacin (CIP) (52.1%, 39.5%, 22.7%and 19.6%). Lower bacterial resistance was determinedagainst amicasin, gentamicine, tobramicine and nitrofurantoin(7.9%, 3.3%, 17.5% and 12.6%). As E. coli isolatedsamples were investigated, bacterial resistance wasdetected against ampicilline, CIP, levofloxacin and TMP/SMX (58.1%, 40.8%, 36.1% ve 39.5%). Nitrofurantoin,amicasin, gentamicine and tobramicine were found assensitive antibiotics (90.3%, 88.9%, 79.4% and 69.9%).Conclusion: High bacterial resistance was determinedagainst to most preferred empiric antibiotics which areTMP/SMX, AMS and also CIP. J Clin Exp Invest 2013; 4(3): 356-359Key words: antibiogram; drug resistance; urine culture
    Keywords antibiogram ; drug resistance ; urine culture ; Medicine ; R
    Language English
    Publishing date 2013-09-01T00:00:00Z
    Publisher Modestum Publishing LTD
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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