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  1. Article ; Online: Genomic analysis of cardiac surgery-associated Mycobacterium chimaera infections in Italy.

    Arash Ghodousi / Emanuele Borroni / Marta Peracchi / Giorgio Palù / Loredana Fallico / Mario Rassu / Vinicio Manfrin / Paola Mantegani / Vincenzina Monzillo / Riccardo Manganelli / Enrico Tortoli / Daniela Maria Cirillo

    PLoS ONE, Vol 15, Iss 9, p e

    2020  Volume 0239273

    Abstract: One hundred and twenty-two Mycobacterium chimaera strains isolated in Italy from cardiac surgery-related patients, cardiac surgery-unrelated patients and from heater-cooler units, were submitted to whole-genome sequencing and to subsequent SNP analysis. ... ...

    Abstract One hundred and twenty-two Mycobacterium chimaera strains isolated in Italy from cardiac surgery-related patients, cardiac surgery-unrelated patients and from heater-cooler units, were submitted to whole-genome sequencing and to subsequent SNP analysis. All but one strains isolated from cardiac surgery-related patients belonged to Subgroup 1.1 (19/23) or Subgroup 1.8 (3/23). Only 28 out of 79 strains isolated from heater-cooler units belonged to groupings other than 1.1 and 1.8. The strains isolated from cardiac surgery-unrelated patients were instead distributed across the phylogenetic tree. Our data, the first on isolates from Italy, are in agreement with a recent large genomic study suggesting a common source, represented by strains belonging to Subgroups 1.1 and 1.8, of cardiac surgery-related Mycobacterium chimaera infections. The strains belonging to groupings other than 1.1 and 1.8 isolated from heather-cooler units evidently resulted from contaminations at hospital level and had no share in the Mycobacterium chimaera outbreak. One Mycobacterium chimaera strain investigated in this study proved distant from every previously known Mycobacterium chimaera Groups (1, 2, 3 and 4) and we propose to assign to a novel group, named "Group 5".
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A New Model of Chronic Mycobacterium abscessus Lung Infection in Immunocompetent Mice

    Camilla Riva / Enrico Tortoli / Federica Cugnata / Francesca Sanvito / Antonio Esposito / Marco Rossi / Anna Colarieti / Tamara Canu / Cristina Cigana / Alessandra Bragonzi / Nicola Ivan Loré / Paolo Miotto / Daniela Maria Cirillo

    International Journal of Molecular Sciences, Vol 21, Iss 6590, p

    2020  Volume 6590

    Abstract: Pulmonary infections caused by Mycobacterium abscessus (MA) have increased over recent decades, affecting individuals with underlying pathologies such as chronic obstructive pulmonary disease, bronchiectasis and, especially, cystic fibrosis. The lack of ... ...

    Abstract Pulmonary infections caused by Mycobacterium abscessus (MA) have increased over recent decades, affecting individuals with underlying pathologies such as chronic obstructive pulmonary disease, bronchiectasis and, especially, cystic fibrosis. The lack of a representative and standardized model of chronic infection in mice has limited steps forward in the field of MA pulmonary infection. To overcome this challenge, we refined the method of agar beads to establish MA chronic infection in immunocompetent mice. We evaluated bacterial count, lung pathology and markers of inflammation and we performed longitudinal studies with magnetic resonance imaging (MRI) up to three months after MA infection. In this model, MA was able to establish a persistent lung infection for up to two months and with minimal systemic spread. Lung histopathological analysis revealed granulomatous inflammation around bronchi characterized by the presence of lymphocytes, aggregates of vacuolated histiocytes and a few neutrophils, mimicking the damage observed in humans. Furthermore, MA lung lesions were successfully monitored for the first time by MRI. The availability of this murine model and the introduction of the successfully longitudinal monitoring of the murine lung lesions with MRI pave the way for further investigations on the impact of MA pathogenesis and the efficacy of novel treatments.
    Keywords Mycobacterium abscessus ; mouse model ; chronic lung infection ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Lethal Mycobacterium massiliense Sepsis, Italy

    Enrico Tortoli / Rita Gabini / Irene Galanti / Alessandro Mariottini

    Emerging Infectious Diseases, Vol 14, Iss 6, Pp 984-

    2008  Volume 985

    Keywords Mycobacterium ; Mycobacterium massiliense ; bacteremia ; case report ; immunocompromised ; letter ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2008-06-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Mycobacterium iranicum Infection in HIV-infected Patient, Iran

    Abdolrazagh Hashemi-Shahraki / Parvin Heidarieh / Samira Azarpira / Hasan Shojaei / Mohammad Hashemzadeh / Enrico Tortoli

    Emerging Infectious Diseases, Vol 19, Iss 10, Pp 1696-

    2013  Volume 1697

    Keywords Mycobacterium iranicum ; nontuberculous mycobacteria ; HIV-positive ; HIV infection ; Iran ; bacteria ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2013-10-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mycobacterium yongonense in Pulmonary Disease, Italy

    Enrico Tortoli / Alessandro Mariottini / Piera Pierotti / Tullia M. Simonetti / Gian Maria Rossolini

    Emerging Infectious Diseases, Vol 19, Iss 11, Pp 1902-

    2013  Volume 1904

    Keywords tuberculosis and other mycobacteria ; bacteria ; cavitary pulmonary disease ; respiratory infections ; Italy ; Mycobacterium yongonense ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2013-11-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Mycobacterium sherrisii Pulmonary Disease, Burkina Faso

    Emanuele Borroni / Gisèle Badoum / Daniela Cirillo / Alberto Matteelli / Isidore Moyenga / Martial Ouedraogo / Alberto Roggi / Nuccia Saleri / Elisa Tagliani / Enrico Tortoli

    Emerging Infectious Diseases, Vol 21, Iss 11, Pp 2093-

    2015  Volume 2094

    Keywords Mycobacterium sherrisii ; NTM pulmonary disease ; MDR-TB ; multidrug-resistant tuberculosis ; Burkina Faso ; nontuberculous mycobacteria ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2015-11-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Exportation of MDR TB to Europe from Setting with Actively Transmitted Persistent Strains in Peru

    Fermín Acosta / Juan Agapito / Andrea Maurizio Cabibbe / Tatiana Cáceres / Christophe Sola / Laura Pérez-Lago / Estefanía Abascal / Marta Herranz / Erika Meza / Bernice Klotoe / Patricia Muñoz / Gian María Rossolini / Alessandro Bartoloni / Enrico Tortoli / Daniela María Cirillo / Eduardo Gotuzzo / Darío García de Viedma

    Emerging Infectious Diseases, Vol 25, Iss 3, Pp 596-

    2019  Volume 598

    Abstract: We performed a cross-border molecular epidemiology analysis of multidrug-resistant tuberculosis in Peru, Spain, and Italy. This analysis revealed frequent transmission in Peru and exportation of a strain that recreated similar levels of transmission in ... ...

    Abstract We performed a cross-border molecular epidemiology analysis of multidrug-resistant tuberculosis in Peru, Spain, and Italy. This analysis revealed frequent transmission in Peru and exportation of a strain that recreated similar levels of transmission in Europe during 2007–2017. Transnational efforts are needed to control transmission of multidrug-resistant tuberculosis globally.
    Keywords tuberculosis ; Mycobacterium tuberculosis ; MDR ; migration ; exportation ; transmission ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Unusual Methylobacterium fujisawaense Infection in a Patient with Acute Leukaemia Undergoing Hematopoietic Stem Cell Transplantation

    Rosa Fanci / Giampaolo Corti / Alessandro Bartoloni / Enrico Tortoli / Alessandro Mariottini / Patrizia Pecile

    Case Reports in Medicine, Vol

    First Case Report

    2010  Volume 2010

    Abstract: Microorganisms of the genus Methylobacterium are facultative methylotrophic, gram-negative rods that are ubiquitous in nature and rarely cause human disease, mostly in subjects with preexisting causes of immune depression. Methylobacterium fujisawaense, ... ...

    Abstract Microorganisms of the genus Methylobacterium are facultative methylotrophic, gram-negative rods that are ubiquitous in nature and rarely cause human disease, mostly in subjects with preexisting causes of immune depression. Methylobacterium fujisawaense, first proposed as a new species in 1988, has never been reported as a bacterial agent of human infections so far. Here we describe a case of M. fujisawaense infection in a relapsed acute leukaemia undergoing unrelated allogeneic hematopoietic stem cell transplantation. Molecular identification of an M. fujisawaense strain was obtained from multiple mycobacterial blood cultures.
    Keywords Medicine ; R
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Beijing/W Mycobacterium tuberculosis in Italy

    Nicoletta Lari / Laura Rindi / Daniela Bonanni / Enrico Tortoli / Carlo Garzelli

    Emerging Infectious Diseases, Vol 10, Iss 5, Pp 958-

    2004  Volume 959

    Keywords Tuberculosis ; Mycobacterium tuberculosis ; Beijing/W strains ; Molecular epidemiology ; IS6110 RFLP ; Spoligotyping ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2004-05-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: High prevalence of clustered tuberculosis cases in Peruvian migrants in Florence, Italy

    Lorenzo Zammarchi / Enrico Tortoli / Emanuele Borroni / Filippo Bartalesi / Marianne Strohmeyer / Simonetta Baretti / Maria Tullia Simonetti / Carola Liendo / Maria Grazia Santini / Gian Maria Rossolini / Eduardo Gotuzzo / Alessandro Bartoloni

    Infectious Disease Reports, Vol 6, Iss

    2014  Volume 4

    Abstract: Tuberculosis is a leading cause of morbidity for Peruvian migrants in Florence, Italy, where they account for about 20% of yearly diagnosed cases. A retrospective study on cases notified in Peruvian residents in Florence in the period 2001-2010 was ... ...

    Abstract Tuberculosis is a leading cause of morbidity for Peruvian migrants in Florence, Italy, where they account for about 20% of yearly diagnosed cases. A retrospective study on cases notified in Peruvian residents in Florence in the period 2001-2010 was carried out and available Mycobacterium tuberculosis strains were genotyped (MIRU-VNTR-24 and Spoligotyping). One hundred thirty eight cases were retrieved. Genotyping performed in 87 strains revealed that 39 (44.8%) belonged to 12 clusters. Assuming that in each cluster the transmission of tuberculosis from the index case took place in Florence, a large proportion of cases could be preventable by improving early diagnosis of contagious cases and contact tracing.
    Keywords tuberculosis ; immigrants ; migrants ; cluster ; epidemiology ; Peru ; Italy ; Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2014-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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