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  1. Article ; Online: Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future.

    Saura-Esteller, José / de Jong, Milon / King, Lisa A / Ensing, Erik / Winograd, Benjamin / de Gruijl, Tanja D / Parren, Paul W H I / van der Vliet, Hans J

    Frontiers in immunology

    2022  Volume 13, Page(s) 915837

    Abstract: γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen presentation, which makes them a highly promising effector cell compartment for cancer immunotherapy. Novel γδ T-cell-based immunotherapies, primarily focusing on the ... ...

    Abstract γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen presentation, which makes them a highly promising effector cell compartment for cancer immunotherapy. Novel γδ T-cell-based immunotherapies, primarily focusing on the two major γδ T-cell subtypes that infiltrate tumors (
    MeSH term(s) Humans ; Immunotherapy ; Intraepithelial Lymphocytes ; Neoplasms ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; T-Lymphocyte Subsets
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.915837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Three‐dimensional tidal flow in a fjord‐like basin with converging width: An analytical model

    Ross, Lauren / de Swart, Huib / Ensing, Erik / Valle‐Levinson, Arnoldo

    Journal of geophysical research. 2017 Sept., v. 122, no. 9

    2017  

    Abstract: A three‐dimensional analytical model was used to understand tidal dynamics in deep and narrow (fjord‐like) basins. This model allows the width of the basin to decay exponentially with along‐channel distance from the mouth. Both the length scale of ... ...

    Abstract A three‐dimensional analytical model was used to understand tidal dynamics in deep and narrow (fjord‐like) basins. This model allows the width of the basin to decay exponentially with along‐channel distance from the mouth. Both the length scale of exponential convergence Lb∗ and the friction parameter Av∗ (vertical eddy viscosity) were the free parameters. Model results show amplification of the tidal amplitude toward the head of the basin. Amplification depends on the narrowing rate of the funnel‐like width of the channel and on friction. Cross‐channel variations in along‐channel tidal flow are also sensitive to the friction parameter. A typical along‐channel tidal flow distribution was found across the channel when the vertical eddy viscosity was characteristic of a basin with strong friction, or the Stokes number was larger than 0.1 (St > 0.1). Maximum along‐channel tidal velocities (ranging from 0.25 to 0.5 m s⁻¹ depending on width convergence strength) were located in the center of the basin and at the surface. Decreasing values of the Stokes number, St < 0.1, resulted in along‐channel velocity maxima located near the lateral boundaries and subsurface in the middle of the channel. These tidal flow distributions were explained by a critical value of St and were verified with observations from Reloncavi Fjord, Chilean Patagonia yielding good agreement.
    Keywords basins ; friction ; models ; research ; viscosity ; Chile
    Language English
    Dates of publication 2017-09
    Size p. 7558-7576.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 161667-5
    ISSN 2169-9291 ; 2169-9275 ; 0148-0227 ; 0196-2256
    ISSN (online) 2169-9291
    ISSN 2169-9275 ; 0148-0227 ; 0196-2256
    DOI 10.1002/2017JC012820
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: GPS based daily activity patterns in European red deer and North American elk (Cervus elaphus): indication for a weak circadian clock in ungulates.

    Ensing, Erik P / Ciuti, Simone / de Wijs, Freek A L M / Lentferink, Dennis H / Ten Hoedt, André / Boyce, Mark S / Hut, Roelof A

    PloS one

    2014  Volume 9, Issue 9, Page(s) e106997

    Abstract: Long-term tracking using global positioning systems (GPS) is widely used to study vertebrate movement ecology, including fine-scale habitat selection as well as large-scale migrations. These data have the potential to provide much more information about ... ...

    Abstract Long-term tracking using global positioning systems (GPS) is widely used to study vertebrate movement ecology, including fine-scale habitat selection as well as large-scale migrations. These data have the potential to provide much more information about the behavior and ecology of wild vertebrates: here we explore the potential of using GPS datasets to assess timing of activity in a chronobiological context. We compared two different populations of deer (Cervus elaphus), one in the Netherlands (red deer), the other in Canada (elk). GPS tracking data were used to calculate the speed of the animals as a measure for activity to deduce unbiased daily activity rhythms over prolonged periods of time. Speed proved a valid measure for activity, this being validated by comparing GPS based activity data with head movements recorded by activity sensors, and the use of GPS locations was effective for generating long term chronobiological data. Deer showed crepuscular activity rhythms with activity peaks at sunrise (the Netherlands) or after sunrise (Canada) and at the end of civil twilight at dusk. The deer in Canada were mostly diurnal while the deer in the Netherlands were mostly nocturnal. On an annual scale, Canadian deer were more active during the summer months while deer in the Netherlands were more active during winter. We suggest that these differences were mainly driven by human disturbance (on a daily scale) and local weather (on an annual scale). In both populations, the crepuscular activity peaks in the morning and evening showed a stable timing relative to dawn and dusk twilight throughout the year, but marked periods of daily a-rhythmicity occurred in the individual records. We suggest that this might indicate that (changes in) light levels around twilight elicit a direct behavioral response while the contribution of an internal circadian timing mechanism might be weak or even absent.
    MeSH term(s) Activities of Daily Living ; Animals ; Circadian Clocks ; Deer/physiology ; Female ; Geographic Information Systems ; Male ; Motor Activity
    Language English
    Publishing date 2014-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0106997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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