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  1. Article: Bicyclic pyrrolidine inhibitors of

    Ence, Chloe C / Uddin, Taher / Borrel, Julien / Mittal, Payal / Xie, Han / Zoller, Jochen / Sharma, Amit / Comer, Eamon / Schreiber, Stuart L / Melillo, Bruno / Sibley, L David / Chatterjee, Arnab K

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth ... ...

    Abstract Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth inhibition
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.28.582607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Synthesis of chiral titanium-containing phosphinoamide ligands for enantioselective heterobimetallic catalysis

    Ence, Chloe C / Walker, Whitney K / Stokes, Ryjul W / Martinez, Erin E / Sarager, Spencer M / Smith, Stacey J / Michaelis, David J

    Tetrahedron. 2019 June 14, v. 75, no. 24

    2019  

    Abstract: The synthesis of six chiral titanium-containing phosphinoamide ligands is discussed. These ligands assemble chiral heterobimetallic Pd–Ti complexes, enable enantioselective intramolecular allylic aminations with hindered amine nucleophiles and achieve ... ...

    Abstract The synthesis of six chiral titanium-containing phosphinoamide ligands is discussed. These ligands assemble chiral heterobimetallic Pd–Ti complexes, enable enantioselective intramolecular allylic aminations with hindered amine nucleophiles and achieve selectivity up to 53% ee. Mechanistic studies demonstrate the reversibility of the enantio-determining C–N bond forming step, which leads to a gradual increase in the % ee of the reaction over time. These results represent a rare example of enantioselective heterobimetallic catalysis and suggest that these new ligands could find broad application in enantioselective transition metal catalysis.
    Keywords Lewis bases ; amination ; catalytic activity ; chemical bonding ; chemical structure ; enantioselectivity ; ligands ; organic compounds
    Language English
    Dates of publication 2019-0614
    Size p. 3341-3347.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2019.04.063
    Database NAL-Catalogue (AGRICOLA)

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