Article ; Online: Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
2017 Volume 49, Issue 9, Page(s) 1373–1384
Abstract: We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × ... ...
Abstract | We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10 |
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MeSH term(s) | Adaptor Proteins, Signal Transducing/genetics ; Alzheimer Disease/genetics ; Amino Acid Sequence ; Case-Control Studies ; Exome/genetics ; Gene Expression Profiling ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Immunity, Innate/genetics ; Linkage Disequilibrium ; Membrane Glycoproteins/genetics ; Microglia/metabolism ; Odds Ratio ; Phospholipase C gamma/genetics ; Polymorphism, Single Nucleotide ; Protein Interaction Maps/genetics ; Receptors, Immunologic/genetics ; Sequence Homology, Amino Acid | ||||||||||
Chemical Substances | ABI3 protein, human ; Adaptor Proteins, Signal Transducing ; Membrane Glycoproteins ; Receptors, Immunologic ; TREM2 protein, human ; Phospholipase C gamma (EC 3.1.4.3) | ||||||||||
Language | English | ||||||||||
Publishing date | 2017-07-17 | ||||||||||
Publishing country | United States | ||||||||||
Document type | Journal Article | ||||||||||
ZDB-ID | 1108734-1 | ||||||||||
ISSN | 1546-1718 ; 1061-4036 | ||||||||||
ISSN (online) | 1546-1718 | ||||||||||
ISSN | 1061-4036 | ||||||||||
DOI | 10.1038/ng.3916 | ||||||||||
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Database | MEDical Literature Analysis and Retrieval System OnLINE |
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