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  1. AU="Enrico Valletta"
  2. AU="Patan, Rizwan"
  3. AU=Koretzky Gary A
  4. AU="Vardakas, Georgios"
  5. AU="Fogg, Ryan"
  6. AU="Viviane M. Parra"
  7. AU="Kushner, Adam"
  8. AU="Claude Pasquier"
  9. AU="Guomin Zhang"
  10. AU=van der Donk Lieve E H
  11. AU="Reynaerts, Audrey"
  12. AU="Alberts, Susan C"
  13. AU="Kosicki, Jakub Z"
  14. AU=Eifling Michael
  15. AU="Xing, Xinxin"
  16. AU="Baigun, Claudio"
  17. AU="Abu-Hamad, Ghassan"
  18. AU="Mulla, Zuber D"
  19. AU="Schröder, H"
  20. AU=Ruiz Michael Anthony
  21. AU="Kemmoku, Haruka"
  22. AU="Meseguer, M"
  23. AU="Pillaye, Jayshree"
  24. AU="Andrew Pettitt"
  25. AU="Malawski, M"
  26. AU=Marhofer P
  27. AU=Mandel H G
  28. AU="Duffy, Richard"
  29. AU=Kaseb Hatem AU=Kaseb Hatem
  30. AU=Kong Tak?kwan AU=Kong Tak?kwan
  31. AU=Nagaraja Sridevi
  32. AU="Bu, Yingzi"
  33. AU=Seddighi Hamed AU=Seddighi Hamed
  34. AU="De Keyser, Johan"
  35. AU="Zhenqiang Bi"
  36. AU=Wang Jun
  37. AU=Zhang Fuping
  38. AU="Shatilov, D N"

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  1. Artikel ; Online: Nasal CPAP in the Pediatric Ward to Reduce PICU Admissions for Severe Bronchiolitis?

    Melodie O. Aricò / Diana Wrona / Giovanni Lavezzo / Enrico Valletta

    Pediatric Reports, Vol 15, Iss 4, Pp 599-

    2023  Band 607

    Abstract: In treating acute bronchiolitis in infants, the decision to use continuous positive airway pressure (CPAP) often involves infant referral from the pediatric ward to the pediatric intensive care unit (PICU). We present our experience of CPAP use in a ... ...

    Abstract In treating acute bronchiolitis in infants, the decision to use continuous positive airway pressure (CPAP) often involves infant referral from the pediatric ward to the pediatric intensive care unit (PICU). We present our experience of CPAP use in a general pediatric ward, aiming to reduce the pressure on the PICU in recent outbreaks of bronchiolitis. Clinical data of patients less than 12 months of age and admitted for bronchiolitis from 1 October 2021 to 31 March 2023 were retrospectively collected. Of 82 infants admitted for bronchiolitis, 16 (19%) were treated with nasal CPAP (nCPAP group); of the remaining 66, 21 (26%) were treated with a low-flow nasal cannula (LFNC) only, 1 (1%) was also treated a with high-flow nasal cannula (HFNC), 12 (15%) were treated with an HFNC only, and 41 (50%) were treated without oxygen support (no-nCPAP group). Overall, coinfection with RSV and SARS-CoV-2 was observed in three patients and SARS-CoV-2 infection was observed in two patients. None of them required any type of oxygen support. Only 3/16 (19%) infants in the nCPAP group were referred to the PICU due to worsening clinical conditions despite nCPAP support. In our experience of treating epidemic bronchiolitis, nCPAP can be safely managed in a general pediatric ward, thus reducing the burden of admissions to the PICU. Training and regular updating of the pediatric staff, careful monitoring of the patient, and close cooperation with the PICU were instrumental for our team.
    Schlagwörter bronchiolitis respiratory syncytial virus ; high-flow nasal cannula ; continuous positive air pressure ; oxygen administration ; pediatric ward ; pediatric intensive care unit ; Medicine ; R ; Pediatrics ; RJ1-570
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Tubulointerstitial Nephritis and Uveitis Syndrome in a Twelve-Year-Old Girl

    Alessia Paladini / Vittorio Venturoli / Giovanni Mosconi / Loretta Zambianchi / Luigi Serra / Enrico Valletta

    Case Reports in Pediatrics, Vol

    2013  Band 2013

    Schlagwörter Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Home Management of Children With COVID-19 in the Emilia-Romagna Region, Italy

    Gianluca Vergine / Michela Fantini / Federico Marchetti / Marcello Stella / Enrico Valletta / Giacomo Biasucci / Marcello Lanari / Icilio Dodi / Maurizio Bigi / Anna Maria Magista / Francesca Vaienti / Andrea Cella / Paola Affanni / Maria Carla Re / Vittorio Sambri / Susanna Esposito / The Regione Emilia-Romagna COVID-19 Pediatric Working Group (RERCOPed)

    Frontiers in Pediatrics, Vol

    2020  Band 8

    Abstract: In most children, coronavirus disease 2019 (COVID-19) is a mild or moderate disease. Moreover, in a relevant number of cases, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains totally asymptomatic. All these findings seem to ... ...

    Abstract In most children, coronavirus disease 2019 (COVID-19) is a mild or moderate disease. Moreover, in a relevant number of cases, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains totally asymptomatic. All these findings seem to suggest that otherwise healthy children with suspected COVID-19 might be managed in the community in most cases, thus avoiding hospital admission and closely related medical, social and economic problems, including overwhelming hospitals. Unfortunately, home management of children with suspected COVID-19 rarely occurs, and many children with suspected or laboratory-confirmed SARS-CoV-2 infection are frequently hospitalized irrespective of the severity of disease. To evaluate the role of community health houses (CHHs) in the management of children with COVID-19, 1,009 children with suspected SARS-CoV-2 infection were studied in Emilia-Romagna Region, Italy. Among them, 194 (19.2%) resulted positive for SARS-CoV-2. The majority (583, 58%) were tested at home by CHHs, while 426 (42%) were brought to the hospital for testing. The patients who were managed in the hospital had a significantly lower median age than those who were managed at home (2 vs. 12 years, p < 0.001). Exposure to SARS-CoV-2 cases within the family was significantly more frequent among those who were managed at home (82 vs. 46%, p < 0.05). The clinical findings were similar between the children who were managed at home and those who were managed in the hospital. Only one of the children managed at home (0.7%) required hospitalization; in comparison, 26 (48%) of those whose swab samples were taken at the hospital were hospitalized. Our research shows for the first time the importance of CHHs in the management of COVID-19 in children; because of the high frequency of mild to moderate cases, management by CHHs can reduce the care load in hospitals, providing enormous advantages on the familial, medical, social, and economic levels. These findings could be useful for suggesting a territorial rather than hospital-based strategy in pediatrics in the case of a new wave of the epidemic.
    Schlagwörter community health service ; COVID-19 ; home management ; pediatric infectious diseases ; SARS-COV-2 ; Pediatrics ; RJ1-570 ; covid19
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Gastrointestinal presentation of Kawasaki disease

    Marianna Fabi / Elena Corinaldesi / Luca Pierantoni / Elisa Mazzoni / Chiara Landini / Barbara Bigucci / Gina Ancora / Laura Malaigia / Tetyana Bodnar / Giorgia Di Fazzio / Francesca Lami / Enrico Valletta / Cristina Cicero / Giacomo Biasucci / Lorenzo Iughetti / Federico Marchetti / Paola Sogno Valin / Sergio Amarri / Sandra Brusa /
    Monica Sprocati / Giuseppe Maggiore / Ada Dormi / Paolo Lanzoni / Andrea Donti / Marcello Lanari

    PLoS ONE, Vol 13, Iss 9, p e

    A red flag for severe disease?

    2018  Band 0202658

    Abstract: BACKGROUND:Kawasaki disease (KD) is a febrile systemic vasculitis of unknown etiology and the main cause of acquired heart disease among children in the developed world. To date, abdominal involvement at presentation is not recognized as a risk factor ... ...

    Abstract BACKGROUND:Kawasaki disease (KD) is a febrile systemic vasculitis of unknown etiology and the main cause of acquired heart disease among children in the developed world. To date, abdominal involvement at presentation is not recognized as a risk factor for a more severe form of the disease. OBJECTIVE:To evaluate whether presenting abdominal manifestations identify a group at major risk for Intravenous immunoglobulin (IVIG)-resistance and coronary lesions. METHODS:Retrospective study of KD patients diagnosed between 2000 and 2015 in 13 pediatric units in Italy. Patients were divided into 2 groups according to the presence or absence of abdominal manifestations at onset. We compared their demographic and clinical data, IVIG-responsiveness, coronary ectasia/aneurysms, laboratory findings from the acute and subacute phases. RESULTS:302 patients (181 boys) were enrolled: 106 patients with, and 196 patients without presenting abdominal features. Seasonality was different between the groups (p = 0.034). Patients with abdominal manifestations were younger (p = 0.006) and more frequently underwent delayed treatment (p = 0.014). In the acute phase, patients with abdominal presentation had higher platelet counts (PLT) (p = 0.042) and lower albuminemia (p = 0.009), while, in the subacute phase, they had higher white blood cell counts (WBC) and PLT (p = 0.002 and p < 0.005, respectively) and lower red blood cell counts (RBC) and hemoglobin (Hb) (p = 0.031 and p 0.009). Moreover, the above mentioned group was more likely to be IVIG-resistant (p < 0.005) and have coronary aneurysms (p = 0.007). In the multivariate analysis, presenting abdominal manifestations, age younger than 6 months, IVIG- resistance, delayed treatment and albumin concentration in the acute phase were independent risk factors for coronary aneurysms (respectively p<0.005, <0.005, = 0.005 and 0.009). CONCLUSIONS:This is the first multicenter report demonstrating that presenting gastrointestinal features in KD identify patients at higher risk for ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments

    Federico Marchetti / Maurizio Bonati / Alessandra Maestro / Davide Zanon / Francesca Rovere / Alberto Arrighini / Egidio Barbi / Paolo Bertolani / Paolo Biban / Liviana Da Dalt / Andrea Guala / Elisa Mazzoni / Anna Pazzaglia / Paolo Francesco Perri / Antonino Reale / Salvatore Renna / Antonio Francesco Urbino / Enrico Valletta / Antonio Vitale /
    Tiziana Zangardi / Antonio Clavenna / Luca Ronfani

    PLoS ONE, Vol 11, Iss 11, p e

    Multicenter Double Blind Randomized Controlled Trial.

    2016  Band 0165441

    Abstract: The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in ... ...

    Abstract The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in children with gastroenteritis. After failure of initial oral rehydration administration, children aged 1-6 years admitted for gastroenteritis to the pediatric emergency departments of 15 hospitals in Italy were randomized to receive one oral dose of ondansetron (0.15 mg/kg) or domperidone (0.5 mg/kg) or placebo. The primary outcome was the percentage of children receiving nasogastric or intravenous rehydration. A p value of 0.014 was used to indicate statistical significance (and 98.6% CI were calculated) as a result of having carried out two interim analyses. 1,313 children were eligible for the first attempt with oral rehydration solution, which was successful for 832 (63.4%); 356 underwent randomization (the parents of 125 children did not give consent): 118 to placebo, 119 to domperidone, and 119 to ondansetron. Fourteen (11.8%) needed intravenous rehydration in the ondansetron group vs 30 (25.2%) and 34 (28.8%) in the domperidone and placebo groups, respectively. Ondansetron reduced the risk of intravenous rehydration by over 50%, both vs placebo (RR 0.41, 98.6% CI 0.20-0.83) and domperidone (RR 0.47, 98.6% CI 0.23-0.97). No differences for adverse events were seen among groups. In a context of emergency care, 6 out of 10 children aged 1-6 years with vomiting due to gastroenteritis and without severe dehydration can be managed effectively with administration of oral rehydration solution alone. In children who fail oral rehydration, a single oral dose of ondansetron reduces the need for intravenous rehydration and the percentage of children who continue to vomit, thereby facilitating the success of oral rehydration. Domperidone was not effective for the symptomatic treatment of vomiting during acute gastroenteritis.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments

    Federico Marchetti / Maurizio Bonati / Alessandra Maestro / Davide Zanon / Francesca Rovere / Alberto Arrighini / Egidio Barbi / Paolo Bertolani / Paolo Biban / Liviana Da Dalt / Andrea Guala / Elisa Mazzoni / Anna Pazzaglia / Paolo Francesco Perri / Antonino Reale / Salvatore Renna / Antonio Francesco Urbino / Enrico Valletta / Antonio Vitale /
    Tiziana Zangardi / Antonio Clavenna / Luca Ronfani / SONDO (Study ONdansetron vs DOmperidone) Investigators

    PLoS ONE, Vol 11, Iss 11, p e

    Multicenter Double Blind Randomized Controlled Trial.

    2016  Band 0165441

    Abstract: The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in ... ...

    Abstract The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in children with gastroenteritis. After failure of initial oral rehydration administration, children aged 1-6 years admitted for gastroenteritis to the pediatric emergency departments of 15 hospitals in Italy were randomized to receive one oral dose of ondansetron (0.15 mg/kg) or domperidone (0.5 mg/kg) or placebo. The primary outcome was the percentage of children receiving nasogastric or intravenous rehydration. A p value of 0.014 was used to indicate statistical significance (and 98.6% CI were calculated) as a result of having carried out two interim analyses. 1,313 children were eligible for the first attempt with oral rehydration solution, which was successful for 832 (63.4%); 356 underwent randomization (the parents of 125 children did not give consent): 118 to placebo, 119 to domperidone, and 119 to ondansetron. Fourteen (11.8%) needed intravenous rehydration in the ondansetron group vs 30 (25.2%) and 34 (28.8%) in the domperidone and placebo groups, respectively. Ondansetron reduced the risk of intravenous rehydration by over 50%, both vs placebo (RR 0.41, 98.6% CI 0.20-0.83) and domperidone (RR 0.47, 98.6% CI 0.23-0.97). No differences for adverse events were seen among groups. In a context of emergency care, 6 out of 10 children aged 1-6 years with vomiting due to gastroenteritis and without severe dehydration can be managed effectively with administration of oral rehydration solution alone. In children who fail oral rehydration, a single oral dose of ondansetron reduces the need for intravenous rehydration and the percentage of children who continue to vomit, thereby facilitating the success of oral rehydration. Domperidone was not effective for the symptomatic treatment of vomiting during acute gastroenteritis.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes.

    Giovanna Zanoni / Riccardo Navone / Claudio Lunardi / Giuseppe Tridente / Caterina Bason / Simona Sivori / Ruggero Beri / Marzia Dolcino / Enrico Valletta / Roberto Corrocher / Antonio Puccetti

    PLoS Medicine, Vol 3, Iss 9, p e

    2006  Band 358

    Abstract: Background Celiac disease is a small intestine inflammatory disorder with multiple organ involvement, sustained by an inappropriate immune response to dietary gluten. Anti-transglutaminase antibodies are a typical serological marker in patients with ... ...

    Abstract Background Celiac disease is a small intestine inflammatory disorder with multiple organ involvement, sustained by an inappropriate immune response to dietary gluten. Anti-transglutaminase antibodies are a typical serological marker in patients with active disease, and may disappear during a gluten-free diet treatment. Involvement of infectious agents and innate immunity has been suggested but never proven. Molecular mimicry is one of the mechanisms that links infection and autoimmunity. Methods and findings In our attempt to clarify the pathogenesis of celiac disease, we screened a random peptide library with pooled sera of patients affected by active disease after a pre-screening with the sera of the same patients on a gluten-free diet. We identified a peptide recognized by serum immunoglobulins of patients with active disease, but not by those of patients on a gluten-free diet. This peptide shares homology with the rotavirus major neutralizing protein VP-7 and with the self-antigens tissue transglutaminase, human heat shock protein 60, desmoglein 1, and Toll-like receptor 4. We show that antibodies against the peptide affinity-purified from the sera of patients with active disease recognize the viral product and self-antigens in ELISA and Western blot. These antibodies were able to induce increased epithelial cell permeability evaluated by transepithelial flux of [(3)H] mannitol in the T84 human intestinal epithelial cell line. Finally, the purified antibodies induced monocyte activation upon binding Toll-like receptor 4, evaluated both by surface expression of activation markers and by production of pro-inflammatory cytokines. Conclusions Our findings show that in active celiac disease, a subset of anti-transglutaminase IgA antibodies recognize the viral protein VP-7, suggesting a possible involvement of rotavirus infection in the pathogenesis of the disease, through a mechanism of molecular mimicry. Moreover, such antibodies recognize self-antigens and are functionally active, able to increase intestinal ...
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2006-09-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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