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  1. Article ; Online: GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives.

    Nevola, Riccardo / Epifani, Raffaella / Imbriani, Simona / Tortorella, Giovanni / Aprea, Concetta / Galiero, Raffaele / Rinaldi, Luca / Marfella, Raffaele / Sasso, Ferdinando Carlo

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease, affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available for its treatment. Beyond their anti-hyperglycemic effect and the ... ...

    Abstract To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease, affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available for its treatment. Beyond their anti-hyperglycemic effect and the surprising role of cardio- and nephroprotection, GLP-1 receptor agonists (GLP-1 RAs) have shown a significant impact on body weight and clinical, biochemical and histological markers of fatty liver and fibrosis in patients with NAFLD. Therefore, GLP-1 RAs could be a weapon for the treatment of both diabetes mellitus and NAFLD. The aim of this review is to summarize the evidence currently available on the role of GLP-1 RAs in the treatment of NAFLD and to hypothesize potential future scenarios.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/pathology ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/genetics ; Glucagon-Like Peptide-1 Receptor/metabolism ; Liver/metabolism ; Liver/pathology ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology
    Chemical Substances Glucagon-Like Peptide 1 (89750-14-1) ; Glucagon-Like Peptide-1 Receptor
    Language English
    Publishing date 2023-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options.

    Galiero, Raffaele / Caturano, Alfredo / Vetrano, Erica / Beccia, Domenico / Brin, Chiara / Alfano, Maria / Di Salvo, Jessica / Epifani, Raffaella / Piacevole, Alessia / Tagliaferri, Giuseppina / Rocco, Maria / Iadicicco, Ilaria / Docimo, Giovanni / Rinaldi, Luca / Sardu, Celestino / Salvatore, Teresa / Marfella, Raffaele / Sasso, Ferdinando Carlo

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis for type 2 diabetes mellitus (T2DM), while it appears in subjects with ... ...

    Abstract Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis for type 2 diabetes mellitus (T2DM), while it appears in subjects with type 1 diabetes mellitus (T1DM) almost 10 years after the onset of the disease. The impairment can involve both somatic fibers of the peripheral nervous system, with sensory-motor manifestations, as well as the autonomic system, with neurovegetative multiorgan manifestations through an impairment of sympathetic/parasympathetic conduction. It seems that, both indirectly and directly, the hyperglycemic state and oxygen delivery reduction through the vasa nervorum can determine inflammatory damage, which in turn is responsible for the alteration of the activity of the nerves. The symptoms and signs are therefore various, although symmetrical painful somatic neuropathy at the level of the lower limbs seems the most frequent manifestation. The pathophysiological aspects underlying the onset and progression of DN are not entirely clear. The purpose of this review is to shed light on the most recent discoveries in the pathophysiological and diagnostic fields concerning this complex and frequent complication of diabetes mellitus.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetic Neuropathies ; Autonomic Nervous System ; Pain/complications
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors.

    Salvatore, Teresa / Galiero, Raffaele / Caturano, Alfredo / Rinaldi, Luca / Di Martino, Anna / Albanese, Gaetana / Di Salvo, Jessica / Epifani, Raffaella / Marfella, Raffaele / Docimo, Giovanni / Lettieri, Miriam / Sardu, Celestino / Sasso, Ferdinando Carlo

    International journal of molecular sciences

    2022  Volume 23, Issue 7

    Abstract: Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic regulation in diabetes. In addition to their glucose-lowering effects, ... ...

    Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic regulation in diabetes. In addition to their glucose-lowering effects, SGLT2 inhibitors prevent both renal damage and the onset of chronic kidney disease and cardiovascular events, in particular heart failure with both reduced and preserved ejection fraction. These unexpected benefits prompted changes in treatment guidelines and scientific interest in the underlying mechanisms. Aside from the target effects of SGLT2 inhibition, a wide spectrum of beneficial actions is described for the kidney and the heart, even though the cardiac tissue does not express SGLT2 channels. Correction of cardiorenal risk factors, metabolic adjustments ameliorating myocardial substrate utilization, and optimization of ventricular loading conditions through effects on diuresis, natriuresis, and vascular function appear to be the main underlying mechanisms for the observed cardiorenal protection. Additional clinical advantages associated with using SGLT2 inhibitors are antifibrotic effects due to correction of inflammation and oxidative stress, modulation of mitochondrial function, and autophagy. Much research is required to understand the numerous and complex pathways involved in SGLT2 inhibition. This review summarizes the current known mechanisms of SGLT2-mediated cardiorenal protection.
    MeSH term(s) Blood Glucose ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Sodium-Glucose Transporter 2/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Stroke Volume
    Chemical Substances Blood Glucose ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-03-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23073651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study.

    Caturano, Alfredo / Galiero, Raffaele / Vetrano, Erica / Medicamento, Giulia / Alfano, Maria / Beccia, Domenico / Brin, Chiara / Colantuoni, Sara / Di Salvo, Jessica / Epifani, Raffaella / Nevola, Riccardo / Marfella, Raffaele / Sardu, Celestino / Coppola, Carmine / Scarano, Ferdinando / Maggi, Paolo / Calabrese, Cecilia / De Lucia Sposito, Pellegrino / Rescigno, Carolina /
    Sbreglia, Costanza / Fraganza, Fiorentino / Parrella, Roberto / Romano, Annamaria / Calabria, Giosuele / Polverino, Benedetto / Pagano, Antonio / Numis, Fabio Giuliano / Bologna, Carolina / Nunziata, Mariagrazia / Esposito, Vincenzo / Coppola, Nicola / Maturo, Nicola / Nasti, Rodolfo / Di Micco, Pierpaolo / Perrella, Alessandro / Adinolfi, Luigi Elio / Di Domenico, Marina / Monda, Marcellino / Russo, Vincenzo / Ruggiero, Roberto / Docimo, Giovanni / Rinaldi, Luca / Sasso, Ferdinando Carlo

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 1

    Abstract: Background and aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to ... ...

    Abstract Background and aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to deepen our understanding of the specific impact of acute kidney injury (AKI) on the in-hospital mortality in octogenarian patients with COVID-19.
    Methods: This is a prospective observational cohort study, which involved 23 COVID-19 hospital units in the Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. Only patients aged ≥80 years were deemed eligible for the study.
    Results: 197 patients were included in the study (median age 83.0 [82.0-87.0] years; 51.5% men), with a median duration of hospitalization of 15.0 [8.0-25.0] days. From the multivariable Cox regression analysis, after the application of Šidák correction, only the respiratory rate (HR 1.09, 95% CI: 1.04 to 1.14;
    Conclusions: In our investigation, we identified a significant association between AKI and mortality rates among octogenarian patients admitted for COVID-19. These findings raise notable concerns and emphasize the imperative for vigilant monitoring of this demographic cohort.
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14010086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Two copies of isochromosome 5p in refractory cytopenia with multilineage dysplasia: A case report.

    Giudici, Carolina / Lingeri, Riccardo / Patriarca, Carlo / Cavallero, Alessandra / Partenope, Michele / Casasanta, Floredana / Epifani, Raffaella / Giordano, Monica

    Leukemia research reports

    2013  Volume 2, Issue 1, Page(s) 15–17

    Abstract: Isochromosome 5p-i(5)(p10)-represents a rare but recurrent abnormality in myeloid disorders, especially in acute myeloid leukemia. In all published cases, the isochromosome 5p was present in single copy and accompanied by one or more additional anomalies, ...

    Abstract Isochromosome 5p-i(5)(p10)-represents a rare but recurrent abnormality in myeloid disorders, especially in acute myeloid leukemia. In all published cases, the isochromosome 5p was present in single copy and accompanied by one or more additional anomalies, mostly trisomy 8. Here we report a case of refractory cytopenia with multilineage dysplasia with two copies of isochromosome 5p, a single normal chromosome 5and an apparently balanced translocation between long arms of chromosome 7and 10. To our knowledge, the pentasomia 5p has never been described before the presentstudy.
    Language English
    Publishing date 2013-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2706248-X
    ISSN 2213-0489
    ISSN 2213-0489
    DOI 10.1016/j.lrr.2012.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Association between Renal Function at Admission and COVID-19 in-Hospital Mortality in Southern Italy: Findings from the Prospective Multicenter Italian COVOCA Study.

    Galiero, Raffaele / Simeon, Vittorio / Loffredo, Giuseppe / Caturano, Alfredo / Rinaldi, Luca / Vetrano, Erica / Medicamento, Giulia / Alfano, Maria / Beccia, Domenico / Brin, Chiara / Colantuoni, Sara / Di Salvo, Jessica / Epifani, Raffaella / Nevola, Riccardo / Marfella, Raffaele / Sardu, Celestino / Coppola, Carmine / Scarano, Ferdinando / Maggi, Paolo /
    Calabrese, Cecilia / De Lucia Sposito, Pellegrino / Rescigno, Carolina / Sbreglia, Costanza / Fraganza, Fiorentino / Parrella, Roberto / Romano, Annamaria / Calabria, Giosuele / Polverino, Benedetto / Pagano, Antonio / Numis, Fabio Giuliano / Bologna, Carolina / Nunziata, Mariagrazia / Esposito, Vincenzo / Coppola, Nicola / Maturo, Nicola / Nasti, Rodolfo / Di Micco, Pierpaolo / Perrella, Alessandro / Lettieri, Miriam / Adinolfi, Luigi Elio / Chiodini, Paolo / Sasso, Ferdinando Carlo / On Behalf Of Covoca Study Group

    Journal of clinical medicine

    2022  Volume 11, Issue 20

    Abstract: Background. Evidence has shown a close association between COVID-19 infection and renal complications in both individuals with previously normal renal function and those with chronic kidney disease (CKD). Methods. The aim of this study is to evaluate the ...

    Abstract Background. Evidence has shown a close association between COVID-19 infection and renal complications in both individuals with previously normal renal function and those with chronic kidney disease (CKD). Methods. The aim of this study is to evaluate the in-hospital mortality of SARS-CoV-2 patients according to their clinical history of CKD or estimated glomerular filtration rate (eGFR). This is a prospective multicenter observational cohort study which involved adult patients (≥18 years old) who tested positive with SARS-CoV-2 infection and completed their hospitalization in the period between November 2020 and June 2021. Results. 1246 patients were included in the study, with a mean age of 64 years (SD 14.6) and a median duration of hospitalization of 15 days (IQR 9−22 days). Cox’s multivariable regression model revealed that mortality risk was strongly associated with the stage of renal impairment and the Kaplan−Meier survival analysis showed a progressive and statistically significant difference (p < 0.0001) in mortality according to the stage of CKD. Conclusion. This study further validates the association between CKD stage at admission and mortality in patients hospitalized for COVID-19. The risk stratification based on eGFR allows clinicians to identify the subjects with the highest risk of intra-hospital mortality despite the duration of hospitalization.
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11206121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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