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  1. Book: Calcium channel blockers

    Epstein, Stephen E.

    present status and future directions ; symp. held Nov. 17-19, 1983, in Carlsbad, Calif

    (The American journal of cardiology ; 55,3)

    1985  

    Title variant Calcium-channel blockers
    Author's details ed.: Stephen E. Epstein
    Series title The American journal of cardiology ; 55,3
    Keywords Calcium Channel Blockers / therapeutic use / congresses
    Size S. 1B - 221B
    Publisher Dun-Donnelley
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT004677776
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  2. Article ; Online: Persistent Inflammation, Stem Cell-Induced Systemic Anti-Inflammatory Effects, and Need for Repeated Stem Cell Injections: Critical Concepts Influencing Optimal Stem Cell Strategies for Treating Acute Myocardial Infarction and Heart Failure.

    Epstein, Stephen E / Lipinski, Michael J / Luger, Dror

    Journal of the American Heart Association

    2018  Volume 7, Issue 4

    MeSH term(s) Anti-Inflammatory Agents ; Heart Failure ; Humans ; Inflammation ; Myocardial Infarction ; Stem Cells
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2018-02-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.118.008524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mesenchymal Stem Cell Therapy for the Treatment of Heart Failure Caused by Ischemic or Non-ischemic Cardiomyopathy: Immunosuppression and Its Implications.

    Lipinski, Michael J / Luger, Dror / Epstein, Stephen E

    Handbook of experimental pharmacology

    2017  Volume 243, Page(s) 329–353

    Abstract: HF patients with signs and symptoms of worsening heart failure (HF), despite optimal medical therapy, have a poor prognosis. The pathways contributing to HF are multiple, probably accounting, in part, for current treatment approaches not being more ... ...

    Abstract HF patients with signs and symptoms of worsening heart failure (HF), despite optimal medical therapy, have a poor prognosis. The pathways contributing to HF are multiple, probably accounting, in part, for current treatment approaches not being more effective. Stem cells, particularly mesenchymal stem cells (MSCs), have a broad range of activities, making them particularly interesting candidates for a new HF therapeutic. This review presents an overview of the studies examining the efficacy of stem cell studies administered to HF patients, focusing mainly on MSCs. It examines the issues surrounding autologous vs. allogenic stem cells, the results of different routes of administration, and implications deriving from the belief that for stem cells to be effective, they must engraft in the myocardium and exert local effects. Since intravenous administration of stem cells leads to sparse cardiac engraftment, stem cell delivery strategies have uniformly involved catheter-based delivery systems. This becomes problematic in a disease that will almost certainly require delivery of the therapeutic throughout the course of the disease. Importantly, it appears that a critical contributing cause of the progressive cardiac dysfunction experienced by HF patients is the existence of a persistent inflammatory response. Since MSCs exert potent anti-inflammatory effects through paracrine mechanisms, it is possible that intravenous delivery of MSCs may be therapeutically effective. If this concept is valid, it could lead to a transformational change in stem cell delivery strategies.
    MeSH term(s) Cardiomyopathies/complications ; Graft Rejection/prevention & control ; Heart Failure/etiology ; Heart Failure/therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Mesenchymal Stem Cell Transplantation/methods ; Myocardial Ischemia/complications ; Transplantation, Autologous ; Transplantation, Homologous
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2017
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2017_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  4. Article ; Online: Large Animal Model Efficacy Testing Is Needed Prior to Launch of a Stem Cell Clinical Trial: An Evidence-Lacking Conclusion Based on Conjecture.

    Epstein, Stephen E / Luger, Dror / Lipinski, Michael J

    Circulation research

    2017  Volume 121, Issue 5, Page(s) 496–498

    MeSH term(s) Animals ; Clinical Trials as Topic/methods ; Disease Models, Animal ; Evidence-Based Medicine/methods ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Stem Cells/physiology ; Swine ; Treatment Outcome
    Language English
    Publishing date 2017-08-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.117.311562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Paracrine-Mediated Systemic Anti-Inflammatory Activity of Intravenously Administered Mesenchymal Stem Cells: A Transformative Strategy for Cardiac Stem Cell Therapeutics.

    Epstein, Stephen E / Luger, Dror / Lipinski, Michael J

    Circulation research

    2017  Volume 121, Issue 9, Page(s) 1044–1046

    MeSH term(s) Animals ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/therapy ; Humans ; Inflammation/prevention & control ; Injections, Intravenous/methods ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/immunology ; Myocardium/immunology ; Paracrine Communication
    Language English
    Publishing date 2017-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.117.311925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prednisone: the last gasp of immunosuppresive therapy for restenosis prevention.

    Waksman, Ron / Epstein, Stephen E

    European heart journal

    2013  Volume 34, Issue 23, Page(s) 1702–1704

    MeSH term(s) Coronary Restenosis/prevention & control ; Drug-Eluting Stents ; Female ; Humans ; Immunosuppressive Agents/administration & dosage ; Male ; Percutaneous Coronary Intervention ; Prednisone/administration & dosage
    Chemical Substances Immunosuppressive Agents ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2013-06
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/eht125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 640: Show issues

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  7. Article ; Online: The multiple mechanisms by which infection may contribute to atherosclerosis development and course.

    Epstein, Stephen E

    Circulation research

    2002  Volume 90, Issue 1, Page(s) 2–4

    MeSH term(s) Animals ; Aorta/metabolism ; Aorta/pathology ; Arteriosclerosis/etiology ; Arteriosclerosis/genetics ; Arteriosclerosis/microbiology ; Cholesterol, Dietary/administration & dosage ; Helicobacter Infections/microbiology ; Helicobacter pylori ; Lipids/blood ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, LDL/deficiency ; Receptors, LDL/genetics
    Chemical Substances Cholesterol, Dietary ; Lipids ; Receptors, LDL
    Language English
    Publishing date 2002-01-11
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An Aggregate Biomarker Risk Score Predicts High Risk of Near-Term Myocardial Infarction and Death: Findings From BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes).

    Ghasemzadeh, Nima / Brooks, Maria M / Vlachos, Helen / Hardison, Regina / Sikora, Sergey / Sperling, Laurence / Quyyumi, Arshed A / Epstein, Stephen E

    Journal of the American Heart Association

    2017  Volume 6, Issue 7

    Abstract: Background: In a previous study, we found that a biomarker risk score (BRS) comprised of C-reactive protein, fibrin-degradation products, and heat shock protein-70 predicts risk of myocardial infarction and death in coronary artery disease patients. We ... ...

    Abstract Background: In a previous study, we found that a biomarker risk score (BRS) comprised of C-reactive protein, fibrin-degradation products, and heat shock protein-70 predicts risk of myocardial infarction and death in coronary artery disease patients. We sought to: (1) validate the BRS in the independent BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) cohort, (2) investigate whether 1 year of intensive medical therapy is associated with improved BRS, and (3) elucidate whether an altered BRS parallels altered risk.
    Methods and results: Two thousand thirty-two subjects with coronary artery disease were followed for 5.3±1.1 years for cardiovascular events. Biomarkers were measured at baseline and retested in 1304 subjects at 1 year. BRS was determined as the biomarker number above previously defined cut-off values (C-reactive protein >3 mg/L, heat shock protein-70 >0.313 ng/mL, and fibrin-degradation products >1 μg/mL). After adjustment for covariates, those with a BRS of 3 had a 4-fold increased risk of all-cause death and a 6.8-fold increased risk of cardiac death compared with those with a BRS of 0 (95% CI, 2.9-16.0;
    Conclusions: Our results validate the ability of the BRS to identify coronary artery disease patients at very high near-term risk of myocardial infarction/death. After 1 year of intensive medical therapy, the BRS decreased significantly, and the reclassified BRS continued to track with risk. Our results suggest that repeated BRS measurements might be used to assess risk and recalibrate therapy.
    Language English
    Publishing date 2017-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.116.003587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study.

    Aikens, Rachael C / Zhao, Wei / Saleheen, Danish / Reilly, Muredach P / Epstein, Stephen E / Tikkanen, Emmi / Salomaa, Veikko / Voight, Benjamin F

    Diabetes

    2017  Volume 66, Issue 2, Page(s) 543–550

    Abstract: Observational studies have shown that elevated systolic blood pressure (SBP) is associated with future onset of type 2 diabetes, but whether this association is causal is not known. We applied the Mendelian randomization framework to evaluate the causal ... ...

    Abstract Observational studies have shown that elevated systolic blood pressure (SBP) is associated with future onset of type 2 diabetes, but whether this association is causal is not known. We applied the Mendelian randomization framework to evaluate the causal hypothesis that elevated SBP increases risk for type 2 diabetes. We used 28 genetic variants associated with SBP and evaluated their impact on type 2 diabetes using a European-centric meta-analysis comprising 37,293 case and 125,686 control subjects. We found that elevation of SBP levels by 1 mmHg due to our genetic score was associated with a 2% increase in risk of type 2 diabetes (odds ratio 1.02, 95% CI 1.01-1.03, P = 9.05 × 10
    MeSH term(s) Blood Pressure/genetics ; Case-Control Studies ; Causality ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; European Continental Ancestry Group ; Genetic Variation ; Humans ; Mendelian Randomization Analysis ; Odds Ratio ; Polymorphism, Single Nucleotide ; Regression Analysis ; Risk Factors ; Systole
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db16-0868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The dynamics of the coronary collateral circulation.

    Zimarino, Marco / D'Andreamatteo, Mariangela / Waksman, Ron / Epstein, Stephen E / De Caterina, Raffaele

    Nature reviews. Cardiology

    2014  Volume 11, Issue 4, Page(s) 191–197

    Abstract: Coronary collaterals are present at birth, with wide interindividual variation in their functional capacity. These vessels protect jeopardized myocardium, and the number of collaterals and the extent of their coverage are associated with improved ... ...

    Abstract Coronary collaterals are present at birth, with wide interindividual variation in their functional capacity. These vessels protect jeopardized myocardium, and the number of collaterals and the extent of their coverage are associated with improved survival in patients with coronary heart disease. The collateral circulation is not a permanent set of structures, but undergoes dynamic changes with important consequences for cardioprotection. If a severe atherosclerotic lesion develops in an artery supplying tissue downstream of a total occlusion through collateral blood flow, pressure gradients across the collateral bed change. The result is that some of the collateral flow previously supplying the perfusion territory of the totally occluded artery is redirected to the perfusion territory of the donor artery, thus producing a 'collateral steal'. The collateral circulation can regress once antegrade flow in the main dependent artery is re-established, as occurs following the recanalization of a chronic total occlusion. The clinical benefits of coronary revascularization must be cautiously weighed against the risk of reducing the protective support derived from coronary collaterals. Consequently, pharmacological, gene-based, and cell-based therapeutic attempts have been made to enhance collateral function. Although such approaches have so far yielded no, or modest, beneficial results, the rapidly accruing data on coronary collateral circulation will hopefully lead to new effective therapeutic strategies.
    MeSH term(s) Collateral Circulation/physiology ; Coronary Circulation/physiology ; Coronary Disease/physiopathology ; Coronary Vessels/physiopathology ; Hemodynamics/physiology ; Humans
    Language English
    Publishing date 2014-01-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/nrcardio.2013.207
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