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Article ; Online: Radial pseudoaneurysm following coronary angiography in a patient with autosomal dominant polycystic kidney disease.

Emrich, Insa E / Böhm, Michael / Mahfoud, Felix

Clinical research in cardiology : official journal of the German Cardiac Society

2023 Volume 112, Issue 9, Page(s) 1343–1345

MeSH term(s)	Humans ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Coronary Angiography
Language	English
Publishing date	2023-01-23
Publishing country	Germany
Document type	Letter
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-023-02159-7
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Article ; Online: Plasma concentrations of trimethylamine-N-oxide, choline and betaine in patients with moderate to advanced chronic kidney disease and their relation to cardiovascular and renal outcomes.

Obeid, Rima / Awwad, Husain / Heine, Gunnar Henrik / Emrich, Insa E / Fliser, Danilo / Zawada, Adam M / Geisel, Jürgen

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

2024

Abstract: Objectives: Trimethylamine N-oxide (TMAO) is a gut bacteria mediated liver metabolite of dietary betaine, choline, and carnitine which is excreted by glomerular filtration. We studied whether TMAO is associated with cardiovascular disease (CVD) in ... ...

Abstract	Objectives: Trimethylamine N-oxide (TMAO) is a gut bacteria mediated liver metabolite of dietary betaine, choline, and carnitine which is excreted by glomerular filtration. We studied whether TMAO is associated with cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). Methods: Among 478 patients with CKD stage G2 (n = 104), G3a (n = 163), G3b (n = 123), and G4 (n = 88), we studied the association between fasting plasma concentrations of TMAO, choline or betaine at baseline and kidney function, prevalent CVD and future renal outcomes during a mean follow-up of 5.1 years. Results: Decreased glomerular filtration rate was associated with higher plasma concentrations of TMAO, choline and betaine. Baseline concentrations of TMAO were higher in participants with preexisting CVD compared to those without CVD (8.4 [10.1] vs. 7.8 [8.0] μmol/L; p = 0.047), but the difference was not significant after adjusting for confounders. During the follow up, 147 participants experienced CVD or died and 144 reached the predefined renal endpoint. In the adjusted regression analyses, TMAO or choline concentrations in the upper three quartiles (versus the lowest quartile) were not associated with any of the study clinical endpoints. In contrast, the adjusted hazard ratio of plasma betaine in the highest quartile versus the lowest quartile was 2.14 (1.32, 3.47) for the CVD endpoint and 1.64 (1.00, 2.67) for the renal endpoint. Conclusions: Elevated plasma TMAO concentrations were explained by impaired kidney function. Elevated plasma concentrations of betaine, but not that of TMAO or choline predicted adverse outcomes. TMAO might not be an appropriate target to reduce CVD or renal outcomes in patients with preexisting CKD.
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1080003-7
ISSN	1532-8503 ; 1051-2276
ISSN (online)	1532-8503
ISSN	1051-2276
DOI	10.1053/j.jrn.2024.03.009
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Article ; Online: Anämie und Eisenmangel – Behandlungsoptionen bei chronischer Nierenerkrankung und chronischer Herzinsuffizienz.

Emrich, Insa E / Böhm, Michael / Heine, Gunnar H

Deutsche medizinische Wochenschrift (1946)

2020 Volume 145, Issue 24, Page(s) 1775–1780

Abstract: Anemia and iron deficiency are highly prevalent in chronic kidney disease (CKD) and in chronic heart failure. Both may epidemiologically predict future renal and/or cardiovascular events. However, anemia treatment with either erythropoietin or ... ...

Title translation	Anemia and iron deficiency - treatment options in chronic kidney disease and in chronic heart failure.
Abstract	Anemia and iron deficiency are highly prevalent in chronic kidney disease (CKD) and in chronic heart failure. Both may epidemiologically predict future renal and/or cardiovascular events. However, anemia treatment with either erythropoietin or erythropoiesis-stimulating agents failed to induce a prognostic benefit in either CKD or chronic heart failure. Instead, in the subgroup of chronic dialysis patients, liberal intravenous iron supplementation was beneficial, and ongoing clinical trials are testing the prognostic implication of intravenous iron supplementation in chronic heart failure. Finally, HIF stabilizers are a new treatment option for anemia in chronic kidney disease, and safety studies are currently ongoing in CKD patients. Whether patients suffering from chronic heart failure might also benefit from this treatment is currently unknown.
MeSH term(s)	Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/drug therapy ; Anemia, Iron-Deficiency/etiology ; Chronic Disease ; Erythropoietin/administration & dosage ; Erythropoietin/therapeutic use ; Heart Failure/complications ; Hematinics/administration & dosage ; Hematinics/therapeutic use ; Humans ; Iron/administration & dosage ; Iron/therapeutic use ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy
Chemical Substances	Hematinics ; Erythropoietin (11096-26-7) ; Iron (E1UOL152H7)
Language	German
Publishing date	2020-11-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-1133-7849
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Article ; Online: Erratum.

Emrich, Insa E / Heine, Gunnar H

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2017 Volume 32, Issue 1, Page(s) 202

Language	English
Publishing date	2017-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfw435
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: ELOVL2-methylation and renal and cardiovascular event in patients with chronic kidney disease.

Obeid, Rima / Rickens, Patricia / Heine, Gunnar Henrik / Emrich, Insa E / Fliser, Danilo / Zawada, Adam M / Bodis, Marion / Geisel, Jürgen

European journal of clinical investigation

2023 Volume 53, Issue 12, Page(s) e14068

Abstract: Background: Methylation of the Elongation Of Very Long Chain Fatty Acids-Like 2 (ELOVL2) gene promoter may predict premature ageing and cardiovascular risk.: Methods: We studied the cross-sectional associations between blood ELOVL2-methylation and ... ...

Abstract	Background: Methylation of the Elongation Of Very Long Chain Fatty Acids-Like 2 (ELOVL2) gene promoter may predict premature ageing and cardiovascular risk. Methods: We studied the cross-sectional associations between blood ELOVL2-methylation and cardiovascular risk factors in 350 patients with chronic kidney disease (CKD) stage G2-G4 aged between 22 and 90 years. In a follow-up study for a mean of 3.9 years, we investigated the association between baseline ELOVL2-methylation and renal or cardiovascular events including death. Results: ELOVL2-methylation at seven CpG cites increased with age (the correlation coefficients between 0.67 and 0.87, p < 0.001). The ELOVL2-CpGs methylation was lower in patients with CKD stage G2 versus those in stage G3a, G3b and G4, but the differences were explained by age. ELOVL2-CpGs methylation showed no correlations with cardiovascular risk factors after adjusting for age. During the follow-up, 64 patients showed deterioration in renal function or died and 77 showed cardiovascular events or died. The hazard ratio and 95% confidence intervals for renal or cardiovascular events according to baseline ELOVL2-CpGs methylation were not significant after adjustment for covariates. Conclusions: ELOVL2-hypermethylation showed a strong association with age, but was not independently associated with cardiovascular risk factors or with future renal or cardiovascular events in patients with CKD. ELOVL2 gene methylation is not likely to be itself a cause for ageing or illnesses, but it could be rather influenced by other upstream processes that deserve investigation.
MeSH term(s)	Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Follow-Up Studies ; Cross-Sectional Studies ; Kidney/physiology ; Renal Insufficiency, Chronic ; DNA Methylation ; Cardiovascular Diseases/genetics ; Risk Factors
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.14068
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Zs.A 677: Show issues

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Article: Comparison of three creatinine-based equations to predict adverse outcome in a cardiovascular high-risk cohort: an investigation using the SPRINT research materials.

Emrich, Insa E / Pickering, John W / Götzinger, Felix / Kramann, Rafael / Kunz, Michael / Lauder, Lucas / Papademetriou, Vasilios / Böhm, Michael / Heine, Gunnar H / Mahfoud, Felix

Clinical kidney journal

2024 Volume 17, Issue 2, Page(s) sfae011

Abstract: Background: Novel creatinine-based equations have recently been proposed but their predictive performance for cardiovascular outcomes in participants at high cardiovascular risk in comparison to the established CKD-EPI 2009 equation is unknown.: ... ...

Abstract	Background: Novel creatinine-based equations have recently been proposed but their predictive performance for cardiovascular outcomes in participants at high cardiovascular risk in comparison to the established CKD-EPI 2009 equation is unknown. Method: In 9361 participants from the United States included in the randomized controlled SPRINT trial, we calculated baseline estimated glomerular filtration rate (eGFR) using the CKD-EPI 2009, CKD-EPI 2021, and EKFC equations and compared their predictive value of cardiovascular events. The statistical metric used is the net reclassification improvement (NRI) presented separately for those with and those without events. Results: During a mean follow-up of 3.1 ± 0.9 years, the primary endpoint occurred in 559 participants (6.0%). When using the CKD-EPI 2009, the CKD-EPI 2021, and the EKFC equations, the prevalence of CKD (eGFR <60 ml/min/1.73 m Conclusion: Substituting the CKD-EPI 2009 with the CKD-EPI 2021 or the EKFC equation for calculation of eGFR in participants with high cardiovascular risk without diabetes changed the prevalence of CKD but was not associated with improved risk prediction of cardiovascular events for both those with and without the event.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfae011
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Zs.A 6587: Show issues

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Article ; Online: The 2018 ESC/ESH Guidelines for the management of arterial hypertension: A German point of view.

Emrich, Insa E / Böhm, Michael / Mahfoud, Felix

European heart journal

2019 Volume 40, Issue 23, Page(s) 1830–1831

MeSH term(s)	Antihypertensive Agents/therapeutic use ; Blood Pressure/physiology ; Cardiology/organization & administration ; Humans ; Hypertension/therapy ; Practice Guidelines as Topic ; Renal Insufficiency, Chronic
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2019-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehz381
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Zs.MO 640: Show issues

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Article: Therapie der renalen Anämie

Emrich, Insa E. / Böhm, Michael / Heine, Gunnar H.

Dialyse aktuell

2021 Volume 25, Issue 07, Page(s) 280–284

Abstract: Die Einführung von Präparaten mit Erythropoietin (EPO)/Erythropoese stimulierenden Agenzien (ESA) zur Behandlung der renalen Anämie Ende der 1980er-Jahre ermöglichte eine Einsparung von Blutkonserven und eine Verbesserung der Lebensqualität von chronisch ...

Abstract	Die Einführung von Präparaten mit Erythropoietin (EPO)/Erythropoese stimulierenden Agenzien (ESA) zur Behandlung der renalen Anämie Ende der 1980er-Jahre ermöglichte eine Einsparung von Blutkonserven und eine Verbesserung der Lebensqualität von chronisch nierenkranken und v. a. dialysepflichtigen Patienten. Nach den negativen Ergebnissen der großen EPO/ESA-Endpunktstudien Mitte der 1990er-Jahre, erschien mit PIVOTAL 2019 eine randomisierte Studie zur intravenösen Eisentherapie, die eine prognostische Überlegenheit einer Hochdosiseisentherapie gegenüber einer restriktiveren Eisenapplikation zeigte. Mit den HIF-Stabilisatoren (HIF: Hypoxie induzierbarer Faktor) wird jetzt eine weitere – orale – Behandlungsoption der renalen Anämie verfügbar. Phase-II- und Phase-III-Studien zeigten eine Nichtunterlegenheit im Hinblick auf den Hämoglobinanstieg gegenüber einer Behandlung mit EPO/ESA-Präparaten. Da HIF-Stabilisatoren in die Transkription von unterschiedlichsten Genen eingreifen, müssen Sicherheitsstudien weitere wichtige Erkenntnisse liefern.
Language	German
Publishing date	2021-09-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2146225-2
ISSN	1860-3300 ; 1434-0704
ISSN (online)	1860-3300
ISSN	1434-0704
DOI	10.1055/a-1402-8805
Database	Thieme publisher's database

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Zs.A 6979: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Aktuelles zur Herz-Nieren-Interaktion : Zusammenfassung wichtiger klinischer Studien aus 2020.

Emrich, Insa E / Tokcan, Mert / Al Ghorani, Hussam / Schwenger, Vedat / Mahfoud, Felix

Herz

2021 Volume 47, Issue 2, Page(s) 150–157

Abstract: Patients with chronic kidney diseases show an increased cardiovascular morbidity and mortality. Last year a number of important studies on heart-kidney interaction were published, which are summarized and discussed in this article. In the DAPA-CKD study ... ...

Title translation	Current aspects of heart-kidney interactions : Summary of important clinical studies from 2020.
Abstract	Patients with chronic kidney diseases show an increased cardiovascular morbidity and mortality. Last year a number of important studies on heart-kidney interaction were published, which are summarized and discussed in this article. In the DAPA-CKD study and the SCORED study two different sodium-glucose linked transporter 2 (SGLT2) inhibitors (dapagliflozin and sotagliflozin) were found to improve the prognosis of patients with chronic kidney diseases with and without diabetes. The results of the randomized study on the new mineralocorticoid receptor antagonist finerenon (FIDELIO-DKD) also provided a very promising novel treatment approach for patients with diabetic nephropathy. The published data of the ISCHEMIA-CKD study in patients with coronary heart disease and investigations on the influence of transcatheter aortic valve implantation (TAVI) on renal function as well as another study on acute kidney failure after MitraClip® (Abbott, Chicago, IL, USA) implantation provide important indications for future treatment recommendations. The optimal timing of the initiation of kidney replacement therapy in patients with acute kidney damage in intensive care medicine was investigated in two randomized studies, which are correspondingly discussed.
MeSH term(s)	Diabetic Nephropathies/drug therapy ; Humans ; Kidney/physiology ; Renal Insufficiency, Chronic ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Transcatheter Aortic Valve Replacement
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors
Language	German
Publishing date	2021-06-09
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	8262-4
ISSN	1615-6692 ; 0340-9937 ; 0946-1299
ISSN (online)	1615-6692
ISSN	0340-9937 ; 0946-1299
DOI	10.1007/s00059-021-05043-0
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Article ; Online: Niereninsuffizienz im Kontext der kardiopulmorenalen Pathophysiologie.

Schwenger, Vedat / Emrich, Insa E / Mahfoud, Felix / Latus, Jörg / Remppis, Andrew

Der Internist

2021 Volume 62, Issue 11, Page(s) 1153–1165

Abstract: Heart failure and renal insufficiency as well as pulmonary hypertension are pathophysiologically closely associated as a cardio-renal or cardio-pulmonary-renal syndrome. Due to the frequent hospitalization of patients affected by this syndrome, it is of ... ...

Title translation	Renal insufficiency in the context of cardio-pulmonary-renal pathophysiology.
Abstract	Heart failure and renal insufficiency as well as pulmonary hypertension are pathophysiologically closely associated as a cardio-renal or cardio-pulmonary-renal syndrome. Due to the frequent hospitalization of patients affected by this syndrome, it is of high medical and also health economic relevance. Besides the inhibition of the renin-angiotensin-aldosterone system (RAAS), multimodal treatment options are available with mineralocorticoid receptor antagonists, angiotensin receptor-neprilysin inhibitors and sodium-glucose transporter 2 (SGLT-2) inhibitors. Profound knowledge of the pathophysiology and the therapeutic options is as necessary for an optimized medical care as patient-oriented, transdisciplinary and cross-sectoral care.
MeSH term(s)	Angiotensin Receptor Antagonists ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Renal Insufficiency/therapy ; Renin-Angiotensin System ; Stroke Volume
Chemical Substances	Angiotensin Receptor Antagonists ; Mineralocorticoid Receptor Antagonists
Language	German
Publishing date	2021-10-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2913-0
ISSN	1432-1289 ; 0020-9554
ISSN (online)	1432-1289
ISSN	0020-9554
DOI	10.1007/s00108-021-01170-2
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