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  1. Article: 5-HT2 and 3 receptor antagonists suppress the response of rat type I slowly adapting mechanoreceptor: an in vitro study.

    He, Liang / Tuckett, Robert P / English, Kathleen B

    Brain research

    2002  Volume 969, Issue 1-2, Page(s) 230–236

    Abstract: Previous experiments have shown an increase in rat type I mechanoreceptor responsiveness during arterial serotonin (5-hydroxytryptamine) infusion and the presence of serotonin immunostaining in Merkel cells. The current findings demonstrate that the 5-HT( ...

    Abstract Previous experiments have shown an increase in rat type I mechanoreceptor responsiveness during arterial serotonin (5-hydroxytryptamine) infusion and the presence of serotonin immunostaining in Merkel cells. The current findings demonstrate that the 5-HT(2) antagonists ritanserin and ketanserin, as well as the 5-HT(3) antagonist MDL 72222, reduce type I response to a standardized mechanical stimulus in an in vitro skin preparation. In addition, ritanserin blocked the enhancement of type I response produced by 5-HT. These experiments suggest that serotonin is released during mechanical distortion of the Merkel cell membrane and alters action potential generation by the type I ending. In addition, it is possible that serotonin, released from outside the type I complex, influences mechanoreceptor responsiveness. For example, serotonin generated during inflammatory events could enhance type I response to mechanical stimulation and thereby increase symptoms of mechanical allodynia.
    MeSH term(s) Action Potentials/drug effects ; Adaptation, Physiological ; Animals ; Female ; Free Radical Scavengers/pharmacology ; Ketanserin/pharmacology ; Male ; Mechanoreceptors/drug effects ; Mechanoreceptors/physiology ; Organ Culture Techniques ; Physical Stimulation ; Rats ; Rats, Sprague-Dawley ; Ritanserin/pharmacology ; Serotonin/pharmacology ; Serotonin Antagonists/pharmacology ; Skin/blood supply ; Skin/innervation ; Tropanes/pharmacology
    Chemical Substances Free Radical Scavengers ; Serotonin Antagonists ; Tropanes ; Ritanserin (145TFV465S) ; Serotonin (333DO1RDJY) ; Ketanserin (97F9DE4CT4) ; bemesetron (O98T3677PA)
    Language English
    Publishing date 2002-09-27
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/s0006-8993(03)02335-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Substance P axons and sensory threshold increase in burn-graft human skin.

    Ward, R Scott / Tuckett, Robert P / English, Kathleen B / Johansson, Olle / Saffle, Jeffrey R

    The Journal of surgical research

    2004  Volume 118, Issue 2, Page(s) 154–160

    Abstract: Background: Our knowledge of afferent nerve fiber reinnervation of grafted skin following third-degree burn is limited by a lack of quantitative histological and psychophysical assessment from the same cutaneous area. The current study compares fiber ... ...

    Abstract Background: Our knowledge of afferent nerve fiber reinnervation of grafted skin following third-degree burn is limited by a lack of quantitative histological and psychophysical assessment from the same cutaneous area. The current study compares fiber profile and functional recovery measurements in injured and control skin from the same subject.
    Materials and methods: Nerve regeneration and modality-specific sensory thresholds were compared using immunocytochemical labeling with protein gene product 9.5 antibody to stain all axons and anti-substance P to label substance P axons (which are predominantly unmyelinated), as well as computerized instrumentation to obtain psychophysical estimates.
    Results: Compared to control skin, threshold measures of pinprick (P < 0.001), warming (P < 0.001), touch (P < 0.001), and vibration (P < 0.01) were significantly elevated in burn-graft skin and correlated with histological analysis of skin biopsies obtained from the same site. Immunohistochemical staining of all axons innervating the dermis and epidermis revealed a significant reduction in burn-graft relative to control skin (54% decrease, P < 0.0001). In contrast, the incidence of substance P nerve fibers was significantly elevated in burn-graft (177% increase, P < 0.05) and appeared to correlate with patient reports of pruritus and pain.
    Conclusions: Observations support the hypothesis that sensory regeneration is fiber-size-dependent in burn-graft skin. The findings that substance P fiber growth increased while total fiber count decreased and that thermal threshold showed the greatest degree of functional recovery suggest that unmyelinated neurons have the greater ability to transverse scar tissue and reinnervate grafted skin following third-degree burn injury.
    MeSH term(s) Adult ; Axons/physiology ; Burns/physiopathology ; Dermatologic Surgical Procedures ; Humans ; Middle Aged ; Nerve Regeneration ; Nociceptors/physiology ; Pain/physiopathology ; Pruritus/physiopathology ; Recovery of Function ; Sensory Thresholds ; Skin/innervation ; Skin Transplantation ; Substance P/physiology ; Touch ; Vibration
    Chemical Substances Substance P (33507-63-0)
    Language English
    Publishing date 2004-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/S0022-4804(03)00350-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 178: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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